AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsHealth Care
Idiopathic Interstitial PneumoniasIdiopathic Pulmonary FibrosisPulmonary FibrosisLung Diseases, InterstitialCryptogenic Organizing PneumoniaLungConnective Tissue DiseasesBleomycinPulmonary Surfactant-Associated Protein CBronchoalveolar Lavage FluidBronchoalveolar LavageFibrosisBiopsyRespiratory Function TestsTomography, X-Ray ComputedPulmonary Surfactant-Associated Protein AInterleukin-13 Receptor alpha1 SubunitAlveolitis, Extrinsic AllergicCystic FibrosisRadiography, ThoracicSarcoidosis, PulmonaryPulmonary AlveoliFibroblastsRetrospective StudiesPrognosisLung TransplantationBiological MarkersMyofibroblastsHydroxyprolinePyridonesPulmonary Diffusing CapacityPneumocytesVital CapacityRespiratory System AgentsCollagen DiseasesSarcoidosisTransforming Growth Factor beta1CollagenTransforming Growth Factor betaRespiratory AspirationTotal Lung CapacityLung DiseasesScoliosisHypertension, PulmonaryDisease ProgressionMucin-5BDyspneaScleroderma, SystemicArthritis, JuvenilePulmonary EmphysemaMacrophages, AlveolarPurpura, Thrombocytopenic, IdiopathicRespiratory MucosaDisease Models, AnimalMice, Inbred C57BLPrednisoloneCase-Control StudiesImmunohistochemistryPulmonary Surfactant-Associated Protein DAntibiotics, AntineoplasticLung InjuryHSP47 Heat-Shock ProteinsCystitis, InterstitialInterstitial Cells of CajalSeverity of Illness IndexPrimary Graft DysfunctionEpithelial CellsCollagen Type ITreatment OutcomePulmonary MedicineDiagnostic Techniques, Respiratory SystemHemoperfusionRetroperitoneal FibrosisTherapeutic IrrigationPneumoniaEndomyocardial FibrosisCells, CulturedCystic Fibrosis Transmembrane Conductance RegulatorRNA, MessengerAcute DiseaseEpithelial-Mesenchymal TransitionTime FactorsExpectorantsPulmonary Gas ExchangeEmphysemaAcetylcysteinePredictive Value of TestsCardiomyopathy, DilatedExtracellular MatrixAnti-Inflammatory AgentsMatrix Metalloproteinase 7TelomeraseTelomere ShorteningMice, KnockoutActinsPeplomycinEnzyme-Linked Immunosorbent AssayProton TherapyExercise TestCollagen Type V
PneumoniaPneumoniasCritical Care MedInflammation and fibrosisHypertensionNSIPSarcoidosisDiagnosisDiseaseUsual interstitial pneumonitisProgressionPathogenesisClinicalConnectiveLungsDecline in pulmonary functionDiseasesHypersensitivityNintedanibILDsAlveolitisAbnormalitiesCysticPirfenidoneMean pulmonary arterial pressureAcute exacerbationInterstitiumDifferentiationProgressiveHRCTReticularEmphysemaLymphocyticAlveolarPatients diagnosedMortality in patientsParenchyma
Pneumonia44
  • Usual interstitial pneumonia (UIP) is a form of lung disease characterized by progressive scarring of both lungs. (wikipedia.org)
  • Pneumonia" indicates "lung abnormality", which includes fibrosis and inflammation. (wikipedia.org)
  • Pathological findings in usual interstitial pneumonia (UIP) Appearance of usual interstitial pneumonia (UIP) in a surgical lung biopsy at low magnification. (wikipedia.org)
  • The most common considerations include: chronic hypersensitivity pneumonitis non-specific interstitial pneumonia sarcoidosis pulmonary Langerhans cell histiocytosis asbestosis Oxygen therapy may assist with daily living. (wikipedia.org)
  • Other major histopathologic forms of idiopathic interstitial pneumonias include the following: desquamative interstitial pneumonia (DIP), respiratory bronchiolitis interstitial lung disease (RBILD), acute interstitial pneumonitis (AIP), also known as Hamman-Rich syndrome, nonspecific interstitial pneumonia (NSIP), cryptogenic organizing pneumonia (COP) (see Imaging in Bronchiolitis Obliterans Organizing Pneumonia ), and lymphocytic interstitial pneumonia (LIP) (see Lymphocytic Interstitial Pneumonia ). (medscape.com)
  • To retrospectively assess the accuracy of thin-section computed tomography (CT) in distinguishing chronic hypersensitivity pneumonitis (HP) from idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP), with histologic results as the reference standard. (rsna.org)
  • The most frequent diagnosis was usual interstitial pneumonia (UIP) (n = 7). (nih.gov)
