• Interleukin-2 receptor alpha chain (also called TAC antigen, P55 and mainly CD25) is a protein involved in assembly of high-affinity Interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). (wikipedia.org)
  • Finally, some are engineering chimeric antigen receptor (CAR) T-cell systems that attack solid tumors and overcome the harsh barriers of the tumor microenvironment (TME). (genengnews.com)
  • Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
  • Owing to the expression of GPC3 in LUSC tissues, it has been tested as an immunotherapeutic (including chimeric antigen receptor (CAR)- GPC3 T cells), and clinical trials targeting GPC3 are ongoing. (biolifesas.org)
  • The human protein Interleukin-2 receptor subunit alpha is encoded by a gene called IL2RA with a length around 51,6 kb. (wikipedia.org)
  • IL2RA gene orthologues with identical protein functionality are relatively abundant and constant among animal species, especially in mammals subgroups. (wikipedia.org)
  • IL2RA protein can be expressed in many types of neoplastic cells, such as in most B-cell neoplasms, T-cell lymphomas, some acute nonlymphocytic leukemias, neuroblastomas, mastocytosis, Waldenstrom macroglobuliaemia and tumor infiltrating lymphocytes. (wikipedia.org)
  • Interleukin-2 receptor alpha chain is an integral-membrane protein, more precisely Type I transmembrane protein. (wikipedia.org)
  • adhesion G protein-coupled receptor G1. (gsea-msigdb.org)
  • growth factor receptor bound protein 1. (gsea-msigdb.org)
  • The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). (thermofisher.com)
  • Description: Recombinant Human Interleukin-15 Receptor Alpha & Interleukin-15 Fusion Protein is produced by our Mammalian expression system and the target gene encoding Ile31-Asp96&Asn49-Ser162(Asn120Asp) is expressed with a Fc tag at the C-terminus. (influenza-x.org)
  • However, the complement C5a receptor 2 may act as a decoy receptor for C5a, as it has no reported G protein signalling capacity. (guidetomalariapharmacology.org)
  • Another company reported that it is testing a chimeric PD-1 antibody/IL-2 fusion protein that recruits killer immune cells. (genengnews.com)
  • These studies demonstrate that a Cys430-Phe mutation does not prevent the de novo synthesis of the b subunit, but alters the conformation of the mutant protein sufficiently to impair its intracellular transport, resulting in its deficiency in this patient. (embl.de)
  • The protein encoded by this gene is a subunit of the receptor for IL-23 . (wikidoc.org)
  • This protein pairs with the receptor molecule IL-12Rβ1 ( IL12RB1 ), together forming the IL-23 receptor complex, and both are required for IL-23 signaling. (wikidoc.org)
  • This protein associates constitutively with Janus kinase 2 ( JAK2 ), and also binds to transcription activator STAT3 in a ligand-dependent manner. (wikidoc.org)
  • We performed multi-omics approaches in animal and patient studies to demonstrate the clinical feasibility of FLT3 as a viable target of BP-CML by establishing the (1) molecular mechanisms of FLT3-driven drug resistance, (2) diagnostic methods of FLT3 protein expression and localization, (3) association between FLT3 signaling and CML prognosis, and (4) therapeutic strategies to tackle FLT3+ CML patients. (bvsalud.org)
  • This manuscript discusses some important biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule 1 (KIM-1), liver-type FABP (L-FABP), proenkephalin (Penkid), metalloproteinase 2 (TIMP-2), insulin-like growth factor binding protein 7 (IGFBP7) and Dickkopf-3 (DDK3). (biolifesas.org)
  • Description: IL-15RA Antibody: Interleukin 15 (IL-15RA) is a cytokine receptor that specifically binds IL-15 with high affinity. (influenza-x.org)
  • Interleukin-23 receptor is a type I cytokine receptor . (wikidoc.org)
  • CD25 consists of three domains: extracellular (N-terminus), transmembrane (alpha-helix) and cytoplasmic (C-terminus). (wikipedia.org)
  • Moreover, CD25 is an exclusive subunit that entirely binds IL-2, while CD132 binds the shared γc family cytokines (IL-4, IL-7, IL-9, IL-15 and IL-21), and the CD122 subunit binds also IL-15. (wikipedia.org)
  • Interleukin-2 can interact with intermediate-affinity dimeric IL-2 receptor, which consists of beta (CD122) and gamma (CD132) chains or with high-affinity trimeric complex, where also alpha subunit (CD25) constructs the IL-2 receptor and provides enhanced specific binding force. (wikipedia.org)
