GenesGeneticsHuman genomesPathogensQuantitativeAntimicrobial peptidesHumoralResponsesPathwaysTranscriptomeInsectsGeneticPathogenSignallingEvolutionResistanceEmbryoMosquitoPathway2000ChromatinPopulationsCellularFruit flyHost's immune systemSpeciesMicroarrayVariationRegulatesDefenseGene expressionAdaptive responseAMPsModelProteinsProteinRegulationInnate and adaptiveFliesMammalianViralInvestigateEnzymesExpressionCellsESTsInfectionSystemOrganismLynchAnti-cancer immune
Genes27
- I found that about 50% of each genome belongs to the Providencia core genome and about 15% of each genome consists of genes unique to that species. (cornell.edu)
- When I compared orthologs of all eight sequenced Providencia genomes, I found that the percent of each genome that consists of the core genome and the unique genes stays largely the same. (cornell.edu)
- 07.11.2013: This week the second part of the ninth chapter of "The Origins of Genome Architecture" (2007 by Lynch, M.), dealing with "Genes in Pieces", was discussed. (uni-muenster.de)
- While the transcription of innate immunity genes in response to bacterial infection has been well-characterised in the Drosophila model, we recently demonstrated the capacity for such transcription to evolve in flies selected for improved antibacterial defense. (biomedcentral.com)
- The humoral immune response in insects is characterized by cascades of genes whose expression is controlled by a range of recognition proteins that bind pathogen cell wall components and end with the production of a range of secreted host proteins that target bacteria for destruction [ 3 ]. (biomedcentral.com)
- In the present study we constructed and analysed the immune transcriptome of the lepidopteran Antheraea mylitta , an economically important Indian tasar silkmoth with a view to unravel the potential immune-related genes and pathways. (biomedcentral.com)
- A third of the transcriptome showed similarity with previously characterized immune-related genes that included both the known and putative immune genes. (biomedcentral.com)
- Finally, we analysed the expression profiles of 15 potential immune-related genes, and the majority of them were induced more prominently with E. coli compared to Micrococcus luteus . (biomedcentral.com)
- The present study has identified many potential immune-related genes in A. mylitta some of which are vertebrate homologues and others are hitherto unreported putative defence proteins. (biomedcentral.com)
- With reference to insect immunity, the ESTs have been obtained from baculovirus-infected B. mori cultured cells and pupae, but no large scale information on bacteria-induced immune genes is as yet available. (biomedcentral.com)
- Prior information on immune response genes in wild silkmoths is lacking except for a few peripheral studies. (biomedcentral.com)
- We also validated the upregulation of a selected subset of genes from the immune transcriptome by semi-quantitative RT-PCR. (biomedcentral.com)
- 10,000 predicted genes, and close to 275Mb of genome sequence to chromosomes. (boryanakoseva.com)
- Because of this strong selective pressure, immune genes are some of the fastest evolving genes across metazoans, as highlighted in mammals and insects. (boryanakoseva.com)
- Contrasting what was previously found for D. melanogaster, we find little evidence of rapid evolution of the antiviral RNAi genes and high rates of evolution in the Toll pathway. (boryanakoseva.com)
- This suggests that, while immune genes tend to be rapidly evolving in most species, the specific genes that are fastest evolving may depend either on the pathogens faced by the host and/or divergence in the basic architecture of the host's immune system. (boryanakoseva.com)
- Establishment of clonal cell lines carrying fluorescent protein-tagged genome-edited genes for 4D life cell imaging, and assessment of protein interactions and concentrations during mitosis. (embl.org)
- Genes involved in immune defense against pathogens provide some of the most well-known examples of both directional and balancing selection. (ku.edu)
- Antimicrobial peptides (AMPs) are innate immune effector genes, playing a key role in pathogen clearance in many species, including Drosophila. (ku.edu)
- Two such genes in Drosophila encode the enzymes dopa decarboxylase (Ddc) and tyrosine hydroxylase (ple) . (sdbonline.org)
- The differentially expressed genes included those functioning in some important immune reaction and iron metabolism pathways, such as pattern recognition receptors, regulators of the JNK pathway, components of the phagosome pathway, regulators of the melanization response, activators of complement reactions, insulin signaling cascade members, oxidative stress and detoxification proteins. (biomedcentral.com)
