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  • inhibition
  • 13 ) showed that KIT activation depends on protein stabilization by heat shock protein 90 (HSP90), with HSP90 inhibition causing degradation of wild-type KIT and an imatinib-resistant KIT D816V mutant. (aacrjournals.org)
  • IRIS, an international study that compared interferon/cytarabine combination and the first of these new drugs imatinib, with long-term follow up, demonstrated the clear superiority of tyrosine-kinase-targeted inhibition over existing treatments. (wikipedia.org)
  • 2001
  • Since its approval in 2001 for frontline CML management, imatinib has proven to be effective in achieving high remission rates and improving prognosis. (biomedcentral.com)
  • Imatinib was approved for medical use in the United States in 2001. (wikipedia.org)
  • Apoptosis
  • In conclusion, the suppression of PPP2R5C by RNA interference could inhibit proliferation and effectively induce apoptosis in CML cells that were either imatinib sensitive or resistant. (biomedcentral.com)
  • One of these drugs is Imatinib, which inhibits BCR/ABL causing growth to cease and apoptosis to begin. (wikipedia.org)
  • doses
  • Severe congestive cardiac failure is an uncommon but recognized side effect of imatinib and mice treated with large doses of imatinib show toxic damage to their myocardium. (wikipedia.org)
  • Complex
  • Closer examination of the crystal structure of imatinib-kinase complex revealed Tyr-236 was in close proximity to the pyridine ring of imatinib, suggesting there was little or no room for a larger group there. (wikipedia.org)
  • This stabilizes the imatinib Bcr-Abl complex and prevents ATP from reaching its binding site. (wikipedia.org)