  • Description: The BC96 monoclonal antibody reacts with human CD25, the 55 kDa interleukin-2 receptor alpha chain (IL-2Ralpha). (thermofisher.com)
  • By itself, CD25 binds IL-2 only with low affinity. (thermofisher.com)
  • However, CD25 associates with CD122 (IL-2 receptor beta chain) and CD132 (common gamma chain) to form the high affinity IL-2 receptor. (thermofisher.com)
  • CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. (thermofisher.com)
  • B) Mean counts per minute (CPM) (+SEM) uptake of tritiated thymidine in CD25− effector T cells from healthy controls (N = 27) stimulated with mitogenic CD3/28 beads at 2:1 and 0.2:1 bead: cell ratios. (bio-rad-antibodies.com)
  • C) Mean CPM (+SEM) in CD25− effectors v CD25+ Treg cells stimulated with mitogenic CD3/28 beads at 2:1 bead: cell ratio. (bio-rad-antibodies.com)
  • Description: A competitive ELISA for quantitative measurement of Rabbit Soluble IL 1 Receptor 4/ST2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (influenza-x.org)
  • Description: A sandwich ELISA kit for detection of Serine Palmitoyltransferase, Long Chain Base Subunit 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (1elisakits.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) in samples from tissue homogenates, cell lysates or other biological fluids. (1elisakits.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 10 Receptor Alpha (IL10Ra) in samples from tissue homogenates, cell lysates or other biological fluids. (tuberculosisdrugresearch.org)
  • Description: A sandwich ELISA for quantitative measurement of Rat Calpain small subunit 1(CAPNS1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (resourcerecovery.be)
  • Description: A sandwich ELISA kit for detection of Interleukin 18 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (agctsequencing.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Excitatory Amino Acid Transporter 2 (EAAT2) in samples from tissue homogenates, cell lysates or other biological fluids. (lotuskringpoeldijk.nl)
  • Description: A competitive ELISA for quantitative measurement of Porcine Glutamate Receptor, Ionotropic, N Methyl D Aspartate 2C in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (1elisakits.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Collagen Type I Alpha 2 (COL1a2) in samples from serum, plasma, tissue homogenates or other biological fluids. (2sars.com)
  • The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. (wikidoc.org)
  • In several examples, the α4 integrin antagonist is a monoclonal antibody that specifically binds to a α4, β1 or β7 integrin subunit or a cyclic hexapeptide with the amino acid sequence of CWLDVC. (justia.com)
  • Homodimeric alpha chains (IL2RA) result in low-affinity receptor (Kd ~10−8M) with no signalling ability, while dimeric beta (IL2RB) and gamma chains (IL2RG) produce a medium-affinity receptor (Kd ~10−9M). (wikipedia.org)
  • Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. (thermofisher.com)
  • IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. (thermofisher.com)
  • Soluble IL2RA has been isolated and determined to result from extracellular proteolysis during activation of T lymphocytes. (wikipedia.org)
  • Increased serum level of soluble interleukin-2 receptor is associated with a worse response of metastatic clear cell renal cell carcinoma to interferon alpha and sequential VEGF-targeting therapy. (cusabio.com)
  • Data show that interleukin-2 receptor alpha, tumor necrosis factor receptor 1, serum STimulation-2 (IL1RL1 gene product), and regenerating islet-derived 3-alpha were significantly associated with non-relapse mortality. (cusabio.com)
  • It exhibits potent antitumor activity by activating tumor-infiltrating CD8 + and CD4 + T cells and has a better therapeutic window relative to recombinant human IL-2. (genengnews.com)
  • This coupling of subunits brings together Janus kinases JAK1 and JAK3, considering their association with respective cytoplasmic parts of beta and gamma subunits. (wikipedia.org)
  • Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. (thermofisher.com)
  • A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. (embl.de)
  • Molecular and cellular basis of deficiency of the b subunit for factor XIII secondary to a Cys430-Phe mutation in the seventh Sushi domain. (embl.de)
