Immune cell proliferation. Medical search. Frequent questions

siRNA against MITF aswell as against FoxO3a secured cells from apoptosis pursuing PI 3-kinase inhibition. (immune-source.com)
Effect of HSPA8 gene on the proliferation, apoptosis and immune function of HD11 cells. (bvsalud.org)
This gene may affect the proliferation, apoptosis and immune function of chicken macrophages , but the specific mechanism remains unclear. (bvsalud.org)
The purpose of this study was to explore the effect of the HSPA8 gene on the proliferation, apoptosis and immune function of chicken macrophages . (bvsalud.org)
In this study, a chicken HSPA8 overexpression plasmid , interference fragment and corresponding controls were transfected into HD11 cells , and then the expression of the HSPA8 gene , cell proliferation , cell cycle , apoptosis rate and immune function of each group were detected. (bvsalud.org)
The results suggested that HSPA8 promotes the proliferation of and inhibits the apoptosis of HD11 cells and has a proinflammatory effect. (bvsalud.org)
Sunburned cells are those which have initiated apoptosis. (wikipedia.org)
The protective role of GB004 on barrier integrity was further supported by immunostaining experiments demonstrating that GB004 treatment protected epithelial cells from TNFa-induced cell apoptosis, improving both epithelial cell number and tight junction protein ZO-1 staining. (ecco-ibd.eu)
Its roles include regulation of proliferation, promotion of immune system and activation of apoptosis in B cells. (intechopen.com)
In these cells, IL-21 does not promote proliferation but enhances apoptosis and chemotaxis. (intechopen.com)
STAT3 protein is crucial in cell proliferation, apoptosis, and host immune responses. (hawaii.edu)
HIFs exert differential effects on tumor growth and affect important cancer hallmarks including cell proliferation, apoptosis, differentiation, vascularization/angiogenesis, genetic instability, tumor metabolism, tumor immune responses, and invasion and metastasis. (lu.se)

The skin comprises various cell types providing the potential to react to bacterial pathogenicity factors and can thus initiate inflammatory responses if exposed to these factors 5 . (nature.com)
Although mast cells are traditionally thought to function as effector cells in allergic responses, they have increasingly been recognized as important regulators of various immune responses. (ewha.ac.kr)
The direction and fold-change of this differential gene regulation suggests that toxicity testing in monoculture may exaggerate cellular responses to MWCNTs, and coculture of cells may provide a more in-depth assessment of toxicological responses. (cdc.gov)
Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. (frontiersin.org)
Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. (frontiersin.org)
Immune cells abundantly infiltrate tumors, creating a complex environment mediated by repetitive cycles of antitumor responses and immune evasion ( 1 ). (frontiersin.org)
Myeloid innate immune cells, such as granulocytes, monocytes, macrophages and dendritic cells (DCs), play an important role in cancer-cell recognition, initiation of inflammation and antitumor responses ( 2 ). (frontiersin.org)
Hence, myeloid cells play a dual role in cancer as they can initiate antitumor responses and communicate with cells of the adaptive immune system, but also promote local inflammation leading to chronic cancer-associated inflammation ( 5 , 6 ). (frontiersin.org)
The innate immune response by myeloid cells occurs as a succession of events starting at signaling through cytosolic or surface PRRs, followed by effector responses including the release of cytokines, reactive oxygen species (ROS), reactive nitrogen species (RNS), antibacterial peptides and degranulation ( Figure 1 ). (frontiersin.org)
The small beta-glucans fragments are eventually released by the macrophages and taken up by other immune cells leading to various immune responses. (nih.gov)
Although low ROS levels are beneficial to cellular stress responses for the activation of several cellular signaling pathways, abnormally elevated ROS leads to damage to cells and organs, and eventually, to cell death, thereby ROS can be either beneficial or detrimental to health 11 . (nature.com)
Understand the critical roles of B cells, including regulatory B cells (Bregs), in modulating immune responses, tumor responses and/or in auto-immune disorders. (horizondiscovery.com)
Spike proteins enter immune cells, switch off normal immune responses, and trigger pro-inflammatory pathways instead. (theepochtimes.com)
We leverage the power of metabolic and cellular bioengineering, synthetic chemistry and material engineering, and mechanical engineering to achieve controllable modulation of immune responses. (epfl.ch)
Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)