  • Unclassifiable ILDs, autoimmune ILDs, chronic hypersensitivity pneumonitis, sarcoidosis, myositis, Sjögren syndrome, coal worker pneumoconiosis, and idiopathic forms of interstitial pneumonias (eg, idiopathic nonspecific interstitial pneumonia [NSIP]) are among the diseases that may develop a progressive form of chronic fibrosing ILD. (medscape.com)
  • Idiopathic pulmonary fibrosis (IPF) is the most aggressive form of idiopathic interstitial pneumonia (IIP). (ersjournals.com)
  • Asbestosis and environmental causes of usual interstitial pneumonia. (cdc.gov)
  • Recent findings: IPF patients demonstrate a histopathologic pattern of usual interstitial pneumonia. (cdc.gov)
  • In the absence of a known cause or association, a usual interstitial pneumonia pattern leads to an IPF diagnosis, which is a progressive and often terminal fibrotic lung disease. (cdc.gov)
  • Firstly, there are the Idiopathic Interstitial Pneumonias (IIPs) including Idiopathic Pulmonary Fibrosis (IPF), the most common IIP, along with idiopathic non-specific idiopathic pneumonia (iNSIP), acute interstitial pneumonia (AIP) and respiratory bronchiolitis-associated ILD (RB-ILD), to name a few. (springer.com)
  • Acute exacerbations are histologically characterised as diffuse alveolar damage (DAD) superimposed on underlying usual interstitial pneumonia (UIP) [ 3 , 4 ]. (ersjournals.com)
  • Idiopathic interstitial pneumonia should be suspected in any patient with unexplained interstitial lung disease. (merckmanuals.com)
  • 18 F-FDG PET has recently been applied for assessing disease activity in interstitial pneumonia patients ( 11 - 14 ). (snmjournals.org)
  • What is the meaning of interstitial pneumonia? (medicalmarijuana.com)
  • interstitial pneumonia: chronic lung disease affecting the interstitial tissue of the lungs. (medicalmarijuana.com)
  • What is interstitial pneumonia/interstitial thickening? (medicalmarijuana.com)
  • What does interstitial pneumonia mean? (medicalmarijuana.com)
  • Interstitial pneumonia is a disease in which the mesh-like walls of the alveoli become inflamed. (medicalmarijuana.com)
  • Interstitial pneumonia: Another name for Interstitial lung disease (or close medical condition association). (medicalmarijuana.com)
  • The following list attempts to classify Interstitial pneumonia into categories where each line is a subset of the next. (medicalmarijuana.com)
  • Interstitial pneumonia (medical condition): A category of chronic lung diseases characterized by scarring and/or inflammation of the lungs. (medicalmarijuana.com)
  • For example, idiopathic pulmonary fibrosis (IPF) is a clinical term describing a slowly progressive, chronic interstitial pneumonia. (medicalmarijuana.com)
  • Lymphocytic interstitial pneumonia (LIP) is now considered a lymphoproliferative disease. (medicalmarijuana.com)
  • The high-resolution CT and pathologic features of chronic HP frequently overlap with those of nonspecific interstitial pneumonia and usual interstitial pneumonia. (ajronline.org)
  • Furthermore, in some patients the predominant histologic pattern is nonspecific interstitial pneumonia (NSIP) or usual interstitial pneumonia (UIP). (ajronline.org)
  • Surgical biopsy, however, is often needed for the definitive diagnosis of both subacute and chronic HP and for reliable differentiation of chronic HP from idiopathic interstitial pneumonia [ 3 , 4 ]. (ajronline.org)
  • Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and fatal disorder characterized by high-resolution computed tomography (HRCT) and histologic features of usual interstitial pneumonia (UIP) in adults over 50 years of age with exertional dyspnea, abnormal pulmonary function tests (PFTs), and ineffective therapy ( 1 , 2 ). (atsjournals.org)
  • Scarring in the lungs is referred to as pulmonary fibrosis (PF) or Interstitial Pneumonia(IP). (henryford.com)
  • The terms ILD, PF and interstitial pneumonia (IP) are often used interchangeably. (henryford.com)
  • ILD includes lung diseases such as pulmonary fibrosis, non-infectious pneumonia and vasculitis (blood vessel inflammation). (henryford.com)
  • These types of PF are called idiopathic interstitial pneumonia (IIP). (henryford.com)
