Immune system tumor vaccination antigen of tumor. Medical search. Frequent questions

Designed to help HIV-infected patients mount a more vigorous immune response, it was rooted in the principle of non-infectious viral immunization pioneered by Salk in his influenze and polio vaccines, both standards throughout the world today. (wikipedia.org)
Immunotherapies include checkpoint inhibitory antibodies, chimeric antigen receptor (CAR) T-cells, cancer vaccines, and oncolytic viruses. (moffitt.org)
Emerging data suggest that the combination of DC-based vaccination with other cancer therapies may fully unleash the potential of DC-based cancer vaccines and improve patient survival. (moffitt.org)
Since your immune response to COVID-19 vaccination may not be as strong as in people who are not immunocompromised, you may have different recommendations for COVID-19 vaccines. (cdc.gov)
During the last decade a manifold of pre-clinical work was put into investigation of combination of radiotherapy either with additional immune stimulants such as cytokines or vaccines or in combination with antibodies that target immune suppressive molecules such as immune checkpoint inhibitors. (frontiersin.org)
Dendritic cell-based vaccines were tested in many early phase clinical trials in patients with solid tumors, including malignant melanoma. (pbkom.eu)
Our immune systems do a pretty good job of discerning many pathogens and antigens on their own, but vaccines help the immune response to act more quickly to recognize the specific pathogens and antigens that may be harmful if not quickly eradicated. (aimatmelanoma.org)
Preventive vaccines, such as those given to most individuals during childhood, are intended to induce an immune response that will block serious infections by various organisms (mainly bacteria and viruses) or decrease the seriousness of such infection if it occurs. (aimatmelanoma.org)
Most preventive vaccines are not capable of causing illness, other than the typical vaccine reactions resulting from local pain at the injection site (nearly always in a muscle) and a general inflammatory reaction to one or more of the vaccine components-muscle aches, low-grade fever, fatigue-which tend to peak at one to two days after vaccination and then resolve. (aimatmelanoma.org)
Some preventive vaccines are live-attenuated, meaning that the organism itself is used to induce the vaccination, but that organism has been chemically or heat-treated to prevent it from causing fully-developed infection. (aimatmelanoma.org)
Currently, there are two types of preventive COVID-19 vaccines used in the U.S., based on the method they use to deliver the virus genetic material that induces the immune response against Coronavirus: messenger RNA (mRNA) and adenoviral vector. (aimatmelanoma.org)
We believe relapse vaccines will improve survival by putting the patient's immune system back in control. (dcprime.com)
Our team is researching vaccines that could elicit prostate cancer-destructive immune responses," McNeel said. (bioforward.org)
The clinical trial process will help to understand how prostate cancer interacts with the immune system and evaluate antigen-specific DNA vaccines. (bioforward.org)
In certain lymphomas, the immunoglobulin antigen that the lymphoid cell is supposed to be producing becomes mutated, and hence a potential target for vaccines. (oncolink.org)
The main reason, however, is that if Vaccines against cancer are to become the norm one day, various effective strategies must be explored to provide specific immune cells with essential key information. (mpg.de)
The polymer-based nanocarrier is a helpful toolbox to further evaluate antigen-specific vaccines and to develop further vaccine-based therapeutic concepts against cancer,' Nuhn is convinced. (mpg.de)
One thing must be said, however: Several years of further research will be needed before such vaccines can cure patients of tumors. (mpg.de)
Formulation of specific antigens and adjuvants that induce adaptive protecting immune responses against pathogens causing diseases (prophylactic vaccines) or against established tumors (therapeutic vaccines). (invivogen.com)
Despite getting implicated in security against serious pertussis (14 15 degrees of preexposure individual serum antibodies towards the main vaccine antigens haven't been solely correlated with the efficiency of pertussis vaccines (16 -18). (bio-biz-navi.com)
Understanding peculiarities within the display from the organic Compact disc4+ T cell epitope repertoire on MDDC such as for example solid epitope domination FLJ14848 can help to elucidate weaknesses within the individual cellular immune system reaction to pertussis and could provide leads on how best to style new years of pertussis assays and vaccines. (bio-biz-navi.com)
This is one area in which DC vaccines, because of their ability to prime immune responses, could make a big difference. (nature.com)
So far, however, we have seen a discrepancy between the immunogenicity of DC vaccines and their clinical efficacy - for example, some patients who get an immune boost in response to the vaccine nevertheless show no tumour regression. (nature.com)
If vaccines have been very efficient at inducing antibodies to prevent new infections, until now, vaccines are less efficient at inducing T-cell immunity required to kill cancer cells, because tumors targets are self-antigens that have already been tolerized (contrary to a foreign antigen found in virus, bacteria or other pathogens). (telomium.com)
ACIP statements on individual vaccines or immune globulins should be consulted for more details on safety and efficacy and on the epidemiology of the diseases. (cdc.gov)
The final section contains summary tables on the use of vaccines and immune globulins, arranged by immunocompromising condition. (cdc.gov)

