Imidazole via copper. Medical search. Frequent questions

Imidazole is a pure sigma-donor ligand. (wikipedia.org)
For this reason, imidazole can be classified as hard ligand. (wikipedia.org)
Imidazole is a compact, flat ligand. (wikipedia.org)
The histamine molecule is a good ligand, which contains not only N atoms (from imidazole ring and aliphatic ammine) but also hydrogen atoms that are good for hydrogen bond formation and therefore are useful in molecular recognition. (hindawi.com)
Z. Salehi Rozveh, S. P. Aledavoud, S. M. Hosseini, M. Karimi, V. Safarifard , The role of mixed ligand approach in enhancing catalytic activity of copper-based MOFs in knoevenagel condensation. (ac.ir)
To determine ligand exchange kinetic parameters after the imidazole nitrogen anchoring, proton relaxation enhancement NMR data have been collected for the two hydrogen atoms of the imidazole ring in the temperature range 293-315 K at pH 5.2 and globally treated within different kinetic models for ligand exchange. (cnr.it)

Complexes of imidazole itself are of little practical importance. (wikipedia.org)
The donor properties of imidazole are also indicated by the redox properties of its complexes. (wikipedia.org)
There is no evidence for pi backbonding in metal-imidazole complexes, a property that can be attributed to the presence of the pi-donor pyrrole-like NH center. (wikipedia.org)
Nonetheless, complexes between low-valent metals and imidazole are well known, e.g. (wikipedia.org)
Many salts of [M(imidazole-1-R)6]2+ are known (R = alkyl, vinyl, etc.). 2-Methylimidazoles are somewhat bulky ligands owing to the steric clash between the 2-methyl group and other ligands in octahedral complexes. (wikipedia.org)
Especially in cationic imidazole complexes, the N-H center is acidified. (wikipedia.org)
Because of these characteristics some histamine complexes with copper have been reported recently [ 16 , 17 ]. (hindawi.com)
Copper(ii) complexes with short peptides based on the second cell binding site of fibronectin, PHSFN and PHSEN, have been characterized by potentiometric, UV-vis, CD, EPR and NMR spectroscopic methods. (cnr.it)
Both immobilized and free copper complexes were characterized using different techniques such as FT-IR, elemental analysis (CHN), SEM, XRD and TEM, and were utilized as catalysts in one-pot azide-alkyne cycloaddition (AAC) reaction. (sharif.edu)
The gold and copper thiosulfate complexes, along with the thiosulfate, trithionate and tetrathionate anions were modelled using ab-initio density functional theory (DFT). (edu.au)
Spectroscopic (UV-Vis and EPR) and voltammetric studies have been carried out on the copper (ii) complexes with the Ac-PEG11- (PHGGGWGQ) 4-NH2 (L) polypeptide. (cnr.it)

In contrast, imidazole derivatives, especially histidine, are pervasive ligands in biology where they bind metal cofactors. (wikipedia.org)
The hydrogen on the 1-bit nitrogen atom can be transferred to the 3-atom, therefore, imidazole derivatives with same substituent respectively on 4-bit and 5-bit are tautomers. (lookchem.com)
Imidazole derivatives are widely found in nature, such as histamine, histidine and benzimidazole, etc. (lookchem.com)
The chemistry of imidazole and its synthetic derivatives is reviewed in this article. (tsijournals.com)
As a result, the goal of this article is to examine published research on the introduction, chemistry, synthesis, properties, industrial, biological and medicinal applications with efficacy of imidazole derivatives in order to better understand and explore their various properties and pharmacological potentials. (tsijournals.com)
A set of promising moieties (piperidineethanol, quinuclidine, TMEDA, and methyl derivatives of diethanolamine, imidazole, morpholine and piperazine) had similar [Au]R/Cm values to the commercial IEX resins Dowex-1, IRA-410 and Amberlite A26 (-10 mmol/mol). (edu.au)