The normal process of fracture repair begins with an immediate inflammatory response as the innate immune system (macrophages, monocytes, neutrophils, and NK cells) responds with a variety of cytokines that recruit and activate several cell types, including osteoprogenitor mesenchymal stem cells (MSCs), to the site of injury [ 1 , 2 ]. (hindawi.com)
However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and neutrophils. (frontiersin.org)
Based on in vitro studies, beta-glucans act on several immune receptors including Dectin-1, complement receptor (CR3) and TLR-2/6 and trigger a group of immune cells including macrophages, neutrophils, monocytes, natural killer cells and dendritic cells. (nih.gov)
They are internalized and fragmented within the cells, then transported by the macrophages to the marrow and endothelial reticular system. (nih.gov)
As reported in a recent paper in npj Regenerative Medicine , however, axolotl with depleted macrophages (immune cells vital for clearing away dead cells as well as pathogens) showed a modified response to heart injury and impaired regeneration. (jax.org)
It was demonstrated that cancer stem cells cause macrophages, which are immune cells in charge of the initial stage of cancer cell death, to undergo senescence. (newkerala.com)
further investigation showed that macrophages cultured with cancer stem cells exhibit senescence or cellular ageing. (newkerala.com)
while the proliferation of T cells was unchanged, their antitumor activity was suppressed due to the immunosuppressive factors produced by senescent macrophages. (newkerala.com)
The team also demonstrated that supplementing the mice inoculated with cancer stem cells with a molecule called nicotinamide mononucleotide resulted in the proliferation of non-senescent macrophages and reduced the immunosuppressive factors produced by senescent macrophages, preventing tumour growth and leading to increased survival times in mice. (newkerala.com)
however, we measured no change in T lymphocyte proliferation or in the percentage of alveolar macrophages expressing HLA-DP. (cdc.gov)
Total cells, macrophages, and eosinophils recovered in BALF lavage were significantly elevated in the OVA + PM/OVA compared to OVA/OVA group. (cdc.gov)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)
Macrophages are phagocytic cells present in tissues throughout the body. (msdmanuals.com)

Animal cell technology is an area of rapid expansion and one that produces a wide range of high-value products, including vaccines, recombinant proteins, drugs for cardiovascular, respiratory and immune diseases, and monoclonal antibodies. (imperial.ac.uk)
In obesity and dyslipidemia, the metabolic overloading of ER and mitochondria can alter immune cell function and trigger the activation of innate immune signaling proteins positioned on their outer membranes. (georgetown.edu)
Spike proteins trigger chronic inflammation by causing immune dysregulation . (theepochtimes.com)

The precise spatial and temporal impact of immune cells and their cytokines on fracture healing remains obscure. (hindawi.com)
Pathogen clearance is mediated by mechanisms such as phagocytosis, respiratory burst with the production of ROS and RNS and release of bacteriostatic peptides, but also through the cell-extrinsic initiation of inflammation via the release of proinflammatory cytokines and chemokines ( 24 ). (frontiersin.org)
Mounting an immune response involves energetically demanding processes such as immune cell proliferation, new protein synthesis (cytokines, chemokines) and phagocytosis. (georgetown.edu)
In the human Repligut intestinal epithelium assay, GB004 significantly reduced cell death and improved barrier integrity in response to pro-inflammatory cytokines. (ecco-ibd.eu)
reducing the proliferation of pro-inflammatory cytokines (interferon gamma and IL-17). (wakeup-world.com)

Both SALPs showed a low cytotoxicity in all investigated cell types. (nature.com)

These outcomes define a book E-box-regulated network that features Cyclocytidine coordinately with FoxO to modify transcription of apoptotic and cell routine regulatory genes downstream of PI 3-kinase/Akt/GSK3 signaling. (immune-source.com)
RESULTS c-Myc Does Not Regulate Expression of Genes Induced in Response to PI 3-Kinase Inhibition Computational analysis identified overrepresented E-box sequences as well as FoxO-binding sites in the upstream regulatory regions of 8 genes that were induced in proliferating T98G cells in response to 2-4 h of PI 3-kinase inhibition (9). (immune-source.com)
Genes that changed regulation direction were most often involved in the processes of cellular growth and proliferation and cellular immune response and inflammation. (cdc.gov)
it inhibits transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF-alpha (all involved in early T-cell activation). (medscape.com)
R-CHOP has even been reported to activate certain oncogenes (genes that can cause cancer) and favor a specific subset of cells also referred to as sub-clonal populations. (news-medical.net)
Identify genes that, when knocked out, affect the B cell function. (horizondiscovery.com)
The upregulated DEGs were primarily protein‑coding genes enriched in immune and inflammation response pathways, while the downregulated DEGs were mainly coding long non‑coding (lnc)RNAs, indicating the regulatory function of USF1. (spandidos-publications.com)
It was also demonstrated that USF1 directly binds to the promoter region of 2,492 genes, which may be involved in the viral progression and cell proliferation pathways. (spandidos-publications.com)
Promoter region motif analysis indicated that ETV5 has more binding motifs and genes than USF1 itself for USF1‑regulated DEGs, indicating that USF1 may indirectly modulate gene expression by regulating ETV5 expression in Huh7 cells. (spandidos-publications.com)
Barrier integrity was assessed by Transepithelial Endothelial Electric Resistance (TEER), HIF-1a target genes were assessed in cell lysates, and tight junction formation and epithelial monolayer viability were investigated by immunofluorescence staining. (ecco-ibd.eu)

