I-kappa B KinaseI-kappa B ProteinsNF-kappa BTranscription Factor RelAProtein-Serine-Threonine KinasesSignal TransductionPhosphorylationNF-kappa B p50 SubunitTranscription Factor RelBTumor Necrosis Factor-alphaProto-Oncogene Proteins c-relNF-kappa B p52 SubunitEnzyme ActivationCell LineMAP Kinase Kinase KinasesCell NucleusElectrophoretic Mobility Shift AssayActive Transport, Cell Nucleusbeta-Transducin Repeat-Containing ProteinsLipopolysaccharidesCells, CulturedGene Expression RegulationHeLa CellsCARD Signaling Adaptor ProteinsTNF Receptor-Associated Factor 6Protein BindingJurkat CellsTransfectionApoptosisMAP Kinase Kinase Kinase 1TNF Receptor-Associated Factor 2SerineProto-Oncogene ProteinsInterleukin-1Blotting, WesternUbiquitinInterleukin-8Interleukin-1 Receptor-Associated KinasesAnkyrin RepeatInflammationTranscription, GeneticImmunoprecipitationCell Line, TumorMice, KnockoutMAP Kinase Kinase Kinase 3Genes, ReporterUbiquitinationInterleukin-1betaTranscriptional ActivationFibroblastsProteasome Endopeptidase ComplexMolecular Sequence DataMacrophagesCyclooxygenase 2Transcription FactorsMutationHeterocyclic Compounds, 3-RingNitric Oxide Synthase Type IIInterferon Regulatory Factor-3LuciferasesPromoter Regions, GeneticAmino Acid SequenceLysosomal-Associated Membrane Protein 2p38 Mitogen-Activated Protein KinasesAdaptor Proteins, Signal TransducingRNA, MessengerCytokinesSodium SalicylateReverse Transcriptase Polymerase Chain ReactionMice, Inbred C57BLDimerizationJNK Mitogen-Activated Protein KinasesUp-RegulationUbiquitinsGene Products, taxEnzyme InhibitorsLeupeptinsThiocarbamatesDown-RegulationMitogen-Activated Protein KinasesTranscription Factor AP-1RNA, Small InterferingImmunoblottingCell SurvivalCytoplasmWithaniaModels, BiologicalInterleukin-6HEK293 CellsMAP Kinase Kinase 4Inflammation MediatorsTumor Cells, CulturedGenes, DominantProtein Processing, Post-TranslationalOncogene Proteins v-relSKP Cullin F-Box Protein LigasesProtein Structure, TertiaryGene ExpressionToll-Like ReceptorsProto-Oncogene Proteins c-akt