  • Idiopathic fibrotic nonspecific interstitial pneumonia is also a progressive fibrotic lung disease with a significant mortality, although it has a better prognosis than IPF [ 16 ]. (ersjournals.com)
  • Usual interstitial pneumonia (UIP) refers to a morphologic entity defined by a combination of (1) patchy interstitial fibrosis with alternating areas of normal lung, (2) temporal heterogeneity of fibrosis characterized by scattered fibroblastic foci in the background of dense acellular collagen, and (3) architectural alteration due to chronic scarring or honeycomb change. (medscape.com)
  • According to the 2002 American Thoracic Society (ATS)/European Respiratory Society (ERS) consensus statement, IPF is defined as a distinctive type of chronic fibrosing interstitial pneumonia of unknown cause limited to the lungs and with histologic features of UIP on surgical lung biopsy or certain clinical, radiologic, and pulmonary function test findings in the absence of surgical lung biopsy. (medscape.com)
  • Usual interstitial pneumonia (UIP) is more common in men than in women. (medscape.com)
  • The cause of usual interstitial pneumonia (UIP) in patients with idiopathic pulmonary fibrosis (IPF) is unknown by definition (ie, IPF is defined as idiopathic UIP). (medscape.com)
  • Some patients present with a more acute onset of respiratory symptoms that may mimic the clinical presentation of acute interstitial pneumonia (AIP). (medscape.com)
  • Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia marked by progressive lung fibrosis and a poor prognosis. (bvsalud.org)
  • Recent studies have highlighted the potential role of infection in the pathogenesis of IPF and a prior association of the HLA-DQB1 gene with idiopathic fibrotic interstitial pneumonia (including IPF) has been reported. (bvsalud.org)
  • Methods: We performed a meta-analysis of associations of the HLA region with IPF risk in individuals of European ancestry from seven independent case-control studies of IPF (comprising a total of 5,159 cases and 27,459 controls, including the prior study of fibrotic interstitial pneumonia). (bvsalud.org)
  • Idiopathic Pulmonary Fibrosis IPF is a chronic, progressive fibrosing interstitial pneumonia of unknown cause that primarily occurs in older adults. (medscape.com)
Pneumonias6
Critical Care Med2
  • and Department of Radiology and Center for Imaging Science (K.S.L.) and Division of Pulmonary and Critical Care Medicine, Department of Medicine (M.P.C.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. (rsna.org)
  • He completed his residency in internal medicine at the Albert Einstein Healthcare Network Program in Philadelphia and fellowship in pulmonary/critical care medicine and advanced lung disease/lung transplantation at Stanford University Medical Center in Palo Alto, California. (orlandohealth.com)
Inflammation and fibrosis4
  • Classified into 8 histologic subtypes, all are characterized by varying degrees of inflammation and fibrosis and all cause dyspnea. (merckmanuals.com)
  • Systemic sclerosis (SSc) is a heterogeneous autoimmune disease, characterised by vascular damage, inflammation and fibrosis of skin and various visceral organs. (bmj.com)
  • Interstitial lung disease (ILD) is a rare condition characterized by extensive inflammation and fibrosis mainly involving the pulmonary interstitium or alveoli. (koreamed.org)
  • Aramchol's ability to modulate hepatic lipid metabolism was discovered and validated in animal models, demonstrating downregulation of the three key pathologies of NASH: steatosis, inflammation and fibrosis. (prnewswire.com)
Hypertension8
  • Immunostaining for components of those pathways and mucins were performed on lung tissue obtained from patients with IPF (n=20), chronic obstructive pulmonary disease (n=13), idiopathic pulmonary artery hypertension (n=5) and from organ donors (n=6). (bmj.com)
  • In addition, the potential association between pulmonary hypertension (PH), a disease process which is increasingly recognised as having important implications in IPF patients [ 8 ], and subsequent development of an acute exacerbation has not been evaluated. (ersjournals.com)
