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  • patients
  • A 2nd generation small molecule TPO-agonist, eltrombopag (Promacta ) has been shown to increase platelets in healthy subjects and in thrombocytopenic patients with chronic immune thrombocytopenic purpura (ITP) and hepatitis C virus (HCV) infection. (clinicaltrials.gov)
  • Respiratory failure requiring orotracheal intubation (OTI) and mechanical ventilation (MV) is almost always a fatal complication in patients who undergo hematopoietic progenitor transplantation (HPT). (ebscohost.com)
  • Eosinophilic pulmonary syndrome as a manifestation of GVHD following hematopoietic stem cell transplantation in three patients. (ebscohost.com)
  • We report the occurrence of eosinophilic pulmonary syndrome in three patients following allogeneic hematopoietic stem cell transplantation (HSCT), and postulate that this entity is part. (ebscohost.com)
  • To prevent or treat infections that may result from cyclosporine s effect on the immune system, patients will also take inhaled or capsule doses of pentamidine. (clinicaltrials.gov)
  • A 2nd generation small molecule TPO-agonist, eltrombopag (Promacta(Registered Trademark)) has been shown to increase platelets in healthy subjects and in thrombocytopenic patients with chronic immune thrombocytopenic purpura (ITP) and hepatitis C virus (HCV) infection. (comparetrials.com)
  • oncology
  • From 1993-1999, Gale was Senior Physician and Corporate Director of Bone Marrow and Blood Cell Transplantation at Salick Health Care (SHC), Inc. in Los Angeles (now Aptium Oncology), a subsidiary of AstraZeneca. (wikipedia.org)
  • chemotherapy
  • citation needed] Although most fungi - especially Aspergillus - fail to grow in healthy human tissue, significant growth may occur in people whose adaptive immune system is compromised, such as those with chronic granulomatous disease, who are undergoing chemotherapy, or who have recently undergone a bone marrow transplantation. (wikipedia.org)
  • 1994
  • 1994 Dr. Louise Markert demonstrates that babies born with no immune system, a fatal condition known as complete DiGeorge syndrome, can be cured with thymus transplantation. (wikipedia.org)
  • In collaboration with Dr . Shahin Raffi in 1994, a bone marrow-derived endothelial progenitor cell was identified and shown to play an important role in the development of the blood supply of developing tumors. (wikipedia.org)
  • system
  • the immune system to recover in a way that improves white blood cell function. (aamds.org)
  • By this mechanism they provide the immune system with "memory" against previously encountered pathogens. (wikipedia.org)
  • Non-myeloablative bone marrow transplantation uses lower doses of total body irradiation, typically about 2 Gy, which do not destroy the host bone marrow but do suppress the host immune system sufficiently to promote donor engraftment. (wikipedia.org)
  • The fungus settles in a cavity and is able to grow free from interference because critical elements of the immune system are unable to penetrate into the cavity. (wikipedia.org)
  • This observation demonstrated that self was "learned" by the immune system during development and paved the way for research involving induction of immune tolerance and early tissue grafting. (wikipedia.org)
  • He co-authored papers that described "the use of radiation as a means of blocking or resetting the immune system before transplantation of bone marrow or other tissues. (wikipedia.org)
  • Their immune system is not strong enough to fight off the fungus, and it may, for example, colonise the lung, resulting in a pulmonary infection. (wikipedia.org)
  • A weakened immune system leaves patients susceptible to different kinds of infection. (wikipedia.org)
  • Immune system effects - "the immediate decreases in blood lymphocyte counts and serum immunoglobulin concentrations are of slight to moderate degree and are without known adverse effects. (wikipedia.org)
  • Less information is available regarding long-term alterations of the immune system" Two apheresis kit recalls were: Baxter Healthcare Corporation (2005), in which "pinhole leaks were observed at the two-omega end of the umbilicus (multilumen tubing), causing a blood leak. (wikipedia.org)
  • disorders
  • Alterations in the immune response are involved in pathogenesis of many neuropsychiatric disorders including schizophrenia. (wikipedia.org)
  • cartilage
  • 2 MSCs are capable of differentiating along bone, cartilage, muscle and fat lineages. (bmj.com)
  • murine bone
