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  • allografts
  • PAF is known to be released from renal allografts during hyperacute rejection and the PAF antagonist BN 52021 increases cardiac, liver, and skin allograft survival in rats, acting synergistically with azathio-prine and cyclosporine. (barnardhealth.us)
  • In spite of the established role of draining lymph nodes (LN) in induction of rejection of skin allografts, there was much greater involvement of LN after liver than after skin transplantation. (ovid.com)
  • B , the consistent addition of such effector molecules to IFN-stimulated genes signatures seems to be associated with the elimination of NK cell/CTL targets cells, resulting in either the elimination of unwanted pathogenic processes (virally infected cells and cancer cells) or the destruction of normal tissues (autoimmune phenomena) or allografts (acute rejection). (aacrjournals.org)
  • The striking conclusion from that work was that, unlike other adult allografts, the fetal bone escapes immune destruction in spite of the strong allogeneic barriers. (ovid.com)
  • Immunology
  • Research in the Immunology department is based on the principle that a comprehensive understanding of these many components and the interactions between them will reveal multiple opportunities to manipulate the immune system as a weapon against cancer and other maladies. (mdanderson.org)
  • fetal
  • Signaling pathways triggered by the mother's immune system may cause complications during fetal development. (the-scientist.com)
  • We suggest that the survival of an allogeneic fetal graft in an immunologically intact recipient depends on an active and selective immune response directed against the la components associated with the MHC on the embryonic and fetal cells. (ovid.com)
  • Our aim, therefore, was to investigate the specific mechanisms involved in permitting the escape of a fetal bone allograft from rejection. (ovid.com)
  • calcineurin
  • Drugs that are used currently, cyclosporin A and FK506, inhibit calcineurin, which is the enzyme that activates the immune response. (technologynetworks.com)
  • The purpose of the investigation is to develop new and more specific drugs, that inhibit only the immune response triggered by the calcineurin and not all of its other functions", explained the researcher Mercedes Pérez. (technologynetworks.com)
  • In previous studies, the team of Perez had already described a peptide of the protein family RCAN able to join the calcineurin and to inhibit specifically the activation of the immune response. (technologynetworks.com)
  • Our hypothesis is that prolonged therapy with LEA29Y with avoidance of steroids and calcineurin inhibitors and the use of mechanistic and immune monitoring assays will result in a safe and effective drug minimization withdrawal strategy. (immunetolerance.org)
  • cancer
  • A related concept is used in a type of cancer treatment called immunotherapy where the patient's own immune cells are genetically programmed with the CAR gene to mount an immune response against tumour cells. (eurekalert.org)
  • We took this approach from cancer immunotherapy and we used it for the opposite purpose - to turn off unwanted immune responses," says Dr. Levings. (eurekalert.org)
  • This is a molecule with huge potential to regulate immune response," Dr. Anatolij Horuzsko, reproductive immunologist at the Medical College of Georgia Center for Molecular Chaperone/Radiobiology and Cancer Virology, says of HLA-G dimer. (bio-medicine.org)
  • The Contemporary Understanding of the Role of α/β+ CTLs in the Control of Human Cancer Growth and Its Rejection: What Are We Missing? (aacrjournals.org)
  • embryo
  • On the basis of these notions, we propose that the capacity of la determinants expressed on cells of the embryo, to elicit anti-la and IgG alloantibodies in the pregnant mother, determines the capacity of the embryo to escape rejection by the histoincompatible mother. (ovid.com)
  • therapies
  • Reduction or downregulation of MHC class I protein expression using RNA interference (RNAi) ( 19 ) has shown some success in overcoming the limitations of immune rejection in cell-based therapies. (diabetesjournals.org)
  • Recent understanding of the biology of rejection and tolerance has led to the development of novel therapies, in particular blockade of the costimulatory pathway. (immunetolerance.org)
  • stem
  • Inducing immune tolerance to human embryonic stem cell graft is critical for the clinical success of regenerative medicine," commented Dr. Joseph Wu, M.D., Professor of Medicine and Radiology at the Stanford University School of Medicine. (technologynetworks.com)
  • biopsy
  • At 3 years, patients will be offered the option of discontinuing LEA29Y if they fulfill the ITN drug withdrawal criteria including a normal allograft biopsy and quiescent immune monitoring profiles. (immunetolerance.org)
  • Disease
  • All Natural Immune Boosters Proven To Fight Infection, Disease And More. (barnardhealth.us)
  • There are many kinds of stressors that increase our risk for disease, but stressors that threaten our social standing, such as targeted rejection, seem to be particularly harmful. (healthcanal.com)
  • With this finding, it opens up the possibility to build a gene for any disease where the immune system is overactive," says Dr. MacDonald. (eurekalert.org)
  • patients
  • A recent grant from the National Multiple Sclerosis Society is enabling studies of whether down-regulating MHC expression in multiple sclerosis patients can slow or arrest the immune system's attack of the nerve's protective covering. (bio-medicine.org)
  • cell
  • Now we need to quantify more protein biomarkers, assess the tumor mutational landscape, and examine immune cell signatures, too. (the-scientist.com)
  • Selective cell depletion experiments revealed that the immune spleen cell effecting immunity was an Lyt 1+, 2+ T cell. (arvojournals.org)
  • tolerance
  • The Immune Tolerance Network and is sponsored by the National Institute of Allergy and Infectious Diseases , part of the National Institutes of Health. (immunetolerance.org)
  • inflammatory
  • Murphy and colleagues decided to directly investigate whether rejection-related life events affect inflammatory activity by conducting a study that followed 147 healthy adolescent women over 2.5 years. (healthcanal.com)
  • system
  • From extending lifespan to bolstering the immune system, the drug's effects are only just beginning to be understood. (the-scientist.com)
  • They have highly significant and long lasting effects on lipid and carbohydrate metabolism and on the immune system. (dkfz.de)
  • Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. (barnardhealth.us)
  • When a mouse's immune system is deci. (bio-medicine.org)
  • When a mouse's immune system is deciding whether to reject a skin graf. (bio-medicine.org)
  • This problem is of special interest because of its potential relevance to the escape of the allogeneic embryos and fetuses from destruction by the host immune system. (ovid.com)
  • mechanism
  • To identify the mechanism of liver allograft acceptance we have compared skin rejection with liver acceptance in DA rat strain recipients of PVG donors, a major histocompatibility complex (MHC) class I plus II mismatch. (ovid.com)
  • pathways
  • The data collected suggest that recent exposure to targeted rejection does indeed activate the molecular signaling pathways that regulate inflammation. (healthcanal.com)