IRC described the vaccination treatment as utilizing antigen-presenting dendritic cells to stimulate responses to tumor antigens. (wikipedia.org)
First, many cancers acquire mutations that enable them to switch off or circumvent immune system responses that would otherwise make them vulnerable to attack. (newstatesman.com)
Immunotherapy is a promising approach for many oncological malignancies, including glioblastoma, however, there are currently no available tools or biomarkers to accurately assess whole-body immune responses in patients with glioblastoma treated with immunotherapy. (aacrjournals.org)
BACKGROUND: Pneumococcal infections are a major cause of morbidity and mortality in young children and immaturity of the immune system partly underlies poor vaccine responses seen in the young. (ox.ac.uk)
The study aimed to investigate epigenetic changes in early life and to understand the relationship between the epigenome and antigen-specific antibody responses to pneumococcal vaccination. (ox.ac.uk)
Dendritic cells (DC) are responsible for initiating all antigen-specific immune responses. (aacrjournals.org)
Importantly, DCs also help guide the immune system to respond to foreign antigens while avoiding the generation of autoimmune responses to self. (aacrjournals.org)
Upon completion of this activity, the participant should understand the critical roles of dendritic cells in guiding host immune responses, and the details of how they mature, process, and present antigens. (aacrjournals.org)
The TLRs are found to be functionally involved in the recognition of self and non-self-antigens, maturation of DCs and initiation of antigen-specific adaptive immune responses as they bridge innate and adaptive immunity. (tcdb.org)
Immune responses to antigens originating in the central nervous system (CNS) are generally attenuated, as collateral damage can have devastating consequences. (xstrahl.com)
The B16 murine melanoma model was used to compare cytotoxic responses against established tumors in the CNS and in the periphery. (xstrahl.com)
Natural killer (NK) cells are cytotoxic lymphocytes which constitute a significant element of innate immune responses against tumours and cells infected with viruses or parasites. (pbkom.eu)
We are also investigating tissue Tregs and have recently found important roles for these cells in regulating the early innate immune response in both type 1 and type 2 responses. (massgeneral.org)
Projects in the lab are currently aimed at uncovering roles for antigen-specific tissue Tregs in regulating antigen-specific resident memory effector T cell responses in tissue. (massgeneral.org)
We hypothesised that its sustained clinical responses could be related to the stimulation of an anti-cancer immune response. (biomedcentral.com)
Ultimately, ADCs using dolastatins induce DC homing and activate cellular anti-tumour immune responses in patients. (biomedcentral.com)
Yu and co-workers showed that just the mix of chemotherapy with in situ DC vaccination induced effective antigen-specific Compact disc8+ and Compact disc4+ T-cell mediated replies within an advanced-stage breasts Flumazenil cancer tumor model, whereas neither chemotherapy nor DC inoculation elicited antitumor immune system responses when used as single remedies [64]. (antiviralbiologic.com)
Latest scientific trials showed the efficacy of in situ DC vaccination in achieving immunological and scientific responses. (antiviralbiologic.com)
However, extremely strong immune responses have been generated using a "boost" to the immune system, provided by viruses that encode antigens similar to the target. (oncolink.org)
In fact, immature dendritic cells can actually cause the suppression of responses to antigen. (oncolink.org)
Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors. (mpg.de)
Biological tools can be used to either strengthen natural immunity in the context of infectious diseases and cancers or dampen immune responses in the context of auto-immune diseases/inflammatory conditions . (invivogen.com)
Co-inhibitory or co-stimulatory molecules expressed at the surface of immune cells that act as gatekeepers of immune responses. (invivogen.com)
Engineered recombinant antibodies coupled to synthetic PRR ligands that potentiate immune responses by triggering the production of pro-inflammatory cytokines and chemokines. (invivogen.com)
This property favored the induction of strong CD4+ T as well as CD8+ T cell-mediated immune responses against the NY-ESO-1. (fiocruz.br)
Healthy humans develop spontaneous CD8+ T cell responses to melanoma associated antigens (MA) expressed by normal melanocytes. (mdpi.com)
Induction of anti-inflammatory T helper (T H )2 responses via epitope spreading may be an important intrinsic immunoregulatory mechanism geared to limit tissue destruction and promote re-establishment of tissue-specific immune tolerance. (nature.com)
Dendritic cells (DCs) provide an essential link between the innate and adaptive immune responses. (nature.com)

Urbain's idiotypic research showed a "dramatic enhancement of an antiviral immune response by dendritic cells," thus demonstrating the principle of a dendritic cell-enhanced immunity by means of anti-idiotype antibodies. (wikipedia.org)
Due to their proficiency at antigen presentation, DCs are key coordinators in the induction of antitumor immunity. (moffitt.org)
The adaptive immune system, discovered by Paul Ehrlich, involves the production of circulating antibodies that can provide long lasting, systemic immunity that is specific to antigens expressed by a given pathogen. (aacrjournals.org)
These data suggest that CNS tumors may impair systemic antitumor immunity and consequently accelerate cancer progression locally as well as outside the CNS, whereas antitumor immunity may be restored by combining vaccination with radiation therapy. (xstrahl.com)
In recent years there has been a shift in perception of DCs not only as inducers of immune reactivity but also as crucial regulators of immunity, which include ability to induce and maintain tolerance and also as effector cells, which are capable to kill tumor cells (NKDCs). (pbkom.eu)
Research in the Luster lab is varied and has historically focused on chemokines, immune cell trafficking, and resident memory effector and regulatory cells in regulating tissue immunity. (massgeneral.org)
Trm provide the first line of antigen-specific immunity in the tissue and enhanced local immune memory. (massgeneral.org)
Projects are aimed at uncovering the factors and genetic programs that lead to CD8 + Trm differentiation, function and maintenance in the lung to develop new vaccination strategies to improve protective immunity at barrier surfaces. (massgeneral.org)
In 1796, Edward Jenner used cowpox vaccinations to induce immunity to smallpox. (oncolink.org)
Studies to antigen uptake, processing and presentation to T cells, the biology of dendritic cells and the regulation of immunity are aimed to raise our understanding of the immune reactions to tumor cells and improve immunotherapy of cancer. (universiteitleiden.nl)
Dijke, P. ten & Cruz, L.J. (2023), Enhancing anti-tumor immunity through liposomal oxaliplatin and localized immunotherapy via STING activation, Journal of Controlled Release 357: 531-544. (universiteitleiden.nl)
Knowledge of defensive adaptive immunity and its own weaknesses is vital for all of us to have the ability to improve pertussis vaccination. (bio-biz-navi.com)
Immunity results from a complex interplay between the adaptive immune system (which is antigen-specific) and the innate immune system (which isn't). (nature.com)
The generation of anticancer immunity depends on DCs presenting cancer antigens to T cells. (nature.com)
The relationships among stress, coping, and immunity are explored after separate discussions of major conceptual models of stress, the strategies people use to cope with stress, and the growing literature on stress-related immune changes. (iresearchnet.com)
Studies indicate some immunocompromised people do not always build as high a level of immunity after vaccination as immunocompetent people do. (affinitycare.nhs.uk)

One unifying principle under investigation is determining the role of specific chemokine systems in establishing tissue niches for the differentiation and maintenance of specific T cell populations, such as resident memory T cells in the lung and stem-like CD8 + and CD4 + T cells in the tumor microenvironment. (massgeneral.org)
3. Effects of ICD Hallmarks on Immune Cells in Tumor Microenvironment The definition of apoptosis like a non-immunogenic, but silent or tolerogenic, physiological process has been progressively questioned after ICD finding. (antiviralbiologic.com)
CyPep-1 eliminates cancer cells by forming pores in the plasma membrane, releasing cancer specific antigens to the immune system, promoting an inflammatory microenvironment and inducing a tumor-specific immune response by in situ vaccination. (cytovation.com)

