BindsSTAT6AntagonistInterleukin 13Cytokine receptorsIL4RASubunitProteinAntagonistsGeneHigh affinityProstaglandinAntigenTherapeuticTyrosine kinaseStimulationCytokinesMacrophagesLigandCRTH2SignalingInhibitoryMediatesAlphaActivationSubstancesNuclearAsthmaticExpressionShown to bindComplexesAsthmaSignalsTypeTranscriptionCellsHumanRoleCellCloseAnti
Binds9
- Detailed kinetic analyses of the binding properties of the heteromeric complexes suggested a sequential mechanism for the binding of IL-13 to its signaling receptor, in which IL-13 first binds to IL-13R?1 and this then recruits IL-4? (soton.ac.uk)
- The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. (fishersci.com)
- Tralokinumab is an anti-IL-13 blocker, it blocks the cytokine -- this is in contrast to a drug that many of you know, dupilumab [Dupixent], which binds the IL-4 receptor alpha, and it blocks signaling of IL-4 and IL-13 -- so this is a selective IL-13 blocker drug. (medpagetoday.com)
- And then we also have benralizumab that binds to the IL-5 receptor, and IL-5 promotes eosinophil maturation development. (consultantlive.com)
- Then we have dupilumab, which binds to the IL-4 receptor alpha, and it inhibits IL-4 and IL-13 pathways in asthma. (consultantlive.com)
- Binds with low affinity to interleukin-13 (IL13). (cusabio.com)
- 2013). As JAK1 binds IL4RA in response to IL13 binding (Roy et al. (reactome.org)
- Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. (nih.gov)
- The constant region at the carboxyl-terminal end of the heavy chain, called the Fc region, binds to the Fc receptors of neutrophils, eosinophils, macrophages, dendritic cells, B cells, and the natural killer (NK) cells. (medscape.com)
STAT62
- previously designated IL-13 R alpha or NR4) with low affinity, then recruits the IL-4 R alpha chain to form a high affinity receptor, causing downstream STAT6 activation. (reliatech.de)
- This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. (thermofisher.com)
Antagonist1
- Ramatroban is an orally bioavailable, potent, dual antagonist of the thromboxane A 2 (TPr) and PGD 2 (DPr2) receptors. (researchsquare.com)
Interleukin 134
- The protein encoded by this gene is a subunit of the interleukin 13 receptor. (thermofisher.com)
- Andrews, Allison-Lynn , Holloway, John W. , Puddicombe, Sarah M. , Holgate, Stephen T. and Davies, Donna E. (2002) Kinetic analysis of the interleukin-13 receptor complex. (soton.ac.uk)
- The present study examined the ability of the tumor cell surface receptor, interleukin (IL)‑13 receptor α2 (IL13Rα2)‑ and epidermal growth factor receptor (EGFR)‑targeted pseudomonas exotoxin (PE) to sensitize TRAIL‑resistant GBM cells and assessed the dual effects of interleukin 13‑PE (IL13‑PE) or EGFR nanobody‑PE (ENb‑PE) and TRAIL for the treatment of a broad range of brain tumors with a distinct TRAIL therapeutic response. (spandidos-publications.com)
- in humans and mice indicate, for the first time, a role of interleukin-13 receptor alpha1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease. (cusabio.com)
Cytokine receptors2
- Two members of the type 5 subfamily of type I cytokine receptors can serve as receptors for IL-13. (reliatech.de)
- Activation of multiple cytokine receptors is reported to play an important role in asthma via the Janus kinases (JAK) pathway. (ersjournals.com)
IL4RA1
- Together with IL4RA can form a functional receptor for IL13. (cusabio.com)
Subunit2
- This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. (thermofisher.com)
- This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. (thermofisher.com)
Protein5
- The PTGIR gene is located on human chromosome 19 at position q13.32 (i.e. 19q13.32), contains 6 exons, and codes for a G protein coupled receptor (GPCR) of the rhodopsin-like receptor family, Subfamily A14 (see rhodopsin-like receptors#Subfamily A14). (wikipedia.org)
- Adenosine can act at 4 different 7-transmembrane, G-protein-coupled receptors present on the surfaces of both infiltrating leukocytes and resident parenchymal cells. (jci.org)
- protein tyrosine phosphatase, non-receptor. (wikigenes.org)
- Receptor targeted toxins upregulated TRAIL death receptors (DR4 and DR5) and suppressed the expression of anti‑apoptotic FLICE‑inhibitory protein (FLIP) and X‑linked inhibitor of apoptosis protein (XIAP). (spandidos-publications.com)
- Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. (cusabio.com)
Antagonists2
- As growing lines of evidence have supported a proinflammatory role for adenosine in the asthmatic lung, interest in adenosine receptor antagonists has risen. (jci.org)
