Immune graft allogeneic stem cell transplantation. Medical search. Frequent questions

It is closely linked with graft-versus-host disease (GvHD), as the underlying principle of alloimmunity is the same. (wikipedia.org)
CD4+CD25+ regulatory T cells (Treg) can be used to suppress GvHD without loss of beneficial GvT effect. (wikipedia.org)
Whereas graft-versus-host-disease (GvHD) has a negative impact on the host, GvL is beneficial for patients with hematopeietic malignancies. (wikipedia.org)
After HSC transplantation both GvL and GvHD develop. (wikipedia.org)
The interconnection of those two effects can be seen by comparison of leukemia relapse after HSC transplantation with development of GvHD. (wikipedia.org)
When transplanting T-cell depleted stem cell transplant, GvHD can be partially prevented, but in the same time the GvL effect is also reduced, because T-cells play an important role in both of those effects. (wikipedia.org)
There are some strategies to suppress the GvHD after transplantation or to enhance GvL but none of them provide an ideal solution to this problem. (wikipedia.org)
When transplanting HSC during AML, T-cells are usually selectively depleted to prevent GvHD while NK cells help with the GvL effect which prevent leukemia relapse. (wikipedia.org)
When using non-depleted T-cell transplant, cyclophosphamide is used after transplantation to prevent GvHD or transplant rejection. (wikipedia.org)
Other strategies currently clinically used for suppressing GvHD and enhancing GvL are for example optimization of transplant condition or donor lymphocyte infusion (DLI) after transplantation. (wikipedia.org)
Graft-versus-host disease ( GvHD ) is a syndrome , characterized by inflammation in different organs. (wikipedia.org)
GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
The white blood cells present within the transplanted tissue then attack the recipient's body's cells, which leads to GvHD. (wikipedia.org)
GvHD occurs when the donor's immune system's white blood cells reject the recipient. (wikipedia.org)
GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
[11] About one-third to one-half of allogeneic transplant recipients will develop acute GvHD. (wikipedia.org)
The inclusion of ATG resulted in a significantly lower rate of chronic GVHD after allogeneic transplantation than the rate without ATG. (bmj.com)
The plain English version would read: "In this two year, open-label trial, our company's antihuman T-lymphocyte immune globulin (ATG) halved the rate of chronic graft-versus-host disease (GVHD) in people who had previously undergone allogeneic haematopoietic stem-cell transplantation, but made no difference to mortality. (bmj.com)
Monitor for severe acute graft-versus-host disease (GVHD) and steroid-refractory GVHD. (nih.gov)
BACKGROUND: In patients undergoing allogeneic hematopoietic stem-cell transplantation (HSCT), a calcineurin inhibitor plus methotrexate has been a standard prophylaxis against graft-versus-host disease (GVHD). (bvsalud.org)
CONCLUSIONS: Among patients undergoing allogeneic HLA-matched HSCT with reduced-intensity conditioning, GVHD-free, relapse-free survival at 1 year was significantly more common among those who received cyclophosphamide-tacrolimus-mycophenolate mofetil than among those who received tacrolimus-methotrexate. (bvsalud.org)
The GvHD Hub remains dedicated to bringing you the latest information regarding COVID-19 and its implications in patients undergoing hematopoietic stem cell transplantation, as well as addressing the unmet medical needs in the field. (scientificeducationsupport.com)
GvHD is a common complication of allogeneic hematopoietic stem cell transplantation and is a major cause of posttransplant mortality and morbidity. (scientificeducationsupport.com)
Allogeneic hematopoietic stem cell transplantation is a curative therapy for hematological malignancies, but its efficacy is limited by graft-versus-host disease (GVHD). (lidsen.com)
The immune cell receptor channel P2X7 and its ligand adenosine 5'-triphosphate (ATP) have been implicated in GVHD pathogenesis. (lidsen.com)
However, graft-versus-host disease (GVHD) is a very serious complication and a major cause of morbidity and mortality after allogeneic HSCT. (lidsen.com)
Graft-versus-host disease (GVHD) is a serious complication that may occur in patients receiving allogeneic hematopoietic stem cell transplant (HSCT). (lidsen.com)
Key target indications for the platforms include Graft versus Host Disease (GvHD), Systemic lupus erythematosus (SLE), Systemic Sclerosis (SSc) and high-risk tibial fractures. (lifecarenews.in)
Acute Graft-versus-host disease (GvHD) is a life-threatening complication after leukemia treatment with allogeneic stem cell transplantation i.e. the transplantation of cells from another person. (gesundheitsindustrie-bw.de)
GvHD occurs when the transplanted immune cells are overly active and damage the receiving patient's healthy tissue. (gesundheitsindustrie-bw.de)
A team of hematology marrow transplant department of the Saint-Louis Hospital AP-HP, the Paris University and INSERM (U976 unit) in collaboration with the Pasteur Institute, led the work on graft against host disease (GVHD) using liquid chromatography coupled with mass spectrometry to study the metabolome of allogeneic patients at Saint-Louis hospital AP-HP. (pasteur.fr)
Graft against the host (GVHD) is a major complication that may occur after a allograft, and is characterized by tissue damage induced by donor immune cells which react against those of the recipient. (pasteur.fr)
Recent advances in the understanding of immunological mechanisms of GVHD have shown that activation of donor immune cells is tightly regulated by the microenvironment tissue or digestive microbiota changes after transplantation. (pasteur.fr)
Indoles derivatives are ligands of the receptor Aryl Hydrocarbon (AhR), which regulates the activation and differentiation of immune cells and could therefore contribute to limiting the risk of immune reaction to allogeneic origin of GVHD. (pasteur.fr)
These results published in the journal Nature Communications highlight the major changes in the human metabolome after allograft, associated with alterations of the patient's metabolism or its microbiota, which may represent potential therapeutic targets new for the prevention or treating the graft against the host (GVHD). (pasteur.fr)
Graft-versus-host disease (GVHD) presents a barrier to its wider application. (uky.edu)
Butyrate-producing Clostridia directly result in the increased presence of regulatory T cells in the gut, which are protective in GVHD development. (uky.edu)
Reduced number of goblet cells and Paneth cells have been shown to associate with GVHD and has a significant impact on the micro- and mycobiome density and their composition. (uky.edu)
The two vaccine doses were well tolerated with only 3% patients developing a reactivation of graft versus host disease (GvHD). (mdc-berlin.de)
The major risk with these procedures is the development of GVHD and several precautions have been put in place to avoid this unfavorable clinical event, such as the infusion of CD3 depleted high pure NK cells or the selection of HLA matched donors [ 8 ]. (biomedcentral.com)
Important insights into NK cell function in cancer eradication originated from the knowledge gained from mismatched NK cells in allo-SCT setting, where these innate immune effectors mediate a remarkable graft-versus-leukemia (GvL) effect towards tumor cells of recipient without attacking their normal tissues, thus limiting the onset of GVHD. (biomedcentral.com)
Moreover, it has been demonstrated HLA-mismatched NK cells in haploidentical allo-SCT improve the overall survival of patients affected by acute myeloid leukemia by controlling tumor relapse without causing GVHD. (biomedcentral.com)
Donor immunity emerging post-transplant plays a pivotal role in the protection against pathogens, such as Aspergillus, CMV and EBV, as well as in the development of graft-versus-host disease (GVHD) and graft-versus-leukemia effect. (ulisboa.pt)
We are particularly interested in developing strategies that may be translated into the clinical setting, such as the use of pathogen-specific T cells, donor regulatory T cells for GVHD and disease-specific T cells, with the aim of improving patient survival. (ulisboa.pt)
Second, the use of the patient's own bone marrow cells for gene replacement does not result in graft-versus-host disease (GVHD), a major complication of current allogeneic transplant. (nih.gov)
This article is a summary of the European Society for Blood and Marrow Transplantation (EBMT) webinar entitled 'Pathophysiology of acute and chronic GvHD, novel therapeutic strategies in the preclinical phase' delivered by Ernst Holler on May 5th, 2020. (gvhdhub.com)
The restoration of hematopoiesis together with the donor's immune system can lead to a major immune reaction, graft- versus -host disease (GvHD). (gvhdhub.com)
Researchers at Baylor College of Medicine and collaborating institutions have engineered immune cells to control two major life-threatening complications, namely graft-vs-host disease (GvHD) and cancer relapse, which typically emerge after treating leukemia with allogeneic hematopoietic stem cell transplantation (allo-HSCT). (texaschildrens.org)
Graft-versus-host disease (GVHD) is a life-threatening complication that can occur after certain stem cell or bone marrow transplants . (medlineplus.gov)
GVHD may occur after a bone marrow, or stem cell, transplant in which someone receives bone marrow tissue or cells from a donor. (medlineplus.gov)
GVHD does not occur when people receive their own cells. (medlineplus.gov)
HSCT patients are presumed immunocompetent if they are at least 24 months post-HSCT, are not receiving immunosuppressive therapy, and do not have graft- versus-host disease (GVHD). (cdc.gov)
The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)

