CalcificationScrotal calcinosis is a rareMetastaticDystrophic calcinosis cutisRaynaudCutis universalisUniversalisEtiologyPathogenesisInflammatory myopathyDermatomyositisPulmonary fibrosisJuvenileDiagnosisTumoralAutoimmuneJIIMMyositisPatientsSubtypesDepositionBenignInsolubleGranulomatousOccursSymptomsRareRecurrenceAsymptomaticTherapiesDepositsSkinSecondarySurgicalMalesDamageCasesTreatmentMetabolismIncludeManagement
Calcification7
- Idiopathic scrotal calcinosis is a cutaneous condition characterized by calcification of the skin resulting from the deposition of calcium and phosphorus occurring on the scrotum. (wikipedia.org)
- Some believe that calcinosis seen in this lesion is not idiopathic calcification, but rather dystrophic calcification, perhaps related to an epidermal cyst that preceded the lesion. (utoronto.ca)
- It remains unclear whether calcified epidermal cysts are the result of dystrophic calcification of preceding epidermal cysts that are affected by inflammation followed by cystic dilation, calcification, cyst wall rupture, and granulomatous reactions, 1 or if they are truly idiopathic growths without any triggering factor such as foreign body infiltration, metabolic or hormonal disorder, or trauma. (lww.com)
- Calcification of idiopathic calcinosis is usually localized to a specific area such as the genital area or chest [ 1 , 2 ]. (biomedres.info)
- Idiopathic basal ganglia calcification (IBGC) is a rare, intractable disease with unknown etiology. (springeropen.com)
- Idiopathic basal ganglia calcification (IBGC), also called Fahr disease, is a rare and intractable disease. (springeropen.com)
- Using laboratory test results (serum calcium and phosphate levels) and clinical history, calcinosis circumscripta can be further categorized into four subtypes: dystrophic, iatrogenic, metastatic, and idiopathic calcification. (tmu.edu.tw)
Scrotal calcinosis is a rare3
- Idiopathic scrotal calcinosis is a rare, benign entity seen in the scrotum, comprised of calcified nodules, and some areas show foreign body-type granulomatous reaction. (utoronto.ca)
- Idiopathic scrotal calcinosis is a rare benign disease which presents with multiple asymptomatic various sized nodules on the scrotal skin wall. (biomedres.info)
- Idiopathic scrotal calcinosis is a rare metabolic disorder and commonly presents as a solitary skin lesion. (biomedres.info)
Metastatic3
- Calcinosis cutis is classified into 4 major types according to etiology: dystrophic, metastatic, iatrogenic, and idiopathic. (medscape.com)
- It is commonly classified as metastatic, dystrophic, idiopathic or iatrogenic. (medicaljournals.se)
- Calcinosis cutis is a group of idiopathic skin calcifications that are classified into four major types according to aetiology: idiopathic, metastatic, iatrogenic, or injury and dystrophic calcinosis. (biomedres.info)
Dystrophic calcinosis cutis3
- DYSTROPHIC CALCINOSIS CUTIS - Dystrophic calcinosis cutis, the most common form of calcinosis cutis, results from local tissue injury. (medilib.ir)
- Treatment principles - The treatment of dystrophic calcinosis cutis associated with autoimmune connective tissue disease is often difficult. (medilib.ir)
- Although early reports documenting poor wound healing and sinus track formation led to the historical avoidance of surgical procedures for dystrophic calcinosis cutis, subsequent reports suggest that surgery can be effective for some patients. (medilib.ir)
Raynaud2
- A 34-year-old woman with history of scleroderma (CREST variety-ie, calcinosis cutis, Raynaud phenomenon, esophageal motility disorder, sclerodactyly, and telangiectasia) developed dyspnea that worsened upon exertion. (medscape.com)
- Pulmonary arterial hypertension (PAH) is commonly associated with the CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia) syndrome. (wesstong.com)
Cutis universalis1
- These include calcinosis cutis circumscripta, calcinosis cutis universalis, tumoral calcinosis, and transplant-associated calcinosis cutis. (medscape.com)
Universalis1
- The distribution pattern of the calcific deposits enables initial division into calcinosis circumscripta and calcinosis universalis. (tmu.edu.tw)
Etiology2
- See "Calcinosis cutis: Etiology and patient evaluation" . (medilib.ir)
- Inclusion body myositis is a form of idiopathic inflammatory myositis (IIM)of unknown etiology. (rheumaknowledgy.com)
Pathogenesis2