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In the present work we reported the synthesis, characterization, and biological activity results of a copper mixed complex (see Figure 1 ), with hsm and nalidixic acid. (hindawi.com)
A new strategy for the enantioselective synthesis of tetrahydrofuran imidazole based human histamine H3 and H4 receptor potential agonists was designed based on the lead structures imifuramine and OUP-16. (uni-regensburg.de)
Copper enzymes are important in the Significance biosynthesis of natural products, hormones and neurotrans- mitters, proton pumping for adenosine triphosphate synthesis, The bioinorganic chemistry of copper is currently confined to a and the metabolism of iron and copper (1, 2). (docslib.org)
Synthesis, Spectroscopic and Electrochemical Studies of Isomeric Dichloro-bis-[N (1)-Alkyl-2-(Arylazo) Imidazole]-Osmium (II). (google.lt)
Synthesis, spectral characterisation, redox studies of isomeric dichloro-bis-[1-alkyl-2-(naphthyl-(α/β)-azo) imidazole] ruthenium (II). (google.lt)
For the second part of the study, a simple strategy based on the in-situ synthesis of the glutathione stabilized silver/copper alloy nanoparticles (Ag/Cu alloy NPs) in nylon 6 provided a fast procedure for fabricating a colorimetric probe for the detection of Ni²⁺ in water samples. (ru.ac.za)

Imidazole is between the two nitrogen atoms of five membered heterocyclic compounds containing. (lookchem.com)
In the arena of five membered heterocyclic structures, the imidazole nucleus exhibits a range of properties. (tsijournals.com)

The imidazole side chain of histidine residues in proteins are common binding sites for metal ions. (wikipedia.org)
Copper in biological systems is usually found surrounded by imidazole moieties from histidine residues [ 13 , 14 ]. (hindawi.com)

The imidazole ring is a five-membered ring structure with 3C and 2N atoms, with N present in the first and third positions and containing a hydrogen attachment sphere and an electron contributor nitrogen system [ 1 ]. (tsijournals.com)
All the copper atoms occupy similar coordination sites formed by imidazole, peptidic nitrogen atoms and carbonyl oxygen atoms in a square base pyramidal geometry. (cnr.it)

There are some interesting reagents in acyl imidazole compounds. (lookchem.com)
The relationship between imidazole and natural compounds is very close. (lookchem.com)
therefore under the stress caused by the disease, copper may be available for coordination with some endogenic or exogenic compounds like peptides and drugs, respectively. (hindawi.com)
Imidazole is observed in a variety of key genetic compounds. (tsijournals.com)
These compounds are absorbed into the copper surface, creating a film. (fs-pcba.com)

A mixed copper complex with deprotonated nalidixic acid (nal) and histamine (hsm) was synthesized and characterized by FTIR, UV-Vis, elemental analysis, and conductivity. (hindawi.com)

Unlike the free amino acid, the histidine residue (i.e., as a component of a peptide or protein), coordinates solely via the imidazole substituent. (wikipedia.org)

Copper ions bind to biomolecules (e.g., peptides and proteins) playing an essential role in many biological and physiological pathways in the human body. (mdpi.com)
Like water and the amide bond in peptides, the imidazole ring can act as both a hydrogen bond acceptor and donor. (yourdictionary.com)

The pKa of protonated imidazolium cation is about 6.95, which indicates that the basicity of imidazole is intermediate between pyridine (pKa of pyridinium = 5.23) and ammonia (pKa = 9,24 of ammonium). (wikipedia.org)
To create imidazole, he employed glyoxal and formaldehyde in ammonia. (tsijournals.com)
The copper cluster is formed by of carbonyl sulfide and ammonia (18-20). (docslib.org)
The performance of the resins was compared in B/R tests using an artificial leach liquor (pH ‚ÄövÑvÆ10.2) containing gold (20 ppm), copper (200 ppm), ammonia (1.3 M) and thiosulfate (0.1 M). Gold sorption by the resin was followed by periodic sampling of the liquor and AAS analysis, over a 24 hour period. (edu.au)