Graft-versus-tumor effect (GvT) appears after allogeneic hematopoietic stem cell transplantation (HSCT). (wikipedia.org)
This response is mediated largely by cytotoxic T lymphocytes (CTL) but it can be employed by natural killers (NK cells) as separate effectors, particularly in T-cell-depleted HLA-haploidentical HSCT. (wikipedia.org)
For some forms of hematopoietic malignancies, for example acute myeloid leukemia (AML), the essential cells during HSCT are, beside the donor's T cells, the NK cells, which interact with KIR receptors. (wikipedia.org)
Chronic graft- versus -host disease (cGvHD) is a major cause of morbidity after hematopoietic stem cell transplantation (HSCT). (haematologica.org)
Hematopoietic stem cell transplantation (HSCT) is an important therapeutic option for patients with non-malignant diseases as well as high-risk and refractory hematopoietic malignancies. (haematologica.org)
As a result, HSCT is often attributed to an increased risk of health complications, the most severe being chronic graft- versus -host disease (cGvHD). (haematologica.org)
Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). (karger.com)
Hematopoietic stem cell transplantation (HSCT) is a standard form of cellular therapy for patients suffering from malignant hematological diseases. (lidsen.com)
Despite the improvement in the management of patients, allogeneic HSCT remains associated with severe immunological complications. (pasteur.fr)
The main research focus of our laboratory is the study of immune reconstitution after hematopoietic stem cell transplantation (HSCT) in humans and the development of strategies that modulate immune responses and tolerance post-transplant. (ulisboa.pt)
2020/2022 CMV infection and CMV-specific T-cell reconstitution in unrelated donor allo-HSCT after in vivo T-cell depletion with ATG: a comparative study of prophlylaxis with letermovir versus standard of care preemptive. (ulisboa.pt)
The ability to correct genetic hematopoietic diseases by gene therapy has a number of advantages over current therapies that involve allogeneic hematopoietic stem cell transplantation (HSCT). (nih.gov)
We are evaluating whether allogeneic HSCT can reconstitute normal hematopoiesis in MonoMAC and reverse the hematological abnormalities in MDS, if MDS is present at the time of transplant. (nih.gov)
While allogeneic HSCT is the conventional curative treatment for immunodeficiency and MDS, patients with MonoMAC, because of an intact T-cell population and co-existing infection, represent a profile not generally encountered in the setting of allogeneic HSCT. (nih.gov)
The biological questions with MonoMAC center around whether the individual leukocyte compartments that are lost in MonoMAC (B-lymphocytes, NK cells, and monocytes) will be constituted with HSCT, and whether the residual recipient T-lymphocytes will represent an impediment to engraftment. (nih.gov)
We analyzed the effect of the interval from TBI to hematopoietic stem cell transplantation (HSCT) on the outcome of HSCT. (elsevierpure.com)
Discussion and conclusion: Although recipient immune system at HSCT might be affected by the timing of TBI, the duration between the start of TBI and HSCT did not influence the outcome of HSCT using myeloablative conditioning with TBI and CY. (elsevierpure.com)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) involves the infusion of stem cells following administration of high-dose chemotherapy or total body irradiation for either tumor control or to prevent solid transplant rejection. (gvhdhub.com)
Allo-HSCT is an important treatment strategy, which allows administration of myeloablative therapy and the elimination of cancer cells by the transplanted donor T and natural killer (NK) cells in a phenomenon known as the graft- versus -leukemia (GvL) effect. (gvhdhub.com)
Right now, hematopoietic stem cell transplantation (HSCT) is the foremost dependable healing treatment with amazing comes about for patients with HLAmatched family or disconnected givers. (alliedacademies.org)
We performed a review chart audit of 12 children who experienced allogeneic HSCT for WAS to report our involvement. (alliedacademies.org)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
PHASES OF IMMUNE RECOVERY specialists, HSCT unit and clinic staff, and public health pro- fessionals. (cdc.gov)
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)