Although inflammation is an important process to combat infections and to accelerate wound healing, overactivation of the immune system can lead to detrimental effects such as chronic skin inflammation 12 . (nature.com)
In this study, we determined the effects of keratinocytes on mast cell accumulation during Th17-mediated skin inflammation. (ewha.ac.kr)
Corticosteroids are immunosuppressive and affect the replication, movement, and activity of virtually all cells involved with inflammation. (medscape.com)
While organelles like endoplasmic reticulum (ER) and mitochondria form functionally specialized units, they need to coordinate with each other to provide the metabolic robustness and adaptability needed by the immune cells to transition between activation and resolution phases of inflammation. (georgetown.edu)

The adaptive immune response, primarily comprised of T and B lymphocytes, has important implications in the fracture healing process as well [ 3 , 4 ]. (hindawi.com)
Cells that are impacted in Psoriasis include dendritic cells, T lymphocytes, and keratinocytes. (wikipedia.org)
Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer of lymphocytes, and a large proportion of patients are either unresponsive or develop resistance towards R-CHOP-the standard treatment regimen. (news-medical.net)
White blood cells or lymphocytes are the soldiers of our immune system that patrol the body via the lymphatic system. (news-medical.net)
Lymphoma, a type of blood cancer, results from the uncontrolled proliferation of lymphocytes. (news-medical.net)
Lymphocytes, B and T cells, can respond selectively to thousands of non-self materials. (lu.se)

Here we investigated gene expression and secretion of soluble factors elicited by GB004 treatment on immune cells and epithelial cells, human monolayer assays and immune co-culture studies to further explore its protective mechanism. (ecco-ibd.eu)

In LPS-stimulated human monocyte-derived dendritic cells and Langerhans-like cells, the peptides blocked IL-6 secretion, downregulated expression of maturation markers and inhibited dendritic cell migration. (nature.com)
Dendritic cells are present in the skin (as Langerhans cells), lymph nodes, and tissues throughout the body. (msdmanuals.com)
Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)
Follicular dendritic cells are a distinct lineage (a different cell type than conventional dendritic cells), do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)

Similar to mouse epidermal keratinocytes, SCF was highly expressed in the human HaCaT keratinocyte cell line following stimulation with IL−17. (ewha.ac.kr)
Further, keratinocytes promoted mast cell proliferation following stimulation with IL−17 in vitro. (ewha.ac.kr)
Moreover, we demonstrate that Atm-deficient T cells display impaired proliferation capacity upon stimulation, due to replication stress. (nih.gov)
MSCs are able to evade the host cell immune system due to their low expression of major histocompatibility complex (MHC) class I molecules and complete lack MHC class II molecules and other costimulatory molecules (CD40, CD40L, CD80, and CD86) required for immune cell stimulation [ 15 - 17 ]. (hindawi.com)
One way to evaluate T-cell immune health is to measure the proliferation of a patient's T cells in response to stimulation with an antigen or mitogen. (the-scientist.com)
In the BioMAP human co-culture assay, cells were treated with GB004 one hour prior to stimulation and incubated for 24-168 hours. (ecco-ibd.eu)
Repligut human stem-cell-derived monolayer platforms were used to assess GB004 effects under unstimulated or TNFa stimulation conditions. (ecco-ibd.eu)
GB004 demonstrated activity in 11 of 12 systems in the BioMAP human co-culture assay, which covers a range of disease-relevant immune and non-immune mechanisms under stimulation conditions. (ecco-ibd.eu)