  • All patients fulfilled the 2013 American College of Rheumatology/European League Against Rheumatism criteria, had mild ILD at baseline diagnosed by High-Resolution Computed Tomography (HRCT), available baseline and ≥1 annual follow-up pulmonary function tests and no concomitant pulmonary hypertension or airflow obstruction. (bmj.com)
  • Sarcoidosis-associated pulmonary hypertension. (templehealth.org)
  • Human herpesvirus 8 (HHV-8) antibodies were detected in 1 of 33 patients with pulmonary hypertension (including in 1 of 16 with idiopathic pulmonary arterial hypertension), 5 of 29 with cystic fibrosis, and 3 of 13 with interstitial lung disease. (cdc.gov)
  • No relationship between HHV-8 infection and pulmonary hypertension was found. (cdc.gov)
  • Recently, 2 articles from 1 group suggested that HHV-8 has a role in the pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) ( 2 , 3 ). (cdc.gov)
  • HHV-8 latency-associated nuclear antigen-1 and HHV-8 viral cyclin gene were identified in the lung tissue of 10 (62.5%) of 16 patients with IPAH, whereas only 1 (7.1%) of 14 patients with associated pulmonary hypertension (PH) had HHV-8 gene sequences in lung tissue ( 2 ). (cdc.gov)
NSIP1
Sarcoidosis6
Diagnosis5
  • This registry will collect data on the strategies used to achieve a diagnosis of Idiopathic Pulmonary Fibrosis (IPF) and Chronic Fibrosing Interstitial Lung Disease with Progressive Phenotype (ILD) and the treatment and management efforts applied throughout study follow-up, clinical outcome events and patient reported outcome data. (stanford.edu)
  • Speak to us about why you think it's so important for us to make the diagnosis of fibrosing interstitial lung disease early. (medscape.com)
  • Patients with idiopathic pulmonary fibrosis (IPF) experience progressive respiratory failure and have a median survival of less than 3 y after diagnosis ( 1 ). (snmjournals.org)
  • As an illustrative example, the diagnosis of idiopathic pulmonary fibrosis (IPF) among interstitial lung disease (ILD) patients is used for this work. (aaai.org)
  • Grace Hyun J. Kim Domain Knowledge-Assisted Automatic Diagnosis of Idiopathic Pulmonary Fibrosis (IPF) Using High Resolution Computed Tomography (HRCT) (Student Abstract) Proceedings of the AAAI Conference on Artificial Intelligence, 34 (2020) 13979-13980. (aaai.org)
Disease50
  • UIP is thus classified as a form of interstitial lung disease. (wikipedia.org)
  • Some forms of DPLD are related to occupational, environmental, drug, and/or radiation exposure, as well as systemic illness such as collagen-vascular disease (see Interstitial Lung Disease Associated With Collagen-Vascular Disease ). (medscape.com)
  • Pathologically, all DPLDs manifest histologically with disease largely within the interstitial compartment of the lung. (medscape.com)
  • Joshua Mooney, MD, MS, is a board certified pulmonologist and critical care physician who specializes in the care of interstitial lung disease and lung transplant patients. (stanford.edu)
  • He performs health services and outcomes research focused on understanding and improving the lives and care of patients with advanced lung disease and is actively involved in clinical trials to improve outcomes in interstitial lung disease. (stanford.edu)
  • He is director of the Interstitial Lung Disease Program at the University of Southern California in Los Angeles, and professor of interstitial lung disease at Imperial College London. (medscape.com)
  • Ron du Bois is a gentleman and a scholar, and one of the pioneers in the field of interstitial lung disease , and you're so lucky to have that influence. (medscape.com)
  • Drugs used to manage connective tissue disease (CTD) associated with interstitial lung disease (ILD) (CTD-ILD) include nintedanib, corticosteroids, and antineoplastic agents. (medscape.com)
  • Prednisone therapy is best prescribed in consultation with a pulmonary disease specialist. (medscape.com)
  • Nintedanib is indicated to slow the rate of decline in pulmonary function in patients who have interstitial lung disease (ILD) associated with scleroderma. (medscape.com)
  • Interstitial Lung Disease (ILD) is a group of respiratory conditions affecting the lung interstitium often associated with progressive respiratory failure. (springer.com)