  • We studied the defect responsible for deficiency of the b subunit for factor XIII in the first known case of this condition. (embl.de)
  • Several frequent point mutations, single nucleotide polymorphism (SNP), have been identified in or in close proximity to IL2RA gene in the population. (wikipedia.org)
  • The gene polymorphisms at the loci of IL2RA rs2104286 and rs12722489 are closely associated with susceptibility to MS in the Chinese. (cusabio.com)
  • Weight discount plan Modifies Pioglitazone's Have an impact on on Hepatic PPAR γ-Regulated Mitochondrial Gene Expression Pioglitazone (Pio) is a thiazolidinedione (TZD) insulin-sensitizing drug whose outcomes end end result predominantly from its modulation of the transcriptional practice of peroxisome proliferator-activated-receptor-gamma (PPARγ). (scalegen.com)
  • However, while extracellular part is able to function as a binding site for Interleukin-2, short cytoplasmic domain lacks an ability to induce intracellular signalling and therefore needs to oligomerise with other IL-2 receptor subunits. (wikipedia.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) in tissue homogenates, cell lysates and other biological fluids. (1elisakits.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Simian Interleukin 2 (IL2) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (gkts.net)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 18 (IL18) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (agctsequencing.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Interleukin 18 (IL18) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (agctsequencing.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mini Samples Mouse Interleukin 18 (IL18). (agctsequencing.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Collagen Type I Alpha 2 (COL1a2) in serum, plasma, tissue homogenates and other biological fluids. (2sars.com)
  • NMR structure of the interferon-binding ectodomain of the human interferon receptor. (wikidoc.org)
  • The interleukin-2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL-2 receptor complex (Kd ~10−11M). (wikipedia.org)
  • After activation of the receptor by its ligand, heterodimerisation of beta and gamma intracellular domains takes place. (wikipedia.org)
  • The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is structurally related to IL-2RA, an additional IL-2-specific alpha subunit necessary for high affinity IL-2 binding. (influenza-x.org)
  • [2] [11] Efforts to engineer a more potent IFNα2 elicited a cellular response similar to IFNβ, suggesting that the affinity of type I IFNs for IFNAR has an important role in regulating the downstream response. (wikidoc.org)
  • Type I IFN receptor forms a ternary complex, composed of its two subunits IFNAR1 and IFNAR2, and a type I IFN ligand. (wikidoc.org)
  • Ligand binding to either subunit is required for and precedes dimerization and activation of the receptor. (wikidoc.org)
  • Each subunit of IFNAR contains an N-terminal ligand binding domain (with two or four fibronectin type II-like subdomains, for IFNAR2 and IFNAR1, respectively), a transmembrane (TM) domain, and a cytoplasmic domain. (wikidoc.org)
  • [7] Each type I IFN ligand contains a "hotspot", or a sequence of conserved amino acids that are involved in binding to the receptor, specifically the high affinity receptor IFNAR2, which determines the affinity of each ligand for the receptor. (wikidoc.org)
  • Structural analysis of type I IFN receptor with different type I IFN ligand subtypes revealed a similar binding site for the different agonists. (wikidoc.org)
  • To determine how the latter mutation impaired b subunit synthesis, recombinant b subunit bearing the mutation was expressed in BHK cells. (embl.de)
  • Il-2R exist in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). (lu.se)
  • Location of IL2RA in human genome is on the short arm of 10th chromosome (10p15.1). (wikipedia.org)
  • 1:50 dilution will block 70-80% of CTLL proliferative response to 50 units of r.human IL-2 and will stain 70% of PHA-activated human T cells (by FACS) 10µl will stain 106 IL-2R positive cells for FACS analysis or sorting. (prottech.com.cn)
  • ACKR1 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. (guidetomalariapharmacology.org)
  • The solution structure of the 16th CCP module from human complement factor H has been determined by a combination of 2-dimensional nuclear magnetic resonance spectroscopy and restrained simulated annealing. (embl.de)