Antibodies recognize specific configurations (epitopes, or antigenic determinants) on the surfaces of antigens (eg, proteins, polysaccharides, nucleic acids). (msdmanuals.com)
Ambirix vaccine contains inactivated (killed) hepatitis A virus and 'surface antigen' (proteins from the surface) parts of the hepatitis B virus as active substances. (precisionvaccinations.com)
Researchers have identified proteins produced early in the development of multiple types of cancer that the immune system can recognize as foreign and therefore mount an attack against. (dogcancer.com)
These proteins are called tumor antigens. (dogcancer.com)
The purpose of this study is to determine if vaccination with these proteins could prime the immune system to identify cancer in the early stages and defend against it. (dogcancer.com)
One insight is the identification of tumor antigens (small proteins recognized as "foreign" by the immune system) that stimulate the T-cells of the immune system. (oncolink.org)
To improve the immunogenicity of idiotype proteins we utilized dendritic cells (DCs) as antigen-presenting cells. (tech-strategy.org)
Epitope spreading is defined as the diversification of epitope specificity from the initial focused, dominant epitope-specific immune response, directed against a self or foreign protein, to subdominant and/or cryptic epitopes on that protein (intramolecular spreading) or other proteins (intermolecular spreading). (nature.com)
The important components of this system are various cell membrane-associated proteins such as complement receptor 1 (CR1), complement receptor 2 (CR2), and decay accelerating factor (DAF). (medscape.com)
Proteins and cells in the blood are also part of the immune system. (medlineplus.gov)
When the immune system detects an antigen, it responds by producing proteins called antibodies that destroy the harmful substances. (medlineplus.gov)

Expose the body to harmless fragments (antigens) from disease-causing viruses or bacteria and our immune system will produce antibodies and white blood cells (T cells) to attack what it recognises as foreign material. (newstatesman.com)
It drives a significant immune response in the breast and helps the Herceptin and Perjeta antibodies to create a more complete response. (moffitt.org)
Antibodies and antigens fit tightly together because their shape and other surface properties (eg, charge) are complementary. (msdmanuals.com)
Immune checkpoint inhibitors such as the anti-programmed death 1 (PD-1) receptor antibodies have recently been approved to treat relapsed and refractory cHL and have significantly improved the outcome of patients with rrcHL. (wjon.org)
Predicated on the specificity from the immune system effector substances and cells immunotherapies with particular T cells or healing antibodies may represent book strategies for the treating multiple myeloma soon. (tech-strategy.org)
The cancer immunotherapy field has made tremendous progress, thanks to the development of antibodies against immune-suppressing molecules, such as PD-1 and CTLA-4, that are expressed by cancer cells. (nature.com)
The antibodies against the SARS-CoV-2 can be produced after vaccination, to prevent the COVID-19 disease caused by SARS-CoV-2 virus. (who.int)

After each injection, we saw an expansion of T cells specific to the vaccine antigens in his blood, so it was clear that the DC treatment boosted the immune response against the cancer. (nature.com)

Xstrahl, a global leader in the delivery of superficial radiation therapy devices and preclinical radiation research systems, announced its Radiant™ Aura treatment solution has received U.S. Food and Drug Administration (FDA) 510(k) clearance. (xstrahl.com)
In its collaboration with the University of Bergen, Norway, DCprime has established a preclinical mouse model to study DCP-001 vaccinations in monotherapy and in combination therapy settings. (dcprime.com)
In preclinical studies, which will be presented at the upcoming 2019 CIMT Annual Meeting, DCprime was able to demonstrate that human antigen presenting cells (APCs) efficiently process DCP-001 through phagocytosis. (dcprime.com)

This CMN-001 is an autologous, tumor antigen-loaded dendritic cell immunotherapy. (moffitt.org)
The active components of CMN-001 are autologous, matured dendritic cells, which have been co-electroporated with both in vitro transcribed (IVT) RNA from an autologous tumor specimen and CD40L RNA. (moffitt.org)
Indeed, if antigen identification and their immunogenicity definition are expensive and time-consuming, the planning of tumor cell lysates is certainly at the mercy of restrictions also, among which, mainly, the paucity of autologous tumor cells amenable to ex girlfriend or boyfriend vivo manipulation. (antiviralbiologic.com)
The CTLs got solid cytotoxic activity against autologous tumor lysate-pulsed DCs and major myeloma cells. (tech-strategy.org)

show that exposing cells of the adaptive immune system, namely T cells, to radiation even results in their Ca2 + -dependent activation. (frontiersin.org)
B cells and T cells of the adaptive immune system use receptors that recognize antigens, or their derived peptides, in a highly specific manner. (nature.com)

3 Vaccination of mice with these antigens showed promising results, delaying or preventing multiple cancer types without side effects. (dogcancer.com)
Cytokine analysis of tissues from brain tumor-bearing mice detected elevated TGFβ secretion from microglia and in the serum and TGFβ signaling blockade reversed tolerance of tumor antigen-directed CD8 T cells. (xstrahl.com)
Underlining the requirement of an intact host immune system for the full therapeutic benefit of dolastatins, the anti-tumour effect was far less pronounced in immune-compromised mice. (biomedcentral.com)
The data which were presented yesterday at the 7th CCBIO Annual Symposium showed that DCP-001 was able to suppress tumor growth in humanized immunocompetent mice. (dcprime.com)
Importantly, the vaccination significantly delayed the tumor development and prolonged the mice survival, highlighting the potential application of CNTs as a vaccine delivery system to provide superior immunogenicity and strong protection against cancer. (fiocruz.br)
Immunization using the fusion cells secured mice against tumor problem and expanded the success of tumor-established mice without eradication from the tumor cells. (tech-strategy.org)
The researchers found that a single vaccination with the antigen α-lactalbumin prevents breast cancer tumors from forming in mice, while also inhibiting the growth of already existing tumors. (biopharminternational.com)
In the study, genetically cancer-prone mice were vaccinated-half with a vaccine containing α-lactalbumin and half with a vaccine that did not contain the antigen. (biopharminternational.com)

Toll-like receptors (TLRs) control immune functions. (tcdb.org)
The tripartite TLRs are type I integral transmembrane receptors that are involved in recognition and conveying of pathogens to the immune system. (tcdb.org)
Due to the presence of specific receptors dendritic cells (DCs) are able to respond to both intra- and extracellular antigens. (pbkom.eu)

While low radiation doses mostly seem to enhance immune cell infiltration into tumors, higher doses do induce immunogenic cancer cell death, and create an immune stimulatory micro-environment for the attracted immune cells. (frontiersin.org)
These in vitro data suggest that in vivo, upon intradermal injection, DCP-001 will induce a strong inflammatory response, and is ingested by both resident and attracted host APCs, which subsequently prime tumor-reactive T cells. (dcprime.com)
Co-stimulatory molecules are presenting along with the antigen by APCs to induce an aggressive response by the T-cells. (oncolink.org)
She also discussed clinical trials that combine immunotherapies with each other or other anti-cancer treatments to help induce an immune response to fight cancer. (cancerresearch.org)
The aim of DC vaccination is to boost cancer-specific effector T cells that can not only fight existing cancer but also induce immunological memory to control the recurrence of cancer. (nature.com)