In common with other 3-substituted imidazoles, histidine can coordinate to metals via either of two nonequivalent tautomers. (wikipedia.org)

Only the imine nitrogen (HC=N-CH) of imidazole is basic, and it is this nitrogen that binds to metal ions. (wikipedia.org)
With this in mind, the interactions of different quinolones with copper and other metal ions have been investigated for years [ 15 ]. (hindawi.com)
ZIOS naturally and specifically draws out copper ions using the crystal frameworks of its hydrogen bonds. (inverse.com)
However, some pre- three copper ions located at the corners of a near-isosceles tri- vious microbiological evidence showed that thiocyanate may be angle and facilitates a direct thiocyanate conversion into cya- degraded by cell-free extracts of haloalkaliphilic thiocyanate- nate, elemental sulfur, and two reducing equivalents without utilizing SOB in the presence of an electron acceptor via a involvement of molecular oxygen . (docslib.org)
TcDH contains a unique metal site comprising Crated into proteins for the purposes of copper trafficking three copper ions in a configuration that enables two-electron and storage (3, 4) and electron transport and catalysis (5-7). (docslib.org)
Here we present an unpreviously reported type of a Copper enzymes comprise a rather diverse, but not numerous, polynuclear center consisting of three copper ions, which form group of biocatalysts. (docslib.org)

A transition metal imidazole complex is a coordination complex that has one or more imidazole ligands. (wikipedia.org)
Six imidazole ligands fit comfortably around octahedral metal centers, e.g. (wikipedia.org)
Imidazole ligands are isomers of N-heterocyclic carbenes. (wikipedia.org)

alkenyllithiums and aryllithiums to be prepared, and subsequent further trans-metalation at low temperatures provides the corresponding copper reagents [6]. (marysfamilymedicine.org)

The free amino acid can coordinate through the imidazole and either or both of the carboxylate and amine. (wikipedia.org)

They report that the His15 imidazole group of the lysozyme binds to the Cu(II) center of CuST in the equatorial position while the CuST unit is fixed axially by several weak coordination and hydrogen bonds. (tus.ac.jp)
A novel copper(II) metal-organic framework (MOF) has been synthesized by modifying the reaction conditions of a 1D coordination polymer. (tdl.org)

Biocatalytic copper centers are generally involved in the activation via initial formation of (NCS)2Cu, comprises multiple stages, and and reduction of dioxygen, with only few exceptions known. (docslib.org)

Alkaline of imidazole is slightly stronger than pyrazole and pyridine. (lookchem.com)

Given that millions of tons of copper are produced annually worldwide and it is ubiquitous across industries, maintaining low levels of copper contaminants in water streams is a present concern," write lead authors Ngoc T. Bui and Hyungmook Kang. (inverse.com)

The unshared electron pair of 1-bit nitrogen atom in imidazole ring participates in the cyclic conjugation, reduces the electron density of the nitrogen atom, and makes hydrogen of the nitrogen atom easily leave in the form of hydrogen. (lookchem.com)
The unshared electron pair of 3-bit nitrogen atom in imidazole ring doesn't participates in the cyclic conjugation, while it occupies the sp2 hybridized orbital, can accept protons, and form salt with strong acid. (lookchem.com)
Voltammetric measurements on these systems point out the cooperativity in the electron transfer processes among the copper (ii) sites during their reduction. (cnr.it)

Since metals like zinc, copper cobalt have a tendency to bind to non-specific sites, imidazole chelation may become useful. (yourdictionary.com)
This "sponge" material the scientists used is called ZIOS (zinc imidazole salicylaldoxime) and can even stand up to acidic copper mine runoff. (inverse.com)