- Interplay of pericentromeric genome organization and chromatin landscape regulates the expression of Drosophila melanogaster heterochromatic genes. (ccmb.res.in)
- Using state-of-the-art quantitative single-cell transcription live imaging and genome-wide methods to capture 3D genome contacts, João discovered promoter proximal tethering elements, features that physically pair promoters of distal genes to achieve synchronized transcriptional co-bursting. (ucp.pt)
- It takes a genome: How a clash between our genes and modern life is making us sick. (ncsu.edu)
- 2007). [Review of Evolution of genes and genomes on the Drosophila phylogeny]. (ncsu.edu)
- These range from receptors for microbial aggressors, to intracellular signaling cascades, which control the expression of immune response genes, and the genes encoding potent antimicrobial peptides," Dr. Hoffmann explained. (newswise.com)
- The defense response in B. tabaci involves genes related to the immune response as described in model organisms such as Drosophila melanogaster. (huji.ac.il)
Genetics6
- He joined the faculty of the University of British Columbia in 2003 where he is now a Professor in the Department of Medical Genetics, a Faculty Member of the Genome Science and Technology program, the Interdisciplinary Oncology Graduate Program, the Genetics Graduate Program and the Health Brain Research Centre. (wikipedia.org)
- We are interested in the population genetics and evolutionary genomics of adaptation , mainly by using the fruit fly Drosophila melanogaster as an experimentally tractable model. (unifr.ch)
- To address these longstanding problems we combine population genetics and population genomics, functional genetics, transcriptomics, physiology, and experimental evolution and apply them to natural and laboratory populations of D. melanogaster that are phenotypically differentiated for fitness-related traits. (unifr.ch)
- Áron Szabó and his colleagues from the Institute of Genetics of the ELKH Biological Research Centre (BRC) conducted a study on glial degradation pathways in a model organism, the fruit fly Drosophila melanogaster in the laboratory led by Gábor Juhász. (brc.hu)
- Human genetics: The hidden text of genome-wide associations. (ncsu.edu)
- He described his scientific journey in the keynote lecture on April 3, 2013, the opening night of the Genetics Society of America's 54th Annual Drosophila Research Conference in Washington, D.C., April 3-7, 2013. (newswise.com)
Human genomes1
- After initial sequencing of the Drosophila and human genomes was co-PI on the NIH program to sequence the rat genome, and was also a PI on the international effort to sequence the malaria mosquito genome, which involved >30 principal scientists from 11 different countries. (wikipedia.org)
Pathogens10
- Phagocytosis has been considered as an essential defense mechanism of immune response to pathogens among eukaryotes, which are also implicated in diverse physiological processes, including development, apoptotic, tissue repair, and host defense ( 4 ). (frontiersin.org)
- Among the insects, only the dipterans ( Drosophila and various mosquito species) have been widely investigated for their immune responses towards diverse pathogens. (biomedcentral.com)
- While Drosophila melanogaster are frequently exposed to various pathogens, little is known about D. melanogaster's ecology, or if they are representative of other Drosophila species in terms of pathogen pressure. (boryanakoseva.com)
- The innate immune system is the first line of defense encountered by invading pathogens. (sdbonline.org)
- Delayed and/or inadequate innate immune responses can result in failure to combat pathogens, whereas excessive and/or inappropriate responses cause runaway inflammation. (sdbonline.org)
- however, Toll activation in response to infection leads to degalactosylation, which raises the immune response to an adequate level and contributes to the prompt elimination of pathogens. (sdbonline.org)
- The immune system deploys effectors that are able to limit or kill pathogens, in turn, invaders developed various counteractive mechanisms. (brc.hu)
- This host-pathogen coevolution resulted in the development of various forms of immune defenses and virulence factors in both hosts and pathogens. (brc.hu)
- The group focused on innate immunity, the ancient arm of the immune defense that provides generalized protection against common pathogens. (newswise.com)
- At the crux of the Hoffmann lab body of work is the Toll receptor, a protein that straddles the cell membranes of immune system "sentinel" cells, detecting molecular nametags of pathogens from the outside and transducing messages to the inside, activating and orchestrating defense against infection. (newswise.com)
Quantitative4
- Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population of fully sequenced inbred Drosophila melanogaster strains when flies developed in different environments (25 °C and 18 °C). We find a substantial fraction of the transcriptome exhibited genotype by environment interaction, implicating environmentally plastic genetic architecture of gene expression. (nature.com)
- 2/ Drosophila melanogaster as a model for the cellular immunology of phagocytes, and a tool for genome wide quantitative screens for the control of cytokine production by phagocytes. (cerclefser.org)
- Single-cell sorting for single cell quantitative genome, transcriptome, CRISPR/Cas9 genome editing and in vitro studies. (embl.org)
- Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster. (ncsu.edu)
Antimicrobial peptides2
- Using this laboratory-friendly and natural host, D. melanogaster, I determined how these bacteria differ in their ability to cause host mortality, replicate within the fly and trigger the fly's immune response as measured by transcription of antimicrobial peptides. (cornell.edu)
- In Drosophila , the humoral immune response is characterized by the rapid induction of a battery of antimicrobial peptides (AMPs). (biomedcentral.com)
Humoral2
- The insect immune response is comprised of cellular and humoral components. (biomedcentral.com)
- Here we implement a pooled genome re-sequencing approach to investigate the consequences of 39 generations of bidirectional selection in White Leghorn chickens on a humoral immune trait: antibody response to sheep red blood cells. (biomedcentral.com)
Responses10
- The NF-κB family of transcription factors are master regulators of innate immune responses and their dysregulation can lead to chronic inflammation and cause diseases like inflammatory bowel disease and cancer. (doria.fi)
- Therefore, immune responses are tightly regulated from initiation to resolution and are repressed during the steady state. (sdbonline.org)
- however, the function of glycans of host organisms in innate immune responses is less well known. (sdbonline.org)
- The Drosophila renal system is an important contributor to host defense and can modulate immune responses in an organ autonomous manner, responding to environmental changes such as desiccation. (biomedcentral.com)
- The evolved molecular networks that regulate immune responses are the result of this constant fight and their basic components are inherited across generations via vertical gene transfer. (brc.hu)
- Early Weaning Stress in Pigs Impairs Innate Mucosal Immune Responses to Enterotoxigenic E. coli Challenge and Exacerbates Intestinal Injury and Clinical Disease. (ncsu.edu)
- 2022. Immune profile and responses of a novel Dengue DNA vaccine encoding EDIII-NS1 consensus design based on Indo-African sequences. . (ncbs.res.in)
- While we now know the central nervous system is subject to active immunosurveillance and immune responses [ 3 ], glioblastoma has been proven to induce both local and systemic immunosuppression thereby evading the immune response. (scientificarchives.com)
- Immunity was mainly seen in the context of antibodies and vaccination" - the responses of the adaptive (acquired) immune response, he said. (newswise.com)
- Adenoviruses can be genetically modified to increase their infectivity or improve the anti-cancer immune responses induced by the virus, e.g., through the expression of immunostimulatory molecules. (helsinki.fi)
Pathways2
- We find substantial differences in the rates of evolution of immune pathways between D. innubila and D. melanogaster. (boryanakoseva.com)
- Innate immune pathways act synergistically to constrain RNA virus evolution in Drosophila melanogaster. (salehlab.eu)
Transcriptome3
- In this study, we have constructed and analysed an immune transcriptome following bacterial challenge of the Indian tasar wild silkmoth, Antheraea mylitta , an economically important lepidopteran cultivated for silk production. (biomedcentral.com)
- We chose to examine the fat body transcriptome since it is a major immune organ in insects, analogous to the mammalian liver. (biomedcentral.com)
- The Effects of Weak Genetic Perturbations on the Transcriptome of the Wing Imaginal Disc and Its Association With Wing Shape in Drosophila melanogaster. (ncsu.edu)
Insects2
- However, unlike mammals, the insects lack an adaptive immune system. (biomedcentral.com)
- Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects. (salehlab.eu)
Genetic4
- Pooled genome sequencing was carried out for each selected line at generation 39 (HAS39 and LAS39) allowing the identification of regions of high differentiation ( F ST ). Due to the bidirectional selection regime, the identified selection signatures would result primarily from selection on standing genetic variants [ 10 , 19 ]. (biomedcentral.com)
