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  • mechanistic
  • We have taken a mechanistic approach to determining species-specific differences in the bioactivation of the antiepileptic drug FBM, 2-phenyl-1,3-propanediol dicarbamate, which may be applied to new compounds with structural and metabolic similarities. (aspetjournals.org)
  • Where successful, these assays could speed up the discovery and mechanistic understanding of HLA-linked hypersensitivities, and guide the development of safer drugs. (pnas.org)
  • IDRs
  • TNFα/TVX induced unique gene expression changes that clustered separately from TNFα/levofloxacin, a drug not associated with IDRs. (mdpi.com)
  • characteristic
  • The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. (nih.gov)
  • patient
  • PATIENT A woman who developed three episodes of drug-induced hepatitis within 3 years as a result of successive treatment with two tricyclic antidepressants, trimipramine and desipramine, and one neuroleptic derivative, cyamemazine. (semanticscholar.org)
  • metabolite
  • however, it is very difficult to demonstrate that a reactive metabolite is responsible for an IDR, and most drugs have the potential to form several reactive metabolites. (aspetjournals.org)
  • responses
  • The pharmacologic interaction with immune receptors (p-i) model states that drugs can induce the formation of HLA-drug complexes that can activate T-cell immune responses directly without requiring a specific peptide ligand ( 8 ). (pnas.org)
  • cause
  • High-dose intravenous benzylpenicillin is an effective treatment for neurosyphilis although it can cause potentially life-threatening drug-induced neutropenia. (plos.org)
  • immune-mediated
  • In approximately 8% of recipients, abacavir is associated with significant immune-mediated drug hypersensitivity, which is strongly associated with the presence of the HLA-B*57:01 allele ( 1 , 2 ). (pnas.org)
  • widely
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as analgesics and antipyretics in the United States. (aspetjournals.org)
  • mechanism
  • This sensitive measurement of oxygen dynamics revealed important information on the drug mechanism of action and transient subthreshold effects. (springer.com)
  • understood
  • print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood. (ehealthme.com)