Heparin mimetics are synthetic and semi-synthetic compounds that are highly sulfated, structurally distinct analogs of glycosaminoglycans. (bioglyco.com)
Antigens3
When the immune system does not distinguish self and non-self antigens, it leads to an autoreactive T-cell response. (wikipedia.org)
Michael Breimer started his research in the Department of Medical and Physiological Chemistry isolating and structurally characterising blood group AB(O)H and related carbohydrate antigens. (gu.se)
Blood group phenotypes relating to expression of ABO antigens in individual kidneys were identified. (gu.se)
Recognition1
During more recent years, his reseach has been conducted in the field of regenerative medicine, focussed on antigen expression and immune recognition of human embryonic stem cells and bioartificial heart valves, the latter tissues being of animal origin. (gu.se)
System1
Using the Svennerholm system of abbrevations, gangliosides are designated G for ganglioside, plus subscript M, D, or T for mono-, di-, or trisialo, respectively, the subscript letter being followed by a subscript arabic numeral to indicated sequence of migration in thin-layer chromatograms. (lookformedical.com)
Human2
Here, we describe multiple models that exist to study human noroviruses in nonhuman hosts and related viruses in their native hosts. (basicmedicalkey.com)
Animal models are based either on studies of human viruses in animals, often requiring the use of immunocompromised hosts and/or host-adapted viruses, or the use of related viruses in their natural hosts. (basicmedicalkey.com)
Studies3
After his PhD examination, his biochemical studies relating to ABO-incompatible organ transplantation continued in the Department of Surgery. (gu.se)
Alternatively, many studies have been carried out using related caliciviruses as HuNoV surrogate models. (basicmedicalkey.com)
The understanding of the main types of lipids provides a solid foundation for advancing in biochemistry and other related studies. (hellovaia.com)
Lipids4
The understanding of the main types of lipids provides a solid foundation for advancing in biochemistry and other related studies. (studysmarter.co.uk)
The present invention relates to cationic lipids which are used to enhance delivery of biologically active agents, particularly polynucleotides, proteins, peptides, and drug molecules, by facilitating transmembrane transport or by encouraging adhesion to biological surfaces. (justia.com)
It relates particularly to cationic lipids comprising ammonium groups. (justia.com)
Gangliosides, forming a class of lipids complemented by sugar chains, influence the lateral distribution of membrane proteins or membrane-binding proteins, act as receptors for viruses and bacterial toxins, and mediate several types of cellular signaling. (bvsalud.org)
Membrane7
Here, we show that gangliosides in the HIV-1 membrane are the key molecules for mDC uptake. (plos.org)
Here we show that gangliosides, basic components of the host cell's plasma membrane, have an important role in this process. (plos.org)
Gangliosides are known to be incorporated into the viral envelope membrane during the process of viral particle budding and here we show that they serve as viral attachment factors: they are recognized and enable HIV-1 uptake by mDCs. (plos.org)
Thus, in addition to the well-known function of gangliosides as host cell receptors that mediate virus (e.g., polyoma and SV40) attachment and transport from the plasma membrane to the ER, we now demonstrate that they can also act as determinants for capture by mDCs. (plos.org)
Furthermore, we identify a moiety composed of sialyllactose on HIV-1 membrane gangliosides as the specific domain recognized by mDCs. (plos.org)
The complex composition of the cell membrane comprises phospholipids, glycolipids, and cholesterol, as well as intrinsic and extrinsic proteins, and its functions are influenced by cytoplasmic components which include Ca.sup. (justia.com)
GM3 was used as another ganglioside on the membrane. (bvsalud.org)
Lipid4
Kang, Young-Sun 2019-09-09 00:00:00 Lipid rafts (LRs) play crucial roles in complex physiological processes, modulating innate and acquired immune responses to pathogens. (sagepub.com)
Gangliosides incorporated into supported lipid bilayers (SLBs) have been widely applied as a model system to examine these biological processes. (bvsalud.org)
