• Current cellular adoptive therapies consist of the ex-vivo expansion of TILs from resected tumors and transferred back to the patients' bodies with support of interleukin -2 (IL-2). (wikipedia.org)
  • This therapy has shown to be more effective in treating solid tumors than other cellular adoptive immunotherapies such as CAR T cell therapy. (wikipedia.org)
  • The optimization, development and characterization of gene and cell therapy products (immunotherapy) targeting human metastatic tumors. (uclahealth.org)
  • Effect and characterization of immunotherapy (including checkpoint inhibitors, dendritic cells, adoptive cell transfer, etc.) and targeted therapy in human metastatic tumors. (uclahealth.org)
  • 4 According to the number of tumor-infiltrating lymphocytes, tumors can be divided into three phenotypes: immune-inflamed, immune-excluded, and immune-desert types. (nature.com)
  • Immune-inflamed tumors are called hot tumors, while the latter two are collectively referred to as cold tumors, and they respond poorly to immunotherapy. (nature.com)
  • We use systems biology approaches to decipher the molecular T cell states associated with successful immune attack or immune failure in human and mouse tumors. (unil.ch)
  • In collaboration with Hi-TIDe's Tumor microenvironment & biomarkers group and T cell discovery group , we capture tumor-infiltrating lymphocytes in human tumors in action, at the steady state or following adoptive T-cell therapy and other therapeutic perturbations, and interrogate them exhaustively to unveil the underlying T cell intrinsic signaling regulatory networks. (unil.ch)
  • Unlike chemotherapy or radiation which directly attack tumors, immunotherapy helps train the immune cells to recognize markers on cancer cells and boosts their killing capability. (theusaknowledge.net)
  • One of the reasons for the low effectiveness of treatment for pancreatic tumors is the weak anti-tumor immune response. (bookinghealth.com)
  • In experiments on mice, the researchers found that the microenvironment of pancreatic tumors contains very few dendritic cells. (bookinghealth.com)
  • For DSc activation doctors use antigens of a patient's own tumor or lysate of allogeneic (donor) dendritic cells, which contains antigens common to different tumors. (bookinghealth.com)
  • Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. (nshealth.ca)
  • Over the last Etretinate few years, immunotherapy has Etretinate demonstrated impressive efficacy for many tumors. (mindunwindart.com)
  • Immunotherapy is currently considered as a promising next-generation therapeutic strategy for various cancers thanks to its ability to modulate cell-specific immune responses toward tumors [ 1 ], which has gradually remodeled the landscape of clinical anticancer modality [ 2 ]. (thno.org)
  • Vaccination using optimized strategies may increase response rates to immune checkpoint inhibitors (ICI) in some tumors. (unav.edu)
  • Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
  • Furthermore, in immunocompetent mice bearing 4T1 cells tumors, Wpep-DGL/Pt activated immune cells and induced cell death proving their dual function of chemotherapeutic and immunomodulatory efficacy. (thno.org)
  • Her research interest focuses on the molecular oncology and immunotherapies of solid tumors and she published more than 40 peer reviewed papers. (stanford.edu)
  • Chen J, Wang S, Jia S, Ding G, Jiang G, Cao L. Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profile in Pancreatic Cancer Derived Exosomes Treated Dendritic Cells by Microarray Analysis. (jcancer.org)
  • The expression profiles of long noncoding RNAs (lncRNAs) and mRNAs of PEX-treated dendritic cells are unknown. (jcancer.org)
  • During RT, alterations in signaling pathways result in changes in the local immune microenvironment. (nature.com)
  • Furthermore, inflammatory mediators released by irradiated dying cells can attract and regulate immune cells in the tumor microenvironment (TME), further killing cancer cells. (nature.com)
  • Her primary areas of study are Immune system, Cancer research, Transcriptome, Tumor microenvironment and Cancer. (research.com)
  • Her study explores the link between Tumor microenvironment and topics such as Immunotherapy that cross with problems in Cell biology. (research.com)
  • In contrast, the microenvironment of lung cancer, which responds well to immunotherapy, contains 80 times more dendritic cells. (bookinghealth.com)
  • The HCC microenvironment is highly immune system suppressive (Prieto et al. (mindunwindart.com)
  • However, increasing data has indicated that the clinical potential of most immunotherapies is usually hampered by immunosuppressive status of the tumor microenvironment (TME) [ 7 ]. (thno.org)
