• Because of the HCTZ component, TEKTURNA HCT is contraindicated in patients with anuria or hypersensitivity to sulfonamide-derived drugs like HCTZ. (tekturna.com)
  • Hypersensitivity reactions may range from urticaria to anaphylaxis. (tekturna.com)
  • Hypersensitivity reactions such as anaphylactic reactions and angioedema of the face, extremities, lips, tongue, glottis, and/or larynx have been reported in patients treated with aliskiren and have necessitated hospitalization and intubation. (tekturna.com)
  • [ 8 ] which is due to Staphylococcus aureus infection rather than to a probable drug hypersensitivity-type reaction. (medscape.com)
  • Promethazine hydrochloride injection is contraindicated in patients who have demonstrated an idiosyncratic reaction or hypersensitivity to promethazine or other phenothiazines. (fda.gov)
  • Fluid and electrolyte status should be regularly monitored particularly in the elderly, in those with significant renal and hepatic impairment, and in patients receiving digoxin and drugs with pro-arrhythmic effects. (pillintrip.com)
  • Hydrochlorothiazide tablets are indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. (nih.gov)
  • Indapamide has severe interactions with at least 48 other drugs. (rxlist.com)
  • Care should be taken with severe hepatic and renal impairment which may alter drug metabolism and excretion. (pillintrip.com)
  • Concomitant use of Aldactide with other potassium-sparing diuretics, angiotensin-converting enzyme (ACE) inhibitors, nonsteroidal anti-inflammatory drugs, angiotensin II antagonists, aldosterone blockers, heparin, low molecular weight heparin or other drugs or conditions known to cause hyperkalaemia, potassium supplements, a diet rich in potassium or salt substitutes containing potassium, may lead to severe hyperkalaemia. (pillintrip.com)
  • Caution should be observed in patients with acute or severe liver impairment as vigorous diuretic therapy may precipitate encephalopathy in susceptible patients. (pillintrip.com)
  • It is concluded that Emotional stress can precipitate severe, reversible left ventricular dysfunction in patients without coronary disease. (binaryoptionstradinglist.com)
  • Drug toxicity includes acute kidney injury. (wikipedia.org)
  • Hydrochlorothiazide, a sulfonamide, can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma. (pillintrip.com)
  • Symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation. (pillintrip.com)
  • These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including lisinopril and hydrochlorothiazide. (globalrph.com)
  • Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. (globalrph.com)
  • Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics, or antihypertensive drugs). (pfizermedicalinformation.com)
  • Thiazides may cause hyperuricaemia and precipitate attacks of gout in some patients. (pillintrip.com)
  • Common anticancer chemotherapeutic agents causing drug-induced thrombotic microangiopathy via immune-mediated mechanism or dose-dependent toxicity or both [ 4 , 7 ]. (hindawi.com)
  • Lung toxicities resulting from the chemotherapeutic agent bleomycin encompass a variety of pathological changes, including bronchiolitis obliterans organizing pneumonia, interstitial pneumonitis and progressive interstitial fibrosis. (biomedcentral.com)
  • CA catalyzes the reversible reaction in which carbon dioxide (CO 2 ) is hydrated (H 2 O) to form carbonic acid (H 2 CO 3 ) (i.e. (entokey.com)
  • While urine is the most common matrix for drug-of-abuse testing, SCs undergo extensive Phase I and Phase II metabolism, resulting in almost undetectable parent compounds in urine samples. (bvsalud.org)
  • Since seized urine samples after consuming novel SCs may be unavailable in a timely manner, human hepatocytes, human liver microsomes and human transporter overexpressed cell lines are physiologically-relevant in vitro systems for performing metabolite identification, metabolic stability, reaction phenotyping and transporter experiments to establish the disposition of SC and its metabolites. (bvsalud.org)
  • TMA caused by drugs is called drug-induced TMA (DTMA) [ 4 ], and cancer therapeutic agents are among the most common medications reported to cause DTMA. (hindawi.com)
  • Adverse drug reaction (ADR, or adverse drug effect) is a broad term referring to unwanted, uncomfortable, or dangerous effects that drugs (including medications ) may have. (msdmanuals.com)
  • Her physicians should review her current medications for their teratogenic potential, and drugs that pose a significant teratogenic risk should be discontinued if possible. (medscape.com)
  • At least 2 systems are used to classify the risk associated with specific medications: the US Food and Drug Administration (FDA) system and the automated Teratogen Information System (TERIS). (medscape.com)