Mouse colon impacted by acute graft-versus-host disease. (wikipedia.org)
In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
In the classical sense, acute graft-versus-host disease is characterized by selective damage to the liver , skin (rash), mucosa , and the gastrointestinal tract . (wikipedia.org)
Acute graft versus host disease (aGVHD) is a common complication following allogeneic hematopoietic stem cell transplantation (AHSCT) caused by cellular and inflammatory factors, including those arising from monocytes and dendritic cells as integral parts of the immune system. (magiran.com)
For conditioning for transplantation, patients were given a reduced dosage of chemotherapy so that the acute tolerance of the transplantation was very good. (disabled-world.com)
Kids with acute leukemia, lymphomas, and people present process hematopoietic stem cell transplantation, particularly allogeneic transplantation, are additionally at excessive threat of PJP. (gentaurprices.com)
Nevertheless, acute and chronic rejection, graft versus host disease, and the inability to identify suitable donors continue to be challenges and limit broader application of cell and organ transplantation to the many patients that could benefit. (lidsen.com)
INTRODUCTION: Vaccination against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is approved and recommended for immunocompromised patients such as patients after allogeneic stem cell transplantation (allo-SCT). (mdc-berlin.de)
Aplastic anemia due to the progressive failure of the bone marrow, malignant neoplasias such as acute myeloid leukemia, liver tumors and squamous cell carcinoma are some of the possible evolutions of Fanconi Anemia. (bvsalud.org)

Graft-versus-host disease Hematopoietic stem cell transplantation Thompson LF, Tsukamoto H, Chernogorova P, Zeiser R (January 2013). (wikipedia.org)
This is called graft-versus-host disease. (mdanderson.org)
NEW YORK, NY / ACCESSWIRE / July 16, 2021 / Kadmon Holdings, Inc. (Nasdaq:KDMN) today announced that the U.S. Food and Drug Administration (FDA) has approved REZUROCK ™ (belumosudil) 200 mg once daily (QD) for the treatment of adult and pediatric patients 12 years and older with chronic graft-versus-host disease (cGVHD) after failure of at least two prior lines of systemic therapy. (yahoo.com)
Not to be confused with Host-versus-graft disease . (wikipedia.org)
Micrographs of grades of skin graft-versus-host disease: Ranging from grade I GvHR (with minimal vacuolization in the epidermis) to grade II GvHR (with vacuolization and dyskeratotic bodies) to grade III GvHR (with sub epidermal cleft formation) and finally to grade IV GvHR (with separation of the dermis from the epidermis). (wikipedia.org)
Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
[6] Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands . (wikipedia.org)
Merkel cell carcinoma, a rare type of skin cancer, is an aggressive and fast-growing disease that has been associated with mortality rates higher than other types of skin cancer, including melanoma," said Dr. (merck.com)
Organ transplantation may also improve neurologic function in various disorders with neurologic manifestations such as Wilson disease (liver transplantation), familial amyloidosis with neuropathy (liver transplantation), and diabetic neuropathy (pancreas transplantation). (medscape.com)
Overall and disease-free survival, relapse, transplantation-related death, and engraftment did not differ substantially between the groups. (bvsalud.org)
Chronic graft-versus-host disease (cGVHD) is major cause of morbidity and mortality following allogeneic hematopoietic cell transplantation (HCT). (bvsalud.org)
ABSTRACT Introduction: The perception of prejudice against, and stigmatization of, sickle cell disease (SCD) leads the patient to perceive a different treatment, due to the disease stigma and maybe related to a worse quality of life (QoL). (scielo.br)
Objectives: Describe and evaluate the perception of the prejudice against the disease and its impact on the quality of life of patients with sickle cell disease. (scielo.br)
However, in sickle cell disease (SCD) primarily due to repeated blood transfusions and hemolysis-induced recycling of iron, its supplementation during pregnancy remains questionable and may be harmful. (scielo.br)
My brother has a rare blood disease for which he had a stem cell transplant in February. (helsinkiphotofestival.com)
A consequence of allogeneic stem cell transplantation can be graft-versus-host disease, which can be a life-threatening side effect. (helsinkiphotofestival.com)
In graft-versus-host disease, the donor's immune cells (graft) attack the cells of the patient (host). (helsinkiphotofestival.com)
The transplantation of stem cells from a healthy donor (allogeneic) offers the chance of cure for patients with an aggressive form of chronic lymphocytic leukemia (CLL), irrespective of genetic prognostic factors and the prior course of the disease. (disabled-world.com)
Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the GCLLSG CLL3X Trial. (disabled-world.com)
BioSenic is currently preparing a fundraising to be organized in Q3/Q4 2023 to initiate the Phase III clinical trial in chronic graft versus host disease (cGVHD) in Q1 2024. (lifecarenews.in)
Rezurock patient-reported outcomes correlated with clinical response in chronic graft-versus-host disease. (medthority.com)
Results from a pooled analysis of Rezurock (belumosudil) for the treatment of chronic graft-versus-host disease (cGVHD) show certain organ clinical responses correlated with clinically meaningful changes in patient-reported outcomes (PROs). (medthority.com)
Therefore, for any specific patient, the transplant physician may be faced with a myriad of potential choices, including decisions concerning which donor to prioritize where there is more than one, the optimal selection of specific umbilical cord blood units and which conditioning and graft-versus-host disease prophylactic schedule to use. (nih.gov)
Induced pluripotent stem cells (iPSCs) generated from patient fibroblasts could potentially be used as a source of autologous cells for transplantation in retinal disease. (nature.com)
This important proof-of-concept finding supports the development of personalized iPSC-based transplantation therapies for retinal disease. (nature.com)
This concept started from the observation that bone marrow transplantation can provide stromal cells able to synthesize intact collagen type I, replacing deficient patient cell function and ameliorating disease symptoms [5]. (stemcellslab.net)
Therefore, the authors concluded that transplantation of isolated healthy allogeneic MSCs might cure the disease. (stemcellslab.net)
2015/2021 Repair of tissue and organ damage in refractory chronic graft versus host disease after hematopoietic stem cell transplantation by the infusion of purified allogeneic donor regulatory T lymphocytes. (ulisboa.pt)
For this research we are using the genetic disease, canine leukocyte adhesion deficiency (CLAD), as a model for applying advances in understanding of stem cell biology to enhance gene transfer into the hematopoietic stem cells. (nih.gov)
It also carries risks of potential harms, including infection, graft-versus-host disease (where certain immune cells from the donor attack the normal tissue of the transplant recipient), and death. (cancer.gov)
People who lost diversity in their gut microbiome also had a higher likelihood of dying from graft-versus-host disease. (cancer.gov)
Previous studies from single hospitals have shown that people undergoing allogeneic stem-cell transplantation often have disruptions in their gut microbiome, including an increase in numbers of potentially disease-causing species of bacteria and an overall loss of diversity. (cancer.gov)
And antibiotic use after transplant, which can disrupt the microbiome, is associated with a higher risk of death from any cause and specifically from graft-versus-host disease. (cancer.gov)
They then looked for associations between diversity of the gut microbiome and survival following transplantation, as well as the incidence of graft-versus-host disease. (cancer.gov)
Graft-versus-host disease and graft-versus-leukemia responses. (medlineplus.gov)
Cell Therapy for Parkinsons Disease: What Next? (lu.se)
This disease is characterized by the malfunctioning of the DNA repair mechanism, which present an increase in the rate of spontaneous damage, among these spontaneous chromosomal instability, and hypersensitivity of cells to the chromosomal breaking effect induced by clastogenic agents 2-3 . (bvsalud.org)

