Idiopathic orbital inflammatory. Medical search. Frequent questions

It is a benign, nongranulomatous orbital inflammatory process characterized by extraocular orbital and adnexal inflammation with no known local or systemic cause. (wikipedia.org)
Idiopathic orbital inflammation has a varied clinical presentation depending on the involved tissue. (wikipedia.org)
It can range from a diffuse inflammatory process to a more localized inflammation of muscle, lacrimal gland or orbital fat. (wikipedia.org)
Pediatric IOI accounts for about 17% of cases idiopathic orbital inflammation. (wikipedia.org)
proposes that organisms resembling Mollicutes cause orbital inflammation by destroying the cytoplasmic organelles of parasitized cells. (wikipedia.org)
The histopathology of idiopathic orbital inflammation is described as nondiagnostic and diverse. (wikipedia.org)
They include inflammation of the extraocular muscles (myositis) with tendinous involvement, orbital fat stranding, lacrimal gland inflammation and enlargement (dacryoadenitis), involvement of the optic sheath complex, uvea, and sclera, a focal intraorbital mass or even diffuse orbital involvement. (wikipedia.org)
Histopathologic examination showed "idiopathic inflammation": infiltration of the lac-rimal gland by a mixed population of inflammatory cells consisting primarily of mature lymphocytes, as well as eo-sinophils, plasma cells, and neutrophils, without other histologic abnormality. (aao.org)
and idiopathic orbital inflammation. (reviewofophthalmology.com)
Idiopathic inflammatory myopathy is characterized by inflammation of the muscles used for movement ( skeletal muscles ), The primary symptom is muscle weakness, which develops gradually over a period of weeks to months or years, Other symptoms include joint pain and general tiredness (fatigue). (online-sciences.com)
Idiopathic Inflammatory Myopathies are a heterogeneous group of disorders characterized by: Proximal muscle weakness and non-suppurative inflammation of skeletal muscle with predominantly lymphocytic infiltrates. (online-sciences.com)
Idiopathic inflammatory myopathies are characterized by inflammation of muscles (myositis) and other body systems, The diagnosis can be challenging because of the many potential clinical features and extra-muscular manifestations. (online-sciences.com)
In polymyositis, "myos-" refers to the muscles , "poly-" means many, and "-itis" refers to inflammation, so polymyositis is an inflammatory disorder that involves many muscle groups around the body. (online-sciences.com)
Inflammatory orbital disease, also called idiopathic orbital inflammatory syndrome and non-specific orbital inflammation, refers to eye disorders that involve the orbit. (orbit-eyecenter.com)
Computed tomography examination of the orbit revealed diffuse inflammation involving multiple orbital structures. (jhsmr.org)
This article describes a potential causal association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and orbital inflammation. (jhsmr.org)
Dinkin M, Feinberg E, Oliveira C, Tsai J. Orbital inflammation with optic perineuritis in association with COVID-19. (jhsmr.org)
Bilateral orbital inflammation in a 6-month old with SARS-CoV-2 infection. (jhsmr.org)
Idiopathic orbital inflammation: review of literature and new advances. (jhsmr.org)
Important cytoprotective mechanisms activated by oxidative inflammatory conditions are mediated by nitrated fatty acids that covalently modify proteins to limit inflammation and oxidant stress. (aspetjournals.org)
Tolosa-Hunt syndrome (THS) is a painful ophthalmoplegia caused by nonspecific inflammation of the cavernous sinus or superior orbital fissure. (medscape.com)
Nonspecific inflammation (noncaseating granulomatous or nongranulomatous) within the cavernous sinus or superior orbital fissure is the cause of the constant pain, which characterizes the onset of this disorder. (medscape.com)
patients experience unilateral onset of acute orbital pain and ophthalmoparesis, and the disorder may threaten sight if untreated inflammation extends beyond the cavernous sinus to affect the optic nerve. (medscape.com)
TNFα is a cytokine that is involved in inflammatory and immune responses and is more active in people with pathological inflammation. (eyesoneyecare.com)

Pseudotumor cerebri (also known as idiopathic intracranial hypertension) is a syndrome of increased intracranial pressure without a discernable cause. (aetna.com)

