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  • doses
  • In dogs and rhesus monkeys very high doses of ifosfamide have caused changes in ECG, cardiac histology, and heart function (negative chrono- and inotropic effects). (drugs.com)
  • cytochrome
  • PharmaCyte's Chief Executive Officer, Kenneth L. Waggoner, explained the significance of the successful study saying, "PharmaCyte's treatment for LAPC utilizes cells that produce a particularly potent cytochrome P450 enzyme that is able to activate ifosfamide. (biospace.com)
  • Ifosfamide must be activated by cytochrome P450 enzymes such as those found in the cells to be used in into a short-lived intermediate form that can enter tumor cells and kill them. (biospace.com)
  • chemotherapeutic
  • Ifosfamide is a chemotherapeutic agent that is routinely used to treat a variety of cancers, including testicular cancer and non-Hodgkin's lymphoma. (biospace.com)
  • Uramustine or uracil mustard Melphalan Chlorambucil Ifosfamide Bendamustine Nitrosoureas Carmustine Lomustine Streptozocin Alkyl sulfonates Busulfan Platinum-based chemotherapeutic drugs (termed platinum analogues) act in a similar manner. (wikipedia.org)
  • chloroacetaldehyde
  • The reaction is probably mediated by chloroacetaldehyde, one of the breakdown products of the ifosfamide molecule, which has chemical properties similar to acetaldehyde and chloral hydrate. (wikipedia.org)
  • therapy
  • Limited data have also revealed the development of atrial fibrillation , paroxysmal SVT associated with ischemic changes, premature ventricular depolarizations , tachycardia , and QRS or ST segment prolongations during ifosfamide therapy. (drugs.com)
  • In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of ifosfamide therapy. (drugs.com)
  • The disease can occur as a complication of cyclophosphamide, ifosfamide and radiation therapy. (wikipedia.org)
  • vitro
  • To provide the information required by the FDA, a series of in vitro experiments were performed with unfrozen encapsulated ifosfamide-activating cells in culture that were treated with successive courses of ifosfamide over many days. (biospace.com)
  • interfere
  • Our investigations provide evidence to suggest n-acetylcysteine does not interfere with ifosfamide activity, further supporting its safe use. (uwo.ca)
  • Drug
  • LAGUNA HILLS, Calif.--( BUSINESS WIRE )-- PharmaCyte Biotech , Inc. (OTCQB: PMCB), a clinical stage biotechnology company focused on developing targeted cellular therapies for cancer and diabetes using its signature live-cell encapsulation technology, Cell-in-a-Box ® , today announced that it has successfully completed a "multiple course ifosfamide study" required by the U.S. Food and Drug Administration (FDA). (biospace.com)
  • The activation of evofosfamide to the active drug Br-IPM and the mechanism of action (MOA) via cross-linking of DNA is shown schematically below: Phosphorodiamidate-based, DNA-crosslinking, bis-alkylator mustards have long been used successfully in cancer chemotherapy and include e.g. the prodrugs ifosfamide and cyclophosphamide. (wikipedia.org)