Patients who received a stem cell transplant or engineered cellular therapy, such as chimeric antigen receptor-T cell therapy, especially within the past two years. (y105fm.com)

The cellular or innate immune system was first described by the pathologist Elie Metchnikoff who recognized the existence of cells in the blood and tissues whose role was to identify, capture, and destroy invading pathogens. (aacrjournals.org)
Areas of interest included the role of resident memory T cells in the lung in response to allergens in the asthmatic lung and to respiratory viral pathogens, such as SARS-CoV-2 and influenza, as well to vaccination. (massgeneral.org)
It promotes the inflammatory response, eliminates pathogens, and enhances the immune response. (medscape.com)
Although the complement system is part of the body's innate, relatively nonspecific defense against pathogens, its role is hardly primitive or easily understood. (medscape.com)
The immune system prevents pathogens (like virus, bacteria, fungus…) to invade the human body. (telomium.com)
The immune system produces antibody to neutralize pathogens at distance, but it also kills cells that have already been infected. (telomium.com)
The immune system is made to tolerate the self and to destroy the non-self (pathogens). (telomium.com)

ImmuneFx is a therapeutic vaccine candidate which expresses a bacterial antigen on the surface of a patient's own tumor cells. (precisionvaccinations.com)
When combining dolastatins with tumour-antigen-specific vaccination or blockade of the PD-1/PD-L1 and CTLA-4 co-inhibitory pathways, we observed substantial therapeutic synergies. (biomedcentral.com)
For optimal delivery, the adjuvants can be encapsulated in nanoparticles, liposomes, or immunostimulatory complexes specifically targeting DCs [61,62,63], whereas to guarantee a sufficient availability of immunogenic TAAs, in situ vaccination can be combined with ICD-inducing therapeutic modalities, such as doxorubicine or radiotherapy. (antiviralbiologic.com)
The authors also present updated therapeutic and molecular research advancements in these childhood tumors. (medlink.com)
Increasing knowledge on immune regulation mechanisms and technical advancements have allowed moving from broad to more precise therapeutic strategies. (invivogen.com)
Therapeutic vaccination has the major advantage that the induced immune response selectively attacks tumors while leaving the healthy cells untouched. (universiteitleiden.nl)

Dr. Friedman's overarching goal is to improve outcomes for children with brain tumors, by developing and improving novel, targeted immunotherapies in the lab and then translating these therapies to clinical trials. (rallyfoundation.org)
The significance of this finding for the efficacy of tumor-targeted immunotherapies is largely unknown. (xstrahl.com)

In addition to the direct cytotoxic effect on tumour cells, dolastatins efficiently promoted antigen uptake and migration of tumour-resident DCs to tumour-draining lymph nodes. (biomedcentral.com)
Autologous vaccination with activated autologous dendritic cells (DC) or peripheral blood mononuclear cells (PBMC) which have been exposed to CEA peptide 1 in vitro may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing CEA, thereby inhibiting tumor growth. (medicalterminologydb.com)
Fusions with older in comparison with immature DCs induced higher degrees of T-cell proliferation and activation as evaluated by intracellular IFN-γ appearance and more powerful cytotoxic T-cell activity against the tumor cells. (tech-strategy.org)

One of the promising, less harmful approaches to treatment is virotherapy, a type of immunotherapy that utilizes a virus to kill cancer cells and to stimulate the immune system to attack the tumor. (rallyfoundation.org)
Myeloma plasma cells and myeloma-specific T cells Myeloma tumor cells may include a large number of tumor antigens that may stimulate an elevated repertoire of YIL 781 anti-tumor T cells and result in an induction of more powerful antimyeloma replies. (tech-strategy.org)

These dendritic cells are like immune system factories and make other molecules that activate critical parts of the innate and adaptive immune system. (moffitt.org)
As such, they are the master regulators of the immune response and serve this function by linking the microbial sensing features of the innate immune system to the exquisite specificity of the adaptive response. (aacrjournals.org)
It has long been appreciated that the innate and adaptive arms of the immune system must be coordinated, but it was not until the discovery of dendritic cells (DC) by Ralph Steinman at The Rockefeller University in the early 1980s that we truly understood conceptually how the immune system functions as a coherent unit. (aacrjournals.org)
This review focuses on the latest research showing a high redundancy of mechanisms regulating the activity of NK cells during viral infections and indicating their involvement in the adaptive immune response. (pbkom.eu)
New studies point to the complex interplay between the complement cascade and adaptive immune response, and complement is also being studied in association with ischemic injury as a target of therapy. (medscape.com)

As noted above, a more vigorous dendritic cell presentation of antigens could trigger the immune response by T-cells. (oncolink.org)