- The Drosophila piRNA pathway provides an RNA-based immune system that defends the germline genome against selfish genetic elements. (nih.gov)
- The study, published on 22 June in the journal Nature Ecology and Evolution, revealed the genetic milestones of fungal evolution by comparing 123 complete fungal genomes. (brc.hu)
- In 1990, Dr. Hoffmann's lab replaced the grasshopper with the fruit fly, Drosophila melanogaster , and moved on to a genetic dissection of antimicrobial defense. (newswise.com)
Pathogen4
- This work establishes D. melanogaster-Providencia as a model system for the study of host-pathogen interactions. (cornell.edu)
- The innate immune response is an immediate immune response facilitated by the host to combat pathogen invasion and other harmful stimuli, such as damaged cells and environmental irritants. (doria.fi)
- However, no effective strategies are available so far to control the outbreak of infectious diseases in crustacean aquaculture due to lack of knowledge about host-pathogen interaction, in particular the poor understanding of the host defensing immune function in crustaceans. (frontiersin.org)
- Drosophila melanogaster serves as a powerful model for studying host/pathogen evolution. (boryanakoseva.com)
Signalling1
- A genome engineering resource to uncover principles of cellular organization and tissue architecture by lipid signalling. (ncbs.res.in)
Evolution4
- 11.12.2013: Prof. Ulrich Dobrindt (Microbial Genome Plasticity, Institute of Hygiene) presented a talk entitled "Evolution and adaptation in bacteria" within the MGSE Lecture Series "The Growth of the Evolutionary Thought" in the Kavaliershäuschen. (uni-muenster.de)
- Here, we characterize the genome of Drosophila innubila, a mushroom-feeding species highly diverged from D. melanogaster and investigate the evolution of the immune system. (boryanakoseva.com)
- Balancing selection also acts on AMPs in Drosophila mauritiana, an isolated island endemic separated from D. melanogaster by about 4 Myr of evolution. (ku.edu)
- Genome biology and evolution, 11(9), 2691-2701. (ku.edu)
Resistance2
- The aim of this study is to determine how transgenes that contain a fragment of the LINE-like I transposon lead to an acquired TE resistance in Drosophila. (refine.bio)
- Clostridium butyricum enhances colonization resistance against Clostridioides difficile by metabolic and immune modulation. (cdc.gov)
Embryo3
- High-throughput sorting of tissue-specific nuclei from Drosophila melanogaster embryo as a preparative step in the analysis of genome regulatory activity during tissue development. (embl.org)
- Torso is crucial for development of the fruit fly Drosophila melanogaster and is activated at both poles of the developing embryo. (genestogenomes.org)
- His postdoctoral work culminated in the identification of novel features of genome organization that ensure proper timing of gene expression in the fly embryo. (ucp.pt)
Mosquito4
- The transmission of drug-resistant parasites by the mosquito may be influenced by the altered biological fitness of drug-resistant parasites and different immune reactions or metabolic change in the mosquito. (biomedcentral.com)
- The possible reasons for the transmission of drug-resistant parasites by the mosquito may come from drug-resistant parasites with altered biological fitness [ 4 ] and mosquitoes with different effective immune clearance or metabolic changes against drug-resistant parasites. (biomedcentral.com)
- Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts. (salehlab.eu)
- Uncovering the repertoire of endogenous flaviviral elements in Aedes mosquito genomes. (salehlab.eu)
Pathway3
- In senju mutants, reduced expression of galactose-containing glycans resulted in hyperactivation of the Toll signaling pathway in the absence of immune challenges. (sdbonline.org)
- Toll pathway modulates TNF-induced JNK-dependent cell death in Drosophila . (sdbonline.org)
- To identify novel regulators of JNK-dependent cell death, this study performed a dominant-modifier screen in Drosophila and found that the Toll pathway participates in JNK-mediated cell death. (sdbonline.org)
20001
- Overall design: The fractions of small RNAs (19-29 nt) from ovaries of wild type and 11 transgenic lines of Drosophila melanogaster were sequenced using Illumina HiSeq 2000. (refine.bio)
Chromatin1
- Optimized protocol for assay for transposase-accessible chromatin by sequencing (ATAC-seq) from Drosophila melanogaster brain tissue. (ncbs.res.in)
Populations1
- In Drosophila melanogaster, this is most clearly observed in ancestral African populations. (ku.edu)
Cellular4
- Ecological immunology - design, develop methods to investigate cellular immune response of leaf beetles, across Sweden, towards parasitoid wasps. (nottingham.ac.uk)
