Idiopathic pulmonary fibrosis and liver cirrhosis. Medical search. Frequent questions

Cystic fibrosis is an inherited disease of the exocrine glands affecting primarily the gastrointestinal and respiratory systems. (msdmanuals.com)
Diagnosis is by sweat test or identification of 2 cystic fibrosis-causing gene variants in patients with a positive newborn screening test result or characteristic clinical features. (msdmanuals.com)
Treatment is supportive through aggressive multidisciplinary care along with small-molecule correctors and potentiators targeting the cystic fibrosis transmembrane conductance regulator protein defect. (msdmanuals.com)
Cystic fibrosis (CF) is a life-threatening genetic disease, which in the United States occurs in about 1/3,300 White births, 1/15,300 Black births, and 1/32,000 Asian American births. (msdmanuals.com)
1. Cystic Fibrosis Foundation Patient Registry 2021 Annual Data Report Bethesda, Maryland 2022 Cystic Fibrosis Foundation. (msdmanuals.com)
It encodes a membrane-associated protein called the cystic fibrosis transmembrane conductance regulator (CFTR). (msdmanuals.com)

The present report concerns the role of adenovirus infection in inducing this transformation in an animal model of chronic obstructive pulmonary disease. (ersjournals.com)
It is postulated that this intermediate phenotype may play a major role in the remodelling of the airways in chronic obstructive pulmonary disease associated with persistence of adenovirus E1A DNA. (ersjournals.com)
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide 1 . (ersjournals.com)
People with disabilities are more likely than those without disabilities to have chronic health conditions, live in shared group (also called "congregate") settings, and face more barriers in accessing health care . (cdc.gov)
By the way, emphysema is another nomenclature us to refer to Chronic Obstructive Pulmonary Disease (COPD) , which I will talk about later. (b2bphonelist.com)
Non-neoplastic smoke-related lung disease: chronic obstructive pulmonary disease, small airways disease/respiratory bronchiolitis, Langerhans cell histiocytosis of the lung. (unibo.it)
Although NASH is one of the most common causes of chronic liver disease in in the U.S., it is a disease that is unfamiliar to many Americans. (cohbar.com)
Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, debilitating, and usually fatal interstitial lung disease that affects approximately 100,000 people in the U.S. This orphan disease results in fibrotic scarring of the lungs. (cohbar.com)
Reduced microRNA-503 expression augments lung fibroblast VEGF production in chronic obstructive pulmonary disease. (musc.edu)
Nuclear lung ventilation/perfusion scanning: This is performed to exclude chronic thromboembolic pulmonary hypertension (Group IV PH). (medscape.com)
Chronic Alcohol Abuse: Complications and Consequences People who chronically abuse alcohol are at increased risk for cirrhosis, GI bleeding, pancreatitis, cardiomyopathy, trauma, mental health disorders, and a wide variety of cancers. (medscape.com)
Idiopathic Pulmonary Fibrosis IPF is a chronic, progressive fibrosing interstitial pneumonia of unknown cause that primarily occurs in older adults. (medscape.com)
A chronic, acquired, idiopathic, progressive eruption of the skin that occurs in the context of RENAL FAILURE. (bvsalud.org)

We believe that the previously reported promising clinical results with these compounds represent significant and meaningful opportunities in severe liver diseases, including decompensated cirrhosis and hepatocellular carcinoma. (itbusinessnet.com)
Patients who develop cirrhosis are at risk for complications including liver failure and liver cancer (hepatocellular carcinoma). (cohbar.com)

IPAH is also termed WHO Group I pulmonary hypertension (PH), precapillary pulmonary hypertension, and, previously, primary pulmonary hypertension. (medscape.com)
PPH is also termed precapillary pulmonary hypertension or, as is currently preferred, idiopathic pulmonary arterial hypertension (IPAH). (medscape.com)

