Loading...
  • antiviral
  • As all antiviral therapies fail to boost the immune system, relapse of reactivation is frequent and repeated treatments are required, strongly contributing to the high costs of aSCT. (biomedcentral.com)
  • soluble
  • These results indicate that a specific set of chemokines enhance the inflammatory and protective anti-viral responses mediated by TNF and lymphotoxin, and illustrate how viruses optimize anti-TNF strategies with the addition of a chemokine binding domain as soluble decoy receptors. (nature.com)
  • antigens
  • We show that our microconsensus vaccine design strategy improves immune responses compared with immunization with native FAP, and we show that our vaccine synergizes with anticancer immune therapy targeting the tumor antigens TERT and PSMA in lung and prostate tumor models. (aacrjournals.org)
  • antibody
  • Vedantra's technologies enlist both antibody and T-cell responses that impair and destroy pathogens before they can replicate and cause serious damage in the body. (thefreelibrary.com)
  • Vedantra builds upon advances in antibody and T-cell therapies, using the body's natural immune responses against defined targets to create effective, durable and safe prophylactic and therapeutic vaccines targeting endemic maladies. (thefreelibrary.com)
  • Pigs vaccinated with CNPs-KAg exhibited an enhanced IgG serum antibody and mucosal secretory IgA antibody responses in nasal swabs, bronchoalveolar lavage (BAL) fluids, and lung lysates that were reactive against homologous (H1N2), heterologous (H1N1), and heterosubtypic (H3N2) influenza A virus strains. (frontiersin.org)
  • We examined associations between B and T cell phenotypic profiles and antibody responses to the pentavalent rotavirus vaccine (RV5) in perinatally HIV-infected (PHIV) infants on antiretroviral therapy and in HIV-exposed uninfected (PHEU) infants enrolled in International Maternal Pediatric Adolescent AIDS Clinical Trials P1072 study (NCT00880698). (frontiersin.org)
  • PHIV and PHEU antibody responses to RV5 were modulated by typical HIV-associated immune response modifiers except for the association between CD4+/CD8+FOXP3+CD25+Treg and increased antibody production. (frontiersin.org)
  • cell responses
  • The immune mechanisms that constitute protection are only partially understood, but are presumed to rely on Abs and T cell responses. (jimmunol.org)
  • This is the first study demonstrating correlation in a controlled Plasmodia sporozoite challenge study between protection induced by a recombinant malaria vaccine and Ag-specific T cell responses. (jimmunol.org)
  • In this review, we summarize how key nutrients, including glucose, amino acids, and lipids, and their sensors and transporters shape T cell responses. (frontiersin.org)
  • Second, we summarize recent findings on how specific amino acids and amino acid transporters control T cell responses. (frontiersin.org)
  • Controlling B cell responses is one of the major challenges in Ab-mediated autoimmune diseases, as well as in allotransplantation and xenotransplantation. (jimmunol.org)
  • proportions
  • The lymphocyte percentage and CD3, CD8, and CD20 proportions were similar between flow cytometry and quantitative immunofluorescence on tonsil specimens. (aacrjournals.org)
  • modifiers
  • Five vTNFRs have been described in poxviruses, a viral homolog of host TNFSF receptor CD30 and four TNF inhibitors named cytokine response modifiers B, C, D, and E (CrmB, CrmC, CrmD, and CrmE). (nature.com)
  • novel
  • More recently, the LBS has developed novel, highly multiplex section and volume imaging methods (Histo-cytometry and Ce3D) that allow an unprecedented analysis of cell phenotype, signaling, function, and location in complex tissue settings. (nih.gov)
  • vivo
  • We have begun to test the hypothesis that TACC3 spatially restricts microtubule polymerization in response to guidance signals in Xenopus laevis axons in vivo and ex vivo. (labroots.com)
  • Since the early 2000's, the LBS has conducted analysis of immune cell behavior in vivo using methods of intravital 2-photon imaging that it helped pioneer, providing real-time, high-resolution visualization of immune-cell dynamics in situ . (nih.gov)
  • Different techniques have been developed to measure and enumerate the T-cell response to as many as possible epitopes within one sample directly ex vivo. (springer.com)
  • The role of cytokines and chemokines in anti-viral defense has been demonstrated, but their relative contribution to protective anti-viral responses in vivo is not fully understood. (nature.com)
  • therapeutic
  • A clearer understanding of the molecular pathogenesis may allow for improved therapeutic options or guide personalized prophylactic protocols. (frontiersin.org)
  • Pinpointing these key human immune regulators offers attractive therapeutic perspectives. (babraham.ac.uk)
  • host immune
  • Another common feature uniting all lineages of tumor is the ability to evade destruction by the host immune system. (pnas.org)
  • cellular immune
  • Currently used inactivated SwIAV vaccines administered by intramuscular injection provide homologous protection, but limited heterologous protection against constantly evolving field viruses, attributable to the induction of inadequate levels of mucosal IgA and cellular immune responses in the respiratory tract. (frontiersin.org)
  • In summary, chitosan SwIAV nanovaccine delivered by IN route elicited strong cross-reactive mucosal IgA and cellular immune responses in the respiratory tract that resulted in a reduced nasal viral shedding and lung virus titers in pigs. (frontiersin.org)
  • phenotypes
  • Our GWAS for 54 functionally relevant phenotypes of the adaptive immune system in 489 healthy individuals identifies eight genome-wide significant associations explaining 6%-20% of variance. (babraham.ac.uk)
  • autoimmunity
  • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. (jax.org)
  • receptor
  • Cytokine response modifier D (CrmD) is a secreted receptor for TNF and lymphotoxin containing the smallpox virus-encoded chemokine receptor (SECRET) domain and is expressed by ectromelia virus, the causative agent of the smallpox-like disease mousepox. (nature.com)
  • moreover
  • Moreover, patients who achieve pathologic complete response (pCR), elimination of invasive tumor following therapy, demonstrate better disease-free and overall survival ( 2, 3 ). (aacrjournals.org)
  • secondary
  • The proliferative larval stages of E. granulosus and E. multilocularis can "leak" out of a ruptured cyst ( E. granulosus ) or metastasize ( E. multilocularis ) to another organ or tissue, naturally producing a condition known as secondary CE or AE, respectively. (jimmunol.org)
  • hosts
  • This also allows the parasites to be passaged serially from one intermediate host to another by i.p. implantation of the larvae, simplifying the technical difficulties that would have been involved in cyclic passage through both definitive and intermediate hosts. (jimmunol.org)