- During the past few decades, hemocyte-mediated phagocytosis, as one of the most important innate cellular immune function, has also received great attention in crustacean, and a good progress in elucidating the involvement of hemocyte-mediated phagocytosis, as well as its protective roles and mechanisms, against bacterial and viral infections has been achieved. (frontiersin.org)
- DNA present within cells, collectively known as the genome, is the instruction manual read by the cellular machinery to live and function. (ccmb.res.in)
- However, most positive-strand RNA viruses replicate within a modified organelle co-opted from intracellular membranes of the endomembrane system, which shields viral products from cellular innate immune sensors. (elifesciences.org)
Fruit fly1
- Trained in Molecular and Developmental Biology, João Raimundo has been studying the gene regulatory mechanisms underlying developmental patterning from plants to the fruit fly Drosophila melanogaster. (ucp.pt)
Host's immune system1
- Simultaneously, they also activate the dormant host's immune system to fight against the tumor. (helsinki.fi)
Species3
- Multiple strains representing four species of bacteria belonging to the genus Providencia have been isolated from wild caught Drosophila melanogaster: Providencia sneebia, Providencia burhodogranariea strain B, Providencia burhodogranariea strain D, Providencia rettgeri, and Providencia alcalifaciens. (cornell.edu)
- I sequenced and annotated draft genomes of these four species then compared them to each other. (cornell.edu)
- Four Providencia genomes of isolates originating from the human gut have also been sequenced, which include additional isolates of P. rettgeri and P. alcalifaciens as well as isolates of the species Providencia stuartii and Providencia rustigianii. (cornell.edu)
Microarray1
- Results: We used a cDNA microarray containing 6,000 expressed sequence tags (ESTs) from the whitefly genome to study the parasitoid-whitefly interaction. (huji.ac.il)
Variation4
- My lab is interested in understanding how the variation in genomes of Indians predisposes them to disparities in health and disease. (ccmb.res.in)
- As part of large nation-wide population genomics programs, we map the natural variation in healthy genomes. (ccmb.res.in)
- Association of orthodenticle with Natural Variation for Early Embryonic Patterning in Drosophila melanogaster. (ncsu.edu)
- Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. (ncsu.edu)
Regulates1
- The Mononuclear Phagocyte System (MPS) is a group of cells with crucial functions in our immune system: it mediates and regulates inflammation. (cerclefser.org)
Defense1
- In response to desiccation, ecdysone is produced in MTs and acts in a paracrine fashion to increase PGRP-LC expression, immune responsiveness, and improve host defense. (biomedcentral.com)
Gene expression3
- To understand the differential gene expression in Anopheles following infection with drug-resistant Plasmodium , we conducted a genome-wide transcriptomic profiling analysis of Anopheles stephensi following feeding on mice with drug-resistant or drug-sensitive P. yoelii , observed changes in gene expression profiles and identified transcripts affected by the drug-resistant parasite. (biomedcentral.com)
- Despite having an identical genome, cells can be regulated differently via epigenetic mechanisms that result in cell specific gene expression patterns. (ccmb.res.in)
- A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan amazighs. (ncsu.edu)
Adaptive response1
- For immune traits, the extent of genome involvement in the adaptive response can vary. (biomedcentral.com)
AMPs1
- This suggests that balancing selection may be broadly acting to maintain adaptive diversity in Drosophila AMPs, as has been found in other taxa. (ku.edu)
Model3
- Here, we use both a linear model and control-gene-based approach to show that balancing selection is an important force shaping AMP diversity in Drosophila. (ku.edu)
- Drosophila is a powerful model for the study of factors modulating innate immunity. (biomedcentral.com)
- She established a mouse model of acute cerebral trypanosomiasis that allowed her to propose a mechanism whereby parasite adhesion to blood vessels, named sequestration, and the host immune system, through CD4+ T cells, play a pivotal role in disease. (ucp.pt)
Proteins1
- We also identified several unknown proteins, some of which could have probable immune-related functions based on the results of the ProDom analysis. (biomedcentral.com)
Protein1
- Torso activation depends on the polar accumulation of Torso-like (Tsl), which is the only Drosophila protein known to have a Membrane Attack Complex/ Perforin domain. (genestogenomes.org)
Regulation2
Innate and adaptive2