Differential gene regulation in human small airway epithelial cells grown in monoculture versus coculture with human microvascular endothelial cells following multiwalled carbon nanotube exposure. (cdc.gov)
This study identified differential gene regulation in human small airway epithelial cells (SAECs) grown either in monoculture or in coculture with human microvascular endothelial cells following exposure of the SAECs to multiwalled carbon nanotube s (MWCNTs). (cdc.gov)
The bacteria adhere to nasopharyngeal, pulmonary, and endothelial cells. (stjude.org)
This development occurs under the influence of macrophage colony-stimulating factor (M-CSF), which is secreted by various cell types (eg, endothelial cells, fibroblasts). (msdmanuals.com)

Calcium is also involved in different signaling pathways within skin cells. (wikipedia.org)
The programmed cell death prevents the activity of damaged DNA or pathways that could otherwise lead to cancer. (wikipedia.org)
One mechanism uses Receptor tyrosine kinase activates other cell signaling pathways and eventually MAP kinase. (wikipedia.org)
Their article describes in detail various aspects of tumor biology, including molecular pathways, tumor microenvironment, clonal evolution (selective growth of particular cells) and cell of origin that can help identify potential mechanisms and predictive biomarkers of drug resistance. (news-medical.net)
Molecular signaling pathways control the intracellular decisions of cell growth. (news-medical.net)
Alterations in the B-cell receptor, PI3K-Akt, NF-kB, and JAK-STAT3 pathways can also cause drug resistance. (news-medical.net)
however, antioxidant protection, enhanced immune surveillance and modulation of cell proliferation have been proposed to be the major pathways. (usda.gov)
In this chapter, we will focus on IL-21's biological effects and signaling pathways as well as discuss the potential implications and applications of IL-21 in leukemia cells. (intechopen.com)

LTD4 has been shown to induce cell proliferation, survival and migration in intestinal epithelial cells (Int407) via the CysLT1R. (lu.se)

The Nussenzweig lab explores how the rapid proliferation of immune cells during infection could precipitate cancer. (pewtrusts.org)
In both processes, rapid proliferation gives rise to new tissue, cell fate has to be specified within that tissue, and distinct positional identities have to be established to generate a properly patterned structure. (frontiersin.org)

7] Generally, Psoriasis affects innate and adaptive immune system cells. (wikipedia.org)
We offer a comprehensive service to help you study both adaptive and innate immune systems. (horizondiscovery.com)
Adaptive immune mechanisms recognize and neutralize foreign molecules or microorganisms in a specific manner. (lu.se)
Deficiencies are highly variable with regard to symptoms, phenotype, genotype, severity, etc, because many cells and molecules are required for both natural and adaptive immunity . (lu.se)

However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)

It leads to decreased expression of IL-3, IL-4, IL-5, and TNFα, and it inhibits mast cell and neutrophil activation. (medscape.com)
Marik said that a critical aspect of long-term spike protein damage is that it inhibits autophagy, your body's way of recycling damaged cells. (theepochtimes.com)

Adipose-derived MSCs, in particular, pose an attractive option for cell-based therapy due to their relatively decreased morbidity during isolation and potential for expansion and differentiation [ 12 ]. (hindawi.com)
Multipotential differentiation of MSCs into adipogenic, osteogenic, and chondrogenic cell lineages. (hindawi.com)

Lymphotoxin-α (LT-α), also known as tumor necrosis factor-beta (TNF-β), is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. (biolegend.com)
Damage and degeneration of mucosal tissues may be due to a proliferation of cytotoxic T cells or toxic products released by degranulating eosinophils. (medscape.com)
Intracellular antigens (eg, viruses) can be processed and presented to CD8 cytotoxic T cells by any nucleated cell because all nucleated cells express class I MHC molecules. (msdmanuals.com)

Furthermore, SALPs markedly promoted cell migration via EGFR transactivation and ERK1/2 phosphorylation and accelerated artificial wound closure in keratinocytes. (nature.com)
Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) in vivo and in vitro. (uni-regensburg.de)

In contrast, SALPs did not affect proliferation of keratinocytes. (nature.com)
However, the effects of keratinocytes on mast cells were significantly diminished in the presence of anti−CD117 (stem cell factor receptor) blocking antibodies. (ewha.ac.kr)
Keratinocytes are the main cell type of the epidermis. (wikipedia.org)
As cells progress through the various layers to reach the stratum corneum, they undergo a process called cornification which transforms keratinocytes to corneocytes, effectively killing them. (wikipedia.org)
Psoriasis is the proliferation of keratinocytes. (wikipedia.org)