- 4 Additional maintenance asthma controller medications are allowed according to standard practice of care ie, leukotriene receptor antagonists (LTRAs), theophylline, long-acting muscarinic antagonists (LAMAs), and chromones. (who.int)
Gene4
- Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. (fishersci.com)
- This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. (antibodies-online.com)
- Absence of ILC2s leads to utero-placental abnormalities, including poor vascular remodelling, increased Il1b and decreased Il4, Il5 , and Il13 gene expression, and reduced alternative activation of dendritic cells (DCs) and macrophages. (elifesciences.org)
- The aim of the present study was to analyze gene variability in interleukin (IL)2, IL4 (and its receptor alpha, IL4R alpha), IL10, and IL13, which were selected based on literature review and/or their functional relevance, in Czech patients with RAS and in healthy controls. (muni.cz)
High affinity2
- ii) the number of IL-13Ralpha1+ bronchial submucosal mast cells in subjects with asthma and normal controls and (iii) the effect of IL-13 priming on HLMC expression of high-affinity IgE receptor (FcepsilonRI), stem cell factor receptor (CD117), histamine release, proliferation, and survival. (nih.gov)
- IL‑13 R alpha 1 has been shown to combine with the IL-4 R alpha to form a high-affinity receptor complex capable of transducing an IL-13-dependent proliferative signal. (rndsystems.com)
Prostaglandin2
- The Prostacyclin receptor, also termed the prostaglandin I2 receptor or just IP, is a receptor belonging to the prostaglandin (PG) group of receptors. (wikipedia.org)
- 8. Iwasaki M, Nagata K, Takano S, Takahashi K, Ishii N, Ikezawa Z. Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis. (southernbiotech.com)
Antigen1
- Innate lymphoid cells (ILCs) lack antigen receptors but are equipped with receptors for cytokines, hormones, and paracrine signals enabling them to sense their environment and respond quickly by producing factors that influence parenchymal cells and other resident immune cells. (elifesciences.org)
Therapeutic3
- It has been regarded as the most successful therapeutic target among the 9 prostanoid receptors. (wikipedia.org)
- Here we discuss the history of the study of adenosine receptor ligands for asthma and how enhanced understanding of adenosine receptor biology may aid in the rational exploitation of these receptors as therapeutic targets. (jci.org)
- Here, we review tumor-NK cell interactions, discuss the mechanisms by which NK cells generate an antitumor immune response, and discuss NK cell-based therapeutic strategies targeting activating, inhibitory, and co-stimulatory receptors. (frontiersin.org)
Tyrosine kinase1
- In human blood monocytes, where the type I interleukin-4 (IL4) receptor (IL4R1) is the predominant IL4 receptor type, IL4 leads to tyrosine phosphorylation of Janus kinase 1 (JAK1), rather than constitutively bound JAK2, JAK3 or Non-receptor associated tyrosine kinase 2 (TYK2). (reactome.org)
Stimulation3
- Stimulation of opioid mu receptors accentuates pruritus, while stimulation of kappa receptors and blockage of mu receptors suppress pruritus. (medscape.com)
- Method Cells isolated from asthma patients and healthy subjects were treated with PI3Kδ or JAK inhibitors, and/or dexamethasone, before T-cell receptor stimulation. (figshare.com)
- However, CD56 dim NK cells can produce cytokines, specifically IFN-γ, after cell triggering via NKp46 of NKp30 activating receptors or after stimulation with combinations of IL-2, IL-12, and IL-15 ( 7 ). (frontiersin.org)
Cytokines1
- Th1-type lymphocytes that secrete cytokines, such as interferon-gamma and soluble IL-2 receptor, are possible inducers of granuloma formation. (medscape.com)
Macrophages2
- report findings in adenosine deaminase-deficient mice that suggest the occurrence of anti-inflammatory actions of adenosine in the lung, mediated through A 1 adenosine receptors on macrophages. (jci.org)
- Consequently, glucocorticoids (GC) in macrophages are able not only to activate the GC receptor (GR) but also the MR, and the balance between both effects determines macrophage fate. (uni-goettingen.de)
Ligand3
- To determine the binding contributions of the individual components of the IL-13 receptor to IL-13, we have employed surface plasmon resonance and equilibrium binding assays to investigate the ligand binding characteristics of shIL-13R?1, shIL-13R?2, and IL-4R? (soton.ac.uk)
- Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. (fishersci.com)
- This cytokine is a ligand for interleukin 4 receptor. (antibodies-online.com)
CRTH21
Signaling2
- ATP, released by cells, is rapidly metabolized by extracellular nucleotidases to adenosine, a potent signaling molecule that can activate several cell surface receptors to produce myriad effects on both parenchymal and immune cells throughout the body (Figure 1 ). (jci.org)