The Immune Response Corporation (IRC) was a pharmaceutical company that worked in the development immunotherapeutic products. (wikipedia.org)
The Immune Response Corporation filed a patent on this invention entitled: "Idiotypic Vaccination Against B-Cell Lymphoma" in May 1990. (wikipedia.org)
The inference is that, in many cases, cancers that arise within our bodies are controlled or even eradicated by an immune response before they can cause us harm. (newstatesman.com)
First, it can infect and kill cancer cells while stimulating a robust immune response against the tumor. (rallyfoundation.org)
As the virus replicates, the foreign gene can enable the production of substances that enhance the immune response against the tumor. (rallyfoundation.org)
Changes in epigenetic profiles throughout early childhood and their relationship to the response to pneumococcal vaccination. (ox.ac.uk)
They are exceptionally efficient at antigen presentation and also adept at generating just the right type of T cells in response to a given pathogen. (aacrjournals.org)
Given their central role in controlling the immune response in patients with cancer, DCs are emerging as a critical cell type that must be considered as we come to understand basic cancer immunobiology. (aacrjournals.org)
CDC has updated select ways to operate healthcare systems effectively in response to COVID-19 vaccination. (cdc.gov)
and, in response to antigen, are subsequently secreted by plasma cells. (msdmanuals.com)
The role of chemokines in regulating the immune response to tumors and cancer immunotherapy is also studied. (massgeneral.org)
Studies on SARS-CoV-2 in the lab focus on strategies to increase the breadth and cross-reactivity of the T and B cell response to vaccination to generate a pan coronavirus vaccine. (massgeneral.org)
Post-vaccination exposure to any of these organisms generally induces a highly protective and boosting immune response in your body, in most cases making it unnecessary to repeat the vaccine series or to receive a booster vaccination. (aimatmelanoma.org)
In fact, specific anticancer medicines (such as anthracyclines or platinum compounds) and physical restorative modalities can promote the modulation of a subset of DAMPs in malignancy cells that are capable of inducing both apoptosis and an antigen-specific immune response [72]. (antiviralbiologic.com)
Active immunotherapy against cancer is less effective, mainly because cancer cells have developed strategies to escape the normal immune response. (oncolink.org)
The vaccine formulations targeting these antigens have caused a relatively weak immune response. (oncolink.org)
Recently, cells called antigen presenting cells (APCs) were discovered to play a pivotal role in the immune response. (oncolink.org)
Granulocyte macrophage colony stimulating factor (GM-CSF) is another chemical that stimulated the maturation of dendritic cells and which could be used to augment the immune response. (oncolink.org)
And: 'By binding them to nanopolymers, we were able to throttle the immune response to the desired level,' explains Nuhn. (mpg.de)
These cell lines proliferated in response to autologous major myeloma cells and DCs pulsed with autologous however not allogeneic tumor lysate and secreted mostly IFN-γ and tumor necrosis aspect (TNF)-α indicating they are YIL 781 type-1 T cells (Th1 and Tc1). (tech-strategy.org)
The immune response consists of an initial magnification phase, which can either be deleterious as in autoimmune disease or beneficial as in vaccinations, and a later downregulatory phase to return the immune system to homeostasis. (nature.com)
Animal models have therefore been useful, as the peptide specificity of the initial immune response can be manipulated, genetically identical animals used, and the immune response over time in different lymphoid organs and in the target tissue can be assessed. (nature.com)
Treatment of human autoimmune diseases must take into consideration the dynamic nature of both the magnification and downregulatory phases of the immune response. (nature.com)
Evidence continues to accumulate supporting the hypothesis that tissue damage during an immune response can lead to the priming of self-reactive T and/or B lymphocytes, regardless of the specificity of the initial insult. (nature.com)
This also alters the primary and secondary immune response," said Dörner. (medscape.com)
Wounds heal more poorly, the protective action against infections and above all malignancies, as well as the immune response to vaccinations, decreases. (medscape.com)
One reason could be that if there isn't a pre-existing immune response against the cancer, blocking these molecules may not be enough. (nature.com)
Ribonucleoproteins released outside cells are interpreted by the immune system as a virus escaping the classical immune response, thus requiring a more profound and diverse immune response. (telomium.com)
higher doses or more frequent boosters may be required, although even with these modifications, the immune response may be suboptimal. (cdc.gov)
Stress becomes detrimental when coping strategies are ineffective, demands exceed ability to cope, or activation of psychological, behavioral, and physiological response systems is sustained or unusually intense. (iresearchnet.com)
Although all stress response systems work in concert, the immune system has received considerable attention because of its role in infection and disease. (iresearchnet.com)
Because both biological and psychological response systems are activated, some theorists argue that stress is an emotion. (iresearchnet.com)
Immunodeficiency disorders occur when the body's immune response is reduced or absent. (medlineplus.gov)
The immune system response also involves a process called phagocytosis. (medlineplus.gov)

Rather than attempting to determine the exact antigen on the cancer cells themselves, an alternative approach has been to isolate and to study the immunogobulins that our bodies have produced in recognition of these foreign antigens. (oncolink.org)
These cells, such as dendritic cells, process foreign antigens and then present them to T-cells, causing their intense activation. (oncolink.org)

As a Rally Researcher and the primary investigator at the University of Alabama at Birmingham, Gregory Friedman, M.D. is devoted to studying malignant brain tumors in hopes of developing new and improved immunotherapies to treat children with recurrent tumors. (rallyfoundation.org)
Over the last 30 years, treatment for pediatric malignant brain tumors has improved marginally, with enhancements made in surgical techniques, new strategies for delivering radiation, and a few new traditional chemotherapy agents. (rallyfoundation.org)
The team's first-generation virus is currently in a Phase I clinical trial for children with brain tumors and has, so far, shown great promise. (rallyfoundation.org)
Pediatric-type diffuse high-grade gliomas continue to be one of the most difficult types of brain tumors to treat in children, given their infiltrative nature and low probability of successful gross total resection. (medlink.com)
Recognizing that brain tumors contained heterogeneous cell populations, gliomas were classified based on the morphological appearance and presumed histogenesis of the predominant cell type. (medlink.com)

According to Dr Douglas McNeel, director of solid tumor immunology research at the UW Carbone Cancer Center, as recently as 10 years ago there were only a handful of immunotherapies available. (bioforward.org)
A vaccination as tumor therapy - with a vaccine individually created from a patient's tissue sample that " attaches" the body's own immune system to cancer cells: the basis for this long-term vision has now been achieved by a team of researchers from the MPI for Polymer Research and the University Medical Center Mainz, in particular from the Departments of Immunology and Dermatology. (mpg.de)
Ferry A. Ossendorp is Professor Molecular Vaccin Biology and head of the Tumor Immunology group in the department Immunology of the Leiden University Medical Centre. (universiteitleiden.nl)
For more than 25 years Ferry Ossendorp is investigating the immune system and cancer and is now head of the Tumor Immunology Group. (universiteitleiden.nl)

The doctor and his team are currently studying a cold sore virus that has been genetically altered so it cannot harm normal brain cells but can infect and kill tumor cells, all while stimulating the patient's own immune system to attack the tumor. (rallyfoundation.org)

The same antibody molecule can cross-react with related antigens if their epitopes are similar enough to those of the original antigen. (msdmanuals.com)
Understanding of naturally processed Compact disc4+ T cell epitopes expressed on individual monocyte-derived dendritic cells (MDDC) following the handling of entire bacterial cells by usage of a system of immunoproteomics technology. (bio-biz-navi.com)
Comparative paucity within the organic epitope screen of MDDC not really dominated by epitopes from known defensive antigens can hinder the potency of immune system recognition of provides successfully relied on nationwide vaccination applications since we were holding introduced within the 1940s and 1950s (1 2 Nevertheless over the last 10 years a rise of whooping coughing continues to be reported (3 -9). (bio-biz-navi.com)

