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  • expression
  • Can gBlocksĀ® Gene Fragments be used for microinjection as single guide RNA (sgRNA) expression cassettes for CRISPR applications? (idtdna.com)
  • However, long RNAs are known to trigger the innate immune response in many cells, which increases the expression of dozens of genes and can affect cell viability and general health [4- (idtdna.com)
  • The virus and wasp are in a mutualistic symbiotic relationship: expression of viral genes prevents the wasp's host's immune system from killing the wasp's injected egg and causes other physiological alterations that ultimately cause the parasitized host to die. (wikipedia.org)
  • vivo
  • Efficient in vivo delivery of small interfering RNA (siRNA) to immune cells could thus enable novel treatment strategies with broad applicability. (harvard.edu)
  • However, without modifications to the RNA backbone or inclusion of inverted bases at either end, siRNA instability in the plasma makes it extremely difficult to apply this technique in vivo. (wikipedia.org)
  • replication
  • There are several steps in the HIV life cycle that may be interfered with, thus stopping the replication of the virus. (wikipedia.org)
  • Although these experiments were conducted using genotype 1a and 1b HCV RNA, the miR-122 binding sites are highly conserved across different genotypes, and miR-122 is also required for replication of infectious type 2a HCV. (wikipedia.org)
  • miR-122 stimulates translation of HCV RNA, but not to a sufficient extent to explain its effects on viral replication, indicating that a second stage of the viral replication cycle must also be regulated. (wikipedia.org)
  • Cas9
  • 2014) Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos . (idtdna.com)
  • interferons
  • In general, type I and II interferons are responsible for regulating and activating the immune response. (wikipedia.org)
  • All interferons share several common effects: they are antiviral agents and they modulate functions of the immune system. (wikipedia.org)
  • mediates
  • Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy. (springer.com)
  • selective
  • Objectives: To demonstrate the feasibility and emphasize the importance of noninvasive aerosol delivery of Akt1 small interfering RNA (siRNA) as an effective and selective option for lung cancer treatment. (redorbit.com)
  • macrophages
  • Chief among the innate immune receptors in macrophages are a family of receptors called the Toll-like receptors that reside on the plasma membrane as well as within endosomal vesicles. (ke-i.org)
  • innate and adaptive
  • Among them are immunologic factors that play a critical role because they contribute to innate and adaptive immune rejection ( 7 ), recurrence of autoimmunity ( 8 ), and toxicity associated with immunosuppressive agents ( 9 , 10 ). (diabetesjournals.org)