Graft-versus-leukemia (GvL) is a specific type of GvT effect. (wikipedia.org)
Healthcare providers call this "graft-versus-tumor" effect (GVT). (clevelandclinic.org)
In addition, Henri constantly feared graft-versus-host. (helsinkiphotofestival.com)
The main risk still remains the "graft-versus-host reaction", in which donor cells attack the patient's own cells, which are foreign to them. (disabled-world.com)
Persistent lymphopenia, graft versus host illness, poor immune reconstitution, and prolonged use of corticosteroids are vital threat components for PJP. (gentaurprices.com)
The curative effect of stem cell transplantation relies on alloreactivity of donor T cells against cancer cells, which is known as Graft-versus-Leukaemia (GvL). (ox.ac.uk)
The Graft-Versus-Leukemia Effect in AML. (ox.ac.uk)
Among the different approaches of anti-tumor adoptive cell transfer, allogeneic stem cell transplantation (allo-SCT) represents the first and most consolidated form of immunotherapy on the basis of its graft versus tumor (GvT) effect. (biomedcentral.com)
Two patients created review IV intense graft-versus-host malady, and 1 passed on on day +99. (alliedacademies.org)

An autologous stem cell transplant uses the patient's own cells for treatment. (mdanderson.org)
The patient has low blood counts until the replaced cells replenish the patient's body with healthy cells. (mdanderson.org)
The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
If the donor cells aren't a close enough match, the patient's body may recognize the donor cells as foreign and reject them. (mdanderson.org)
Using a patient's own cells for transplantation would avoid these pitfalls and is possible with induced pluripotent stem cells (iPSCs). (nature.com)
In an allogeneic stem cell transplant, the blood-forming stem cells in a patient's bone marrow are destroyed using high doses of chemotherapy or radiation therapy. (cancer.gov)
Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)

Nevertheless, diagnosis and management of perioperative complications of organ transplantation still plays a prominent role in determining the postoperative course of allograft recipients. (medscape.com)
Future developments in the field of organ transplantation, including newer immunosuppressive medications and xenograft, pluripotent stem cell and neural tissue transplantation, will further change the spectrum of neurologic and other complications in transplant recipients. (medscape.com)
Neurologic complications are related to the surgical procedure of transplantation, posttransplant immunosuppression, opportunistic infection, or the inherent disorders that led to transplantation. (medscape.com)
The variety of conditions that led to organ failure requiring transplantation may also be associated with neurologic complications, including amyloid and diabetic neuropathy. (medscape.com)
Neurologic complications of organ transplantation occur internationally with a similar frequency as in the United States. (medscape.com)
It is crucial to control the transplanted donor immune cells so that the effect is strong enough to eliminate the leukemia cells but not strong enough to lead to complications in other tissues and organs. (disabled-world.com)
Through established protocols 2 , fibroblasts from a skin biopsy can be returned to a pluripotent state and serve as a renewable, autologous source of replacement cells that avoids the ethical complications of hESCs. (nature.com)