Dr. Michael Charlton, Professor of Medicine and Chief of Hepatology at the University of Chicago, commented, "The Galecto program is forging a new path in liver disease with its focus on patients with decompensated cirrhosis, a very serious condition with high mortality. (itbusinessnet.com)
Finger clubbing also may occur, without evident underlying disease, as an idiopathic form or as a Mendelian dominant trait. (medscape.com)
Liver Disease. (policylab.us)
The purpose of the study is to evaluate how safe and effective an investigational study drug is compared to a placebo (both groups will receive injections, but the placebo contains no active medication) in the treatment of liver disease. (policylab.us)
If you or any of your family members have a confirmed or suspected diagnosis of Alpha-1 Liver Disease, you may be eligible. (policylab.us)
Idiopathic pulmonary fibrosis is a common type of interstitial lung disease that results in scarring of lung tissue. (symptoma.com)
Fibrosis of lungs results in coughing and shortness of breath , two characteristic features of the disease. (symptoma.com)
This is a protein, which is pathologically overexpressed in a long list of disease states where immune suppression and scar formation or fibrosis are the key abnormalities involved. (epicentrx.com)
In the third quarter of 2022, Galecto announced that four of five evaluable myelofibrosis patients in an intermediate assessment experienced a ≥ 1-grade reduction in collagen fibrosis of the bone marrow, an improvement suggesting that GB2064 could impact the progression of the disease and potentially be disease modifying. (galecto.com)
While there are generally no symptoms until late in the disease process, the initial inflammation often leads to fibrosis (scarring) of the liver, which can progress to cirrhosis (advanced, late-stage scarring). (cohbar.com)
Bui Huu H, Ha Thuc N, Thi Le HP, Thi Thanh TD, Luong Bac A, Tiribelli C, Pontisso P, Gallotta A, Paneghetti L, Fassina G. Characterization of SCCA-IgM as a biomarker of liver disease in an Asian cohort of patients. (xeptagen.com)
Approximately 37% of adults, and as many as 70% of individuals with type 2 diabetes (T2D), have nonalcoholic fatty liver disease (NAFLD). (medicalcriteria.com)
Both NAFLD and NASH are also associated with an increased risk of cardiovascular disease, cardiovascular and liver-related mortality, and impaired health-related quality of life. (medicalcriteria.com)
Sullivan S, Jirapinyo P, Kumbhari V. Clinical Care Pathway for the Risk Stratification and Management of Patients With Non-alcoholic Fatty Liver Disease. (medicalcriteria.com)
Further supporting a less stringent transplantation rule are a low rate (about 4%) of death or graft loss in alcohol-related liver disease patients who experience a relapse and lack of significant differences in survival between non-relapsers, occasional drinkers and problem drinkers. (pearls4peers.com)
1 A 2019 multicenter, prospective study in the U.S. also found that early liver transplant for alcohol-related liver disease was associated with comparable patient and graft survival as those without alcohol-related liver disease at 5 years post-transplant but increased risk of death at 10 years. (pearls4peers.com)
Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients. (pearls4peers.com)
Predicting recidivism after orthoptic liver transplantation for alcoholic liver disease. (pearls4peers.com)
Early liver transplantation for alcohol-associated liver disease: need for engagement and education of all stakeholders. (pearls4peers.com)
Medicaid policy and liver transplant for alcohol-related liver disease. (pearls4peers.com)
National trends and long-term outcomes of liver transplant for alcohol-associated liver disease in the United States. (pearls4peers.com)
Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease characterized by elevated pulmonary artery pressure with no apparent cause. (medscape.com)
Equally important, the echocardiogram helps to exclude secondary causes of, or contributors to, pulmonary hypertension, such as left-sided heart disease (eg, left ventricular dysfunction, valvular heart disease). (medscape.com)

The significance of the genetic diagnosis of telomerase-mediated pulmonary fibrosis to lung transplant management has not been examined. (ersjournals.com)

Going forward, Galecto will focus on development opportunities for the treatment of severe liver diseases. (itbusinessnet.com)
In this way, Dr. Reid explained, AdAPT-001 may be used to treat diseases such as cirrhosis of the liver, congestive heart failure, hypertrophic scarring, idiopathic pulmonary fibrosis, and acute respiratory distress syndrome (ARDS), for which the common denominator is an abnormally large amount of fibrosis or scarring from TGF-β overexpression. (epicentrx.com)