  • Idiopathic pulmonary fibrosis (31%) and connective-tissue disease related ILD (21.7%) were the two most common subtypes. (springer.com)
  • Interstitial lung disease (ILD) encompasses a heterogeneous group of respiratory disorders characterised by inflammation and/or fibrosis of the lung interstitium. (springer.com)
  • The aim of this study was to evaluate the risk factors for and outcomes of acute exacerbations in patients with advanced idiopathic pulmonary fibrosis (IPF), and to examine the relationship between disease severity and neovascularisation in explanted IPF lung tissue. (ersjournals.com)
  • The relationship between neovascularisation and disease severity (in terms of histological severity of disease and pulmonary function) has been studied previously [ 9 , 11 ]. (ersjournals.com)
  • In addition, we examined the relationship between neovascularisation and disease severity (in terms of histological tissue type, pulmonary function and PH) in the explanted lung tissue of patients with advanced IPF. (ersjournals.com)
  • Overview of Interstitial Lung Disease Interstitial lung diseases are a heterogeneous group of disorders characterized by alveolar septal thickening, fibroblast proliferation, collagen deposition, and, if the process remains unchecked. (merckmanuals.com)
  • HRCT, which distinguishes airspace from interstitial disease, is the most useful test and is always done. (merckmanuals.com)
  • Objectives To identify the predictive clinical characteristics and establish a prediction model for the progression of mild interstitial lung disease (ILD) in patients with systemic sclerosis (SSc). (bmj.com)
  • 1 Interstitial lung disease associated with SSc (SSc-ILD) is a common complication and leading cause of death in SSc. (bmj.com)
  • Patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) had slower rates of decline in lung function over 1 year when treated with nintedanib (Ofev), an intracellular inhibitor of tyrosine kinases, according to a post-hoc analysis from a larger trial known as INBUILD. (medpagetoday.com)
  • Progressive pulmonary fibrosis is an age-related degenerative interstitial lung disease that affects an increasing number of population in California and worldwide. (ca.gov)
  • He specializes in pulmonary medicine and critical care with a special interest in advanced and interstitial lung disease. (orlandohealth.com)
  • As a specialist in pulmonary medicine and critical care, Dr. Garrido treats patients with injuries or disease of the lungs, trachea, diaphragm and other parts of the respiratory system. (orlandohealth.com)
  • Aberrant vascular remodeling contributes to the progression of many aging-associated diseases, including idiopathic pulmonary fibrosis (IPF), where heterogeneous capillary density, endothelial transcriptional alterations and increased vascular permeability correlate with poor disease outcomes. (researchgate.net)
  • Interstitial lung disease is a term used to refer to a particular type of inflammation of the interstitium of the lungs. (medicalmarijuana.com)
  • Idiopathic pulmonary fibrosis (IPF) is one of more than 130 types of interstitial lung disease (ILD). (nationaljewish.org)
  • How Can Interstitial Lung Disease Phenotypes Guide Care? (medscape.com)
  • To compare survival of patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) versus idiopathic pulmonary fibrosis (IPF) and patients with systemic sclerosis-associated ILD (SSc-ILD) versus other CTD-ILD followed at our center. (jrheum.org)
  • Interstitial lung disease (ILD) represents a heterogeneous group of diseases that involves inflammation and interstitial fibrosis of the lung parenchyma. (jrheum.org)
  • The most common types of ILD include idiopathic pulmonary fibrosis (IPF) and connective tissue disease (CTD)-associated ILD (CTD-ILD). (jrheum.org)
  • H ypersensitivity pneumonitis (HP) is a diffuse granulomatous interstitial lung disease caused by inhalation of various antigenic organic particles [ 1 ]. (ajronline.org)