  • Integrative analyses of similar to 500 mice and similar to 1,000 patients revealed a common MAPK-MYC genetic pathway that accelerated time to progression from precursor states across genetically heterogeneous MM. MYC-dependent time to progression conditioned immune evasion mechanisms that remodeled the BM microenvironment differently. (unav.edu)
  • Although there is ample evidence that the chemotherapeutic drugs trigger an immune response, the efficient tumor rejection or regression is not guaranteed probably due to the massive immunosuppression within the tumor microenvironment. (thno.org)
  • This work represents a novel approach for cancer immunotherapy by integrating nanotechnology and platinum-based therapeutics which not only efficiently exerts the chemotherapeutic cytotoxic effect on tumor cell but also restores immune response of immunological cells within the tumor microenvironment. (thno.org)
  • During the early phase of tumor development, immune cells could spontaneously infiltrate into the tumor microenvironment to evoke an immune response and fight against the growth of the tumor. (thno.org)
  • The primary types of cellular adoptive immunotherapies are T cell therapies. (wikipedia.org)
  • Other therapies include CAR-T therapy, CAR-NK therapy, macrophage-based immunotherapy and dendritic cell therapy. (wikipedia.org)
  • Although immunotherapy with immune checkpoint blockade and targeted therapy was used to treat and improve the survival of patients with several types of cancers, such as non-small cell lung cancer, many patients still develop disease progression even after receiving these therapies. (wikipedia.org)
  • Dr. Gustafson and his team are focused on developing and translating cell- and immune-based therapies for the treatment of cancer, autoimmunity and other diseases into clinical trials. (mayo.edu)
  • These therapies boost the immune system's ability to detect and destroy cancer cells by exposing it to tumor-specific antigens or genetically modified immune cells programmed to recognize cancer. (theusaknowledge.net)
  • Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
  • All the above-mentioned cells are estimated to be important for the adoptive TIL transfer therapies. (kuickresearch.com)
  • This also includes immune therapies that have failed. (bookinghealth.com)
  • Identification of immune-system pathways that predict how patients will probably respond to different therapies, making it possible to better match patients to treatments that will work best for them. (roswellpark.org)
  • Unfortunately, many patients still progress and acquire resistance to immunotherapy and molecularly targeted therapies. (biomedcentral.com)
  • Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)
  • In this respect, the introduction of checkpoint inhibitors to unleash the activity of tumor-reactive T cells has been a milestone in cancer immunotherapy. (nature.com)
  • Immune Checkpoint Inhibitors in Cancer Therapy-How Can We Improve Clinical Benefits? (mdpi.com)
  • Checkpoint inhibitors work by blocking proteins that inhibit T-cell response, thereby removing restraints on the immune system and allowing T-cells to proliferate and kill cancer cells. (theusaknowledge.net)
  • The pancreatic tumor does not respond to cytokines, immune checkpoint inhibitors, and adoptive cell therapy. (bookinghealth.com)
  • Nonspecific immunotherapies, including cytokines (such as IFN, IL-2, TGF- inhibitors, and so forth) and cytokines-induced killer cells (CIK) (Lee et al. (mindunwindart.com)
  • Alternative inhibitory receptors have been identified that may be targeted for anti-tumor immune therapy, such as lymphocyte-activation gene-3 (LAG-3), as have several potential target oncogenes for molecularly targeted therapy, such as tyrosine kinase inhibitors. (biomedcentral.com)
  • In this mini-review we will discuss the latest clinical data from clinical trials for immune-checkpoint inhibitors for the treatment of HCC. (stanford.edu)
  • NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
  • By binding to these antigens, monoclonal antibodies can flag cancer cells for destruction by the immune system. (theusaknowledge.net)
  • This approach involves isolating patient's dendritic cells, loading them with tumor antigens and reinfusing to induce a wider immune reaction. (theusaknowledge.net)
  • Adoptive cell transfer involves engineering patient's own T-cells to create receptors on their surface that recognize specific tumor antigens. (theusaknowledge.net)
  • Dendritic cells (DCs) are immune cells that recognize antigens (targets for attack) and show them to T-cells. (bookinghealth.com)
