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  • Molecules
  • Peroxisomes are well known for their metabolic activities: they are responsible for oxidising various organic molecules and breaking down substances that are harmful to cells, such as free radicals.The Franco-American study identified their important function in the immune system, showing that peroxisomes receive signals from the cell receptors that recognise outside aggressors. (inra.fr)
  • We hypothesized that mitochondria (originating from saprophytic bacteria) damaged and released from the injured tissues may contain molecules that are recognized by the immuneologic system as "foreign" and therefore induce a strong immune response, similar to sepsis. (frontiersin.org)
  • Her research seeks to understand the mechanisms regulating the disappearance of synapses by focusing on how immune-related molecules mediate this process. (sciencemag.org)
  • Researchers
  • A team of researchers from the SingHealth Duke-NUS Academic Medicine Centre's Viral Research and Experimental Medicine Centre found that immune cells undergoing stress and an altered metabolism are the reasons why some individuals become sick from viral infections while others do not, when exposed to the same virus. (news-medical.net)
  • Researchers from the Garvan Institute of Medical Research have developed a new method to spot rare immune cells that are reactive against cancer cells, from within a patient's own immune system. (news-medical.net)
  • Researchers from the University of Michigan used nanopaticles injection to prevent the immune cells of the body from impairing the healing of injured brain and spinal cord. (news-medical.net)
  • Researchers with the Virginia Bioinformatics Institute at Virginia Tech have released an upgrade to the institute's ENteric Immunity SImulator (ENISI) software, which models immune responses to beneficial and harmful bacteria that enter the gastrointestinal tract of mice, pigs, and humans. (innovations-report.com)
  • However, in 2012 researchers from the Institut Pasteur, INRA and Inserm showed that it also played a part in the immune response against bacteria(1). (inra.fr)
  • The researchers were then able to demonstrate that patients with illnesses related to a lack of or altered peroxisomes showed an impaired immune response set off by the virus. (inra.fr)
  • DKFZ researchers Heiko Weyd and Peter Krammer now plan to utilize this highly efficient immune blockade to suppress undesired immune responses, which are the cause, for example, of allergies and potentially life-threatening autoimmune diseases. (dkfz.de)
  • In experiments with immune cells in the Petri dish, the researchers have already been able to show that this is a functioning active principle. (dkfz.de)
  • The molecular response of an organism -- be it mouse or man -- to pathogenic invasion is controlled by circadian rhythms, researchers found. (medpagetoday.com)
  • From their analysis, the researchers discovered 89 independent gene variants over 53 sites that were linked to the genome associated with regulating the production of immune system cells. (medicalnewstoday.com)
  • The researchers say that understanding the genes affecting the immune system and the risk for autoimmune disease could be the first step toward developing personalized therapies dependent upon an individual's needs. (medicalnewstoday.com)
  • Immunology
  • The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance," Nature Immunology , vol. 10, no. 1, pp. 92-100, 2009. (hindawi.com)
  • Despite advances in cancer immunology research, questions such as how the immune system interacts with a growing tumor, and which components of the immune system play significant roles in responding to immunotherapy are still not well understood. (springer.com)
  • cellular
  • The data implicate that cellular immune responses play a critical role in nerve xenograft rejection but that further identification of the major effector cells mediating the rejection is required for developing effective means to prevent peripheral nerve xenograft rejection. (hindawi.com)
  • sepsis
  • Note that this study demonstrates that the circadian molecular clock controls the expression and function of toll-like receptor 9 (TLR9), which in turn modulates the response to vaccination and sepsis models in mice. (medpagetoday.com)
  • In mice exposed to infection at the highest and lowest time of activity in the 24-hour light-dark cycle of an immune protein known as toll-like receptor 9 (TLR9), those whose exposure was at the nadir of TLR9 expression had much more severe sepsis, according to Erol Fikrig, MD, of Yale University, and colleagues. (medpagetoday.com)
  • inflammatory
  • Acetylation: a novel method for modulation of the immune response following trauma/hemorrhage and inflammatory second hit in animals and humans," Surgery , vol. 144, no. 2, pp. 204-216, 2008. (hindawi.com)
  • Among the mice with cecal ligation, not only was survival worse in those immunized at the lowest time point for immune expression, but levels of inflammatory mediators such as interleukin-6 and chemokine MCP-1 also were substantially increased. (medpagetoday.com)
  • Moreover, administration of damaged mitochondria induced Systemic Inflammatory Response Ssyndrome (SIRS) in animals. (frontiersin.org)
  • system
  • If they don't receive antiretroviral therapy (ART), most HIV patients see a progressive weakening of their immune system. (news-medical.net)
  • This research illustrates the double function of peroxisomes and highlights the close link between metabolism and the immune system. (inra.fr)
  • They now plan to develop this biological principle into a therapy method that specifically blocks allergic reactions or autoimmune responses without suppressing the whole immune system. (dkfz.de)
  • The idea is to block an undesired immune response against the allergen or autoantigen very specifically while not suppressing the whole immune system," said DKFZ immunologist Krammer. (dkfz.de)
  • However, immune system dysfunction can also lead to excessive activation, such as mast cell hyperstimulation during allergic responses, or the broad immune system activation caused by septic shock. (qiagen.com)
  • However, they note that further research is needed in order to better understand the role of genetics in the "complex dynamics of the immune system. (medicalnewstoday.com)
  • Vaccines and cancer immunotherapies work by activating the immune system with biochemical signals. (acs.org)
  • A new study shows that the immune system can also respond to physical cues such as the texture of injected nanoparticles, potentially opening up new ways to design therapies for cancer and other diseases. (acs.org)
  • First, they made two sets of nanoparticles from titanium dioxide, a compound that doesn't usually trigger the immune system. (acs.org)
  • mucosal
  • Similarly, we observed decreased specific mucosal anti-MP IgA response in patients with IM. (gu.se)
  • activate
  • To test whether physical cues could help activate an immune response, Mei X. Wu of Massachusetts General Hospital and Xi Xie of Sun Yat-Sen University designed an experiment that allowed them to isolate shape-based and biochemical cues. (acs.org)
  • protein
  • The booster vaccination included various combinations of the Ad26.Mos.HIV components or a different mosaic component, called MVA-Mosaic, and/or two different doses of clade C HIV gp140 envelope protein containing an aluminum adjuvant to boost immune responses. (medicalnewstoday.com)
  • specific
  • A quantitative understanding of the kinetics of the immune response to treatment is crucial in designing treatment strategies, such as dosing, timing, and predicting the response to a specific treatment. (springer.com)
  • mechanism
  • Although the immune response is predominantly controlled at the transcriptional level, microRNA-mediated RNA interference is emerging as an important regulatory mechanism that operates at the translation level. (nih.gov)
  • therapies
  • Mathematical modeling and simulation of immune-modifying therapies can help to offset the costs of drug discovery and development, and encourage progress toward new immunotherapies. (springer.com)
  • Search
  • To search for potential immunologic markers for GC, we analyzed antibody responses against H. pylori in risk groups of cancer development. (gu.se)