• It probably will be similar to Stelara, since Stelara also binds IL23 (and IL12 in addition). (crohnsforum.com)
  • IL23 is a heterodimeric cytokine composed of p19 and p40 subunits, the latter being shared with IL12. (cisbio.net)
  • Cisbio's Human IL23 assay is highly specific for IL23 and does not cross react with IL12. (cisbio.net)
  • IL23 is part of the response against infection as it upregulates the expression of MMP9 (matrix metalloprotease 9), increases angiogenesis, and reduces CD8 T cell infiltration into tumors. (cisbio.net)
  • The IL23/Th17 pathway as a therapeutic target in chronic inflammatory diseases. (nih.gov)
  • In oncology and immuno-oncology, IL23 has been studied for its effects on T cell infiltration and its promotion on TH17 cell development. (cisbio.com)
  • 24. TH17/IL23 cytokine gene polymorphisms in bullous pemphigoid. (nih.gov)
  • IL23 is a heterodimeric cytokine composed of p19 and p40 subunits, the latter being shared with IL12. (cisbio.com)
  • Signal transducer and activator of transcription 4 (STAT4) is believed to bind Interleukin-23 receptor (IL23R) in response to Interleukin-23 (IL23). (reactome.org)
  • 1999). This is a black box event because there is no direct evidence of STAT4 binding in response to IL23. (reactome.org)
  • IL23 is part of the response against infection as it upregulates the expression of MMP9 (matrix metalloprotease 9), increases angiogenesis, and reduces CD8 T cell infiltration into tumors. (cisbio.com)