Tolosa-Hunt syndrome is typically associated with an inflammatory lesion in the cavernous sinus or orbital fissure, often requiring steroids for symptom resolution. (um.edu.my)
Pathological involvement beyond the cavernous sinus, superior orbital fissure, or apex of the orbit occurs rarely, and the disorder is part of a continuum with idiopathic orbital pseudotumor, with which it shares histopathologic features. (medscape.com)
ICHD-II diagnostic criteria for Tolosa-Hunt syndrome in idiopathic inflammatory syndromes of the orbit and/or the cavernous sinus. (medscape.com)
An ophthalmoplegic syndrome, affecting all age groups, with characteristics of acute attacks (lasting a few days to a few weeks) of periorbital pain, ipsilateral ocular motor nerve palsies, ptosis, disordered eye movements and blurred vision usually caused by a non-specific inflammatory process in the cavernous sinus and superior orbital fissure. (nih.gov)

It is the most common painful orbital mass in the adult population, and is associated with proptosis, cranial nerve palsy (Tolosa-Hunt syndrome), uveitis, and retinal detachment. (wikipedia.org)
Idiopathic orbital inflammatory syndrome, also known as orbital pseudotumor, was first described by Gleason in 1903 and by Busse and Hochheim. (wikipedia.org)
Overall, radiographic features for idiopathic orbital inflammatory syndrome vary widely. (wikipedia.org)
Initial evaluation suggested a possible idiopathic orbital inflammatory syndrome as underlying cause for his symptoms. (bvsalud.org)
In this report, we describe a case of Tolosa-Hunt syndrome preceded by several years' history of idiopathic recurrent facial palsies. (um.edu.my)
The spontaneous resolution of THS in our case as well as prior facial nerve involvement supports the hypothesis that Tolosa-Hunt syndrome is part of a spectrum of idiopathic recurrent cranial neuropathy. (um.edu.my)
Purpose: Orbital pseudotumor (or pseudotumor orbitae) is a benign entity, also known as idiopathic orbital inflammatory syndrome (IOIS), which encompasses a wide range of non-tumoral, space occupying lesions of the orbit. (unicatt.it)
High levels of inflammatory biochemical markers are associated with an increased risk among patients with acute coronary syndrome (ACS). (westjem.com)
The objective of the current study was to evaluate the prognostic significance of the systemic inflammatory response syndrome (SIRS) among ACS patients with no clinical or radiological evidence of congestive heart failure (CHF). (westjem.com)
Burning mouth syndrome (BMS) is an idiopathic condition characterized by a continuous burning sensation of the mucosa of the mouth, typically involving the tongue, with or without extension to the lips and oral mucosa. (medscape.com)
In a classification by etiology or cause, idiopathic burning mouth syndrome (BMS) is considered "primary BMS" (or "true BMS"), whereas "secondary BMS" has an identifiable cause. (medscape.com)

Armstrong BK, Murchison AP, Bilyk JR. Suspected orbital myositis associated with COVID-19. (jhsmr.org)
Mangan MS, Yildiz E. New onset of unilateral orbital myositis following mild COVID-19 infection. (jhsmr.org)

Idiopathic orbital inflammatory (IOI) disease refers to a marginated mass-like enhancing soft tissue involving any area of the orbit. (wikipedia.org)
Orbital pseudotumor has also been observed in association with Crohn's disease, systemic lupus erythematosus, rheumatoid arthritis, diabetes mellitus, myasthenia gravis, and ankylosing spondylitis all of which strengthen the basis of IOI being an immune-mediated disease. (wikipedia.org)
A differential diagnosis includes lymphoproliferative lesions, thyroid ophthalmopathy, IgG4-related ophthalmic disease, sarcoidosis, granulomatosis with polyangiitis, orbital cellulitis and carotid-cavernous fistula. (wikipedia.org)
The best imaging modality for idiopathic orbital inflammatory disease is contrast-enhanced thin section magnetic resonance with fat suppression. (wikipedia.org)
IgG4-related disease ( IgG4-RD ), formerly known as IgG4-related systemic disease , is a chronic inflammatory condition characterized by tissue infiltration with lymphocytes and IgG4 -secreting plasma cells , various degrees of fibrosis (scarring) and a usually prompt response to oral steroids . (mdwiki.org)
type 1 autoimmune pancreatitis , interstitial nephritis , Riedel's thyroiditis , Mikulicz's disease , Küttner's tumor , inflammatory pseudotumors (in various sites of the body), mediastinal fibrosis and some cases of retroperitoneal fibrosis . (mdwiki.org)
What are the Different Types of Inflammatory Orbital Disease? (orbit-eyecenter.com)
There are different types of inflammatory orbital disease based on the region that is affected in your eye. (orbit-eyecenter.com)
Inflammatory orbital disease occurs due to an underlying condition. (orbit-eyecenter.com)
What are the Signs and Symptoms of Inflammatory Orbital Disease? (orbit-eyecenter.com)
How is Inflammatory Orbital Disease Diagnosed? (orbit-eyecenter.com)
Inflammatory orbital disease is diagnosed based on the patient's medical history, eye examination, laboratory tests, and imaging studies such as an orbital MRI (magnetic resonance imaging) or CT (computed tomography) scan. (orbit-eyecenter.com)
What are the Treatment Options for Inflammatory Orbital Disease? (orbit-eyecenter.com)
How can you Prevent Inflammatory Orbital Disease? (orbit-eyecenter.com)
In selected cases of refractory disease or presence of side effects or even comorbidities that limit systemic therapies, radiotherapy could play a role in the management because it has been demonstrated that irradiation is effective in suppressing the inflammatory process. (unicatt.it)
Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory disorder associated with fibrosis and abundant tissue lymphoplasmacytic infiltrations. (hindawi.com)
We strongly recommend considering the diagnosis of GO with elevated IgG4 in patients with an established diagnosis of GD, elevated serum IgG4 levels, and clinical features of ophthalmic disease overlapping with those of IgG4-related orbital disease. (hindawi.com)
It may occur as a monophasic illness, recurrent isolated optic neuritis, and recurrent optic neuritis in the context of multifocal inflammatory CNS disease. (medscape.com)
Eleiwa T, Abdelrahman SN, ElSheikh RH, Elhusseiny AM. Orbital inflammatory disease associated with COVID-19 infection. (jhsmr.org)
The classic/idiopathic type is, per its name, of unclear etiology, although it can be seen in association with upper respiratory tract or gastrointestinal infection, inflammatory bowel disease, or pregnancy. (eyewiki.org)

