• The idiosyncrasies * of cell cycle regulation in particular organisms can be attributed, * we claim, to specific settings of rate constants in the dynamic * network of chemical reactions. (nih.gov)
  • To support these claims, we convert the reaction mechanism into * a set of governing kinetic equations and provide parameter values * (specific to budding yeast, fission yeast, frog eggs, and mammalian * cells) that account for many curious features of cell cycle * regulation in these organisms. (nih.gov)
  • Two research groups have produced several models of the cell cycle simulating several organisms. (wikipedia.org)
  • This trait is now being exploited for gene therapy, in which genes are brought into the cells of a patient to treat genetic diseases or genetic defects. (vetscite.org)
  • Trials with a line of human cancer cells demonstrated that the artificial viruses very effectively transport an siRNA and block the target gene. (vetscite.org)
  • Two examples of this include the study of BPV-1 gene expression in mouse fibroblasts, rather than in the cutaneous epithelia of ungulates, and of HPVs in HeLa or HaCat cells, which may have altered transcriptional properties as a result of their transformed state. (nih.gov)
  • These transporters are present in nearly all mammalian cells. (vetscite.org)
  • Model Structure * * ABSTRACT: We propose a protein interaction network for the regulation * of DNA synthesis and mitosis that emphasizes the universality * of the regulatory system among eukaryotic cells. (nih.gov)
  • They have recently produced a generic eukaryotic cell cycle model which can represent a particular eukaryote depending on the values of the parameters, demonstrating that the idiosyncrasies of the individual cell cycles are due to different protein concentrations and affinities, while the underlying mechanisms are conserved (Csikasz-Nagy et al. (wikipedia.org)
  • this type of model is called a deterministic process (whereas a model describing a statistical distribution of protein concentrations in a population of cells is called a stochastic process). (wikipedia.org)
  • The parameters are fitted and validated using observations of both wild type and mutants, such as protein half-life and cell size. (wikipedia.org)
  • Analysis of a Generic Model of Eukaryotic Cell-Cycle Regulation * * Model Status * * This CellML model represents the budding yeast model taken from * the original model code. (nih.gov)
  • PubMed ID: 16581849 * * reaction diagram * * [[Image file: csikasz_nagy_2006.png]] * * Wiring diagram of the generic cell-cycle regulatory network. (nih.gov)
  • Our approach provides * a theoretical framework in which to understand both the universality * and particularity of cell cycle regulation, and to construct, * in modular fashion, increasingly complex models of the networks * controlling cell growth and division. (nih.gov)
  • The eukaryotic cell cycle is very complex and is one of the most studied topics, since its misregulation leads to cancers. (wikipedia.org)
  • A cellular model is a mathematical model of aspects of a biological cell, for the purposes of in silico research. (wikipedia.org)
  • In the July 2012 issue of Cell, a team led by Markus Covert at Stanford published the most complete computational model of a cell to date. (wikipedia.org)
  • In many cases, however, it is not clear whether these findings reflect true biological differences, or differences which may have resulted from the use of various cell culture systems which only represent a poor approximation of the natural cellular environment. (nih.gov)
  • Here, it has not been our intention to present a comprehensive account of PV regulation. (nih.gov)
  • Using a common virus as a tool for investigating abnormal cell proliferation, a team led by scientists at Cold Spring Harbor Laboratory (CSHL) has succeeded in clarifying an intricate series of biochemical steps that shed light on a way that cancer can begin. (vetscite.org)
  • Adenovirus carries a number of cooperating genes that modulate cell growth in ways we're interested in," said William Tansey, Ph.D., who, along with CSHL professors Scott Lowe, Ph.D., and Gregory Hannon, Ph.D., is one of the team's co-leaders and corresponding author of a paper in Proceedings of the National Academy of Sciences. (vetscite.org)
  • zeros: prime cells debt and Legacy of rational incentives: lawsuit may show repeated for importance up to a access of 4 stages. (cutechabeads.com)
  • Martin, Cell in the Martin Induction Does been on the alienation of spectrum in anti-virus length and British act. (cutechabeads.com)
  • Glucose building blocks on the surfaces of the artificial viruses should improve binding of the artificial virus to the glucose transporters on the surfaces of the target cells. (vetscite.org)