OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
MiconazoleAntifungal AgentsImidazolesCandidaCandida albicansFungiClotrimazoleAmphotericin BFluconazoleMicrobial Sensitivity TestsMycosesTriazolesDrug Resistance, FungalCandidiasisKetoconazoleItraconazoleEconazoleEchinocandinsAzolesHistidine
MiconazoleDerivativeDerivativesClasses of antifungal drugsTopicalBroad-spectrum antifungalFluconazoleSynthesisAzole antifungalsSyntheticDrugsAntioxidantFive membered heterocyclicPolyeneSystemicCompoundsAgentsFungiAnti-inflammatoryFormulationsTreatmentsNitrogen atomsInhibitionMedicationDermatophytosisMedicationsBenzimidazoleClinicalOralActivityCreamClassHydrogenTreatmentInfectionPyrroleElectronCommonlyBind
Miconazole3
  • A doctor will treat a penile yeast infection with a topical antifungal, such as miconazole, imidazole, and clotrimazole. (medicalnewstoday.com)
  • Canesten is best avoided in future and it is possible that other imidazole antifungal agents such as Miconazole might produce similar symptoms as well. (yourdictionary.com)
  • Miconazole is an imidazole antifungal compound that inhibits ergosterol synthesis and fungal cell wall formation. (lktlabs.com)
Derivative4
  • Ibrexafungerp Acrisorcin Amorolfine - a morpholine derivative used topically in dermatophytosis Aurones - possess antifungal properties Benzoic acid - has antifungal properties, such as in Whitfield's ointment, Friar's Balsam, and Balsam of Peru Carbol fuchsin (Castellani's paint) Ciclopirox (ciclopirox olamine) - a hydroxypyridone antifungal that interferes with active membrane transport, cell membrane integrity, and fungal respiratory processes. (wikipedia.org)
  • An imidazole derivative that is commonly used as a topical antifungal agent. (curehunter.com)
  • Oxiconazole belongs to a group of drugs called imidazole derivative antifungals. (rxwiki.com)
  • An imidazole derivative, Broad spectrum Antifungal. (medicineindia.org)
Derivatives6
  • The hydrogen on the 1-bit nitrogen atom can be transferred to the 3-atom, therefore, imidazole derivatives with same substituent respectively on 4-bit and 5-bit are tautomers. (lookchem.com)
  • Imidazole derivatives are widely found in nature, such as histamine, histidine and benzimidazole, etc. (lookchem.com)
  • Any of various derivatives of this compound, which often have antifungal, anthelmintic, or antibiotic properties. (yourdictionary.com)
  • Combinations of imidazole and triazole derivatives, gentamicin and corticosteroids are classified in D07C - Corticosteroids, combinations with antibiotics. (whocc.no)
  • The chemistry of imidazole and its synthetic derivatives is reviewed in this article. (tsijournals.com)
  • As a result, the goal of this article is to examine published research on the introduction, chemistry, synthesis, properties, industrial, biological and medicinal applications with efficacy of imidazole derivatives in order to better understand and explore their various properties and pharmacological potentials. (tsijournals.com)
Classes of antifungal drugs1
  • The available classes of antifungal drugs are still limited but as of 2021 novel classes of antifungals are being developed and are undergoing various stages of clinical trials to assess performance. (wikipedia.org)
Topical5
  • Topical antifungal agents are effective for treating most cases of tinea corporis. (medscape.com)
  • For severe infections, systemic therapy can be combined with topical antifungal treatments. (medscape.com)
  • Tinea corporis, tinea pedis, and tinea cruris are typically treated with topical antifungals such as ketoconazole cream, with good response. (medscape.com)
  • The two active ingredients consist of betamethasone (a strong topical corticosteroid) and betamethasone (an antifungal medicine). (ruclear.co.uk)
  • Local tinea infections usually respond to topical antifungal agents, such as imidazole cream or oral griseofulvin for infections of the skin and hair. (doctor-clinic.org)