In the next clinical trial," continues Sugita, "we plan to use allogeneic iPS-retinal pigment epithelial cells from HLA homozygote donors. (neurosciencenews.com)
The clinical data after the transplantation will allow us to see if the iPS cell bank is truly useful or not. (neurosciencenews.com)
The German CLL Study Group proved this in a multi-centric clinical phase II study led by Professor Dr. Peter Dreger, senior consultant and head of the division of stem cell transplantation at the Department of Internal Medicine V at Heidelberg University Hospital. (disabled-world.com)
BioSenic is a leading biotech company specializing in the development of clinical assets issued from: (i), the allogeneic cell therapy platform ALLOB and (ii) the Arsenic TriOxide (ATO) platform. (lifecarenews.in)
Recent clinical trials evaluating allogeneic retinal grafts derived from human embryonic stem cells (hESCs) show the procedure to be safe and potentially effective 1 . (nature.com)
Later, Arnold Caplan's group described mesenchymal stem/stromal cells (MSCs) as multipotent mesenchymal cell populations which can differentiate into several tissue types, and demonstrated roles for MSCs in the regeneration of bone, cartilage or ligaments in animal and clinical studies [2-4]. (stemcellslab.net)
This project represents a pre-clinical model for gene transfer into hematopoietic stem cells. (nih.gov)
The long-term objective is to develop strategies that will allow levels of expression of CD18 in hematopoietic cells of children with leukocyte adhesion deficiency (LAD) that are sufficient to reverse the clinical phenotype. (nih.gov)
Our data presentations at ESMO underscore Regeneron's ability to apply a deep understanding of cancer biology, genetics and the immune system to advance the development of meaningful combinations for cancer types that have high unmet need," said Israel Lowy, Senior Vice President, Translational and Clinical Oncology at Regeneron. (biospace.com)
Proliferation of microorganisms on or within body sites without detectable host immune response, cellular damage, or clinical expression. (cdc.gov)

Hematopoietic cell transplantation is an intensive therapy used to treat high-risk hematological malignant disorders and other life-threatening hematological and genetic diseases. (uky.edu)

To understand the different types of stem cell transplants and how they work, we spoke with Borje S. Andersson, M.D., Ph.D. Here's what he had to say. (mdanderson.org)
What are the types of stem cell transplants? (mdanderson.org)
Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
Moreover, children who received transplants approached growth curves similar to the children transplanted with allogeneic complete bone marrow [6]. (stemcellslab.net)
Allogeneic hematopoietic stem cell transplants (allo-HSCTs) dramatically reduce HIV reservoirs in antiretroviral therapy (ART) suppressed individuals. (wisc.edu)
The idea to use transplants of dopa- ment of protocols that allow generation of fully functional mine-producing cells to substitute for the lost midbrain and safe midbrain dopamine neurons from stem cells. (lu.se)

American Society for Transplantation and Cellular Therapy Cord Blood Special Interest Group (2020). (duke.edu)
2020/2023 Development of Chimeric Antigen Receptor T cell therapy targeting oncological-associated chondroitin sulfate as cancer treatment. (ulisboa.pt)
2020/2021 Development of a novel chimeric antigen receptor T cell therapy using B-cell activating factor, for triple targeting of B-cell specific receptors for multiple myeloma and other mature B cell neoplasms. (ulisboa.pt)

cGVHD is a complication that can occur following allogeneic stem cell transplantation, resulting in significant morbidity and mortality. (medthority.com)
Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)

The biology of GvT response is still not fully understood but it is probable that the reaction with polymorphic minor histocompatibility antigens expressed either specifically on hematopoietic cells or more widely on a number of tissue cells or tumor-associated antigens is involved. (wikipedia.org)
This is an immune disorder that causes deep tissue infections. (clevelandclinic.org)
Bone marrow, the spongy tissue inside our bones, is the factory for blood cells. (mdanderson.org)
White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
A realistic hope of modern medicine is to replace damaged tissue with healthy cells grown in the lab. (neurosciencenews.com)
In order to avoid tissue rejection, they used autologous iPSCs-iPSCs that were created from the recipient's own skin cells. (neurosciencenews.com)
However, immune responses and tissue rejection are big issues to overcome when transplanting tissue derived from other individuals. (neurosciencenews.com)
There are many genetic variations of MHCs, and after transplantation, if the MHCs of the transplanted cells are not recognized by the T cells of the host immune system, there is an immune response and the tissue is rejected. (neurosciencenews.com)
The merger also enables Biosenic to add to its innovative cell therapy platform and strong IP for tissue repair protection with an entirely new arsenal of various anti-inflammatory and anti-autoimmune formulations using the immunomodulatory properties of ATO/OATO. (lifecarenews.in)
The tissue source of the MSCs was in most cases not decisive, and cells from various tissue sources were explored. (stemcellslab.net)
The low survival rate or dysfunction of extracellular matrix (ECM)-based engineered organs caused by the adverse effects of unfavourable local microenvironments on seed cell viability and stemness, especially the effects of excessive reactive oxygen species (ROS), prompted us to examine the importance of controlling oxidative damage for tissue transplantation and regeneration. (biomedcentral.com)
We sought to improve the tolerance of seed cells to the transplant microenvironment via antioxidant pathways, thus promoting transplant efficiency and achieving better tissue regeneration. (biomedcentral.com)
Tissue necrosis caused by both oxidative stress and the inflammatory response further prevents nutrients and oxygen from reaching viable cells, which contributes to expanding the necrotic area and leads to implant failure [ 7 ]. (biomedcentral.com)
eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
Before a transplant, tissue and cells from possible donors are checked to see how closely they match the recipient. (medlineplus.gov)
People who receive closely matched bone marrow tissue and cells usually do better. (medlineplus.gov)
Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)

Dr. Kurtzberg is an internationally renowned expert in pediatric hematology/oncology, pediatric blood and marrow transplantation, umbilical cord blood banking and transplantation, and novel applications of cord blood and birthing tissues in the emerging fields of cellular therapies and regenerative medicine. (duke.edu)
2 cGvHD is a multisystemic disorder that occurs due to foreign donor immune cells attacking the recipient's tissues. (haematologica.org)
Notes lead author Sunao Sugita, "In order to make iPSC transplantation a practical reality, the current goal is to create banks of iPSC-derived tissues that can be transplanted into anyone as they are needed. (neurosciencenews.com)
Autoimmune diseases are usually complex and multifactorial, characterized by aberrant production of autoreactive immune cells and/or autoantibodies against healthy cells and tissues. (frontiersin.org)
Autoimmune diseases are complex diseases characterized by the loss of immunological tolerance to self-antigens and sustained aberrant immunological response against healthy cells and tissues, leading ultimately to the overproduction of autoreactive immune cells and/or autoantibodies ( 1 , 2 ). (frontiersin.org)
It is caused by immune incompatibility between the graft (donor) and recipient tissues. (scientificeducationsupport.com)
The graft cells recognize the recipient tissues as foreign and mount an immune response against them. (scientificeducationsupport.com)
This life-threatening disorder develops when donor (graft) immune cells cause inflammatory damage to recipient (host) tissues. (lidsen.com)
A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)