Imidazole is used in the decontamination of His-tagged proteins using restrained Metal Attraction Chromatography (IMAC). (tsijournals.com)

Imidazole is stable to acid, and has antioxidant activity. (lookchem.com)
Further transformation of acid chloride to imidazole can be achieved vai bromomethyl ketone. (uni-regensburg.de)
Imidazole is amphiprotic, which means it may behave as an acid as well as a base. (tsijournals.com)
The most prevalent amino acid is 'histidine,' which has an imidazole on the side chain [ 3 ]. (tsijournals.com)
Sulfuric acid, copper salt, compd. (pharosproject.net)
These were the fluorescent pyridylazo-2-naphthol-poly(acrylic acid) nanofiber probe, the colorimetric probe based on glutathione-stabilized silver/copper alloy nanoparticles and the colorimetric probe based on 2-(2'-Pyridyl)-imidazole functionalized nanofibers. (ru.ac.za)

NO interaction with these polynuclear copper species is characterized by the reduction of the copper sites through the formation of two different intermediate complex species. (cnr.it)

One example of an imidazolate complex from biochemistry is found at the active site of copper-containing superoxide dismutase. (wikipedia.org)

Cu(OH) TMEDA] 2 Cl 2 catalyzes an intermolecular coupling of arylboronic acids with imidazoles in dichloromethane at room temperature to provide a variety of N -arylimidazoles in very good yields. (organic-chemistry.org)
2015. Imidazole catalyzes chlorination by unreactive primary chloramines. . (oregonstate.edu)

The electronic spectrum of the blue copper protein plastocyanin has been studied by ab initio multiconfigurational second-order perturbation theory (the CASPT2 method). (lu.se)

Imidazole is an extremely polar fragment with an estimated dipole of 3.61D that is entirely solvable in water [ 2 ]. (tsijournals.com)

The hsm-copper(II) system may be used to mimic the environment of this metal ion in some biological systems. (hindawi.com)

The first step is cleaning, which removes organic contaminants such as oil and oxidation films from the copper foil, the main component of the OSP. (fs-pcba.com)

N-methylimidazole is slightly more basic than imidazole but is otherwise similar, if more lipophilic. (wikipedia.org)
Canesten is best avoided in future and it is possible that other imidazole antifungal agents such as Miconazole might produce similar symptoms as well. (yourdictionary.com)
Find similar words to imidazole using the buttons below. (yourdictionary.com)
The way the sponge absorbs the copper is naturally fast, cost-effective because ZIOS is cheap to make, and would only need to be maintained every few weeks - which is longer than other similar frameworks are able to be stable in water. (inverse.com)
All organometallics in which the metal M is less electronegativethan copper, and all organometallic species of similar electronegativity but withweaker carbon-metal bonds, are potential candidates for transmetalation reac-tions [3]. (marysfamilymedicine.org)

The crystal structure of the title compound comprises polymeric chains formed by two independent copper(II) polyhedra, [CuN 2 O 2 ] and [CuN 4 O 2 ], which are linked by sulfate anions and stabilized by extended hydrogen-bonding, C-H⋯π and π-π inter-actions. (iucr.org)
Scheme2.2), and subsequent treatment with the THF-soluble copper salt CuCN 2LiCl [7]then aﬀords the functionalized arylcopper compound 5. (marysfamilymedicine.org)
The compound used in OSP surface treatment is a water-based compound that is part of azole groups, such as benzimidazoles, imidazoles, and benzotriazoles. (fs-pcba.com)

Structure of imidazole. (tsijournals.com)
This copper is collected in the reusable ZIOS structure and can be extracted and used in new manufacturing processes. (inverse.com)

Heinrich Debus synthesised imidazole for the first time in 1858, but several imidazole products had been found as young as the 1840's. (tsijournals.com)

Thus, treatment of the iodoalkenyl azide 10 with nBuLi at 100 C (Scheme 2.3),followed by transmetalation with ZnI2 in THF and then by a second transmeta-lation with CuCN 2LiCl, produces the copper species 11. (marysfamilymedicine.org)

