Amyloidosis results from the accumulation of pathogenic amyloids-most of which are aggregates of misfolded proteins-in a variety of tissues. (medscape.com)
Fibroblasts1
Inhibition of iduronic acid biosynthesis by ebselen reduces glycosaminoglycan accumulation in mucopolysaccharidosis type I fibroblasts. (uu.se)
Amyloid3
[ 2 ] Many classic eponymic diseases were later found to be related to a diverse array of misfolded polypeptides (amyloid) that contain the common beta-pleated sheet architecture. (medscape.com)
[ 5 ] Only 10% of amyloidosis deposits consist of components such as glycosaminoglycans (GAGs), apolipoprotein-E (apoE), and serum amyloid P-component (SAP), while nearly 90% of the deposits consist of amyloid fibrils that are formed by the aggregation of misfolded proteins. (medscape.com)
The aim of this study was to comprehensively identify proteins that are enriched in amyloid plaques using unbiased proteomics in two subtypes of early onset AD: sporadic early onset AD (EOAD) and Down Syndrome (DS) with AD. (researchsquare.com)
Type1
Native or wild-type quaternary protein structure is usually born from a single translated protein sequence with one ordered conformation with downstream protein interactions. (medscape.com)
Present2
Since the air contains various pollutants, particles, microorganisms and potential pathogens, a system must be present to clear the airways to avoid accumulation of agents causing infection or inflammation. (biomedcentral.com)
Thousands of copies of the circular mtDNA are present in most cell types that are packaged by TFAM into higher-order structures called nucleoids1. (regenerativemedicine.net)
Surface2
Surfactants are compounds that lower the surface tension of a liquid, the interfacial tension between two liquids, or that between a liquid and a solid. (absoluteastronomy.com)
An interface is a surface forming a common boundary among two different phases, such as an insoluble solid and a liquid, two immiscible liquids or a liquid and an insoluble gas. (absoluteastronomy.com)
Studies1
Many studies have further demonstrated that SARS-CoV-2 (COVID-19) has dramatically increased the risks of CVDs due to inflammation, so PGRN has drawn much more attention among scholars. (biomedcentral.com)
ApoE2
Only 10% of amyloidosis deposits consist of components such as glycosaminoglycans (GAGs), apolipoprotein-E (apoE), and serum amyloid P-component (SAP), while nearly 90% of the deposits consist of amyloid fibrils that are formed by the aggregation of misfolded proteins. (medscape.com)
Apolipoprotein E − / − (APOE − / − ) mice were employed in this study to establish the important role of Alvelestat in valve calcification. (biomedcentral.com)
Pancreatic3
Significant increases in serum lipase levels and pancreatic neutrophil numbers were observed at 1 and 2 h after L-arginine administration, respectively. (bvsalud.org)
Human pancreatic islet amyloid polypeptide (hIAPP) and beta amyloid (Aβ) can accumulate in Type 2 diabetes (T2D) and Alzheimer's disease (AD) brains and evidence suggests that interaction between the two amyloidogenic proteins can lead to the formation of heterocomplex aggregates. (nature.com)
hIAPP is cleaved from the pre-pro form of IAPP and subsequently converted into a 37-amino acid structure by pancreatic β-cell secretory granules 7 . (nature.com)
Serum4
In addition, IR, a possible pathogenesis of NAFLD, had positive correlation with the raised plasma levels of apoB48-containing lipoproteins, which might be due to impaired hepatic ability of clearing TG-rich lipoproteins caused by excessive production of intestinal chylomicrons (CMs) and accumulation of serum CM remnants [ 13 , 14 ]. (hindawi.com)
Chymase in exocytosed rat mast cell granules effectively proteolyzes apolipoprotein AI-containing lipoproteins, so reducing the cholesterol efflux-inducing ability of serum and aortic intimal fluid. (jci.org)
In this study we found that remnant chymase, by proteolyzing human serum and human aortic intimal fluid, prevents these two physiologic fluids from effectively inducing cholesterol efflux from cultured macrophage foam cells. (jci.org)
Western blot analysis showed that granule remnants degrade apoAI in serum and in internal fluid. (jci.org)
Remnants1
Chymase in granules released from degranulated rat serosal mast cells, i.e., in granule remnants, proteolyzes human high density lipoprotein3 (HDL3), and so reduces its ability to induce cholesterol efflux from macrophage foam cells in vitro. (jci.org)
Lipoproteins1
It has been suggested that defective production and/or secretion of apo B lipoproteins were highly associated with fatty degeneration of the liver and might involve impaired synthesis of very low-density lipoproteins (VLDL), resulting in the accumulation of TG in the liver [ 12 ]. (hindawi.com)
Neutrophils1
NE (Neutrophil elastase) is a serine protease mainly existed in neutrophils azurophilic granules [ 4 ], which is involved in a variety of physiological processes like formation of neutrophil extracellular trap and degradation of extracellular matrix and proteins [ 5 , 6 ]. (biomedcentral.com)
Fatty1
Nonalcoholic fatty liver disease (NAFLD) is common clinicopathological syndrome characterized by fatty degeneration of hepatocytes and lipid accumulation, of which, natural history includes nonalcoholic simple fatty liver (NAFL), nonalcoholic steatohepatitis (NASH), and associated liver cirrhosis and hepatocellular carcinoma (HCC) [ 1 , 2 ]. (hindawi.com)
Protein4
Native or wild-type quaternary protein structure is usually born from a single translated protein sequence with one ordered conformation with downstream protein interactions. (medscape.com)
