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  • responses
  • The basic premise of the eu-FEDS hypothesis is that both soluble and cell surface associated glycoproteins, present in the reproductive system and expressed on gametes, suppress any potential immune responses, and inhibit rejection of the fetus. (wikipedia.org)
  • fetus
  • It is believed that the ancestors of modern viviparous mammals evolved after an infection by this virus, enabling the fetus to better resist the immune system of the mother. (wikipedia.org)
  • regulatory
  • Csf-2, in turn, induces myeloid cells (including dendritic cells and macrophages) to produce regulatory factors like retinoic acid and IL-10, which support the conversion and expansion of regulatory T cells, a population of cells known to be critical for maintaining immune tolerance in the gut. (sciencemag.org)
  • discovery
  • Burnet and Medawar were ultimately credited for "the discovery of acquired immune tolerance" and shared the Nobel Prize in Physiology or Medicine in 1960. (wikipedia.org)
  • The David H. Murdock Research Institute (DHMRI) has acquired the Immune Tolerance Institute (ITI) as part of the North Carolina-based Institute's mission to accelerate the discovery and development of breakthrough treatments for a range of immune-related diseases. (centerwatch.com)
  • prevents
  • In addition, inducing peripheral tolerance in the local microenvironment is a common survival strategy for a number of tumors that prevents their elimination by the host immune system. (wikipedia.org)
  • towards
  • In their Nobel Lecture, Medawar and Burnet define immune tolerance as "a state of indifference or non-reactivity towards a substance that would normally be expected to excite an immunological response. (wikipedia.org)
  • Although
  • Although Owens did not use the term immune tolerance, his study showed the body could be tolerant of these foreign tissues. (wikipedia.org)
  • These data suggest that the use of rituximab combined with FVIII is a potentially useful treatment for patients with inhibitors resistant to standard immune tolerance, although sustained inhibitor eradication is uncommon. (nih.gov)
  • treatment
  • Margaret Petroff believes that decoding additional secrets to immune tolerance could lead to treatment breakthroughs for a variety of conditions. (msu.edu)
  • Margaret Petroff, an associate professor in the Department of Pathobiology and Diagnostic Investigation at Michigan State University (MSU), believes that decoding additional secrets to immune tolerance could lead to treatment breakthroughs for a variety of conditions. (msu.edu)
  • host
  • Though some pathogens can evolve to become less virulent in host-pathogen coevolution, tolerance does not refer to the change in the pathogen, but can be used to describe the changes in host physiology. (wikipedia.org)