At this point, our concern shifted from orbital cellulitis to dacryoadenitis, either infectious or inflammatory. (aao.org)
She was initially diagnosed with probable orbital cellulitis secondary to sinusitis. (jhsmr.org)

IgG4-RD likely accounts for most cases of idiopathic retroperitoneal fibrosis. (msdmanuals.com)
Inflammatory MCP-1 and fibrosis (collagen, fibronectin, plasminogen activator inhibitor-1, and osteopontin) renal biomarkers were significantly reduced in the CXA-10 (2.5 mpk) group. (aspetjournals.org)
Anti-fibrotic drugs such as pirfenidone have been developed for the treatment of idiopathic pulmonary fibrosis. (biomedcentral.com)
In 2011, pirfenidone was the first drug approved in Europe for the treatment of idiopathic pulmonary fibrosis [ 18 ] following its approval in the United States in 2014. (biomedcentral.com)

Ophthalmologists should be aware of this presentation when assessing patients with COVID-19 who present with orbital inflammatory symptoms. (jhsmr.org)

Treatment of idiopathic inflammatory orbital pseudotumours by radiotherapy. (bmj.com)

21. Savas A, Deda H, Erden E, Kanpolat Y: Differential Diagnosis of Idiopathic Inflammatory Trigeminal Sensory Neuropathy from Neurinoma with Biopsy: Case Report. (alisavas.com.tr)

It's a strong anti-inflammatory. (totalhealthmagazine.com)
The anti-inflammatory effects of the Cur derivatives were evaluated using macrophage RAW 264.7 stimulated with lipopolysaccharide. (researchgate.net)
The anti-inflammatory and antifibrotic effects, as well as glomerular protection, were not observed in the enalapril-treated group. (aspetjournals.org)
Taken together, these findings demonstrate that, at the appropriate dose, the nitrated fatty acid CXA-10 exhibits anti-inflammatory and antifibrotic effects in the kidney and limits renal injury in a model of CKD. (aspetjournals.org)

Violaceous discoloration of eyelids, often associated with peri-orbital edema (Peri-orbit = Eyelids). (online-sciences.com)

Rheumatologists routinely prescribe and manage patients on Humira for rheumatoid arthritis, juvenile idiopathic arthritis , psoriatic arthritis, ankylosing spondylitis, Crohn's/ulcerative colitis, plaque psoriasis, and hidradenitis suppurativa. (eyesoneyecare.com)

Orbital and adnexal lymphoma is associated with systemic lymphoma in 30-35% of cases. (medscape.com)
The median age at presentation for orbital and adnexal lymphoma is older than 60 years. (medscape.com)
Depending on the site of involvement, ocular lymphoma can be either intraocular or orbital and adnexal. (medscape.com)

Erythema of the upper and lower eyelids did not extend beyond the orbital rim. (contemporarypediatrics.com)

Imaging modalities used in the diagnosis of optic neuritis include orbital MRI and optical coherence tomography (OCT). These tools can be particularly helpful if the clinical history or physical examination findings are atypical for ON. (clevelandclinic.org)