  • Early recognition of the disease and prevention of long-term antigen exposure are necessary to avoid progression to irreversible fibrosis [ 5 ]. (ajronline.org)
  • BACKGROUND: The burden of nontuberculous mycobacterial (NTM) pulmonary disease (PD) is increasing globally. (koreamed.org)
  • Interstitial lung disease (ILD) is a large group of disorders that can affect the small air sacs (alveoli) or surrounding structures (interstitium) of the lung. (henryford.com)
  • Idiopathic pulmonary fibrosis (IPF) is a type of scarring lung disease without a known cause. (henryford.com)
  • Patients evaluated in the Henry Ford Interstitial Lung Disease Clinic undergo a thorough history and physical exam. (henryford.com)
  • Idiopathic pulmonary fibrosis (IPF) is a severe, chronic, progressive, fibrotic interstitial disease of unknown etiology, which remains an unmet need despite approved treatments which are limited by side effects. (prnewswire.com)
  • I helped establish the British Thoracic Society (BTS) Interstitial Lung Disease Registry, which now holds over 3,000 patient records from 60 centres in the UK. (imperial.ac.uk)
  • Idiopathic pulmonary fibrosis (IPF) is a chronic devastating disease affecting 50 to 300 individuals per million with a median survival time of ∼3 yrs [ 1 ]. (ersjournals.com)
  • however, rheumatologists, interstitial lung disease nurses and a histopathologist were often not available. (asthmafoundation.org.nz)
  • [ 1 ] . Rates of interstitial lung disease are somewhat higher in men than in women, and the epidemiology is markedly affected by age and occupational exposures. (medscape.com)
  • Of patients referred to a pulmonary disease specialist, an estimated 10-15% have a DPLD. (medscape.com)
  • The term UIP is often used interchangeably with idiopathic pulmonary fibrosis (IPF), but other clinical conditions are associated with UIP, although less commonly, including collagen vascular disease, drug toxicity, chronic hypersensitivity pneumonitis, asbestosis, familial IPF, and Hermansky-Pudlak syndrome. (medscape.com)
  • The reported overall prevalence of interstitial lung disease in New Mexico is 80.9 per 100,000 males and 67.2 per 100,000 females, corresponding with annual incidence rates of 31.5 per 100,000 per year in males and 26.1 per 100,000 per year in females. (medscape.com)
  • BACKGROUND: Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease with a variable clinical trajectory. (bvsalud.org)
  • Angiotensin-converting enzyme 1 gene polymorphisms in patients with systemic sclerosis-associated interstitial lung disease: a single centre retrospective observational study. (cdc.gov)
  • A retrospective study was made in Riyadh, Saudi Arabia, on the impact of pulmonary rehabilitation on respiratory parameters and health care utilization in a group of outpatients with chronic lung diseases other than chronic obstructive pulmonary disease. (who.int)
  • Patient data were coded programme included a combination of pulmonary disease (COPD), through at inclusion in the database to preserve a stationary cycle, treadmill, arm ergom- an individually tailored programme of confidentiality. (who.int)
  • Hypersensitivity pneumonitis, also known as extrinsic allergic alveolitis, is an uncommon non-immunoglobulin E (IgE), T-helper cell type 1 (Th1)-mediated inflam- matory pulmonary disease with systemic symptoms resulting from repeated inhalation and subsequent sensitization to a large variety of aerosolized antigenic organic dust particles. (cdc.gov)
Usual interstitial pneumonitis2
  • The term usual interstitial pneumonitis (UIP) has also often been used, but again, the -itis part of that name may overemphasize inflammation. (wikipedia.org)
  • The underlying histopathology of IPF is usual interstitial pneumonitis (UIP). (medscape.com)
Progression3
  • In case of idiopathic pulmonary fibrosis, certain medications like nintedanib and pirfenidone can help slow the progression. (wikipedia.org)
  • A multivariate Cox proportional hazards model showed higher RI-SUV and higher extent of fibrosis score as independent predictors of shorter progression-free survival. (snmjournals.org)
  • TNF-alpha inhibitors were previously investigated as a method for decreasing the progression of fibrosis in patients with IPF. (medscape.com)