The expressions of zona occludens 1 protein (ZO-1), occludin, and secretory immunoglobulin A (sIgA) in the colon were detected by immunostaining to investigate the intestinal barrier function. (hindawi.com)
Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 7.9 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
The largest part of tau secreted from AD nerve terminals and released in cerebral spinal fluid (CSF) is C-terminally truncated, soluble and unaggregated supporting potential extracellular role(s) of NH 2 -derived fragments of protein on synaptic dysfunction underlying neurodegenerative tauopathies, including Alzheimer's disease (AD). (oncotarget.com)
20221
17498 Imaizumi A, Obata T, Kershaw J, Tachibana Y, Abe Y, Shibata S, Nitta N, Aoki I, Yasui M, Higashi T. Quantitative measurement of diffusion-weighted imaging signal using expression-controlled aquaporin-4 cells: Comparative study of 2-compartment and diffusion kurtosis imaging models PLoS One 2022 17(4):e0266465. (riken.jp)
Eosin1
Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin. (lookformedical.com)
Protease5
Here, we used high-throughput docking to screen 6000 compounds within the DrugBank library for their potential to bind and inhibit the SARS-CoV-2 3 CL main protease, a chymotrypsin-like enzyme that is essential for viral replication. (bvsalud.org)
For 19 candidate hits, parallel in vitro fluorescence-based protease-inhibition assays and Vero-CCL81 cell-based SARS-CoV-2 replication-inhibition assays were performed. (bvsalud.org)
One hit, diclazuril (an investigational anti-protozoal compound), was validated as a SARS-CoV-2 3 CL main protease inhibitor in vitro (IC50 value of 29 µM) and modestly inhibited SARS-CoV-2 replication in Vero-CCL81 cells. (bvsalud.org)
Another hit, lenvatinib (approved for use in humans as an anti-cancer treatment), could not be validated as a SARS-CoV-2 3 CL main protease inhibitor in vitro, but serendipitously exhibited a striking functional synergy with the approved nucleoside analogue remdesivir to inhibit SARS-CoV-2 replication, albeit this was specific to Vero-CCL81 cells. (bvsalud.org)
A protease mutant, TR-2, which was able to be activated only by chymotrypsin but not by trypsin, could also initiate replication in the bronchial epithelium, when activated by chymotrypsin before inoculation into mice. (nih.gov)
Lymphocytes1
However, ts 1 survivors and normal mice possessed the same proportions of splenic lymphocytes carrying either allele for Lyt 1 and Lyt 2 surface markers. (nih.gov)
Precursor1
Inactive Sendai virus grown in LLC-MK(2) cells, which possessed an uncleaved precursor glycoprotein, F, and was noninfectious to tissue culture cells, neither grew nor caused pathological changes in the lung of mice. (nih.gov)
Markers1
Biological markers were measured 1, 2, and 8 h after L-arginine administration. (bvsalud.org)
Results2
The results imply participation of exocytosed mast cell granules in foam cell formation in atherogenesis. (jci.org)
The results suggest two mechanisms by which ts 1 survivors exhibit resistance to CVB3(m) induction of myocarditis, namely, the rapid production of high-titered anti-CVB3(m) neutralizing antibody in response to CVB3(m) inoculation and altered cell-mediated immune responses against CVB3(m) induced viral or novel cellular antigens. (nih.gov)
Role2
Apolipoprotein (apo) B48 is an apolipoprotein synthesized and secreted by the intestine and plays an important role in the control of lipid transport [ 11 ]. (hindawi.com)
Would the real role(s) for secretory PLA2s please stand up. (jci.org)
Western1
Western Blotting was used to detect apolipoprotein (apo) B48 expression. (hindawi.com)
Formation1
However, the structure and consequences of the formation of these complexes remains to be determined. (nature.com)
Release1
Here we show that sub-toxic doses of extracellular-applied human NH 2 tau 26-44 (aka NH 2 htau) -which is the minimal active moiety of neurotoxic 20-22kDa peptide accumulating in vivo at AD synapses and secreted into parenchyma- acutely provokes presynaptic deficit in K + -evoked glutamate release on hippocampal synaptosomes along with alteration in local Ca 2+ dynamics. (oncotarget.com)
Production1
This covers the production of several cytokines and chemokines including interleukin 1 (IL-1), interleukin 6 (IL-6), tumor necrosis factor- alpha (TNF-α) and chemokine (C-C motif) ligand 2 (CCL2) [ 4 ]. (biomedcentral.com)
Native1
If the echo density of the structures in query approximate the brightness of native pelvic bone and sonographic “gain” and “dynamic vary” are judged appropriate, hyperechogenicity is judged present treatment with cold medical term [url=https://www.museyokutawato.gov.ph/pills/Disulfiram/]disulfiram 500 mg without prescription[/url]. (ehd.org)
Study1
Its life span is between 2 and 3 weeks, which facilitates the study of its biology. (frontiersin.org)
Chemical2
Thus, in 1962, Yamakawa completed the corrected chemical structure of sulfatide. (wikipedia.org)
The structure and chemical properties may vary with the species and type of releasing cell. (lookformedical.com)
Disease2
Rapid repurposing of existing drugs as new therapeutics for COVID-19 has been an important strategy in the management of disease severity during the ongoing SARS-CoV-2 pandemic. (bvsalud.org)
Epidemiological and clinical evidence suggests a strong association between Type 2 diabetes (T2D) and Alzheimer's disease (AD), with T2D patients having a significantly higher risk of developing AD compared to non-diabetic individuals 1 , 2 , 3 . (nature.com)