Models of animal cell culture systems have a wide range of potential applications, such as analysis and prediction of experimental results, optimisation of culture conditions for prolonged viability, and perhaps most importantly, the investigation of fundamental metabolic processes and their subsequent elucidation. (imperial.ac.uk)
The integration of these three research tools represents a unique, novel, and interdisciplinary approach to addressing the complicated research and industrial problem of model-based control and optimisation of mammalian cell culture processes. (imperial.ac.uk)
The immune system consists of a large number of molecules and processes, and immunodeficiencies can therefore be caused by genetic alterations at many loci. (lu.se)

Gene expression of mesenchymal stem cells related to cell proliferation and collagen secretion. (medscimonit.com)
This new information has helped us discover that vitamin D also influences the immune system and helps differentiate cells, regulate blood pressure, insulin secretion and more. (wakeup-world.com)

Interleukin-21 (IL-21) is produced by activated T cells and it plays many diverse roles by regulating the functions of normal and abnormal cells. (intechopen.com)
A complete blood cell count (CBC) with differential should be obtained, including examination of the peripheral blood smear if the differential is abnormal. (medscape.com)
Disorders characterized by abnormal proliferation of primary cells of the immune system or by excessive production of immunoglobulins. (bvsalud.org)

Bacteria can release endotoxins like lipopolysaccharide (LPS) or other pathogenicity factors such as lipopoteins/peptides (LP) from their cell envelope, even due to treatment with conventional antibiotics, being able to activate Toll-like receptors (TLRs) and induce a strong inflammatory response. (nature.com)
Cell lines and transfected cell systems augment this study with particular emphasis on perturbations in the biology of selectins, integrins, matrix adhesion, and chemokine receptors. (stjude.org)
Recent research suggests that almost every cell in our body has receptors for vitamin D, which indicates a much stronger role for this vitamin than previously thought. (wakeup-world.com)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)

We observed increases in dermal mast cells in imiquimod-induced psoriatic dermatitis in mice accompanied by the expression of epidermal stem cell factor (SCF), a critical mast cell growth factor. (ewha.ac.kr)
8] The proliferation of epidermal cells is associated with an increase in skin sloughing. (wikipedia.org)

Two fundamentals aspects of cell behaviour any model must include are metabolism and the cell cycle. (imperial.ac.uk)
The population balance framework is used to capture cell cycle effects while a single-cell model takes account of some features of intracellular metabolism. (imperial.ac.uk)

Multipotent mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have the capacity to differentiate into a variety of cell types (Figure 1 ), including adipocytes, chondrocytes, and osteocytes [ 9 , 10 ]. (hindawi.com)
A more long-term treatment involves transplanting blood-forming stem cells from a healthy donor. (nih.gov)
This involves removing some of the patient's own stem cells, adding a normal copy of the ADA gene, and then returning the modified cells to the patient. (nih.gov)
Only one U.S. patient and one U.K. patient had to resume enzyme-replacement therapy because the modified stem cells didn't take hold. (nih.gov)
A low dose of chemotherapy was used to help the modified stem cells establish themselves. (nih.gov)
If successful, it could increase access to treatment by allowing modified stem cells to be shipped to local hospitals. (nih.gov)
ice with healthy immune systems are exposed to cancer stem cells, which cause macrophage ageing and tumour growth. (newkerala.com)
A variety of cells, the most significant of which are cancer stem cells, make up malignant tumours. (newkerala.com)
A group of researchers at Hokkaido University's Institute for Genetic Medicine, under the direction of Associate Professor Haruka Wada, looked into the ways in which cancer stem cells avoid the immune system in mouse models. (newkerala.com)
The majority of studies on cancer stem cells have been carried out in vitro or in immunodeficient mice models, which do not account for a fully functioning immune response. (newkerala.com)
The team identified interleukin 6 (IL-6) produced by cancer stem cells as the molecule responsible for triggering these effects. (newkerala.com)
Leukocytes are produced in stem cells in bone marrow. (lu.se)

Taken together, our results revealed that the Th17-mediated inflammatory environment promotes mast cell accumulation through keratinocyte-derived SCF. (ewha.ac.kr)