- Results identified FAM120A in the IL13/IL13Ralpha2 signaling pathway as a key mediator of invasion and liver metastasis in colon cancer. (cusabio.com)
Inhibitory1
- NK cell activation and the triggering of effector functions is governed by a complex set of activating and inhibitory receptors. (frontiersin.org)
Mediates1
- In the mouse model that mimics atopic dermatitis in humans, the histamine (H4) receptor mediates both TH-2 inflammation and pruritus. (medscape.com)
Alpha4
- IL-13 R alpha 1 and IL-13 R alpha 2 each have three extracellular fibronectin type III domains, two cytokine receptor homology modules and a WSXWS motif typical of the class I cytokine receptor family, but IL-13 R alpha 2 has a much shorter cytoplasmic tail. (reliatech.de)
- The Company's lead product candidate, rademikibart (formerly known as CBP-201), is an antibody designed to target interleukin-4 receptor alpha (IL-4Rα) in development for the treatment of atopic dermatitis (AD) and asthma. (fox5sandiego.com)
- Bronchial submucosal mast cell IL-13 receptor alpha 1 expression is higher in asthmatics than normal controls. (cusabio.com)
- TORONTO and HOUSTON, March 30, 2023 (GLOBE NEWSWIRE) -- Medicenna Therapeutics Corp. ("Medicenna" or "the Company") (NASDAQ: MDNA TSX: MDNA), a clinical stage immunotherapy company, today announced updated data from its Phase 1/2 ABILITY study of MDNA11, a next-generation IL-2 with superior CD122 (IL-2 receptor beta) binding without CD25 (IL-2 receptor alpha) affinity thereby preferentially stimulating cancer killing effector T cells and NK cells. (tmcnet.com)
Activation4
- IP is classified as a relaxant type of prostenoid receptor based on its ability, upon activation, to relax certain pre-contracted smooth muscle preparations and smooth muscle-containing tissues such as those of pulmonary arteries and veins. (wikipedia.org)
- Proinflammatory and bronchoconstrictive actions of adenosine in the asthmatic lung are well recognized, with the latter being mediated, in part, through A 1 receptor activation on airway smooth muscle. (jci.org)
- Classical macrophage activation is inhibited by the CD200 receptor (CD200R). (uni-muenchen.de)
- PPAR-d is a nuclear receptor that receives the Th2 cytokine signals and turns on a cascade of genes and proteins that results in M2 macrophage activation. (webwire.com)
Substances1
- These neurons appear to be located more superficially and are more sensitive to pruritogenic substances than pain receptors. (medscape.com)
Nuclear1
- Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
Asthmatic1
- While both proinflammatory and anti-inflammatory signals can be sent depending on the specific adenosine receptor activated, adenosine produces a net proinflammatory effect in the asthmatic airway. (jci.org)
Expression1
- Differential expression of the chemokine receptors by the Th1- and Th2-type effector populations within circulating CD4 + T cells. (southernbiotech.com)
Shown to bind1
- Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. (rndsystems.com)
Complexes1
- 2002), it is believed that IL4 similarly triggers binding of JAK1 to IL4 receptor complexes. (reactome.org)
Asthma1
Signals1
- It signals via its cognate receptor, a complex of IL-13 receptor ?1 chain (IL-13R?1) with IL-4R? (soton.ac.uk)
Type1
- Some evidence suggests that EoE might be driven by type 2 inflammation, and dupilumab's effect on the shared receptor of IL-4 and IL-13 directly counters that pathway. (medscape.com)
Transcription1
- Group 2 ILCs (ILC2s), are characterized by the transcription factor GATA-3 and the IL-33 specific receptor ST-2. (elifesciences.org)
Cells1
- The IL-13 receptor, IL-13Ralpha1, is expressed on most leukocytes, except T-cells. (nih.gov)
Human1
- Studies using animals genetically engineered to lack IP and examining the actions of EP4 receptor agonists in animals as well as animal and human tissues indicate that this receptor serves various functions. (wikipedia.org)
Role1
- The mineralocorticoid receptor (MR) plays an essential role in regulating fluid and electrolyte homeostasis. (uni-goettingen.de)
Cell1
- The Company's second product candidate, icanbelimod (formerly known as CBP-307), is a modulator of S1P1 T cell receptors and is in development for the treatment of ulcerative colitis (UC). (fox5sandiego.com)
Close1
- In particular, IL-4 is located in close proximity to IL13 on the chromosome. (fishersci.com)
Anti1
- Anti-interleukin-5 (IL-5), anti-IL-13, or anti IL-4 receptor-α therapy is recommended only in the context of a clinical trial. (reachmd.com)