For instance, C57BL/6J mice are resistant to hepatic, renal and cardiac fibrosis but susceptible to pulmonary and intestinal fibrosis. (biomedcentral.com)
However, BALB/c mice are resistant to pulmonary fibrosis but susceptible to hepatic fibrosis. (biomedcentral.com)
Nonalcoholic steatohepatitis (NASH), a subtype of NAFLD characterized by inflammation, ballooning, and Mallory's hyaline on liver biopsy, can lead to hepatic fibrosis, cirrhosis, and hepatocellular cancer (HCC). (medicalcriteria.com)

Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. (nature.com)

Pulmonary hypertension is common among patients with idiopathic pulmonary fibrosis. (symptoma.com)
Vascular disorders of the lung: thromboembolism, pulmonary infarction and hemorrhage, pulmonary hypertension (primary and secondary). (unibo.it)
In approximately a third of patients with pulmonary arterial hypertension (PAH), Doppler echocardiography demonstrates right-to-left shunting across a patent foramen ovale. (medscape.com)
Chest radiography: A chest radiograph may help identify secondary causes of, or contributors to, pulmonary hypertension. (medscape.com)
In December 2013, the FDA approved orally administered treprostinil (Orenitram) extended-release tablets for the treatment of pulmonary arterial hypertension in WHO group I patients to improve exercise capacity. (medscape.com)

The result was a significant decrease in the proliferation of the cells but not of lung fibroblasts collected from patients without fibrosis. (worldhealth.net)
As a result of this meeting and in accordance with guidance received from the FDA, Galecto's next step in the development of GB1211 is to initiate a long-term, randomized, placebo-controlled, Phase 2a trial in patients with decompensated NASH cirrhosis, which will evaluate efficacy and tolerability at additional dose levels. (itbusinessnet.com)
Reported data from three additional evaluable myelofibrosis patients in the Phase 2a MYLOX-1 trial with GB2064 for the treatment of myelofibrosis that showed one patient experienced a 1-grade reduction in reticulin fibrosis at nine months and, following an initial increase of collagen fibrosis score of 1 grade at six months, experienced a 1-grade reduction of collagen fibrosis at nine months. (galecto.com)
Because the trial has exceeded the pre-defined target of a ≥ 1 grade reduction in collagen fibrosis in at least three out of 16 evaluable patients, Galecto believes that MYLOX-1 has reached the dual goal of confirming LOXL2 as an attractive fibrosis target and demonstrating that GB2064 has clinically meaningful antifibrotic activity. (galecto.com)
A transplant can allow patients to live a normal, fully functioning life after transplant. (nvdonor.org)
While these findings need to be expanded to other cohorts, caution should be exercised when approaching the transplant evaluation and management of this subset of pulmonary fibrosis patients. (ersjournals.com)
Oxidative stress in the blood of patients with alcohol-related liver cirrhosis. (medscicaserep.com)
Cagnin M, Biasiolo A, Gallotta A, Martini A, Ruvoletto M, Quarta S, Fasolato S, Angeli P, Fassina G, Pontisso P. Low levels of squamous cell carcinoma antigen IgM complexes in serum are predictors of better survival in patients with liver cirrhosis. (xeptagen.com)
In patients with posthepatitis B cirrhosis, allele C in IL-10-819 locus may be related to spleen deficiency with overabundance of dampness syndrome, and TT genotype in IL-10-819 locus may be related to liver stagnation syndrome. (jcimjournal.com)
Although many centers impose a 6-month sobriety rule before patients can be listed for liver transplant, this rule has been increasingly challenged based on the results of more recent studies and ethical issues. (pearls4peers.com)
Outcomes of early liver transplantation for patients with severe alcoholic hepatitis. (pearls4peers.com)
Here we discuss the transformative experimental strategies that are being leveraged to dissect the key cellular and molecular mechanisms that regulate fibrosis, and the translational approaches that are enabling the emergence of precision medicine-based therapies for patients with fibrosis. (nature.com)