Its mechanism of action is thought to be through modulation of the immune system with reduction of inflammatory mediators involved in eczematous reactions. (medscape.com)
Such findings may relate to roles of Se in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. (usda.gov)

Nor were there any cases of the patient's immune system attacking its own cells or the transplanted cells. (nih.gov)

The formation of sunburn cells is in response to the damage done by UVB exposure. (wikipedia.org)
While single-cell models of pulmonary exposure are often used to determine the potential toxicity of nanomaterial s in vitro, previous studies have shown that coculture cell models better represent the cellular response and crosstalk that occurs in vivo. (cdc.gov)
beta-glucans are ubiquitously found in both bacterial or fungal cell walls and have been implicated in the initiation of anti-microbial immune response. (nih.gov)
They modify the immune response of the body to diverse stimuli. (medscape.com)
These agents modify the body's immune response to diverse stimuli and therefore have anti-inflammatory properties. (medscape.com)
and Research Scientist James Godwin, Ph.D. , explored the role of the immune response in heart regeneration in the axolotl (salamander). (jax.org)
Zinc is essential for the regulation of immune response. (eurekamag.com)
We also explored the effects of supplementation on immune response. (eurekamag.com)
The intrinsic metabolic flexibility of immune cells directly influences their effector functions that shape the outcome of the immune response. (georgetown.edu)
The normal immune response for infected immune cells is to release type 1 interferons, this gives signals to other immune cells to enhance defense against viral particles. (theepochtimes.com)
Through immune response evasion, these cells can grow new malignant tumours. (newkerala.com)
The lack of effectiveness of cancer stem cell-targeting drugs indicates that the immune response or lack thereof is more important than previously considered. (newkerala.com)
We hypothesized that, in CBD, failure of IL-10 to modulate the beryllium-specific, cell-mediated immune response would result in persistent, maximal cytokine production and T lymphocyte proliferation, thus contributing to the development of granulomatous lung disease. (cdc.gov)
The aim of this study was to assess how exposure to fine PM collected from Sacramento, CA, shapes the allergic airway immune response in BALB/c mice undergoing sensitization and challenge with ovalbumin (OVA). (cdc.gov)
There are two hallmark phenotypes of allergic asthma: (1) inflammatory, due to a T helper cell type 2 (Th2)-mediated immune response resulting in elevated inflammatory cells in the airways, and (2) airway hyper-reactivity, during which volume and flow of inhaled air decreases as a consequence of airway constriction. (cdc.gov)
Several investigators have proposed that eosinophilic ulcers develop as a result of a T-cell-mediated immune response. (medscape.com)

Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
Extracellular antigens (eg, from many bacteria) that are phagocytosed or endocytosed can be processed into peptides and complexed with surface class II MHC molecules on professional APCs, which specialize in presenting antigens to CD4 helper T (Th) cells. (msdmanuals.com)

Phosphatidylinositol (PI) 3-kinase/Akt signaling plays a critical function in cell proliferation and success partly by legislation of FoxO transcription elements. (immune-source.com)
But spike protein reduces this signaling in infected cells, and uninfected cells will also take in and become damaged by the spike protein as the infection goes out of control. (theepochtimes.com)
The signaling mechanisms of IL-21 in different cell types have been identified. (intechopen.com)

Prior to MKTP, T-cell subsets and chemokines. (umassmed.edu)

Intriguingly, perivascular tumor cells. (lu.se)
Intriguingly, perivascular tumor cells can also express HIF-2α, thereby forming a "pseudohypoxic" phenotype that further contributes to tumor aggressiveness. (lu.se)

New review article in Chinese Medical Journal details the potential mechanisms of resistance to the R-CHOP chemotherapy regimen in patients with diffuse large B-cell lymphoma. (news-medical.net)
Of them, diffuse large B-cell lymphoma (DLBCL) is the most common Non-Hodgkins lymphoma and is highly aggressive and fast-growing. (news-medical.net)
Clinically, grade 3B follicular lymphoma is treated like diffuse large B-cell lymphoma . (medscape.com)

In this review, we discuss how rudimentary defense mechanisms deployed by myeloid cells can promote tumor progression. (frontiersin.org)
Procedure for Cyclex's Luminetics T cell activation assay The T-cell immune status of patients with conditions such as AIDS indicates disease progression. (the-scientist.com)
In normal cell cycles STAT3's activation is fleeting, but in many cancer cell lines aberrantly activated STAT3 promotes cancer progression. (hawaii.edu)

bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)
Our data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte pro- liferation. (cdc.gov)
exogenous rhIL-10 has a limited effect on cytokine production and no effect on T lymphocyte proliferation or HLA expression. (cdc.gov)
CMIR)3 and, in the presence of persistent Ag, in the stricted, beryllium salt-specific T lymphocyte proliferation (1-3). (cdc.gov)