  • If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. (rxlist.com)
  • Indapamide has serious interactions with at least 42 other drugs. (rxlist.com)
  • Indapamide has moderate interactions with at least 165 other drugs. (rxlist.com)
  • Visit the RxList Drug Interaction Checker for any drugs interactions. (rxlist.com)
  • Due to system maintenance, the drug interactions feature you are attempting to access is temporarily unavailable. (medscape.com)
  • Psychopharmacology, as the term is used here, refers to the study of the interactions of drugs with the central nervous system (CNS), including physical, behavioral, and subjective effects. (druglibrary.net)
  • Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. (medilib.ir)
  • Consult drug interactions database for more information. (medilib.ir)
  • Drug Bioavailability Bioavailability refers to the extent and rate at which the active moiety (drug or metabolite) enters systemic circulation, thereby accessing the site of action. (msdmanuals.com)
  • UDP-Glucuronosyltransferases (UGTs) are important in the elimination of most xenobiotics, including 5-( p -hydroxyphenyl)-5-phenylhydantoin (HPPH), the major, reputedly nontoxic, metabolite of the anticonvulsant drug phenytoin. (aspetjournals.org)
  • The glucuronidation and elimination of endogenous compounds ( e.g. , bilirubin) and xenobiotics, including HPPH, the major, para -hydroxylated metabolite of the anticonvulsant drug phenytoin (diphenylhydantoin) ( Butler, 1957 ), are catalyzed by a superfamily of membrane-bound isozymes known collectively as UGTs ( Dutton, 1980 ). (aspetjournals.org)
  • accidental or intentional) or to elevated blood levels or enhanced drug effects that occur during appropriate use (eg, when drug metabolism is temporarily inhibited by a disorder or another drug). (msdmanuals.com)
  • PIs could cause DTMA either by an immune mechanism or dose-dependent/cumulative toxicity. (hindawi.com)
  • Sulfur-containing products are the predominant metabolites and are thought to be primarily responsible, together with spironolactone, for the therapeutic effects of the drug. (nih.gov)
  • A very few cases of mixed cholestatic/hepatocellular toxicity, with one reported fatality, have been reported with spironolactone administration. (pfizermedicalinformation.com)
  • Spironolactone, an ingredient of ALDACTAZIDE, has been shown to be a tumorigen in chronic toxicity studies in rats (see Precautions section). (pfizermedicalinformation.com)
  • Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic symptoms (DRESS), alopecia, pruritus. (pfizermedicalinformation.com)
  • Yet similarly, anti-malarial drugs, particularly of the quinine-like class of quinolines commonly used in treatment and prevention of disease, are also increasingly recognized to exert potentially chronic psychiatric adverse effects that may also contribute to this global burden of morbidity [ 2 ]. (biomedcentral.com)
  • TEN is most commonly drug induced. (medscape.com)
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. (globalrph.com)
  • Balancing Drug Benefits and Adverse Effects Obviously, a drug (or any medical treatment) should be used only when it will benefit a patient. (msdmanuals.com)
  • Because he did not respond to a four-day course of the antibiotic treatment and showed worsening dyspnea, our patient was admitted to the medical intensive care unit, and underwent a thoracoscopic right middle lobe wedge biopsy to investigate possible bleomycin-induced lung toxicity. (biomedcentral.com)
  • In this article, we discuss the precipitating factors for cumulative toxicity of ixazomib, resulting in DTMA, diagnostic workup, and management of DTMA. (hindawi.com)
  • The idiosyncratic relationship between diagnostic delay and stage of oral squamous cell carcinoma. (tractorgallery.net)
  • This review concludes with a discussion of the potentially confounding role of the adverse effects of anti-malarial drugs, particularly of the quinoline class, in the unique attribution of certain psychiatric effects to malaria, and of the need for a critical reevaluation of the literature in light of emerging evidence of the chronic nature of these adverse drug effects. (biomedcentral.com)
  • As will become obvious, there are many areas in which basic knowledge about the mechanisms of action of psychoactive drugs does not exist. (druglibrary.net)
  • Monitor serum potassium levels when using concomitantly with other drugs known to increase the risk of hypokalaemia induced by thiazide diuretics. (pillintrip.com)
  • Three months after the treatment, he presented at the emergency department at Stony Brook University Medical Center, having suffered from progressive shortness of breath for three days but without any other obvious precipitating factors. (biomedcentral.com)