Digital clubbing is classified into primary (ie, idiopathic, hereditary) and secondary forms. (medscape.com)

BOSTON, Aug. 15, 2023 (GLOBE NEWSWIRE) - Galecto, Inc. (NASDAQ: GLTO), a clinical-stage biotechnology company and world leader in galectin biology, focused on the development of novel treatments for fibrosis and cancer, today announced topline results from its Phase 2b GALACTIC-1 trial evaluating the safety and efficacy of inhaled GB0139 for the treatment of idiopathic pulmonary fibrosis (IPF). (itbusinessnet.com)
BOSTON , April 28, 2023 (GLOBE NEWSWIRE) -- Galecto, Inc. (NASDAQ: GLTO), a clinical-stage biotechnology company and world leader in galectin biology focused on the development of novel treatments for fibrosis and cancer, today announced its operating and financial results for the quarter ended March 31, 2023 . (galecto.com)

The Galecto team is delivering on development plans for our novel therapies, and we continue to expect top-line results from our Phase 2b GALACTIC-1 trial of our lead product GB0139 in idiopathic pulmonary fibrosis this August. (galecto.com)

Despite this, its prevalence is increasing and by some estimates 27 million Americans will be living with NASH by 2030. (cohbar.com)
NASH is a progressive condition that starts with an excess buildup of fat in the liver, leading to inflammation and liver damage. (cohbar.com)

Genotype-related clinical characteristics and myocardial fibrosis and their association with prognosis in hypertrophic cardiomyopathy. (nature.com)

There is evidence that mouse strain differences influence susceptibility to fibrosis and this appears to be organ specific. (biomedcentral.com)
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. (nature.com)

Typically, the echocardiogram demonstrates evidence of increased pulmonary arterial (PA) pressure, accompanied by an enlarged right ventricle (see the image below). (medscape.com)

The pathway underlies a number of conditions ranging from idiopathic pulmonary fibrosis to scleroderma, kidney fibrosis, and liver cirrhosis. (worldhealth.net)

A total of 44 studies were included covering 21 mouse strains and focusing on fibrosis in the lung, liver, kidney, intestine and heart. (biomedcentral.com)

Symptoms of idiopathic pulmonary fibrosis are nonspecific, with dyspnea and non-productive cough being the most common. (symptoma.com)

Even though IPF remains defined by its idiopathic adjective, its most frequent identifiable genetic cause is inherited mutations in the telomerase genes [ 8 ]. (ersjournals.com)
In humans, a number of genetic factors have been linked to the development of fibrosis in a variety of different organs. (biomedcentral.com)
Such mouse strain studies may prove useful in elucidating the genetic as well as epigenetic factors in humans that could help determine why some people are more susceptible to the development of certain organ specific fibrosis than others. (biomedcentral.com)

Several histologic subtypes are associated with pulmonary arteriopathy in IPAH, one of which involves in situ thrombosis. (medscape.com)

Optimization of a murine and human tissue model to recapitulate dermal and pulmonary features of systemic sclerosis. (musc.edu)
Fibrosis is the formation or development of excess fibrous connective tissue in an organ or tissue as a reparative or reactive process, as opposed to a formation of fibrous tissue as a normal constituent of an organ or tissue. (wikidoc.org)

Cough Suppression Cough can be one of the most vexing symptoms of Idiopathic Pulmonary Fibrosis. (symptoma.com)
The severity of cough is not related to the severity of the fibrosis. (symptoma.com)

Our Pulmonary & Critical Care Medicine faculty participate in clinical trials that are sponsored by the NIH, industry, and the University. (uth.edu)
Below is a listing of our current clinical trials in pulmonary & critical care medicine. (uth.edu)
It has long been thought to be relentlessly progressive and irreversible, but both preclinical models and clinical trials in various organ systems have shown that fibrosis is a highly dynamic process. (nature.com)

It is sometimes accompanied by systemic fibrosis. (bvsalud.org)