It may decrease the proliferation of immune cells, resulting in low autoimmune activity. (medscape.com)
It may decrease proliferation of immune cells, which results in lower autoimmune activity. (medscape.com)
Hundreds of research studies suggest that vitamin D can help prevent a multitude of conditions, from osteoporosis to autoimmune disorders, immune function, cardiovascular disease, cancer and more. (wakeup-world.com)

However, beta-glucans of different sizes and branching patterns may have significantly variable immune potency. (nih.gov)
On a functional level, proneural CSC lines caused a significantly stronger TGF-beta-dependent suppression of NKG2D expression on CD8(+) T and NK cells in vitro providing a mechanistic explanation for the reduced immune infiltration of proneural GBMs. (uni-regensburg.de)

thus, tissue-specific influences are important for promoting mast cell accumulation and survival in the skin and the gastrointestinal tract. (ewha.ac.kr)
Although the study size was small, the survival rates were higher than for stem cell transplantation. (nih.gov)

A buildup of these breaks lead to errors in DNA that can trigger cells to grow and divide abnormally, increasing the risk of cancer in people with Nijmegen breakage syndrome. (medlineplus.gov)
This vigorous cellular replication comes with a price: When DNA is copied at a rapid pace to produce large numbers of cells, it is at risk of accruing damage, including the sorts of chromosome breaks and rearrangements that may trigger the development of lymphomas. (pewtrusts.org)

In addition to TAMs, solid tumors are also infiltrated by immunosuppressive, immature myeloid progenitor cells, commonly referred to as monocytic or polymorphonuclear myeloid-derived suppressor cells (M/PMN-MDSC) ( 11 - 13 ). (frontiersin.org)

The immune system abnormalities increase susceptibility to recurrent infections, such as bronchitis, pneumonia, sinusitis, and other infections affecting the upper respiratory tract and lungs. (medlineplus.gov)

The nibrin protein helps maintain the stability of a cell's genetic information through its roles in repairing damaged DNA and regulating cell division. (medlineplus.gov)
I will also assess whether a protein known to recognize and bind to spots of DNA damage can protect dividing B cells from genomic rearrangements at these sites-work that could point toward novel therapies for cancers that develop in the cells of the immune system. (pewtrusts.org)
The coronavirus spike protein (red) mediates the virus entry into host cells. (theepochtimes.com)
Different strategies to target hypoxic cancer cells and/or HIFs include hypoxia-activated prodrugs and inhibition of HIF dimerization, mRNA or protein expression, DNA binding capacity, and transcriptional activity. (lu.se)

1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)

Dyer's woad (Isatis indigotica Fort), is a Chinese herb that promotes a healthy immune system. (nutrametrix.com)

Usually, when cells have been infected with viral particles, the cells will try to break these particles down and remove them as waste. (theepochtimes.com)
However, neither virally altered cells nor viral DNA is identified in biopsy specimens of typical eosinophilic ulcer. (medscape.com)

Using T cell-specific Atm-knockout models, as well as allogeneic transplantation experiments, we pinpoint impaired immune surveillance as a contributor to cancer predisposition and development. (nih.gov)

The resulting cell is flat, has no nucleus, and is surrounded by a cellular envelope. (wikipedia.org)
Studies detail the herb's ability to promote normal blood coagulation time, support normal coronary blood flow and promote normal oxygen use by cardiac muscles, support the immune system and promote cellular health. (nutrametrix.com)
Molecular Components of the Immune System The immune system consists of cellular components and molecular components that work together to destroy antigens (Ags). (msdmanuals.com)

Biomarkers, cell viability and proliferation were assessed. (ecco-ibd.eu)
Finding cancer stem cell biomarkers and creating treatments that specifically target these cells have been the main goals of research. (newkerala.com)

There are more microorganisms in the intestinal tract than the total number of cells in the body. (selfgrowth.com)

The fluorochrome-labeled 359-81-11 antibody is useful for intracellular immunofluorescent staining and flow cytometric analysis to identify LT-α -producing cells within mixed cell populations. (biolegend.com)