The cell-based immune therapy, based on that invention, Sipuleucel-T, more commonly known as Provenge, became the first FDA-approved immunotherapeutic cancer vaccine. (wikipedia.org)
According to the American Cancer Society, brain and spinal cord tumors are the second most common cancers in children after leukemia. (rallyfoundation.org)
The result is the immunogenic cell death of tumor cells, accompanied by an auto-vaccination preventing the recurrence of cancer. (pipelinereview.com)
Moffitt Cancer Center continues to distinguish itself as a world leader in the development of novel immunotherapy treatments, capitalizing on the natural power of the body's immune system to defend itself against the growth and spread of cancerous cells. (moffitt.org)
This is why this important component of cancer treatment should be combined with immune therapies to shift the balance toward immune activation against tumor cells. (frontiersin.org)
demonstrate for the first time in pre-clinical model systems that radiotherapy can be combined with vaccination with syngeneic whole-tumor cell vaccine generated by high hydrostatic pressure, mimicking in cancer patients autologous vaccine from their own tumor cells. (frontiersin.org)
Despite significant recent improvements in the field of immunotherapy, cancer remains a heavy burden on patients and healthcare systems. (mdpi.com)
The Vaccination Against Canine Cancer Study (VACCS trial) is currently underway. (dogcancer.com)
The Vaccination Against Canine Cancer Study (VACCS trial) is a clinical trial evaluating a new vaccine for dogs that aims to prevent multiple types of cancer. (dogcancer.com)
Cancer immunotherapy is not a standard in clinical treatment of tumors, while first attempts were made several years ago. (pbkom.eu)
Bcr/abl, or tumor associated antigens (TAA) in cancer cells may be used theoreticaly in cancer therapy. (pbkom.eu)
This processes change intracellular signaling roads regulating cell proliferation and/or apoptosis of cancer cells and effect the tumor growth progression. (pbkom.eu)
A nine amino acid peptide fragment of carcinoembryonic antigen (CEA), a protein that is overexpressed in several cancer cell types, including gastrointestinal, breast, and non-small cell lung. (medicalterminologydb.com)
Immunotherapy, a type of cancer treatment that helps one's immune system fight cancer, is still relatively new. (bioforward.org)
This kind of immuno-based therapy, by activating immune cells that are specific for the tumor, may be foundational to the future of cancer treatments. (bioforward.org)
If we can develop tumor-specific vaccinations for prostate cancer, the disease could become much more like high blood pressure, like a chronic condition," he said. (bioforward.org)
Effective immunotherapy for chronic diseases and cancer, however, will require the optimization of many aspects of the immune system. (oncolink.org)
This review highlights past approaches and describes more recent developments that suggest newer strategies for piquing our immune system for the treatment and prevention of cancer. (oncolink.org)
These tumor specific antigens are the result of mutations that cancer cells undergo, and in many cases that involve viral carcinogens, viral antigens. (oncolink.org)
The new funds will primarily be directed towards clinical development of Cytovation's lead asset CyPep-1, a proprietary first-in-class targeted tumor membrane immunotherapy engineered to selectively target cancer cells. (cytovation.com)
For the vaccine to target the tumor, you need to know: What distinguishes tumor tissue from healthy tissue - in other words, which specific antigens are found on the cancer? (mpg.de)
This complex structure comprises CNTs as delivery system for the Cancer Testis Antigen named NY-ESO-1, allied to a synthetic Toll-Like Receptor agonist. (fiocruz.br)
Cancer patients oftentimes display an intact immune system equipped with special forces, trained to recognize foreign cells as intruders and ready to eliminate them. (juvital.de)
To delude the immune system, cancer cells frequently try to disguise themselves in a very sophisticated manner in order to match healthy body cells. (juvital.de)
This tumor vaccine shall demonstrate essential cancer cell detection signals to the body's immune system and shall train it accordingly to recognize those cancer cells as foreign. (juvital.de)
1. According to Avrameas/Pasteur institute Paris and Tallberg Helsinki, the so-called Polymerisation process freezes the tumour tissue, reduces it to small pieces and emphasizes the essential defining features of the surface structure of the cancer cells with the help of additives. (juvital.de)
Prior to tumor vaccination, it is important that the immune system of the cancer patient is active or newly activated through various therapy possibilities, like thymus extracts. (juvital.de)
Even if the back-formation of tumors in metastasized melanoma, ovarial and kidney cancer is observed by Tallberg, tumor vaccination serves primarily as prevention of new metastases. (juvital.de)
At the German Cancer Congress in Berlin 2010 it was stressed that vaccinations of tumor tissue could prevent the development of metastases and therefore significantly improve the survival rates for different types of cancers. (juvital.de)
The ASI-therapy can also lower significantly the relapse frequency of possible operable liver-and lung metastases as part of the primary "colorectal cancer" tumor. (juvital.de)
In a 10-year study, Schirrmacher could lower the relapse frequency by 50% for operable liver tumors as part of primary "colorectal cancer" tumors. (juvital.de)
A so-called prospective randomized stage-III study was introduced there, in which advanced skin cancer patients lived longer through an active tumor-specific vaccination. (juvital.de)
Prof. Wölfel comments in "Deutsches Ärzteblatt", volume 106, edition 48, 2009 page 2407 "After knowing that the immune system can recognize most of the tumour antigens, the scientific challenge lies in conquering the mechanisms of the tumors with which they escape the immune system", namely the more advanced a cancer disease is, the more escape routes a tumor has already developped. (juvital.de)
The heterokaryons produced by cancer-DC fusion cells combine the equipment needed for immune system stimulation YIL 781 with display of a big repertoire of antigens. (tech-strategy.org)
Viruses are recognized as foreign invaders by the immune system, but cancer is not. (biopharminternational.com)
Recently the research findings from the laboratory and in experimental animals are translated to an early clinical study in which cancer patients are injected with and experimental tumor-specific peptide-conjugate vaccine. (universiteitleiden.nl)
Patients with new or recurring solid tumors receiving treatment within one year of their initial vaccine dose, regardless of their type of cancer therapy. (y105fm.com)
Review the updated vaccination guidelines for cancer patients on the National Comprehensive Cancer Network website. (y105fm.com)
In this approach, you take DC-precursor cells from the blood of a cancer patient, differentiate and activate them in culture, load them with tumour antigens, and then inject the cells back into the patient. (nature.com)
Another potentially big area is using DCs for preventive vaccination of people with cancer mutations, such as BRCA1 , to prevent progression from premalignant to malignant disease. (nature.com)
Cancer immunotherapies are treatments based on the activation of the immune system to cure cancer. (telomium.com)
When a cancer has accumulated far too many mutations, the immune system can start to see the cancer as non-self and attack the tumor with the help of anti-PD1. (telomium.com)
However, in most cases, cancer is still too similar to the self to be detected as non-self, and tumors are tolerated by the immune system which does not attack them. (telomium.com)
At Telomium, we develop a new kind of "vaccine" to reprogram the immune system and make it believe that cancer self-elements (like telomerase) are dangerous virus. (telomium.com)
Then, the immune system destroys all cells (the cancer cells) containing the target, like if there were infected cells. (telomium.com)
If one had the technology to make the immune system believe that a self element of the tumor (like telomerase or another tumor antigen) is not from the self, but is a virus, the T lymphocyte would then destroy cancer cells now seen as cells infected by a putative virus. (telomium.com)
To become really efficient cancer vaccine need to break immune tolerance. (telomium.com)
Active treatment with high-dose corticosteroids, alkylating agents, antimetabolites, transplant-related immunosuppressive drugs, cancer chemotherapeutic agents classified as severely immunosuppressive, tumor-necrosis factor (TNF) blockers, and other biologic agents that are immunosuppressive or immunomodulatory. (affinitycare.nhs.uk)
Examples of antigens include bacteria, viruses, toxins , cancer cells, and foreign blood or tissues from another person or species. (medlineplus.gov)
The 9vHPV targets five by parents as one of the top 5 reasons for not initiating the additional cancer-causing HPV types: HPV 31, 33, 45, 52, and HPV vaccination series. (cdc.gov)