Furthermore, components such as gangliosides in membranes and lipid rafts are known to play important roles in the adoption of pathways and the generation of discrete neurotoxic oligomers. (bvsalud.org)
From a physicochemical standpoint, this is related to their ability to self-organize into nanoscopic domains, even at molar concentrations of one per 1000 lipid molecules. (bvsalud.org)
Composition1
In this work, we explored how ganglioside composition affects the kinetics of SLB formation using the vesicle rupturing method on a solid surface. (bvsalud.org)
Lymphoid3
Particular embodiments of the disclosure concern modulation of particular immune cell surface proteins to enhance adoptive cell therapy, and in specific cases the immune cells are lymphoid cells, including at least T cells, tumor infiltrating lymphocytes, or B cells, for example. (justia.com)
Using a 4NQO-induced oral squamous cell carcinoma (OSCC) model with abundant and absent tenascin-C, we demonstrated that tenascin-C enforced an immune-suppressive lymphoid stroma via CCL21/CCR7 signaling, leading to increased metastatic tumors. (cnrs.fr)
Ablation of tenascin-C or CCR7 blockade inhibited the lymphoid immune-suppressive stromal properties, reducing tumor growth, progression, and metastasis. (cnrs.fr)
Serum2
Elevated levels of circulating immune complexes in unfractionated serum were directly detectable during early tumour development although, following serum fractionation, immune complexes were identified at both early and late stages of tumour growth. (nih.gov)
The present findings suggest that the detection of immune complexes in unfractionated samples of late tumour-bearer serum using a C1q-binding assay is masked by the increasing production of tumour-specific antibodies and by a shift from complement fixing to non-complement-fixing tumour-specific antibodies. (nih.gov)
Chains1
The binding groove is made up of four broadly interconnected pockets that are occupied by the alkyl chains of glycolipid and two detergent molecules. (wikipedia.org)
Protein1
Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 7.9 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
Viral1
Hence, these results demonstrate that gangliosides can act as viral attachment factors, in addition to their well known function as cellular receptors for certain viruses. (plos.org)
Molecules1
CD1 molecules are structurally related to the major histocompatibility complex (MHC), belonging to MHC class I-like genes. (wikipedia.org)
CD1b also presents endogenous gangliosides to specific T cells so they can commence autoimmune diseases such as multiple sclerosis. (wikipedia.org)
Isolated fractions were examined for their capacity to bind [125I]C1q as a measure of immune complex levels, and for their ability to bind soluble tumour-specific antigen as well as to react with antigens expressed at the surface of viable hepatoma cells. (nih.gov)
Present1
The present disclosure concerns methods and compositions related to cell therapies for any purpose, including at least for treatment of cancer of any kind. (justia.com)
Type2
In the early phase, the ganglioside type and concentration influence the adsorption kinetics of vesicles and their residence/lifetime on the surface before rupturing. (bvsalud.org)
The propagation of patch edges catalyzes the process and depends on the ganglioside type. (bvsalud.org)
Show1
Here, using GM1, GM3, and GD3 ganglioside micelles as models, we show that the sugar distributions and cationic amino acids within Aß N-terminal region modulate oligomerization of Aß temporally, and dictate the stability and maturation of oligomers. (bvsalud.org)
Cell2
When the immune system does not distinguish self and non-self antigens, it leads to an autoreactive T-cell response. (wikipedia.org)
Embodiments of the disclosure encompass methods and compositions related to cell therapy treatment, including for cancer. (justia.com)
Critical1
Our pH-dependent experiments confirm that the polar/charged head groups of the gangliosides have a critical role in these steps and phases of SLB formation kinetics. (bvsalud.org)
Major1
Inherent immune suppression represents a major challenge in the treatment of human cancer. (cnrs.fr)
Entry1
You can also upload a video entry or images related to this topic. (encyclopedia.pub)
Expression1
The methods and compositions relate to modulation of expression of multiple genes whose products are involved in suppression of the cells, in particular aspects. (justia.com)