With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
Peripheral blood mononuclear cells (PBMCs) were isolated by Ficoll-Hypaque gradient from the blood samples collected at days 0, 7, 14, 28, and final day of transplantation. (magiran.com)
Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
Morphologically, in the peripheral blood, these cells resemble mature lymphocytes. (medscape.com)

Engraftment failure and delays, likely due to diminished cord blood unit (CBU) potency, remain major barriers to the overall success of unrelated umbilical cord blood transplantation (UCBT). (duke.edu)
We report UK consensus guidelines on the selection of umbilical cord blood units, the hierarchy of donor selection and the preferred conditioning regimens for umbilical cord blood transplantation, with a summary of rationale supporting these recommendations. (nih.gov)

REZUROCK represents a new treatment paradigm for thousands of cGVHD patients, including those with difficult-to-treat manifestations like fibrosis,' said Corey Cutler, MD, MPH, FRCPC, Associate Professor of Medicine at Harvard Medical School and Medical Director, Adult Stem Cell Transplantation Program at the Dana-Farber Cancer Institute. (yahoo.com)
License Application (sBLA) seeking accelerated approval for KEYTRUDA, Merck's anti-PD-1 therapy, for the treatment of adult and pediatric patients with recurrent locally advanced or metastatic Merkel cell carcinoma (MCC). (merck.com)
KEYNOTE-017 represents the longest observation to date of patients with advanced Merkel cell carcinoma receiving anti-PD-1 therapy in the first-line setting, and demonstrated durable tumor control in these patients. (merck.com)
We look forward to working closely with the FDA throughout the review process and to bringing KEYTRUDA to patients with Merkel cell carcinoma. (merck.com)
KEYTRUDA, as a single agent, is indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have high PD-L1 expression [Tumor Proportion Score (TPS) ≥50%] as determined by an FDA-approved test, with no EGFR or ALK genomic tumor aberrations. (merck.com)
The aim of this study was to assess whether the lnc-DC plays a role in patients with aGVHD by measuring its expression levels compared to non-aGVHD patients on specific time intervals following transplantation. (magiran.com)
Participants included 38 patients who underwent primary allogeneic bone marrow transplantation. (magiran.com)
Organ transplantation has developed at an incredibly rapid pace since its introduction in the 1950s, and it has become a life-saving procedure for patients with end-stage organ failure. (medscape.com)
For a large percentage of patients, highly sensitive tests were conducted regularly to detect any remaining leukemia cells after the transplantation. (disabled-world.com)
In about half of these patients, no remaining CLL cells were detected in the blood in the long term, which was highly predictive for the lack of recurrence for the follow-up period (up to eight years, on average about four years). (disabled-world.com)
Allogeneic stem cell transplantation is a very stressful and risky form of therapy, which could previously not be carried out on the generally older patients affected by CLL. (disabled-world.com)
Allogeneic haemopoietic stem cell transplantation offers a potentially curative treatment option for a wide range of life-threatening malignant and non-malignant disorders of the bone marrow and immune system in patients of all ages. (nih.gov)
In this project, the team of Dr. David Michonneau and Professor Gérard Socié (INSERM U976 / Saint Louis Hospital AP-HP / University of Paris) was interested in the study of the metabolome of allogeneic patients in the hospital Saint- Louis AP-HP in the hematology-transplant adult service. (pasteur.fr)
A conditioning regimen and medications given to patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HCT) are capable of disturbing the homeostatic crosstalk between the microbiome and the host immune system and of leading to dysbiosis. (uky.edu)
Since infections represent a relevant cause of transplant related mortality we analyzed the advent of immunization to SARS-CoV-2 vaccination in a bicentric population of allogeneic transplanted patients. (mdc-berlin.de)
DISCUSSION: We showed in our bicentric allo-SCT patient cohort, that a humoral response could be achieve after the regular approved schedule, especially for those patients who underwent immune reconstitution and were free from immunosuppressive drugs. (mdc-berlin.de)
In the early 80s' donor lymphocyte infusions (DLI) with allo-activated haplo-identical cells from family members were infused in patients affected by hematological diseases or solid tumors. (biomedcentral.com)
There are so many variables in play locally, including how we treat our patients, and environmental and genetic influences on the microbiome that vary across geographical regions," said Steven Pavletic, M.D., a stem-cell transplant specialist at NCI's Center for Cancer Research , who was not involved in the study. (cancer.gov)
Additional presentations at ESMO include subgroup analyses of Libtayo in advanced non-small cell lung cancer (NSCLC), focusing on such populations as squamous cell carcinoma and patients with varying levels of PD-L1 expression. (biospace.com)
Patients with coordinated kin or parent benefactors (MSD) and coordinated irrelevant benefactors (URD) display the most noteworthy survival rates up to 80%, particularly in case transplantation happens at an early age with a URD. (alliedacademies.org)
Patients with CLL have a higher-than-normal white blood cell count, which is determined by complete blood count (CBC). (medscape.com)
The cells of origin in most patients with CLL are clonal B cells arrested in the B-cell differentiation pathway, intermediate between pre-B cells and mature B cells. (medscape.com)

The graft contains donor T cells (T lymphocytes) that can be beneficial for the recipient by eliminating residual malignant cells. (wikipedia.org)

For example, people who have stem cell transplantation go through intensive chemotherapy before treatment. (clevelandclinic.org)
We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)

As the name of this effect indicates, GvL is a reaction against leukemic cells of the host. (wikipedia.org)
GvL is a part of the reaction of the graft against the host. (wikipedia.org)
Immunologic variations from the norm of WAS incorporate T-cell lymphopenia, flawed proliferative reaction to CD3 cross-linking, disabled counter acting agent reaction to polysaccharide antigens, flawed monocyte chemotaxis, anomalies of fortified dendritic cells, and an expanded lymphocyte apoptosis with age. (alliedacademies.org)

