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  • antigens
  • Human and monkey sera from individuals exposed to Plasmodium falciparum were characterized by indirect immunofluorescence, in vitro parasite growth inhibition, and immunoprecipitation of 125 I-labeled parasite antigens followed by analytical sodium dodecylsulfate-polyacrylamide gel electrophoresis (SDS-PAGE). (ajtmh.org)
  • Traditionally, scientists studying the immune system have had to search for antigens on an individual basis and identify the protein sequence of these antigens ("epitopes") that would stimulate an immune response. (wikipedia.org)
  • vitro
  • In general there was a good correlation between fluorescence titer and the ability of a serum to inhibit parasite growth in vitro. (ajtmh.org)
  • The proteins bound by human sera with high and low in vitro inhibitory capacities were compared by SDS-PAGE. (ajtmh.org)
  • The human sera which did not inhibit parasite growth in vitro well differed from those which did by failing to efficiently bind certain parasite components having molecular weights in the range of 200,000, 70,000-85,000, and 45,000. (ajtmh.org)
  • innate immune
  • Compromises to innate immune cell functioning can interfere with, or reflect, adaptive processes and translate into shifts in cytokine patterns that are either pro- or anti-inflammatory [ 11 ]. (medsci.org)
  • 13 These polysaccharidic components are widely used for bacterial classification, responsible for non-immunological and immunological interactions of bacteria with hosts and also involved in the avoidance of host innate immune mechanisms-such as resistance to phagocytosis, complement-mediated killing, and the bactericidal activity of antimicrobial peptides. (iranjournals.ir)
  • In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. (wikipedia.org)
  • strains
  • Some variance was seen in the ability of a given serum to inhibit different strains of the parasite. (ajtmh.org)
  • 7,8 Similar results have been reported by other studies and serum resistance has been considered as a tool to assess the virulence in FC-associated strains. (iranjournals.ir)
  • 9 However, lesions have also been reported in chickens infected by serum-sensitive strains 10 and the relationship between virulence and serum resistance is complicated in the chicken. (iranjournals.ir)
  • proteins
  • Hardcastle SL, Brenu EW, Johnston S, Nguyen T, Huth T, Ramos S, Staines D, Marshall-Gradisnik S. Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients. (medsci.org)
  • The serum-induced genes have been associated with processes relevant to wound healing, including genes directly involved in remodeling the clot and extracellular matrix, as well as genes encoding signal proteins for inflammation, the development of new blood vessels, and regrowth of epithelial tissue. (wikipedia.org)
  • genes
  • Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. (wikipedia.org)
  • As a result, they designed the "Lymphochip" cDNA microarray, which contained 13,000 genes and was enriched for genes of importance to the immune system. (wikipedia.org)
  • Blocking
  • A significant relationship between blocking and tumour size was also established, although this only applied to immune protected mice. (springer.com)
  • However, analysis of the combined data from sequentially bled immune protected mice in relation to different phases of tumour behaviour, did not support the notion that blocking, and more particularly the persistence of CIC, contribute to tumour regrowth and dissemination. (springer.com)
  • coli
  • As a control test an E. coli strain was subjected to the same experiment and found completely sensitive to the bactericidal activity of complement in calf and guinea pig fresh sera. (iranjournals.ir)
  • cell
  • Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. (wikipedia.org)
  • Usually, the starting point is a crude, heterogeneous group of molecules in a whole cell extract, such as a cell lysate, growth medium or blood serum. (wikipedia.org)
  • living cells
  • Immunological dysregulation can be caused or influenced by changes in serum immune protein levels, which play a key role in living cells by allowing specific interactions with other molecules [ 1 ]. (medsci.org)
  • high
  • The results showed that P. multocida B:2 is highly resistant to positive serum, containing high levels of IgG and IgM obtained from calves after vaccination, and complement activity in normal fresh calf serum. (iranjournals.ir)
  • response
  • however, their presence in the bloodstream causes little to no immune response until death or degradation of the microfilariae or adult worms. (wikipedia.org)
  • Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. (wikipedia.org)
  • that is, the whole pathogenic peptide sequence is not necessary to initiate an immune response. (wikipedia.org)
  • positive
  • Negative sera behaves negative, positive sera like positive on plate without Ag. (protocol-online.org)
  • This organism also grew rapidly in the normal fresh calf serum and the mixture of positive serum as well as normal fresh calf serum. (iranjournals.ir)
  • This is done so that the fetal rhesus D positive erythrocytes are destroyed before the immune system of the mother can discover them and become sensitized. (wikipedia.org)
  • system
  • Evaluation of Pasteurella multocida serotype B:2 resistance to immune serum and complement system', Veterinary Research Forum , 8(3), pp. 179-184. (iranjournals.ir)
  • The destructive effects of fresh serum on gram-negative bacteria is assumed to be one of the consequences of the activity of host complement system. (iranjournals.ir)
  • recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. (wikipedia.org)
  • Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. (wikipedia.org)
  • Study
  • He also took part in the development in the first immune serum against the bubonic plague (black pest), in collaboration with the discoverer of its pathogenic agent, Yersinia pestis, by Alexandre Yersin (1863-1943), and went to Portugal to study and to help fight an epidemic at Oporto. (wikipedia.org)
  • studies
  • Hellstrom, I. , and Hellstrom, K. E. , 1969, Studies on cellular immunity and its serum-mediated inhibition in Moloney virus-induced mouse sarcomas. (springer.com)
  • blood cells
  • The term usually refers to blood serum, the clear, straw-colored, liquid portion of the plasma that does not contain fibrinogen or blood cells, and remains fluid after clotting of blood. (thefreedictionary.com)
  • Four years later, in 1899, he described a similar destructive process involving complement, "hemolysis", in which foreign red blood cells are ruptured or "lysed" following exposure to immune serum. (wikipedia.org)
  • specific
  • For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions. (wikipedia.org)
  • role
  • Although not intending to address any aspect of immunity at the start of their experiment, these researchers observed that the expression profiles of serum-stimulated fibroblasts were far richer than anticipated and suggested an important physiological role for fibroblasts in healing wounds. (wikipedia.org)