Although tumor-promoting functions have been attributed to other granulocytes, like eosinophils ( 17 ), basophils ( 18 ) and mast cells ( 19 ), further research is required to fully elucidate their role in cancer, as antitumoral roles have also been described ( 20 , 21 ). (frontiersin.org)

Gene therapy restored immune system function to children with an inherited immune disorder with fewer side effects than existing therapies. (nih.gov)
Replacing the defective ADA with injections of the normal enzyme once or twice a week can treat the condition, but it doesn't restore full immune function and must be taken for life. (nih.gov)
T cell function declines with age. (eurekamag.com)
The increase in serum zinc concentration was associated with the enhancement of T cell function mainly because of an increase in the number of T cells. (eurekamag.com)
Taken orally, it is used for promoting cardiovascular health, promoting healthy cell function and supporting a healthy immune system. (nutrametrix.com)
2) T cell deficiencies affect the function in killing infected cells or helping other immune cells. (lu.se)

We further find a reduced T cell abundance in B cell lymphomas from Atm-defective mice and A-T patients. (nih.gov)
Prior studies have focused on driving cardiomyocyte proliferation to improve cardiac regeneration in mice. (jax.org)

Osteoprogenitor MSCs not only differentiate into bone, but they also exert modulatory effects on immune cells via a variety of mechanisms. (hindawi.com)
PRR on myeloid cells can be triggered by pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs), but also indirectly by secondary mechanisms such as complement activation and circulating antibodies (Abs), resulting in cytolytic and phagocytic effector mechanisms. (frontiersin.org)
These mechanisms are often used by cancer cells to surive and spread. (lu.se)

In this paper, we review the current literature on both in vitro and in vivo studies on the role of the immune system in fracture repair, the use of MSCs in the enhancement of fracture healing, and interactions between MSCs and immune cells. (hindawi.com)
In vivo, a substantially increased infiltration of immune cells was observed in mesenchymal GBMs, while immune infiltrates were rare in proneural GBMs. (uni-regensburg.de)

Current understanding of mammalian cell cultures lies in the association of their metabolic behaviour to their antibody production output. (imperial.ac.uk)
At the epicenter of this immune and metabolic reprogramming ( immunometabolism ) are organelles that compartmentalize specific metabolic reactions. (georgetown.edu)

neutrophil chemoattractant, production of reactive oxygen, fibroblast proliferation. (biolegend.com)
Patients with TB cause impaired cell-mediated immunity and were admitted and the other 2 groups were compromise neutrophil functions [5]. (who.int)

When the body is invaded by viruses, bacteria, or parasites, antibody-producing B cells swiftly expand their ranks to help clear the infection. (pewtrusts.org)
The main objective of the project is to study the effects of hyperosmotic pressure on the antibody production process in the GS-NS0 cell line, with particular attention to the antibody production mechanism. (imperial.ac.uk)
3) T cell deficiencies result usually in combined immunodeficiencies (CIDs), where both T cells and antibody production are defective. (lu.se)

In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)

In the Luminetics Assay, T cells are stimulated with an antigen or mitogen first, followed by separation of specific T-cell subsets. (the-scientist.com)

Anatomy48

Organisms15

Diseases14

Chemicals and Drugs88

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes59

Disciplines and Occupations1

Information Science3

Health Care1

Apoptosis12

Responses15

Macrophages13

Proteins3

Cytokines5

Cytotoxicity1

Genes10

Inflammation4

Lymphocytes6

Assays1

Dendritic cells4

Stimulation8

Endothelial cells4

Pathways8

Epithelial cells1

Rapid proliferation2

Adaptive4

Monocytes1

Inhibits2

Differentiation2

Cytotoxic3

Migration2

Keratinocytes5

Processes3

Secretion2

Abnormal3

Receptors4

Epidermal2

Metabolism2

Stem Cells12

Keratinocyte1

Modulation2

Patient's1

Response16

Molecules2

Signaling3

Chemokines1

Tumor cells2

Diffuse large B-3

Progression3

Lymphocyte4

Autoimmune3

Significantly2

Survival2

Trigger2

Immunosuppressive1

System abnormalities1

Protein4

Disorders1

Promotes1

Viral2

Impaired immune surveillance1

Cellular3

Biomarkers2

Intestinal1

Intracellular1

Roles1

Function6

Mice2

Mechanisms3

Vivo2

Metabolic2

Neutrophil2

Antibody3

Vitro studies1

Subsets1