PD-1 and its ligands, PD-L1 and PD-L2, thereby activating T lymphocytes which may affect both tumor cells and healthy cells. (merck.com)
CD8+ T cells, also called cytotoxic T lymphocytes (CTL), are one subtype of T cell ( 6 ), characterized by robust production of interferon (IFN)-γ and cytolytic activities via perforin (PRF)/granzymes (GZM) or Fas mechanisms to kill target cells ( 7 ). (frontiersin.org)
The graft usually comes from a human leukocyte antigen (HLA)-matched donor and contains hematopoietic cells as well as immune cells, including T lymphocytes. (gvhdhub.com)

BACKGROUND:Umbilical cord blood has become an important source of hematopoietic stem and progenitor cells for therapeutic applications. (duke.edu)
This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)

Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technologies. (wisc.edu)

First, the use of autologous hematopoietic stem cells for gene therapy obviates the need for a matched bone marrow donor since each individual would serve as his or her own bone marrow stem cell donor. (nih.gov)
Third, use of autologous hematopoietic stem cells would be expected to enhance immune reconstitution after transplant. (nih.gov)
There are no contraindications to autologous hematopoietic stem cell transplantation. (msdmanuals.com)

The activation, differentiation, and development of CD8+ T cells is accompanied by large-scale changes in the coordinated expression of numerous inflammatory cytokines, transcription factors (TFs) and chemokines that are correlated with their survival, effector function, and self-renewal ( 7 ). (frontiersin.org)
Immunosuppression before and after allogeneic transplant has been found to dramatically improve allograft survival and, despite side effects, has been a mainstay of patient management. (lidsen.com)
In a new NCI-funded study, researchers found that, in people with blood cancers who had received an allogeneic hematopoietic stem cell transplant, the health of their gut bacteria was linked with their survival. (cancer.gov)
Notably, we are presenting the first survival data for neoadjuvant Libtayo therapy in cutaneous squamous cell carcinoma and the first results for Libtayo in combination with ubamatamab, our investigational MUC16xCD3 bispecific antibody, in recurrent ovarian cancer. (biospace.com)

KEYTRUDA is an anti-PD-1 therapy that works by increasing the ability of the body's immune system to help detect and fight tumor cells. (merck.com)
These genes are involved in T cell regulation, including interferons, interleukin (IL),tumor necrosis factor (TNF), as well as linker for activation of T cells (LAT), cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), and adapter proteins. (frontiersin.org)
In the last few years, a renewed interest on adoptive cellular therapies emerged in the field of tumor-immunology due to the remarkable advances in regard to our knowledge of the mechanisms employed by immune system to fight cancer counterbalanced by the pathogenic loops deployed by tumors to escape immune responses. (biomedcentral.com)
Several protocols of adjuvant therapies based on NK cell allo-reactivity have been extensively used in clinics for both hematologic and non-hematologic malignancies either alone or in combination with antibodies and tumor-sensitizing drugs. (biomedcentral.com)

[ 1 ] . Complex multiorgan failure may require simultaneous transplantation of several organs. (medscape.com)
Successfully transplanting cells and organs from a donor into an immunologically disparate recipient is one of the greatest treatment advances in the history of medicine. (lidsen.com)
A start-up called yuri on Lake Constance enables made-to-measure experiments on the ISS for stem cells, artificial organs, surfaces and materials. (gesundheitsindustrie-bw.de)
And before you go through a stressful therapy like allogeneic transplantation, [we] want to make sure that all of your organs are functioning well. (cancer.gov)

Allogeneic stem cell transplantation is the only known curative therapy. (medscape.com)

METHODS: We retrospectively analyzed data of allo-SCT recipients in two German transplantation centers for safety and serologic response after two and three SARS-CoV-2 vaccinations. (mdc-berlin.de)

With further investigation we may decipher the mechanism of NK reg suppression and operationalize expansion of NK reg cells associated with cGvHD suppression. (haematologica.org)

In large patient populations, we have shown a CD56 bright natural killer (NK) population to strongly associate with a lack of cGvHD and we hypothesize that these cells function to suppress cGvHD. (haematologica.org)
We aimed to isolate and define the characteristics of regulatory NK (NK reg ) cells associated with suppression of cGvHD. (haematologica.org)
Moreover, this is the first paper to clearly establish that a CD56 bright CD3 - CD16 - perforin- NK reg population associates with a lack of cGvHD and has several unique characteristics, including the suppression of helper T-cell function in vitro. (haematologica.org)
Various immune-suppressive cell populations appear to associate with suppression of cGvHD, including T reg cells, B reg cells, M2 macrophages, dendritic cells, and CD56 bright natural killer (NK) cells. (haematologica.org)

Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. (nshealth.ca)

The Role of Cytochrome P450 2J2 in Cancer: Cell Protector, Therapeutic Target, or Prognostic Marker? (lidsen.com)
Indeed, the use of check-point inhibitors, T cells with engineered chimeric antigen receptors (CARs) and bi-specific T cell engagers (BiTE) showed impressive therapeutic potentials in the cure of advanced tumors and are currently being included in the in the armamentarium of clinicians [ 1 ]. (biomedcentral.com)
Mesenchymal stem/stromal cells (MSCs) are increasingly used as an intravenously applied cellular therapeutic. (stemcellslab.net)
We hypothesized that CD8^(+) T cells elicited by therapeutic vaccination during antiretroviral therapy (ART) would be recalled and boosted by treatment with the interleukin 15 (IL-15) superagonist N-803 after ART discontinuation. (wisc.edu)
Additionally, we developed an in situ rat alveolar fossa implantation model to evaluate the long-term therapeutic effects of NAC in bioroot transplantation. (biomedcentral.com)

Kadmon, a Sanofi Company, will present the results at the 2022 American Society for Transplantation and Cellular Therapy (ASTCT) and the Center for International Blood & Marrow Transplant Research (CIBMTR) Tandem Meetings in Salt Lake City, Utah. (medthority.com)