Pathogenesis3
Clinical7
  • Since the medical term for conditions of unknown cause is "idiopathic", the clinical term for UIP of unknown cause is idiopathic pulmonary fibrosis (IPF). (wikipedia.org)
  • We've invited a person whose impressive portfolio of clinical and translational research includes among other things, studies of novel compounds for IPF and other interstitial lung diseases (ILDs). (medscape.com)
  • The natural history of idiopathic pulmonary fibrosis (IPF) is not well defined and its clinical course is variable. (ersjournals.com)
  • HP is often difficult to diagnose because the clinical manifestations are nonspecific and the radiologic and histologic patterns can mimic those of other interstitial and small airway diseases [ 2 ]. (ajronline.org)
  • TEL AVIV, Israel , July 7, 2022 /PRNewswire/ -- Galmed Pharmaceuticals Ltd. (Nasdaq: GLMD) ("Galmed" or the "Company"), a clinical-stage biopharmaceutical company for liver, metabolic, fibrosis and inflammatory diseases, announced today results showing significant effects of Aramchol in pre-clinical model of both lung and gastrointestinal (GI) fibrosis. (prnewswire.com)
  • The new findings, together with the robust anti-fibrotic effects demonstrated in clinical studies of patients with NASH and advanced fibrosis could potentially enable Galmed to quickly transition to Phase 2/3 clinical studies with Aramchol in indications with unmet need and faster development pathways. (prnewswire.com)
  • More than 90% of institutions had access to oxygen therapy, pulmonary rehabilitation and advanced care planning, but access to psychological support and clinical trials was limited (53% and 58%, respectively). (asthmafoundation.org.nz)
Connective1
  • For example, connective tissue diseases-associated lung fibrosis is very common and sometimes leads the prognosis, such as in patients with systemic sclerosis or rheumatoid arthritis [ 13 ]. (ersjournals.com)
Lungs3
  • To examine the mechanisms for increased monocyte/macrophage recruitment in IPF and nonIPF interstitial lung diseases (nonIPF) the localization of monocyte chemoattractant protein-1 (MCP-1) was investigated in 14 cases of IPF, seven cases of nonIPF, and seven normal control lungs (CTRL) by immunohistochemistry using a specific anti-MCP-1 monoclonal antibody, F9. (elsevierpure.com)
  • Sustained lung injuries, aging and increased genomic instability, however, make lungs particularly susceptible to dysrepair and fibrosis. (researchgate.net)
  • It is described by scarring (fibrosis) of the lungs. (nationaljewish.org)
Decline in pulmonary function1
Diseases11
  • Some of these diseases cause fibrosis, scarring or honeycomb change. (wikipedia.org)
  • The interstitial lung diseases (ILDs) frequently result in considerable disability and reduced survival in affected patients. (nih.gov)
  • A handout on this topic is available at http://familydoctor.org/familydoctor/en/diseases-conditions/rheumatoid-arthritis.html . (aafp.org)
  • Hypersensitivity Pneumonitis (HP) one of the most common interstitial lung diseases (ILDs) is characterized by exposure to an inhaled inciting antigen that leads to a host immunologic reaction determining interstitial. (koreamed.org)
  • Pulmonary 5-HT 2B receptor expression in fibrotic interstitial lung diseases. (lu.se)
  • Pulmonary fibrosis is a severe condition in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-ILD, where the underlying mechanism is not well defined and with no curative treatments available. (lu.se)
  • As a group, diffuse interstitial diseases of the lung are uncommon. (medscape.com)
  • ABSTRACT Pulmonary rehabilitation is a tool that is receiving more acceptance in chronic lung diseases. (who.int)
  • A group of 51 patients diagnosed with interstitial lung diseases, bronchiectasis, asthma and scoliosis were studied. (who.int)
  • The pulmonary rehabilitation pro- optimize the quality of life of patients tional approval for conducting the study gramme comprised education, exercise with chronic lung diseases (CLD), was obtained from the institutional and psychosocial support. (who.int)