  • See also Seizure Disorders in Pregnancy , Women's Health and Epilepsy , Antiepileptic Drugs , and Neural Tube Defects . (medscape.com)
  • Women planning to become pregnant should avoid all alcohol consumption, smoking, and use of illegal drugs (eg, cocaine) before and during the pregnancy, because these activities may have serious deleterious effects on the fetus. (medscape.com)
  • According to the TERIS, the teratogenic risk in human pregnancy is undetermined for 91.2% of the drug treatments approved in the United States between 1980 and 2000. (medscape.com)
  • Many patients will require more than 1 drug to achieve blood pressure goals. (globalrph.com)
  • Systemic administration of CAIs is extremely effective in reducing IOP in most patients but is accompanied by side effects that can range from mild and annoying to debilitating and life threatening, the latter necessitating discontinuation of these drugs. (entokey.com)
  • Many patients will require more than one drug to achieve blood pressure goals. (tekturna.com)
  • Use TEKTURNA HCT as initial therapy in patients who are likely to need multiple drugs to achieve their blood pressure goals. (tekturna.com)
  • Risks are increased in patients with personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (eg. (drugcentral.org)
  • This is not a complete list of side effects and other serious side effects or health problems may occur as a result of the use of this drug. (rxlist.com)
  • Addiction can occur at recommended dosages and if the drug is misused or abused. (drugcentral.org)
  • General Principles of Poisoning Poisoning is contact with a substance that results in toxicity. (msdmanuals.com)
  • The following adverse reactions have been reported and, within each category (body system), are listed in order of decreasing severity. (pfizermedicalinformation.com)
  • Fibrates decrease the synthesis of bile acid by down-regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase expression, therefore making it easier for cholesterol to precipitate and increasing the risk for gallstones. (wikipedia.org)
  • In combination with statin drugs, fibrates cause an increased risk of rhabdomyolysis, idiosyncratic destruction of muscle tissue, leading to kidney failure. (wikipedia.org)
  • Also, consider yourself generic 100mg kamagra soft overnight delivery erectile dysfunction drugs associated with increased melanoma risk. (mein-schoenefeld.info)
  • Amelioration of allergic reactions to blood or plasma. (fda.gov)
  • Fibrates may be compared to statin drugs, which reduce LDL-cholesterol (LDL-C) and have only limited effects on other lipid parameters. (wikipedia.org)
  • This review, inspired by an earlier seminal work [ 3 ], synthesizes over a century of critical literature from psychiatry and malariology-ranging from anecdotal historical observations to evidence from modern randomized controlled trials-to explore the evolving understanding of the psychiatric effects of malaria and of anti-malarial drugs. (biomedcentral.com)
  • Lastly, the psychiatric effects of anti-malarial drugs, particularly of the quinoline class, are reviewed, including a discussion regarding the potential confounding effect that these may have had on symptoms historically associated with malaria. (biomedcentral.com)
  • Call your doctor for medical advice about serious side effects or adverse reactions. (rxlist.com)
  • Brinzolamide, a drug with similar structural and binding effects at the enzyme CA II, was developed by Alcon Pharmaceuticals Inc. and approved for clinical use in 1998. (entokey.com)
  • The psychoactive component of the effect of drugs is due to their effects on the CNS rather than on the peripheral system, and it is the CNS with which we are concerned. (druglibrary.net)
  • Egg whites, milk or animal charcoal which forms insoluble precipitate mercury. (modernforensic.in)
  • Clinical trials have shown that the combination of statins and fibrates results in a significantly greater reduction in LDL-C and triglyceride levels and greater increases in high-density lipoprotein cholesterol (HDL-C) compared with monotherapy with either drug. (wikipedia.org)
  • Drug Absorption Drug absorption is determined by the drug's physicochemical properties, formulation, and route of administration. (msdmanuals.com)
  • Next, scroll down the page to locate the link to the drug you are searching for and then click on the link. (globalrph.com)
  • This case illustrates that eosinophilic pneumonia may be a late sequela of bleomycin toxicity, and may respond dramatically to steroid treatment. (biomedcentral.com)
  • 2) The rx list web site will open here with the drug search completed. (globalrph.com)