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Transcription Factor TFIIIBRNA Polymerase IIITATA-Box Binding ProteinTranscription, GeneticTranscription FactorsTranscription Factors, TFIIITATA-Binding Protein Associated FactorsTATA BoxDNA-Binding ProteinsPromoter Regions, GeneticMolecular Sequence DataSaccharomyces cerevisiaeBase SequenceSp1 Transcription FactorGene Expression RegulationRNA, TransferSaccharomyces cerevisiae ProteinsBinding SitesProtein BindingTranscriptional ActivationTrans-ActivatorsNuclear ProteinsTranscription Factor TFIIBBasic Helix-Loop-Helix Transcription FactorsRNA, MessengerAmino Acid SequenceTranscription Factor AP-1Cell LineRepressor ProteinsDNAForkhead Transcription FactorsMutationHomeodomain ProteinsGene Expression Regulation, DevelopmentalSignal TransductionBasic-Leucine Zipper Transcription FactorsCell NucleusHeLa CellsTranscription Factor AP-2

PolymeraseGeneComplexSubunitSubunitsPolymerase III transcriptionTRNARepressionPromoterDistinctProteinsTATAInitiation siteGeneral transcrComponents

Polymerase3

• This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. (wikipedia.org)
• The product of this gene, a TFIIB-like factor, is directly recruited to the TATA box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. (wikipedia.org)
• High levels of RNA polymerase III gene transcription are achieved by facilitated recycling of the polymerase on transcription factor IIIB (TFIIIB)-DNA complexes that are stable through multiple rounds of initiation. (elsevierpure.com)

Gene1

• Transcription factor IIIB 50 kDa subunit (TFIIIB50) also known as b-related factor 2 (BRF-2) is a protein that in humans is encoded by the BRF2 gene. (wikipedia.org)

Complex1

• The high stability of the TFIIIB-DNA complex is conferred by TFIIIB90 binding to TFIIIB70-TBP-DNA complexes. (elsevierpure.com)

Subunit1

• Transcription factor IIIB 50 kDa subunit (TFIIIB50) also known as b-related factor 2 (BRF-2) is a protein that in humans is encoded by the BRF2 gene. (wikipedia.org)

Subunits4

• This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. (wikipedia.org)
• POLR3F binds both TFIIIB90 and TBP, 2 subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). (prospecbio.com)
• 11. The Brf1 and Bdp1 subunits of transcription factor TFIIIB bind to overlapping sites in the tetratricopeptide repeats of Tfc4. (nih.gov)
• This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. (nih.gov)

Polymerase III transcription4

• 1. Distinct roles of transcription factors TFIIIB and TFIIIC in RNA polymerase III transcription reinitiation. (nih.gov)
• 12. p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB. (nih.gov)
• 17. Inhibition of RNA polymerase III transcription by BRCA1. (nih.gov)
• 20. Nhp6 is a transcriptional initiation fidelity factor for RNA polymerase III transcription in vitro and in vivo. (nih.gov)

TRNA8

• 2. TFIIIC-independent in vitro transcription of yeast tRNA genes. (nih.gov)
• 5. Regulation of tRNA synthesis by the general transcription factors of RNA polymerase III - TFIIIB and TFIIIC, and by the MAF1 protein. (nih.gov)
• 6. Function of TFIIIC, RNA polymerase III initiation factor, in activation and repression of tRNA gene transcription. (nih.gov)
• 9. A minimal promoter for TFIIIC-dependent in vitro transcription of snoRNA and tRNA genes by RNA polymerase III. (nih.gov)
• 15. Requirement of Nhp6 proteins for transcription of a subset of tRNA genes and heterochromatin barrier function in Saccharomyces cerevisiae. (nih.gov)
• 18. Alternative outcomes in assembly of promoter complexes: the roles of TBP and a flexible linker in placing TFIIIB on tRNA genes. (nih.gov)
• The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. (nih.gov)
• This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. (nih.gov)

Repression1

• One explanation for transcriptional repression is the reduced accessibility of transcription factors. (rupress.org)

Promoter1

• Isoform 2 is required for transcription of the U6 promoter. (nih.gov)

Distinct1

• General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. (nih.gov)

Proteins1

• Our findings indicate that mitotic chromosomes in general and ribosomal genes in particular, although highly condensed, are accessible to transcription factors and chromatin proteins. (rupress.org)

TATA2

• The product of this gene, a TFIIB-like factor, is directly recruited to the TATA box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. (wikipedia.org)
• 7. Identical components of yeast transcription factor IIIB are required and sufficient for transcription of TATA box-containing and TATA-less genes. (nih.gov)

Initiation site1

• TFIIIB recruits and positions pol III over the initiation site and remains stably bound to the DNA through multiple rounds of re-initiation by RNA POLYMERASE III . (nih.gov)

General transcr1

• One of several general transcription factors that are specific for RNA POLYMERASE III. (nih.gov)

Components1

• To directly test this hypothesis and to investigate the dynamics of mitotic chromatin, we evaluate the exchange kinetics of several RNA polymerase I transcription factors and nucleosome components on mitotic chromatin in living cells. (rupress.org)