- Owing to its importance and contributions to the innate and adaptive immune function in relation to human and animal health, phagocytosis still remains of great interests to many scientists. (frontiersin.org)
- The focus of this thesis was to develop and characterize several genetically modified oncolytic adenoviruses expressing either OX40L alone or OX40L and CD40L, two co-stimulatory molecules capable of engaging both the innate and adaptive arms of the immune system to fight the tumor. (helsinki.fi)
Flies1
- Interestingly, Toll activation in immune-challenged wild type (WT) flies reduced the expression of galactose-containing glycans. (sdbonline.org)
Mammalian2
- In the recent years a strong resemblance has been observed between the insect immune system and the mammalian innate immune mechanisms suggesting their common origin. (biomedcentral.com)
- Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role in heterochromatin structure is unclear. (cipsm.de)
Viral1
- Defective viral genomes from chikungunya virus are broad-spectrum antivirals and prevent virus dissemination in mosquitoes. (salehlab.eu)
Investigate1
- Here we use a genomic approach to investigate the consequences of long-term, bidirectional selection on a single immune trait from a base population of randombred White Leghorn chickens [ 16 ]. (biomedcentral.com)
Enzymes1
- That's why many immune cells use enzymes like perforin to puncture the membranes of pathogenic cells, dysregulating and often killing them. (genestogenomes.org)
Expression2
- Coinfections in D. melanogaster with P. sneebia and P. rettgeri, which induces greater antimicrobial peptide expression and is less virulent than P. sneebia, allowed me to conclude that P. sneebia is actively avoiding recognition by the immune response. (cornell.edu)
- Desiccation primes immune responsiveness by elevating PGRP-LC expression specifically in MTs. (biomedcentral.com)
Cells5
- It acts as an immune barrier that prevents direct contact of bacteria with midgut epithelial cells during blood digestion. (bvsalud.org)
- Flow cytomery applications used by EMBL researchers: Cell cycle analysis and Phenotyping of immune cells. (embl.org)
- In order to maintain genome integrity cells employ a set of well conserved DNA damage checkpoints. (duke.edu)
- Edelfosine is incorporated by highly proliferating cells, e.g. activated immune cells. (refine.bio)
- IL-22 has been identified as a cancer-promoting cytokine that is secreted by infiltrating immune cells in several cancer models. (cipsm.de)
ESTs1
- We generated a total of 1412 ESTs, of which 31% could be ascribed to putative immune functions. (biomedcentral.com)
Infection1
- Antiviral Immune Response and the Route of Infection in Drosophila melanogaster. (salehlab.eu)
System5
- This means that presence of a type 3 secretion system does not correlate to those found to be virulent toward D. melanogaster. (cornell.edu)
- An efficient immune system is one of the attributes for this evolutionary success. (biomedcentral.com)
- This activity of the renal system may contribute to the immunosenescence observed in Drosophila. (biomedcentral.com)
- Does the virus toll the bell for immune system? (prolekarniky.cz)
- Dr. Hoffmann and his colleagues' expected the innate immune system in the fly to be completely different from that in a mammal, but they were in for a surprise. (newswise.com)
Organism1
- För att upprätthålla liv använder cellerna i en organism intrikata signaleringsräckor för regleringen av fysiologiska processer inom enskilda celler och mellan olika celler och vävnaderna som utgör en organism. (doria.fi)
Lynch5
- 12.12.2013: This week the first part of the eleventh chapter of "The Origins of Genome Architecture" (2007 by Lynch, M.), dealing with "Expansion and Contraction of Organelle Genomes", was discussed. (uni-muenster.de)
- 21.11.2013: This week the tenth chapter of "The Origins of Genome Architecture" (2007 by Lynch, M.), dealing with "Transcript Production", was discussed. (uni-muenster.de)
- 10.10.2013: This week the second part of the eighth chapter of "The Origins of Genome Architecture" (2007 by Lynch, M.), dealing with "Genomic Expansion by Gene Duplication", was discussed. (uni-muenster.de)
- We recently reported the case report of a patient with Lynch Syndrome and glioblastoma treated with nivolumab, an immune checkpoint inhibitor [ 6 ]. (scientificarchives.com)
- Immune checkpoint inhibition has proven great success initially in colon cancer with microsatellite instability (MSI) or mismatch repair deficiency (MMR-d), as in Lynch Syndrome [ 8 ], and later with other malignancies associated with the same features [ 9 , 10 ]. (scientificarchives.com)
Anti-cancer immune1
- They were also the first to show that the anti-cancer immune response is linked to mutational antigen (neoantigen) load. (wikipedia.org)