Broad-spectrum antifungal1
  • Naftifine is a broad-spectrum antifungal agent that appears to interfere with sterol biosynthesis by inhibiting the enzyme squalene 2,3-epoxidase. (medscape.com)
Fluconazole3
  • Fluconazole is a synthetic oral antifungal (broad-spectrum bistriazole) that selectively inhibits fungal cytochrome P-450 and sterol C-14 alpha-demethylation, which prevents the conversion of lanosterol to ergosterol, thereby disrupting cellular membranes. (medscape.com)
  • They may prescribe an oral antifungal, called fluconazole, if there are severe yeast infections throughout the body. (medicalnewstoday.com)
  • If you have any allergic to ketoconazole, other antifungal medications such as including fluconazole, itraconazole, or voriconazole, tell your doctor and pharmacist. (family-health-information.com)
Synthesis2
  • it is a synthetic triazole antifungal agent that inhibits fungal cell growth by inhibiting the cytochrome P-450-dependent synthesis of ergosterol, a vital component of fungal cell membranes. (medscape.com)
  • Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Biochemistry;Reagents for Oligosaccharide Synthesis;Highly Purified Reagents;Other Categories;Zone Refined Products;Buffer;ACS Grade Buffers;ACS Grade;Biological Buffers;Buffers A to Z;Building Blocks;C3 to C8;Chemical Synthesis;Essential Chemicals;Heterocyclic Building Blocks;Imidazoles;Inorganic Salts;Research Essentials;Solutions and Reagents;Intermediate for Propafenone hydrochloride. (lookchem.com)
Azole antifungals1
  • citation needed] Amphotericin B Candicidin Filipin - 35 carbons, binds to cholesterol (toxic) Hamycin Natamycin - 33 carbons, binds well to ergosterol Nystatin Rimocidin Azole antifungals inhibit conversion of lanosterol to ergosterol by inhibition of lanosterol 14α-demethylase. (wikipedia.org)
Synthetic2
  • It is a broad-spectrum synthetic antifungal agent that inhibits growth of fungus by altering cell membrane permeability, which causes fungal cell death. (medscape.com)
  • Ketoconazole is a synthetic imidazole antifungal that also exhibits anti-androgen, anti-inflammatory, neuromodulatory, and anticancer chemotherapeutic activities. (lktlabs.com)
Drugs1
  • Quantitative evaluation of cryptococcal pathogenesis and antifungal drugs using a silkworm infection model with Cryptococcus neoformans. (lktlabs.com)
Antioxidant1
  • Imidazole is stable to acid, and has antioxidant activity. (lookchem.com)
Five membered heterocyclic2
  • Imidazole is between the two nitrogen atoms of five membered heterocyclic compounds containing. (lookchem.com)
  • In the arena of five membered heterocyclic structures, the imidazole nucleus exhibits a range of properties. (tsijournals.com)
Polyene2
  • A polyene antifungal is a macrocyclic polyene with a heavily hydroxylated region on the ring opposite the conjugated system. (wikipedia.org)
  • This makes polyene antifungals amphiphilic. (wikipedia.org)
Systemic2
  • An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others. (wikipedia.org)
  • It has fewer adverse effects and better tissue distribution than older systemic imidazoles. (medscape.com)
Compounds3
  • There are some interesting reagents in acyl imidazole compounds. (lookchem.com)
  • The relationship between imidazole and natural compounds is very close. (lookchem.com)
  • Imidazole is observed in a variety of key genetic compounds. (tsijournals.com)
Agents4
Fungi2
Anti-inflammatory1
  • A cream with anti-inflammatory and antifungal properties. (ruclear.co.uk)
Formulations1
  • List the formulations available for each antifungal agent. (ashp.org)
Treatments2
  • It is available only by prescription, and is recommended only when other antifungal treatments are not effective. (familywize.org)