  • Monocytes (a type of leukocytes) for dendritic cell production are harvested from the patient's blood by leukapheresis and are treated with tumor antigens. (bookinghealth.com)
  • Multimodal immunogenic cell death (ICD) together with autophagy often induced by OVs not only presents potent danger signals to dendritic cells but also efficiently cross-present tumor-associated antigens from cancer cells to dendritic cells to T cells to induce adaptive antitumor immunity. (biomedcentral.com)
  • DCs are the most potent antigen-presenting cells, with the capacity to take up, process, and present tumor antigens to T cells and stimulate an immune response, thus providing a rational platform for vaccine development. (ox.ac.uk)
  • Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (nwbio.com)
  • Therefore, chemotherapy depletes the immune system of the patient, leading to dangerous infections. (hindawi.com)
  • Various mathematical models have been studied for cancer treatments with virotherapy, radiotherapy, chemotherapy, and immunotherapy [ 6 - 11 ]. (hindawi.com)
  • The model demonstrated that chemotherapy increases tumorigenicity, whereas CSC-targeted immunotherapy tumorigenicity. (hindawi.com)
  • Pratap proposed a model that describes the nonlinear dynamics between tumour cells, immune cells, and three forms of therapy: chemotherapy, immunotherapy, and radiotherapy [ 14 ]. (hindawi.com)
  • As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery. (nature.com)
  • The emergence of immunotherapy has recently disrupted the paradigm of traditional cancer treatment (including the three traditional treatments RT, chemotherapy, and surgery), and immunotherapy functions by activating the body's immune system to fight cancer. (nature.com)
  • Adoptive T-Cell Transfer and Chemotherapy in the First-Line Treatment of Metastatic And/or Locally Recurrent Nasopharyngeal Carcinoma. (texaschildrens.org)
  • Three months later, when a recurrence-suspected lesion was detected in segment 5 (S5) of his liver, we started adoptive immunotherapies with cytokine-activated killer (CAK) cell infusions, combined with chemotherapy. (springeropen.com)
  • We report here a rare case of a patient who has currently survived almost 10 years with recurrent GBC with peritoneal dissemination and liver metastases, which has been well controlled by a multidisciplinary approach including chemotherapy, immunotherapy, and surgery. (springeropen.com)
  • The major application of CAR-T immunotherapy is to treat hematological malignancies, such as multiple myeloma, chronic lymphocytic leukemia, acute lymphoblastic leukemia and lymphoma. (wikipedia.org)
  • Multiple Myeloma on CureTalks in 2017: CAR T Cell Immunotherapy, Stem Cell Transplants, MRD Testing, MMRF Precision Medicine Model and More. (trialx.com)
  • Recent years have seen the emergence of immunotherapy as a leading form of treatment for multiple myeloma. (trialx.com)
  • We talked to Dr. Saad Usmani of Levine Cancer Institute / Carolinas Healthcare System about the latest advances in immunotherapy for multiple myeloma. (trialx.com)
  • Immunotherapy includes the use of antigen- and nonantigen-specific substances, such as cytokines, as well as adoptive cellular immunotherapy (ACI) [ 3 ]. (hindawi.com)
  • Nevertheless, ex vivo activation with cytokines can restore cytolytic activity of NK cells against GB, indicating that NK cells have potential for adoptive immunotherapy of GB if potent cytotoxicity can be maintained in vivo . (frontiersin.org)
  • Dendritic cells (DC) for cancer immunotherapy protocols are generated most commonly by in vitro differentiation of monocytes with exogenous cytokines (Mo-DC). (nih.gov)
  • High doses of cytokines like IL-2 can be administered to boost anti-cancer immune activity. (theusaknowledge.net)
  • Cytokines like IL-2 stimulate activity and growth of T-cells, NK cells and macrophages - key players in anti-tumor immune response. (theusaknowledge.net)
  • Of note, the TME is rich in immunosuppressive cells (e.g., tumor-associated macrophages (TAMs), regulatory T cells (Tregs), immature dendritic cells (iDCs) and myeloid-derived suppressor cells (MDSCs)), that can suppress antitumor immunity as a result of secretion of various cytokines and chemokines, which enables tumor escape from immune surveillance [ 8 ]. (thno.org)
  • Moreover, TAMs usually display M2-like phenotypes that exert tumor-promoting role in TME, and promote production of related immunosuppressive factors that trigger immunotherapy resistance, including cytokines, chemokines, growth factors and soluble signaling mediators [ 12 ]. (thno.org)
  • A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer. (unil.ch)
  • Autologous (own) dendritic cells are used to treat pancreatic ductal adenocarcinoma. (bookinghealth.com)