More recently, we engaged in developing several novel strategies for CAR T cell therapies of hematologic malignancies and solid tumors. (ulisboa.pt)
Adoptive therapies with genetically modified somatic T cells rendered HIV resistance have shown promise for AIDS therapy. (wisc.edu)
A renewable source of HIV-resistant human T cells from induced pluripotent stem cells (iPSCs) would further facilitate and broaden the applicability of these therapies. (wisc.edu)

Successful treatment of therapy-resistant chronic leukemia using allogeneic stem cell transplantation. (disabled-world.com)
Our study is the largest so far for this patient population and proved that allogeneic stem cell transplantation is a promising therapy option for high-risk CLL and has the potential to cure for this otherwise incurable kind of leukemia," says Professor Dreger, head of the study. (disabled-world.com)
The allogeneic cell and gene therapy platform, developed by BioSenic with differentiated bone marrow sourced Mesenchymal Stromal Cells (MSCs) that can be stored at the point of use in hospitals. (lifecarenews.in)
Stem cell-derived cell transplantation in the eye is one therapy being explored for inherited retinal degenerations such as retinitis pigmentosa (RP). (nature.com)

Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR). (medscape.com)

Summary: Researchers report they have successfully transplanted retinal pigment cells derived from stem cells without rejection or the need of immunosuppressant drugs. (neurosciencenews.com)
Researchers at the RIKEN Center for Developmental Biology (CDB) have successfully transplanted retinal pigment cells derived from stem cells of one monkey into the eyes of other monkeys without rejection and without the need for immunosuppressant drugs. (neurosciencenews.com)
Published in Stem Cell Reports , the study shows that this procedure is possible as long as a set of cells called the MHC are genetically matched between the host monkey and the new retinal cells. (neurosciencenews.com)
The team grew retinal pigment cells from induced pluripotent stem cells (iPSCs) and transplanted them into the damaged retina of a human participant. (neurosciencenews.com)
To test whether MHC matching is a viable method, the team used retinal pigment cells that were grown from monkey iPSCs in the iPS cell bank at the Center for iPS Cell Research and Application, Kyoto University. (neurosciencenews.com)
In vitro, the team saw that T cells failed to respond to the iPSC-derived retinal pigment cells if they were from an MHC-matched monkey. (neurosciencenews.com)
In a separate study published in the same issue of Stem Cell Reports , the researchers saw similar results when they repeated this last experiment with human T cells and HLA-matched or unmatched retinal pigment cells grown from IPSCs. (neurosciencenews.com)
Now that we have established the lack of immune response in monkeys and in human cells in vitro," explains Sugita, "using the iPS cell bank appears to be a viable solution, at least in the case of retinal pigment epithelial cell transplantation. (neurosciencenews.com)

A combined multiorgan transplantation approach may offer a lower rate of allograft rejection and lower immunosuppression needs. (medscape.com)
Transplantation of monkey iPS-RPE cells into the subretinal space in a control monkey (MHC mismatched) was performed without immunosuppression. (neurosciencenews.com)
To generate healthy patient-derived cells, mutations might be repaired with new gene-editing technology based on the bacterial system of clustered regularly interspersed short palindromic repeats (CRISPR)/Cas9, thereby yielding grafts that require no patient immunosuppression. (nature.com)

Healthcare providers may recommend allogeneic stem cell transplantation for severe forms of aplastic anemia. (clevelandclinic.org)
Providers may use allogeneic stem cell transplantation to treat severe forms of thalassemia. (clevelandclinic.org)

Allogeneic stem cell transplantation uses donor stem cells to treat and sometimes cure certain blood disorders and blood cancers. (clevelandclinic.org)
A stem cell transplant is often the best option to treat blood cancers, such as leukemia , lymphoma and multiple myeloma , as well as bone marrow failure syndromes like myelodysplastic syndrome . (mdanderson.org)
Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)

Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumors. (nshealth.ca)

Stem cells from a donor, called a graft , are then infused to replace the destroyed cells, produce new marrow, and rebuild the recipient's immune system. (cancer.gov)
The new, transplanted cells regard the recipient's body as foreign. (medlineplus.gov)
When this happens, the cells attack the recipient's body. (medlineplus.gov)

It could lead to remission or immune control of hematologic malignancies. (wikipedia.org)
Allogeneic hematopoietic stem cell (HSC) is a curative treatment used for many hematologic malignancies and congenital or acquired anomalies of hematopoiesis. (pasteur.fr)
Funding Agency: Fellowship Building the future knowledge in mature B cell malignancies attributed by SPH, APCL and Gilead Sciences. (ulisboa.pt)

The hospital pathogen Pseudomonas aeruginosa requires the sugar-binding proteins LecA and LecB to form biofilms as well as to attach to and penetrate host cells. (gesundheitsindustrie-bw.de)
VM), showed that the recovery of motor functions induced implanted either (1) as a solid piece in the lateral ven- by the grafted fetal dopamine neurons was well cor- tricle6 or a cortical cavity8 adjacent to the denervated related with the extent of graft-derived reinnervation caudate-putamen, or (2) as a crude cell suspension of the host caudate-putamen. (lu.se)

Adaptive immune cells, including B and T cells, have been demonstrated to be primary contributors to the overactive immune response and overproduction of antibodies. (frontiersin.org)

Anatomy35

Organisms10

Diseases47

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment80

Psychiatry and Psychology2

Phenomena and Processes30

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science4

Named Groups5

Health Care24

Geographicals1

GvHD53

HSCT30

Acute9

Disease37

Versus9

Patient's7

Complications7

Clinical10

Hematopoietic cell transplantation1

Transplants6

20203

Morbidity2

Tissue17

Tissues11

Peripheral4

Umbilical cord blood tran2

Patients22

Donor T cells1

Chemotherapy4

Reaction3

Lymphocytes3

Progenitor cells2

Pathophysiology1

Autologous hematopoietic3

Survival4

Tumor4

Organs4

Curative therapy1

Methods1

Associated with cGvHD1

CGVHD4

Immunology1

Therapeutic5

20221

Therapies3

Therapy4

Transplant recipients1

Retinal8

Immunosuppression3

Severe2

Blood cancers3

Tumors1

Recipient's3

Malignancies3

Host2

Antibodies1