  • of pulmonary rehabilitation in to the asthma, interstitial lung diseases (ILD) Specific exercises for the upper and management of patients with CLD or scoliosis. (who.int)
Hypersensitivity2
  • Can CT distinguish hypersensitivity pneumonitis from idiopathic pulmonary fibrosis? (rsna.org)
  • If we're at a loss to give the patient a precise label - whether it's IPF or nonspecific interstitial pneumonitis or hypersensitivity pneumonitis - we at least now know that if they've got fibrosis that's getting worse, we can come up with treatment options for them. (medscape.com)
Nintedanib1
ILDs2
  • Comorbidities, both pulmonary and nonpulmonary, frequently accompany ILDs and contribute to adverse outcomes. (nih.gov)
  • 2B receptor as a target in lung fibrosis, warranting further consideration in targeting fibrotic ILDs. (lu.se)
Alveolitis2
  • A term previously used for UIP in the British literature is cryptogenic fibrosing alveolitis (CFA), a term that has fallen out of favor since the basic underlying pathology is now thought to be fibrosis, not inflammation. (wikipedia.org)
  • The exaggerated immune response to repeated inhalation of these particles leads to infiltration and proliferation of activated pulmonary macrophages and lymphocytes, resulting in lymphocytic alveolitis and bronchiolitis with noncaseating granulomas. (cdc.gov)
Abnormalities1
  • Most patients display restrictive pulmonary function abnormalities, including reduced lung volumes with relative preservation of airflow, a reduction in the diffusion capacity for carbon monoxide (DLCO) with hypoxemia at rest and/or with exercise. (medscape.com)
Cystic3
Pirfenidone2
Mean pulmonary arterial pressure1
  • Neovascularisation was significantly decreased in areas of honeycombing, and was significantly inversely correlated with mean pulmonary arterial pressure in areas of honeycombing. (ersjournals.com)
Acute exacerbation1
Interstitium1
Differentiation2
  • Abnormal differentiation of the respiratory epithelium is a feature of idiopathic pulmonary fibrosis (IPF). (bmj.com)
  • In this work, pathways governing mucus cell differentiation were investigated in lung tissues from patients with IPF and other chronic pulmonary disorders. (bmj.com)
Progressive1
HRCT1
  • Several physiologic and radiologic parameters that predict poor survival in patients with IPF have been identified, including lower forced vital capacity (FVC), diffusion capacity for carbon monoxide (DL CO ), and extent of fibrosis shown by high-resolution CT (HRCT) ( 8 - 10 ). (snmjournals.org)
Reticular2
  • or bronchiolectasis (dilatation of the terminal bronchioles) Predominantly subpleural and basal Often heterogenous distribution, being occasionally diffuse, and may be asymmetrical There may be superimposed CT features such as mild ground-glass opacity, reticular pattern and pulmonary ossification. (wikipedia.org)
  • Frontal chest radiograph demonstrating bilateral reticular and nodular interstitial infiltrates with upper zone predominance. (medscape.com)
Emphysema1
Lymphocytic1
  • Histologically, subacute HP is characterized by the presence of cellular bronchiolitis, noncaseating granulomas, and bronchiolocentric lymphocytic interstitial pneumonitis. (ajronline.org)
Alveolar1
  • A pattern of diffuse alveolar damage and temporally uniform, nonspecific, chronic interstitial pneumonitis may also be seen [ 1 , 3 ]. (ajronline.org)
Patients diagnosed1
  • The purpose of this study is to compare the effect of n-acetylcysteine (NAC) plus standard care with matched placebo plus standard of care in patients diagnosed with idiopathic pulmonary fibrosis (IPF) who have the TOLLIP rs3750920 TT genotype. (stanford.edu)
Mortality in patients1
  • Our results demonstrate that positive RI-SUV is strongly predictive of earlier deterioration of pulmonary function and higher mortality in patients with IPF. (snmjournals.org)
Parenchyma1
  • It is thought to begin with acute injury to the pulmonary parenchyma, leading to chronic interstitial inflammation, then to fibroblast activation and proliferation, and finally progressing to the common endpoint of pulmonary fibrosis and tissue destruction. (medscape.com)