  • UNLABELLED: This is a phase II clinical trial investigating the safety and efficacy of intravenous vaccination with mature autologous dendritic cells (DCs) pulsed ex vivo with a liver tumor cell line lysate (HepG2) in patients with advanced hepatocellular carcinoma (HCC). (ox.ac.uk)
  • HCC is an attractive target for immunotherapy as evidenced by an active recruitment of tumor-infiltrating lymphocytes that are capable of lysing autologous tumor cells in ex vivo studies. (ox.ac.uk)
  • CONCLUSION: Autologous DC vaccination in patients with HCC is safe and well tolerated with evidence of antitumor efficacy assessed radiologically and serologically, with generation of antigen-specific immune responses in some cases. (ox.ac.uk)
  • Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. (nwbio.com)
  • Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA. (nwbio.com)
  • In this two-cohort pilot phase I study, 15 advanced cancer patients received two 4-week cycles of four intradermal daily doses of monocyte-derived dendritic cells preloaded with autologous tumor lysate and matured for 24 h with poly-ICLC (Hiltonol), TNF-α and IFN-α. (cun.es)
  • Though immunotherapies such as immune checkpoint blockade, adoptive T cell therapy, and oncolytic viruses have led to remarkable advances in the treatment of other tumor types (e.g. melanoma, lung, and kidney cancer), these strategies have been less successful in ovarian cancer. (roswellpark.org)
  • IL-2 and IFN-γ), immune checkpoint blockade (ICB) therapy (e.g., anti-PD-1/PD-L1 antibodies), and adoptive T-cell transfer (e.g., chimeric antigen receptor (CAR) T-cell therapy) [ 3 - 5 ]. (thno.org)
  • Single-cell transcriptomics and functional assays defined a high ratio of CD8(+) T cells versus T-reg cells as a predictor of response to immune checkpoint blockade (ICB). (unav.edu)
  • To enhance vaccine potency and improve thus responses to ICI, we analyzed the gene expression profile of an immunosuppressive dendritic cell (DC) population induced during vaccination, with the goal of identifying druggable inhibitory mechanisms. (unav.edu)
  • Background Neoantigens, new immunogenic sequences arising from tumor mutations, have been associated with response to immunotherapy and are considered potential targets for vaccination. (unav.edu)
  • Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
  • Although T- cells are powerful tools that help us defend against cancer through immune responses, errors may still occur during the process, and cancer's anti-tumour effect may vary. (wikipedia.org)
  • Dr. Begonya Comin-Anduix's research focuses on two areas: optimizing immune monitoring techniques and studying approaches to enhance the T-cell responses to human metastatic melanoma. (uclahealth.org)
  • Dr. Gustafson's research also encompasses understanding systemic immunity in humans, how cancer alters the immune landscape in humans and how physical activity may be used to improve immune responses to immunotherapy. (mayo.edu)
  • The purified BDC elicited strong allogeneic mixed leukocyte reactions and HLA classes II- and I-restricted antigen-specific primary immune responses. (nih.gov)
  • The next wave of truly transformative therapeutics should aspire to provide a cure by selectively suppressing pathogenic autoantigen-specific immune responses while leaving the rest of the immune system intact to control infectious diseases and malignancies. (frontiersin.org)
  • The mammalian immune system evolved to protect our bodies from foreign pathogens and intrinsic aberrant malignancies while concurrently preventing deleterious immune responses toward self ( 1 ). (frontiersin.org)
  • Adoptive Transfer of EBV-Specific T Cells Results in Sustained Clinical Responses in Patients with Locoregional Nasopharyngeal Carcinoma. (texaschildrens.org)
  • Immune responses were assessed using an ELIspot assay of interferon-gamma (IFN-gamma) release. (ox.ac.uk)
  • Our experimental models enable the correlation of MM genetic and immunological traits with preclinical therapy responses, which may inform the next-generation immunotherapy trials. (unav.edu)
  • But it can be boosted with a dendritic cell-based cancer immunotherapy, i.e. anti-tumor vaccine. (bookinghealth.com)
  • A Phase II Study Evaluating the Safety and Efficacy of an Adenovirus-ΔLMP1-LMP2 Transduced Dendritic Cell Vaccine in Patients with Advanced Metastatic Nasopharyngeal Carcinoma. (texaschildrens.org)
  • This radio-immunotherapy combination strategy, aimed at resembling viral infection in tumor tissue in combination with a dendritic-cell vaccine and SABR, is safe and shows immune-associated activity and signs of preliminary clinical efficacy. (cun.es)