The concept relies on the affinity of the imidazole side chain for metal cations. (wikipedia.org)

Thiourea protects against copper-induced oxidative damage by formation of a redox-inactive thiourea-copper complex. (oregonstate.edu)
It forms an organic coating that protects the copper and provides a favorable surface for soldering, making it an attractive option for many applications. (fs-pcba.com)

Imidazole is a component of theophylline, which is present in tea leaves and coffee beans and activates the central nervous system. (tsijournals.com)
For more information on SMILES, see https://en.wikipedia.org/wiki/Simplified_molecular-input_line-entry_system . (pharosproject.net)
Cu(imidazole) 2 (SCH 3 )(S(CH 3 ) 2 ) + as a model of CuHis 2 CysMet is the smallest system that gives converged results. (lu.se)

Results from circular dichroism and denaturation of calf thymus DNA (CT-DNA) suggested that increased amounts of copper complex were able to stabilize the double helix of DNA in vitro mainly by formation of hydrogen bonds between chn and the sugars of DNA minor groove. (hindawi.com)
A new complex of copper (II) was synthesized through the reaction of a Schiff-base, 4-(((2-hydroxyethyl)imino)methyl)phenol, with CuCl2·2H2O and, then, immobilization on SBA-15 support. (sharif.edu)

this metal ion could be copper(II) [ 12 ]. (hindawi.com)
The histidine imidazole nitrogen is the anchoring site for the metal ion binding. (cnr.it)

The M-N(imidazole) bond is freely rotating. (wikipedia.org)

However, copper is a chemically active material that can oxidize due to atmospheric moisture, causing problems during high-temperature soldering and reducing board reliability. (fs-pcba.com)
The organic finish helps to protect the copper from oxidation and the effects of moisture and environmental pressure. (fs-pcba.com)

For example, 1-acetyl imidazole is a stable acylating agent, after reaction with pyrrole, it becomes 1-acetyl pyrrole. (lookchem.com)
Reaction of N, N-carbonyldimidazole and carboxyl will get useful reagent acyl imidazole. (lookchem.com)

It is incorpo- copper sites. (docslib.org)

Copper can be good for you in small amounts, but the U.S., Canada, and European countries have also reported unsafe levels of copper in drinking water from time to time. (inverse.com)

Some sulfur- Here we report the discovery and characterization of a pre- oxidizing bacteria (SOB) known to play an important role in viously undescribed copper center that forms the active site of global geochemical cycles can utilize thiocyanate as the sole a copper-containing enzyme thiocyanate dehydrogenase (sug- source of energy and nitrogen . (docslib.org)

Groundwater in 'developing' countries can also contain high copper levels, but pollution is generally at the core of its presence in drinking water throughout the world. (inverse.com)
Surface finishing serves two purposes: protecting the copper from oxidation and providing a surface that is favorable for high solderability during component connection. (fs-pcba.com)
44) Lai N.C., Cong G., Lu Y.C.* 'A high-energy potassium-sulfur battery enabled by facile and effective imidazole-solvated copper catalysts' J. Mater. (yclueeil.com)

Imidazole-containing medicines have a greater reach in clinical medicine for treating a variety of conditions. (tsijournals.com)
Apart from its usage in pharmaceuticals, imidazole has a variety of industrial uses [ 4 ]. (tsijournals.com)

Over 20 copper-containing enzymes that the active site of a not previously described enzyme, thiocya- catalyze a wide-ranging group of chemical reactions have been nate dehydrogenase. (docslib.org)
2-(2′-Pyridyl)-imidazole (PIMH) to Poly(vinylbenzyl chloride) (PVBC) and nylon 6 nanofibers by post-electrospinning treatments using a wet chemical method and graft copolymerization technique, respectively. (ru.ac.za)

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