In fact, this type of antigen was the target of the first monoclonal antibody therapy for a malignancy (B-cell lymphoma) in 1982. (oncolink.org)

TL-532 also demonstrated its remarkable ability to overcome Immune Checkpoint Inhibitor (ICI) tumor-resistance, thus increasing the clinical landscape for ICI combination treatment. (pipelinereview.com)
During the last two decades treatment based on selective stimulation of immune system has became a promising anti-neoplastic strategy, testing in several clinical centers all over the world. (pbkom.eu)
The clinical and experimental studies suggest their use in tumor treatment, viral infections and autoimmunological disorders. (pbkom.eu)
Our data reveal a novel mechanism of action for dolastatins and provide a strong rationale for clinical treatment regimens combining dolastatin-based therapies, such as brentuximab vedotin, with immune-based therapies. (biomedcentral.com)
Bergen, Norway, 25th January 2022 - Cytovation AS, a clinical stage immune-oncology company focused on the development of its first-in-class targeted tumor membrane immunotherapy, announces the successful closing of its Series A financing round, raising a total of NOK 180 million ($20 million). (cytovation.com)
We continue to make excellent progress with CyPep-1 in our Phase I/II CICILIA clinical trial and following promising data from the first monotherapy part of the study, we have begun patient dosing of CyPep-1 in combination with Keytruda in patients with a range of solid tumors. (cytovation.com)
Cytovation AS is a privately held, clinical stage immune-oncology company focused on the development of CyPep-1, a first-in-class tumorolytic agent targeting the cell membrane of tumor cells. (cytovation.com)
With knowledge of the initial immune target, early antigen-specific treatments can block continued tissue damage, epitope spreading and clinical disease. (nature.com)
What's good about this is that the T- and B-cells age together, but all a little differently, each system by itself," said Thomas Dörner, MD, PhD, head of consultation hours for clinical hemostaseology at the Charité University Hospitals in Berlin, Germany. (medscape.com)

Both of these vaccine types deliver the nucleic acid (mRNA or DNA ) that gives our cells instructions for how to make a harmless antigen-a piece of the so-called "spike protein" from the surface of the COVID-19 virus. (aimatmelanoma.org)
Ribonucleoproteins are protein-RNA complexes delivering a temporospatially coordinated activation of a danger signal (by their RNA part) and presentation of the antigen (by their protein part) in the same phagosome, therefore more efficiently mimicking a viral infection, that any other vaccine technologies (even mRNA or viral vectors). (telomium.com)

Even though all self-antigens are normally tolerized, ribonucleoproteins are self-elements commonly known to break immune tolerance (to the self) and cause various autoimmune pathologies. (telomium.com)
Ribonucleoproteins are self-macromolecules complexes that are often mistakenly taken for virus by the immune system and become targets in various autoimmune diseases. (telomium.com)

These nanoscale materials with diameters of less than 100 nanometers are about the size of viruses - the cells of the immune system therefore recognize them very well, eat them and in this way awaken from their dormant mode. (mpg.de)

In turn, myeloid cells are less active in old age due to phagocytosis and antigen presentation, and they get more mutations. (medscape.com)
That's why, in patients from whom we can get tumour samples, we're going to try to identify patient-specific mutations and go after these in the boosting phase of the trial. (nature.com)

In addition to playing an important role in host defense against infection, the complement system is a mediator in both the pathogenesis and prevention of immune complex diseases, such as systemic lupus erythematosus (SLE). (medscape.com)
The exact amount of systemic corticosteroids and the duration of their administration needed to suppress the immune system of an otherwise healthy child are not well defined. (cdc.gov)

It has become evident that radiotherapy has both, immune suppressive, and immune activating properties ( 1 ). (frontiersin.org)
The current research aims to better understand the vaccination mechanisms and develop ways to influence the suppressive environment in tumors to allow effective immunotherapy. (universiteitleiden.nl)

Emerging evidence suggests a key role for epigenetics in the maturation and regulation of the immune system in health and disease. (ox.ac.uk)