  • IL2RA has been used as a marker to identify CD4+FoxP3+ regulatory T cells in mice, and it has been found that a large proportion of resting memory T cells constitutively express IL2RA in humans. (wikipedia.org)
  • The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. (cusabio.com)
  • 2 Complex regulatory networks control MYC activity leading to up-regulation of its expression in response to mitogens or suppression upon growth inhibitory signals. (ashpublications.org)
  • Third, IL-2 therapies aiming at expanding immunosuppressive regulatory T cells in vivo . (frontiersin.org)
  • Furthermore, while differential effects manifest after several days of chronic stimulation, changes to receptor structure, orientation, or stoichiometry have not elucidated the cause for differential signaling via different type I IFN subtypes. (wikidoc.org)
  • Additionally, expression of the IL-2 receptor alpha subunit can be found in non-lymphoid tissues such as lungs (alveolar macrophages), liver (Kupffer cells) and skin (Langerhans cells). (wikipedia.org)
  • However, the apparent molecular weight of the mutant was slightly higher than those of the wild-type and plasma b subunits under nonreducing conditions, probably because of destruction of a disulfide bond. (embl.de)
  • One of the company's IL-2 Indukine molecules, the WTX-124 prodrug, has shown promise in preclinical studies. (genengnews.com)
  • histocom-patibility complex (MHC) molecules plus interleukin (IL)-7. (123dok.net)
  • We are focusing on pro-inflammatory cytokines, such as IL-2 and IL-12, which can stimulate potent antitumor immunity. (genengnews.com)
  • High IL2RA expression is associated with CRLF2-rearranged acute lymphoblastic leukemia. (cusabio.com)
  • Higher frequency of IL2RA SNP could not be detected among multiple sclerosis patients. (cusabio.com)
  • Non covalent dimer of an alpha and a beta chains. (lu.se)
  • hemoglobin subunit beta [Source:HGNC S. (gsea-msigdb.org)
  • IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. (thermofisher.com)
  • IL-15RA is thought to enhance cell proliferation and expression of apoptosis inhibitor Bcl-xL and Bcl-2. (influenza-x.org)
  • D) Mean (+SEM) percentage suppression of effector cell proliferation following activation with CD3/28 beads at 2:1 (closed boxes) and 0.2:1 (open boxes) bead: cell ratios. (bio-rad-antibodies.com)
  • IFNAR is a heteromeric cell surface receptor composed of two subunits, referred to as the low affinity subunit, IFNAR1 , and the high affinity subunit, IFNAR2 . (wikidoc.org)
  • The strategy underlying these CD4 based therapies, i.e. blocking the interaction between gp120 and the CD4 receptor, encompasses advantages distinct from current HAART regimens. (justia.com)
  • The loss of kidney function is the result of a sudden reduction in glomerular filtration rate (GFR), the process through which waste is extracted from the blood and is often reversible 2 . (randox.com)
  • This collection of conditions is associated with vasoconstrictor expression in renal afferent pathways 2 . (randox.com)
  • Several MYC-induced pathways, such as activation of the p53/ARF pathway, changes in expression, and activity of BCL2 proteins or alterations in death receptor signaling have been linked to apoptosis. (ashpublications.org)
  • All four adenosine receptors are expressed on the surface of mouse invariant NKT (iNKT) cells. (guidetomalariapharmacology.org)
  • The mutant as well as wild-type b subunit was synthesized by the cells. (embl.de)
  • The mutant b subunit was secreted from the cells much less effectively than the wild type and remained susceptible to endoglycosidase H, indicating that it was not transported from the endoplasmic reticulum to the Golgi apparatus where the processing of oligosaccharides occurs. (embl.de)
  • Loss of tissue is then repaired in a complex process that involves tissue-resident immune, stromal, and epithelial cells, as well as infiltrating immune cells [ 2 ]. (biomedcentral.com)
  • Posted on 2nd October 2023 at 2:43 pm. (randox.com)
  • [2] IFNAR agonism results in transcriptional changes, with the potential to increase or suppress the transcription of over 2000 different genes. (wikidoc.org)
  • Unlike IL-2RA, IL-15RA is capable of binding IL-15 with high affinity independent of the other subunits. (influenza-x.org)