• Other side effects include granulocytopenia (dose dependent, which improves on cessation of the drug) and aplastic anemia, and in case of propylthiouracil, severe, fulminant liver failure. (wikipedia.org)
  • Vulnerability to infection is extremely high in patients with agranulocytosis, which is the virtual absence of neutrophils in peripheral blood, with ANC typically lower than 100/μL. (medscape.com)
  • This suggests a distinct TH-dependent etiology for both phenotypes, and illustrates how timing of hypothyroxinemia can induce abnormal brain structure and function. (bvsalud.org)
  • These drugs probably inhibit the enzyme thyroid peroxidase (a.k.a. thyroperoxidase), decreasing iodide oxidation, iodination of tyrosyl residues in thyroglobulin, and coupling of iodotyrosyl and iodothyronyl residues. (wikipedia.org)
  • Other drugs that interfere with, or inhibit, granulocyte colony formation may induce agranulocytosis. (orthopedicshealth.com)
  • Acquired agranulocytosis is a rare, drug-induced blood disorder that is characterized by a severe reduction in the number of white blood cells (granulocytes) in the circulating blood. (orthopedicshealth.com)
  • Instruct patients treated with antithyroid drugs as to possible adverse effects and the need for close follow-up. (medscape.com)
  • As neutrophil levels decrease, the susceptibility of patients with acquired agranulocytosis to bacterial infections becomes even greater. (orthopedicshealth.com)
  • this is an idiosyncratic reaction which generally resolves on cessation of drug. (wikipedia.org)
  • Some drugs cause this reaction in anyone given large enough doses. (orthopedicshealth.com)
  • Other drugs may cause the reaction in one person but not in another (idiosyncratic). (orthopedicshealth.com)
  • Symptoms may be improved by treatment with beta-blocking drugs. (medscape.com)
  • The first symptoms of acquired agranulocytosis are usually those associated with a bacterial infection such as general weakness, chills, fever, and/or extreme exhaustion. (orthopedicshealth.com)
  • The most studied drug in this class is lithium, which inhibits thyroid hormone secretion by inhibiting iodotyrosine coupling, thyroidal iodine uptake, and alteration in structure of thyroglobulin, a protein which acts as a substrate for the synthesis of thyroid hormones and storage of inactive forms of T3, T4 and iodine within the lumen of thyroid follicular cells. (wikipedia.org)
  • Reduction of thyroid hormone is accomplished by use of drug therapy, surgical subtotal thyroidectomy, or treatment with radioactive iodine (RAI). (medscape.com)
  • It occurs in about 0.2 to 0.3% of cases treated with antithyroid drugs. (wikipedia.org)
  • In rare cases of acute acquired agranulocytosis, destructive action of certain white blood cell antibodies (leukocyte isoantibodies) may be induced by certain drugs such as phenylbutazone, gold salts, sulfapyridine, aminopyrine, meralluride, and dipyrine. (orthopedicshealth.com)
  • These drugs are no longer used due to high toxicity and adverse effects. (wikipedia.org)
  • However, among the drugs to which a patient may be sensitive are several used in the treatment of cancer (cancer chemotherapeutic agents) and others used as antipsychotic medications (e.g., clozapine). (orthopedicshealth.com)
  • In some instances, the action of some drugs or chemicals suggests that the immune system is involved. (orthopedicshealth.com)
  • In the case of gold, or anti-thyroid drugs, or quinidine, among others, antibodies are created that appear to break the granulocytes down. (orthopedicshealth.com)
  • Instruct patients treated with antithyroid drugs as to possible adverse effects and the need for close follow-up. (medscape.com)
  • Vulnerability to infection is extremely high in patients with agranulocytosis, which is the virtual absence of neutrophils in peripheral blood, with ANC typically lower than 100/μL. (medscape.com)
  • Monitoring of the infant's complete blood count and differential is advisable if there is a suspicion of a drug-induced blood dyscrasia. (nih.gov)