  • The discussion highlighted the opportunity that these engineered immune cells present to cancer treatment and possible use in treatment of other cancers. (trialx.com)
  • Our group focuses on engineering T cell states that are associated with immune rejection in cancers. (unil.ch)
  • Departing from prior knowledge and the above observations, we design novel synthetic T cell states, aspiring to overcome tumor immune resistance and T cell deregulation in order to defeat difficult cancers. (unil.ch)
  • In recent years, immunotherapies have led to remarkable strides in treating certain cancers. (mdpi.com)
  • After decades of research, immunotherapy has now emerged as a revolutionary approach against certain types of cancers. (theusaknowledge.net)
  • Multidisciplinary approach including immunotherapy for such cancers has received much attention in recent years. (springeropen.com)
  • Studies by researchers at Roswell Park, the University of Chicago, and others have identified critical factors which make immunotherapy less effective in ovarian cancer than other cancers. (roswellpark.org)
  • In an attempt to evaluate the immune response of renal cell carcinoma (RCC) patients, tumor lesions and / or blood samples from 12 RCC patients underwent deep T cell receptor (TCR) sequencing. (oncotarget.com)
  • Dendritic cell immunotherapy for patients with metastatic renal cell carcinoma: University of Tokyo experience. (nwbio.com)
  • Bleumer I, Tiemessen DM, Oosterwijk-Wakka JC, Völler MC, De Weijer K, Mulders PF, Oosterwijk E. Preliminary analysis of patients with progressive renal cell carcinoma vaccinated with CA9-peptide-pulsed mature dendritic cells. (nwbio.com)
  • Novel therapeutic strategies have been investigated, and immunotherapy has been recently approved for the treatment of various types of cancer [ 4 ]. (hindawi.com)
  • In this review, we discuss the changes in irradiated cancer cells and immune cells in the TME under different RT regimens and describe existing and potential molecules that could be targeted to improve the therapeutic effects of RT. (nature.com)
  • Different clinics use different approaches and it is still not known at what time, dose, course and intervals dendritic cell therapy for pancreatic cancer should be administered to achieve the best therapeutic results. (bookinghealth.com)
  • Combination with other immunotherapy regimens improve overall therapeutic efficacy. (biomedcentral.com)
  • Thus, TAMs can be considered as a promising therapeutic target for improved immunotherapy, and TAMs-focused molecular targeting agents have made ideal progress in clinical practice. (thno.org)
  • It is hoped that, with rapid development of nanomedicine in cancer immunotherapy, TAMs-focused therapeutic strategies may be anticipated to become an emerging immunotherapeutic modality for future clinical cancer treatment. (thno.org)
  • Karolina Palucka has included themes like Innate immune system and Virology in her Acquired immune system study. (research.com)
  • Innate lymphoid cell is closely connected to Antigen-presenting cell in her research, which is encompassed under the umbrella topic of Dendritic cell. (research.com)
  • Melanoma was the first type of tumor that provided insight into cancer immunotherapy due to its high immunogenicity. (wikipedia.org)
  • Reports of spontaneous regression and tumour infiltration with T-lymphocytes makes melanoma candidate for immunotherapies. (mdpi.com)
  • Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune checkpoint receptors such as programmed death-1 (PD-1), programmed death ligand 1 (PD-L1) or cytotoxic T lymphocyte antigen-4 (CTLA-4). (biomedcentral.com)
  • The inhibition of two immune checkpoints, LAG-3 using relatlimab and PD-1, improved progression-free survival (PFS) to a greater extent than inhibition of PD-1 alone in patients with previously untreated metastatic or unresectable melanoma. (biomedcentral.com)
  • Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J. Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. (nwbio.com)
  • Her Immunotherapy research focuses on Adoptive cell transfer and how it connects with Cell, Cancer, Monoclonal antibody, Antibody and Blockade. (research.com)
  • Her Immunotherapy research is multidisciplinary, incorporating elements of Blockade, Adoptive cell transfer and Sarcoma. (research.com)
  • The concepts of her Cancer cell study are interwoven with issues in Acquired immune system, Antigen, T cell immunity, Immunity and Blockade. (research.com)
  • Her Immunity study combines topics in areas such as Cancer cell, Blockade, Antigen, Cell biology and Immunotherapy. (research.com)
  • PD-1 axis blockade has been proven time and again to be a successful immunotherapy for a wide variety of cancer types, and it is assumed to work by reversing or preventing T cell exhaustion. (acir.org)