Bramstedt KA, Jabbour N. When alcohol abstinence criteria create ethical dilemmas for the liver transplant team. (pearls4peers.com)

Whole-genome studies have provided a useful insight into how gene patterns may influence the development and/or progression of certain pathological pathways, including fibrosis [ 2 ]. (biomedcentral.com)
Fig. 4: Divergent cytokine pathways drive fibrosis. (nature.com)

Lung transplantation is the only intervention that prolongs survival in idiopathic pulmonary fibrosis (IPF). (ersjournals.com)
Idiopathic pulmonary fibrosis (IPF) is progressive and fatal, and lung transplantation is the only therapy that has been shown to prolong survival [ 1 ], [ 2 ]. (ersjournals.com)

Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the industrialized world. (nature.com)

characterized by abnormal levels of liver enzymes. (cdc.gov)

To investigate the relationship between single-nucleotide polymorphisms (SNPs) of interleukin-10 (IL-10) and syndrome types of traditional Chinese medicine (TCM) in posthepatitis B cirrhosis. (jcimjournal.com)

Erupción crónica, adquirida, idiopática y progresiva de la piel que se produce en el contexto de una INSUFICIENCIA RENAL. (bvsalud.org)

The argument for enforcing a 6-month sobriety rule is in part based on earlier studies (often small and/or single center) that reported an association between less than 6 months of sobriety before liver transplantation and relapse. (pearls4peers.com)
5-6 Another frequently cited reason for postponing liver transplantation is to allow the liver enough time to recover from adverse effect of recent alcohol consumption before assessing the need for transplantation. (pearls4peers.com)
Good outcome after liver transplantation for ALD without a 6 months abstinence rule prior to transplantation including post-tranplantation CDT monitoring for alcohol relapse assement- a retrospective study. (pearls4peers.com)
Liver Transplantation 2010;16:91-97. (pearls4peers.com)

Source: Drew, L. Fighting the fatty liver. (cohbar.com)

Asthmatics and people with bronchitis , for example, normally live with their illnesses using bronchodilators or nebulization, and there are pharmacological treatments to control these illnesses. (b2bphonelist.com)
However, despite substantial progress in our understanding of the pathobiology of fibrosis, a translational gap remains between the identification of putative antifibrotic targets and conversion of this knowledge into effective treatments in humans. (nature.com)

Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis. (nature.com)
Defining the activated fibroblast population in lung fibrosis using single-cell sequencing. (nature.com)

Her previous studies examined fibrosis of the bone marrow known as myelofibrosis. (worldhealth.net)

Sickle-cell anemia may cause enlargement and ultimately fibrosis of the spleen . (wikidoc.org)

To rapt attention in a filled-to-capacity conference hall of the San Francisco Marriott hotel, Dr. Tony R. Reid, an invited speaker of a selected abstract at the International American Thoracic Society (ATS) Conference in Fibrosis, and CEO of the San Diego-based biopharmaceutical company, EpicentRx, briefly presented on AdAPT-001. (epicentrx.com)

The research team concluded that the mutation of a specific pathway drives fibrosis in an array of body organs. (worldhealth.net)

Anatomy20

Organisms6

Diseases65

Chemicals and Drugs41

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Psychiatry and Psychology1

Phenomena and Processes24

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Information Science3

Health Care17

Cystic Fibrosis6

Chronic13

Hepatocellular carcinoma2

Precapillary pulmonary hypertension2

Disease23

Diagnosis1

Diseases2

Hepatic3

Epithelial cells1

Hypertension5

Patients12

Primary1

20232

GB01391

NASH2

Hypertrophic1

Susceptibility2

Arterial1

Scleroderma1

Kidney1

Dyspnea1

Genetic3

IPAH1

Tissue2

Cough2

Clinical trials3

Systemic1

Criteria1

Pathways2

Survival2

Organ1

Abnormal1

Syndrome1

Renal1

Transplantation4

Fatty liver1

Treatments2

Fibroblast2

Bone1

Spleen1

Abstract1

Mutation1