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  • Klebsiella
  • GES-2, with a pI value of 5.8, hydrolyzed expanded-spectrum cephalosporins, and its substrate profile was extended to include imipenem compared to that of GES-1, identified previously in Klebsiella pneumoniae . (asm.org)
  • isolates
  • Imipenem-susceptible isolates decreased from 94.1 percent of all tested isolates in 1999 to 72.4 in 2006. (rwjf.org)
  • dehydropeptidase
  • When given alone, imipenem is filtered in the glomerulus and when it reaches the proximal tubule, it is metabolized by a brush-border enzyme called dehydropeptidase I. As a result, under normal circumstances, only 5-20% of it is excreted unchanged in the urine. (blogspot.com)
  • infusion
  • The results indicated that there is a significant decrease in mortality, number of recurrent infection, and ICU stay length, and the number of mechanical ventilator days was associated with extended imipenem infusion during the second year of the study. (pubmedcentralcanada.ca)
  • The use of imipenem with extended infusion over 3 hours enhances its clinical outcomes in the treatment of VAP. (pubmedcentralcanada.ca)
  • clinical
  • This study will demonstrate the stability of imipenem in clinical use at room temperature in tropical countries. (clinicaltrials.gov)
  • The objective of the present proposal is to evaluate the effectiveness of combination therapy of imipenem and sulbactam in patients contracted with A. baumannii, and to correlate the clinical effect with the in vitro synergistic results. (clinicaltrials.gov)
  • Using E. coli TOP10 strain harboring a multi-replicon IncFII K -IncFIB bla KPC−2 -gene carrying plasmid pBIC1a from K. pneumoniae ST-258 clinical isolate BIC-1, we aimed to identify basal gene expression and the effects of imipenem exposure using whole transcriptome approach by RNA sequencing (RNA-Seq). (frontiersin.org)
  • genes
  • Many genes showed small but statistically significant differential expression in response to imipenem. (asm.org)
  • We identified 34 genes that were induced or repressed in biofilms exposed to imipenem more than fivefold compared to the levels of induction or repression for the controls. (asm.org)
  • We also found that genes coding for alginate biosynthesis were induced by exposure to imipenem. (asm.org)
  • 1999
  • Data from a randomized, comparative treatment study support the use of imipenem/cilastatin in the treatment of severe melioidosis [Simpson . (drugs.com)
  • alginate
  • Effective diffusivity measurements showed that the diffusion of imipenem in the alginate layer was not hindered. (biomedsearch.com)
  • Increased levels of alginate production may be an unintended adverse consequence of imipenem treatment in CF patients. (asm.org)
  • drug
  • It is always given in combination with Cilastatin and in most of the documentation that you find online about this drug, it says that they are co-administered to increase the plasma levels of imipenem. (blogspot.com)
  • The metabolites of imipenem are very toxic to the proximal tubular cells and cause tubular necrosis and as a result, the drug on its own would not be useful due to its toxicity. (blogspot.com)
  • Urine
  • In early animal trials, the investigators noted that, despite the fact that it should be readily filtered at the glomerulus, the urine levels of imipenem were consistently far lower than would be expected given the serum levels. (blogspot.com)
  • activity
  • Imipenem may have activity against Mycobacteria spp. (theluckettsfair.com)
  • The epileptogenic activity of imipenem in rats with experimentally induced hypovolaemia or endotoxaemia was investigated by pharmacokinetic-pharmacodynamic modelling of the electroencephalogram effect. (ovid.com)
  • GES-2 activity was less inhibited by clavulanic acid, tazobactam and imipenem than GES-1. (asm.org)