  • However, the exact way by which this cancer immunotherapy works has not been fully elucidated, and recent studies have shown that the mechanism behind PD-1 axis blockade may be more complex than previously thought. (acir.org)
  • TIL therapy isolates tumor-infiltrating lymphocytes (TILs), which are naturally occurring T cells in cancer patients that have already recognised cancer cells and infiltrated into the tumor as an anti-tumor response from their own immune system after tumor resection. (wikipedia.org)
  • Most of them generally follow the same pathway to make immune-activated cytotoxic T lymphocytes (CTLs) abundantly infiltrate into tumor tissues and destroy tumor cells [ 6 ]. (thno.org)
  • Combined local injections of dsRNA analogues (mimicking viral RNA) and repeated vaccinations with tumor-lysate loaded dendritic cells shows efficacy against colon cancer mouse models. (cun.es)
  • This atlas is a concise but comprehensive guide to the diverse patterns of response to immunotherapy as observed on Positron Emission Tomography/Computed Tomography (PET/CT) and other conventional imaging modalities, including CT and Magnetic Resonance Imaging (MRI). (nshealth.ca)
  • Moreover, γδ T cells can directly kill target cells without the involvement of dendritic cells (DCs) and perform dual functional roles in antitumor and anti-infective immunity. (nature.com)
  • The scientist's investigation covers issues in Immune system, Transcriptome, Engineering ethics, Epitope mapping and Immunity. (research.com)
  • Her study in Acquired immune system and T cell immunity are all subfields of Antigen. (research.com)
  • Among most immunosuppressive cells, TAMs, as crucial drivers of immunosuppressive TME, account for the largest proportion of immune cells in the TME (approximately 50% of tumor mass) [ 9 , 10 ], which possess highly heterogeneity and play a complex regulatory role in tumor immunity and immunotherapy due to helping tumor evade immune surveillance [ 11 ]. (thno.org)
  • Wpep-DGL/Pt showed potent antitumor efficacy in MDA-MB-231 cells tumor-bearing nude mice with a deficient immune system, demonstrating targeted delivery of chemotherapeutics and the resultant cytotoxicity. (thno.org)
  • To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy, the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized, and clinical safety and efficacy also need to be proven. (nature.com)
  • Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy, which will inspire further clinical investigations and eventually benefit cancer patients. (nature.com)
  • In this paper, an antitumour model for characterising radiotherapy and immunotherapy processes at different fixed times is proposed. (hindawi.com)
  • In the context of immunotherapy, radiotherapy can exert beneficial abscopal effects. (cun.es)
  • Alternative inhibitory receptors have been identified that may also be targeted for anti-tumor immune therapy. (biomedcentral.com)
  • The therapy initially called CAR-T cell immunotherapy and now named Kymriah by Novartis, is approved to treat children and young adults with a recurrent form of the blood cancer called acute lymphoblastic leukemia (ALL). (trialx.com)
  • We employ systems biology approaches to study molecular T cell states associated with deregulation or immune attack either at the steady state or following T cell therapy in the human and in mouse. (unil.ch)
  • A major requirement for cancer immunotherapy is the development of biomarkers for prognosis and for monitoring therapy response. (oncotarget.com)
  • Summarize the most recent advances in cancer biology, how they intersect with the immune system, and how these considerations are relevant for the biologic therapy of cancer. (sitcancer.org)
  • In this blog, we explore the different types of immunotherapies, their mechanisms of action, current uses in cancer treatment, limitations, and the exciting future possibilities of this transformative therapy. (theusaknowledge.net)
  • There is a novel platform developed by the Scripps Researchers that aim at delivering personalized therapy to the patients that are believed to get hindered due to the complications observed in isolating immune cells in the patients. (kuickresearch.com)
  • In clinical practice, cancer immunotherapies have been well developed in recent years, mainly including cytokine therapy (e.g. (thno.org)
  • These data confirm the presence of tumor-specific TCR within the cancer tissue and suggest the existence of shared epitopes among different patients that might be used as targets for tumor immunotherapy. (oncotarget.com)