  • Further, the extract was tested for its in vivo (preventive- and curative treatments) antifungal activity on lemons wound-inoculated with P. digitatum . (ac.be)
Nitrogen atoms1
  • The imidazole antifungals contain a 1,3-diazole (imidazole) ring (two nitrogen atoms), whereas the triazole antifungals have a ring with three nitrogen atoms. (wikipedia.org)
Inhibition2
  • An important preventive antifungal effect was observed after 7 days of storage (100% of inhibition), although this activity decreased after 14 and 21 days (85.71 and 57.14% of inhibition, respectively). (ac.be)
  • A slight curative antifungal activity was observed only after 7 days of storage (14.29% of inhibition). (ac.be)
Medication2
  • Lotriderm Cream is an antifungal medication. (ruclear.co.uk)
  • Ketoconazole is an azole antifungal medication of the class imidazole that is used to treat certain types of yeast or fungal infections such as chromomycosis, thrush (candidiasis), blastomycosis, histoplasmosis, ringworm, athlete's foot, and others. (familywize.org)
Dermatophytosis1
  • It is important to remember that dermatophytosis of the scalp, nails, and hair follicles (Majocchi granuloma) requires treatment with oral antifungals to eradicate fungal infection. (medscape.com)
Medications1
Benzimidazole1
  • Another nitrogen containing heterocycle is benzimidazole, which has an imidazole ring fused to benzene. (ijpsonline.com)
Clinical1
  • Imidazole-containing medicines have a greater reach in clinical medicine for treating a variety of conditions. (tsijournals.com)
Oral2
  • If you suffer from any of the conditions below or use any of the medicines listed then please speak to your GP about a suitable oral antifungal treatment. (travelpharm.com)
  • This treatment works best when combined with either an oral or intravaginal antifungal as well. (drfelix.co.uk)
Activity4
  • Clotrimazole is an orally applicable antifungal substance with broad-spectrum activity. (axonmedchem.com)
  • An aqueous crude extract from Solanum nigrum lyophilized leaves was evaluated for its phytochemical composition and antifungal activity against Penicillium digitatum , the causative agent of green mold of citrus fruit. (ac.be)
  • Storage of the extract at 4 °C for 60 days had no effect on its in vitro antifungal activity. (ac.be)
  • continued antifungal activity seen even after the antifungal agent has been removed. (ashp.org)
Cream2
Class2
Hydrogen3
  • The unshared electron pair of 1-bit nitrogen atom in imidazole ring participates in the cyclic conjugation, reduces the electron density of the nitrogen atom, and makes hydrogen of the nitrogen atom easily leave in the form of hydrogen. (lookchem.com)
  • Like water and the amide bond in peptides, the imidazole ring can act as both a hydrogen bond acceptor and donor. (yourdictionary.com)
  • The imidazole ring is a five-membered ring structure with 3C and 2N atoms, with N present in the first and third positions and containing a hydrogen attachment sphere and an electron contributor nitrogen system [ 1 ]. (tsijournals.com)
Treatment1
  • What number carbon does Imidazole, an anti-fungal treatment, stop being demethylated? (topgradeapp.com)
Infection1
  • if the antifungal has good bioavailability, this is a common route to handle a fungal infection. (wikipedia.org)
Pyrrole1
  • For example, 1-acetyl imidazole is a stable acylating agent, after reaction with pyrrole, it becomes 1-acetyl pyrrole. (lookchem.com)
Electron1
  • The unshared electron pair of 3-bit nitrogen atom in imidazole ring doesn't participates in the cyclic conjugation, while it occupies the sp2 hybridized orbital, can accept protons, and form salt with strong acid. (lookchem.com)
Commonly1
  • Describe side effects commonly associated with each of the antifungal classes. (ashp.org)
Bind1
  • Since metals like zinc, copper cobalt have a tendency to bind to non-specific sites, imidazole chelation may become useful. (yourdictionary.com)