Or through site-specific application, researchers have found that by injecting the DC vaccine intra-tumorally, they can unlock a whole set of other immune parameters that become activated. (moffitt.org)
CNS melanomas were more tolerogenic than equivalently progressed tumors outside the CNS as antigen-specific CD8 T cells were deleted and exhibited impaired cytotoxicity. (xstrahl.com)
Conversely, tumor antigen-specific vaccination in combination with focal radiation therapy reversed tolerance and improved survival. (xstrahl.com)
The appearance of tumor specific antigens (TSA) e.g. (pbkom.eu)
Subsequent studies and usages have broadened the meaning, so that vaccinate/vaccination and immunize/immunization are now used interchangeably and generally understood to mean the process of administering a biological material into the body with the intent of preventing a specific illness. (aimatmelanoma.org)
The novel vaccine class consists of two components: Firstly, the antigen, which is specific to the tumor cell and is to be recognized by the immune system as an 'enemy', so to speak, and secondly, the immune activator - a 'stinger' that shakes up the immune system. (mpg.de)
If a tumor is diagnosed in the early stages, a race against time begins to produce the patient-specific vaccine as quickly as possible,' Nuhn explains. (mpg.de)
In the last decades, the ASI-therapy or tumor vaccination showed that it can effectively prevent relapses.Future studies and further improvements in identifying the tumor and optimizing its specific defense functions will be a challenge for the future. (juvital.de)
allogeneic stem cell transplantation and donor lymphocyte infusions with or without donor vaccination using patient-derived idiotype and potential program of donor-derived or hRPB14 patient-derived antigen-specific T-cell infusion within this disease may also be discussed. (tech-strategy.org)
These research provide indirect evidence that idiotype-specific T cells may have a regulatory effect on individual tumor B cells. (tech-strategy.org)
To explore the chance of using myeloma cells as the foundation of tumor antigens for immunotherapy myeloma cell lysate-specific CTLs had been generated from sufferers by culturing T cells with autologous DCs pulsed with freeze-thaw lysate from myeloma cells 43. (tech-strategy.org)
Myeloma-specific CTLs may also be propagated and induced through the use of myeloma-DC fusion cells as antigen-presenting cells. (tech-strategy.org)
Understanding the cellular and molecular basis of epitope spreading in various chronic immune-mediated human diseases and their animal models is crucial to understanding the pathogenesis of these diseases and to the ultimate goal of designing antigen-specific treatments. (nature.com)
The hope is that these DCs will activate tumour-specific T cells. (nature.com)
The tumour antigens can either be shared antigens, which are expressed by many cancers, or patient-specific antigens. (nature.com)
With Ralph, it was patient-specific: together with colleagues from other institutes, we studied cells from his tumour to work out which antigenic sequences to go after. (nature.com)
The second section discusses how specific immunocompromising conditions may alter recommendations for vaccination. (cdc.gov)

These data support the proposed mode of action whereby host APCs present DCP-001 antigens to the host immune system following intradermal vaccination. (dcprime.com)

Transplant patients, for example, given powerful drugs that suppress their immune systems in order to prevent organ rejection, are prone to developing tumours. (newstatesman.com)
However, one has always to keep in mind that many challenges do still exist such as what is the best sequence and timing of joint applications, what are the best immunotherapy approaches, how to overcome tumor resistances, what about healthy tissue cytotoxicity, or which biomarkers or matrices of biomarkers are most beneficial for patients stratification, just to mention the most burning ones. (frontiersin.org)
Integration of radiotherapy in multimodal tumor treatments is not to be challenged since above half of the tumor patients do receive it during their diseases history. (frontiersin.org)
Not all patients will express them, and some shared antigens are also expressed by healthy cells. (nature.com)
Eligible patients will be contacted by the vaccination team to book an appointment for a covid vaccine. (affinitycare.nhs.uk)

Tumor cells in transformation process accumulate products of oncogenes and/or loss the functional products of tumor suppressor genes. (pbkom.eu)

He followed up with an anti-idiotype tumor vaccine against lymphocytes "not normally recognized" by the immune system. (wikipedia.org)

Besides cytokines, active stimulation of the immune system can be achieved by vaccination approaches. (frontiersin.org)
This approach is based on the view that immune stimulation is primarily mediated by APCs rather than the tumor cells themselves. (oncolink.org)

Survival rates for medulloblastoma, the most common malignant brain tumor in children, range from 50-to-80 percent. (rallyfoundation.org)
Among the systems affected is the immune system, a key component of overall survival because of its critical role in protection from disease. (iresearchnet.com)

Vac- cination with dendritic cells previously exposed to tumor antigens seems to be one of the most attrac- tive approaches of immunotherapy. (pbkom.eu)
We are pursuing similar vaccination approaches for solid tumors. (dcprime.com)

Dendritic cells can be used as a vaccine by preparing together with either peptides or small portions of tumor antigens and they can then be injected into the body. (moffitt.org)

IFx primes and educates the immune system to destroy tumor cells throughout the body without harming healthy cells and tissues. (precisionvaccinations.com)
The immune system also has the capacity to recognize and destroy. (msdmanuals.com)
Cellular Components of the Immune System The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)
and molecular components that work together to destroy antigens (Ags). (msdmanuals.com)
Further, it has been proven that locally applied radiotherapy does not destroy the immune system in a way that additional immunotherapy is not feasible. (frontiersin.org)

There is this phenomenon of premature aging of the immune system," said Cornelia Weyand, PhD, director of the Center for Translational Medicine at Stanford University, Stanford, California, at the German Rheumatology Congress 2023 in Leipzig, Germany. (medscape.com)

Radiotherapy thereby acts as an adjuvant for the vaccine that contains many tumor-associated antigens (adjuvanticity plus antigenicity) ( Seitz et al. ). (frontiersin.org)

Immune system tissues (especially lymphoid tissue such as the thymus) shrink, and the number and activity of white blood cells drop. (medlineplus.gov)

The approved immune checkpoint inhibitors for relapsed and refractory cHL are nivolumab and pembrolizumab. (wjon.org)

These cytokines are used in the immune system for cell-to-cell communication. (oncolink.org)
Basic research of the T cell immune system in many different aspects is central in his team. (universiteitleiden.nl)
What we see in both the T- and B-cell systems is that they become increasingly innate with age," he said. (medscape.com)
Indeed, each cell of the human body continuously displays degradation products from its internal activity at its surface (through the HLA/MHC system). (telomium.com)

In murine plasmacytoma versions vaccination with DCs fused with mouse 4TOO plasmacytoma cells 44 or J558 myeloma YIL 781 cells 45 was connected with induction of anti-tumor humoral and CTL replies. (tech-strategy.org)

Anatomy23

Organisms8

Diseases60

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes40

Disciplines and Occupations1

Information Science4

Named Groups2

Health Care14

Vaccines26

Responses28

Immunity16

Microenvironment3

Proteins11

Antibodies7

Vaccine antigens1

Preclinical3

Autologous tumor4

Cells of the adaptive immune2

Mice8

Receptors3

Induce5

Chimeric antigen receptor1

Pathogens7

Therapeutic6

Targeted immunotherapies2

Cytotoxic3

Stimulate2

Adaptive5

Dendritic cell1

Response34

Foreign antigens2

Brain tumors5

Immunology4

Patient's1

Epitopes3

Cancer50

Antibody1

Clinical9

Protein2

Autoimmune2

Viruses1

Mutations2

Systemic2

Suppressive2

Maturation1

Specific17

Host immune1

Patients5

Genes1

Anti-idiotype1

Stimulation2

Survival2

Approaches2

Peptides1

Destroy5

20231

Radiotherapy1

Lymphoid1

Checkpoint1

Cell4

Murine1