  • However, some immune cells are immunosuppressive or transform into immunosuppressive phenotypes under specific conditions, leading to the development of radioresistance. (nature.com)
  • To bypass resistance, combination treatment with immunotherapies and single or multiple TKIs have been shown to improve prognosis compared to monotherapy. (biomedcentral.com)
  • In ICB-refractory MM models, increasing CD8(+) T cell cytotoxicity or depleting T-reg cells reversed immunotherapy resistance and yielded prolonged MM control. (unav.edu)
  • Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
  • Thus, therapeutics that induce, restore, and maintain immune tolerance toward these autoantigens represent the "Holy Grail" of treatments for autoimmune diseases. (frontiersin.org)
  • It is estimated from the outcomes received that the approach developed by the researchers have helped the cancer therapeutics and immunotherapy market to expand in the size and provide benefits to millions of patients. (kuickresearch.com)
  • We then outline preclinical approaches that employ CAR-NK cells for GB immunotherapy, and give an overview on the ongoing clinical development of ErbB2 (HER2)-specific CAR-NK cells currently applied in a phase I clinical trial in glioblastoma patients. (frontiersin.org)
  • Cancer immunotherapy approaches designed to surmount tumor suppression take into consideration the pivotal molecular processes involved in the activation of immune system. (thno.org)
  • In addition, suppressor immune cells such as FOXP3 + regulatory T cells (Tregs) exert dominant immune suppression to control autoreactive T and B cells. (frontiersin.org)
  • Feng and Navaratna demonstrated that the initial ratio between regulatory T cells and effector T cells impacts the tumour recurrence time and that the effectiveness of IL-2 use may reverse the immunotherapy outcome [ 15 ]. (hindawi.com)
  • We found that the expanded cells possessed significantly improved immune effector functions, including proliferation, differentiation, and cancer cell killing, both in vitro and in the humanized mouse model. (nature.com)
  • Immune cells such as T-cells are usually isolated from patients for expansion or engineering purposes and reinfused back into patients to fight diseases using their own immune system. (wikipedia.org)
  • For example, many patients with cancer exhibit severe immune dysfunction as a result of tumor-derived factors, treatment-related factors or both. (mayo.edu)
  • Our scientific fraternity achieved a lot this year in the field of cancer treatment, giving new ray of hope to cancer patients with advances in immunotherapy, stem cell transplants and genomic testing. (trialx.com)
  • Despite significant recent improvements in the field of immunotherapy, cancer remains a heavy burden on patients and healthcare systems. (mdpi.com)
  • 4) overcoming local and systemic immune suppression, and 5) proper interpretation of imaging data for brain tumor patients receiving immunotherapy. (escholarship.org)
  • The platform developed by the researchers allow them to detect and isolate important tumor-reactive immune cells in order to advance the overall personalized immunotherapy in the patients. (kuickresearch.com)
  • In this situation, immunotherapy could be a reliable candidate to improve the prognosis of these patients without lowering their quality of life. (springeropen.com)
  • The immune system produces systemic p53 autoantibodies (p53 Abs) in many cancer patients. (stanford.edu)
  • This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. (nshealth.ca)
  • There are certain proteins like PD-1, PD-L1 , and CTLA-4 that act as immune checkpoints, preventing T-cells from attacking cancer. (theusaknowledge.net)
  • One study reported an increased survival benefit with simultaneous RT compared with sequential administration, 8 while another study found no significant difference between the two strategies, 9 possibly because simultaneous RT plus immunotherapy and the administration of an ICI before RT may kill cancer cells as well a substantial number of immune cells, leading to poor systemic response and toxic side effects. (nature.com)
  • Thanks to recent advancements in cell engineering technologies, infusion of ex vivo prepared immune cells have emerged as promising strategies of cancer immunotherapy. (escholarship.org)
  • This included sessions dedicated to systems biology on immunotherapy, immunogenicity and gene expression profiling, biomarkers, and combination treatment strategies. (biomedcentral.com)
  • However, few studies have investigated the role of pancreatic cancer-derived exosomes (PEXs) in DC-meditated immune escape. (jcancer.org)
  • In addition, dendritic cells are less functional in pancreatic cancer. (bookinghealth.com)