12. Batay F, Savaş A, Ugur HC, Kanpolat Y, Kuzu I: Benign Osteoblastoma of the Orbital Part of the Frontal Bone: Case Report. (alisavas.com.tr)

Side-by-side CT coronal images which demonstrate an expansile soft-tissue and osteolytic lesion involving the right zygoma and orbital space. (reviewofophthalmology.com)

In the setting of extensive sclerosis there may be restriction, compression, and destruction of orbital tissue. (wikipedia.org)

Several studies have described cases where onset of orbital pseudotumor was seen simultaneously or several weeks after upper respiratory infections. (wikipedia.org)

Extramarginal zone lymphomas, which account for most primary orbital and adnexal lymphomas, are characterized by an indolent natural history with frequent, continuous extranodal relapses. (medscape.com)

The patient was diagnosed with orbital spindle cell rhabdomyosarcoma and was referred to the Wills Eye Hospital Ocular Oncology service as well as the Thomas Jefferson University Hospital Otolaryngology and Hematology/Oncology departments. (reviewofophthalmology.com)

Currently, as of 2022, there is no available literature specifying a distinct pathophysiology describing ocular involvement in SS, however it can be assumed that auto-inflammatory mechanisms are involved. (eyewiki.org)

Orbital MRI with and without contrast, performed with fat saturation sequences, generally reveals enlargement and enhancement of the affected optic nerve in the acute setting. (clevelandclinic.org)

When characterizing orbital masses, early and accurate diagnosis is crucial to the patient's prognosis. (abstractarchives.com)

IgG4-RD appears to underlie several fibroinflammatory disorders earlier regarded as idiopathic or isolated [ 5 - 7 ]. (hindawi.com)

Action units such as orbital tightening and ear position are listed across all species, however other facial features and some specific changes are different (i.e. flattening of the nose and cheek regions are observed in rats, in contrast to bulging in mice) 15 , 16 . (nature.com)
However, orbital tightening and whiskers position, that are commonly listed as action units in other species, were not included and a grimace scale for assessing pain in cats using facial expressions has not been published. (nature.com)

The patient underwent an orbital biopsy. (reviewofophthalmology.com)

I'd ask about supplementing with it if you have inflammatory conditions, especially autoimmune ones like rheumatoid, ulcerative colitis, Crohn's and psoriasis. (totalhealthmagazine.com)

However, one study by Mottow-Lippe, Jakobiec, and Smith suggests that the release of circulating antigens caused by local vascular permeability triggers an inflammatory cascade in the affected tissues. (wikipedia.org)
[7] Notably, inflammatory cell markers such as CD3, CD163, myeloperoxidase, metalloproteinases, and vascular endothelial growth factors, are found at higher values in the lesioned skin of SS patients compared to non-SS individuals or those with another neutrophilic dermatoses. (eyewiki.org)

A complete systemic workup was performed to exclude other systemic inflammatory diseases. (jhsmr.org)

Five action units (AU) were identified: ear position, orbital tightening, muzzle tension, whiskers change and head position. (nature.com)

Given that Johnathan had not shown any improvement on IV antibiotics, had a reassuring MRI without abscess, and had no systemic signs of infection, we started him on IV steroids (1 mg/kg) for presumed idiopathic orbital inflam-mation (IOI). (aao.org)

Patients should understand that this is an idiopathic condition that is usually self-limited. (medscape.com)

18. Kanpolat Y, Savas A, Bekar A, Berk C: Percutaneous controlled radiofrequency trigeminal rhizotomy for treatment of idiopathic trigeminal neuralgia: a 25-year experience with 1,600 patients. (alisavas.com.tr)
24 Kanpolat Y, Savas A, Bekar A, Berk C: Percutaneous controlled radiofrequency trigeminal rhizotomy for treatment of idiopathic trigeminal neuralgia: a 25-year experience with 1,600 patients. (alisavas.com.tr)

Anatomy2

Diseases7

Information Science1

Inflammation24

Pseudotumor Cerebri1

Cavernous sinus4

Syndrome11

Myositis2

Disease20

Cellulitis2

Fibrosis4

Symptoms1

Radiotherapy1

Differential diagnosis1

Anti-inflammatory4

Orbit1

Juvenile Idiopathi1

Lymphoma3

Eyelids1

Atypical1

Benign1

Lesion1

Tissue1

Onset1

Adnexal1

Rhabdomyosarcoma1

Ocular1

Acute1

Diagnosis1

IgG4-RD1

Facial2

Biopsy1

Rheumatoid1

Vascular2

Diseases1

Muzzle1

Steroids1

Condition1

Treatment2