  • Tolerogenic DCs have been generated in the presence of 1,25(OH) 2 D 3 , the active form of vitamin D 3 , and of vitamin D 3 analogues from both human blood monocytes and murine bone marrow and shown to induce Treg ( 8 , 9 , 10 ). (jimmunol.org)
  • hematopoiesis
  • while a numbers of key growth factors that regulates hematopoiesis have been identified and some of them are currently used for clinical purpose, how bone marrow microenvironment that presents those signals to the hematopoietic progenitors is constructed remains totally obscure. (nii.ac.jp)
  • Apheresis
  • Less information is available regarding long-term alterations of the immune system" Two apheresis kit recalls were: Baxter Healthcare Corporation (2005), in which "pinhole leaks were observed at the two-omega end of the umbilicus (multilumen tubing), causing a blood leak. (wikipedia.org)
  • responses
  • Experimental immunologists study responses to simple antigens through immunization, the deliberate induction of an immune response in animal or human subjects. (wikipedia.org)
  • B cell immune responses are measured by analyzing antibodies produced through the humoral immune response. (wikipedia.org)
  • Although the function of this gene is not yet fully elucidated, initial microarray evidence suggests that it may be involved in immune responses. (wikipedia.org)
  • cell
  • Together, the results of this study lay the groundwork for future studies to explore the role of DNA replication in immune cell generation and function. (jci.org)
  • Since more than one type of immune cell is affected, this disease is classified as a severe combined immunodeficiency disease (SCID). (wikipedia.org)
  • One cell-based replacement technique is called autologous chondrocyte implantation (ACI) or autologous chondrocyte transplantation (ACT). (wikipedia.org)
  • A megakaryocyte (mega- + karyo- + -cyte, "large-nucleus cell") is a large bone marrow cell with a lobulated nucleus responsible for the production of blood thrombocytes (platelets), which are necessary for normal blood clotting. (wikipedia.org)
  • This process indicates that, subsequent to bone marrow transplantation, symmetrical cell divisions into two daughter HSCs must occur. (wikipedia.org)
  • Stem cell self-renewal is thought to occur in the stem cell niche in the bone marrow, and it is reasonable to assume that key signals present in this niche will be important in self-renewal. (wikipedia.org)
  • G-CSF may also be given to the receiver in hematopoietic stem cell transplantation, to compensate for conditioning regimens. (wikipedia.org)
  • Stem cell transplantation may be used if the disease recurs following standard treatment. (wikipedia.org)
  • vivo
  • In this report, we present evidence that two known immunosuppressive neuropeptides, the vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase-activating polypeptide (PACAP), contribute to the development of bone marrow-derived tolerogenic DCs in vitro and in vivo. (jimmunol.org)
  • deficiencies
  • Development of molecular methods of diagnostics and treatment of haematological and oncological diseases and immune deficiencies. (fnkc.ru)
  • clinical
  • Minimal morphological criteria for defining bone marrow dysplasia: a basis for clinical implementation of WHO classification of myelodysplastic syndromes. (hunimed.eu)
  • adaptive
  • The successful initiation of the adaptive immune response requires DC maturation, following signaling through the toll-like receptors and CD40. (jimmunol.org)
  • response
  • Background Hemophagocytic lymphohistiocytosis (HLH) is a life threatening hematological disorder associated with severe systemic inflammation caused by an uncontrolled and ineffective immune response resulting in cytokine storm. (paperity.org)
  • Treatment
  • Development of the new methods of treatment of children with acquired and inherited bone marrow failures. (fnkc.ru)
  • Autologous matrix-induced chondrogenesis, which is also known as AMIC, is a biological treatment option for articular cartilage damage bone marrow stimulating technique in combination with a collagen membrane. (wikipedia.org)
  • liver
  • In mammalian embryology, the first definitive HSCs are detected in the AGM (aorta-gonad-mesonephros), and then massively expanded in the fetal liver prior to colonising the bone marrow before birth. (wikipedia.org)
  • methods
  • In 2007, a patent application was filed on methods for creating human female sperm using artificial or natural Y chromosomes and testicular transplantation. (wikipedia.org)
  • failure
  • Osteoarthritis is a common condition of cartilage failure that can lead to limited range of motion, bone damage and invariably, pain. (wikipedia.org)