- The pathogenesis of calcinosis cutis is not completely understood and a variety of factors allow for different clinical scenarios to occur. (medscape.com)
- The pathogenesis of idiopathic scrotal calcinosis remains controversial. (biomedres.info)
Inflammatory myopathy3
- Dermatomyositis is an idiopathic inflammatory myopathy with characteristic cutaneous findings that occur in children and adults (see the image below). (medscape.com)
- Muscle biopsy indicative of active idiopathic inflammatory myopathy (IIM) in the past 3 months e. (who.int)
- Receiving a permitted background treatment for idiopathic inflammatory myopathy. (who.int)
Dermatomyositis1
- In the setting of dermatomyositis, calcinosis cutis is associated with longer disease duration, fingertip ulcers, and NXP-2 autoantibodies. (medscape.com)
Pulmonary fibrosis2
- To compare survival of patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) versus idiopathic pulmonary fibrosis (IPF) and patients with systemic sclerosis-associated ILD (SSc-ILD) versus other CTD-ILD followed at our center. (jrheum.org)
- The most common types of ILD include idiopathic pulmonary fibrosis (IPF) and connective tissue disease (CTD)-associated ILD (CTD-ILD). (jrheum.org)
Juvenile3
- We are delighted to announce the first PReS Educational Course on Juvenile Idiopathic Inflammatory Myopathies (JIIM), to be held as a hybrid meeting on 7th-8th September 2023 at the Instituto de Medicina Molecular, Lisbon, Portugal. (pres.eu)
- Juvenile idiopathic inflammatory myopathies (JIIM) are rare, autoimmune chronic muscle diseases of childhood with significant potential long-term morbidity. (acrabstracts.org)
- Juvenile myositis (JDM) diagnosed >5 years from screening or juvenile myositis with extensive calcinosis or severe calcinosis. (who.int)
Diagnosis1
- The diagnosis and evaluation of patients with calcinosis cutis is discussed separately. (medilib.ir)
Tumoral1
- Autoimmune hyperphosphatemic tumoral calcinosis in a patient with FGF23 autoantibodies. (childrensmercy.org)
Autoimmune1
- Treatment of calcinosis - Treatment of calcinosis cutis associated with autoimmune connective tissue diseases involves careful consideration of the need for treatment and the selection of an appropriate treatment regimen. (medilib.ir)
JIIM1
- We were able to identify multiple clinical factors associated with long-term damage and calcinosis when JIIM patients become of adult age, which included specific cutaneous and musculoskeletal features. (acrabstracts.org)
Myositis1
- Bivariate analysis was used to test for associations of 94 clinical, demographic, and laboratory factors with two long-term outcomes: a higher Myositis Damage Index (MDI) and the presence of calcinosis on last evaluation. (acrabstracts.org)
Patients4
- Surgery - Surgical removal of calcinosis may be useful for patients with discrete, symptomatic areas of calcinosis cutis as the primary treatment or as an adjunct to medical therapy. (medilib.ir)
- Duration of therapy - Patients who respond to systemic pharmacologic therapies for calcinosis cutis are often maintained on continuous or intermittent treatment for months to years in an attempt to reduce risk for recurrence of disease. (medilib.ir)
- Calcinosis was present in 55% of patients. (acrabstracts.org)
- [ 22 ] It was found to be significantly more common in patients with idiopathic PAH (IPAH) than in those with CTEPH. (medscape.com)
Subtypes1
- The management of the various subtypes of calcinosis cutis will be reviewed here. (medilib.ir)
Deposition4
- Calcinosis cutis is an uncommon disorder characterized deposition of crystals of calsium phosphate (hydroxyapatite) in the skin in various areas of the body. (biomedcentral.com)
- Calcinosis cutis is an uncommon disorder which results in progressive deposition of insoluble calsium salts (crystals of calcium phosphate, hydroxyapatite) in the skin. (biomedcentral.com)
- Calcinosis cutis consists of deposition of calcium salts within the skin. (medicaljournals.se)
- INTRODUCTION - The term "calcinosis cutis" describes the deposition of insoluble calcium salts in the skin and subcutaneous tissue. (medilib.ir)
Benign1
- Benign condition Slow progression throughout life Lesions remain discrete and do not become confluent Incidence: uncommon Age: children and young adults Scrotal calcinosis was first described in 1883 by Lewinski. (wikipedia.org)
Insoluble1
- In all cases of calcinosis cutis, insoluble compounds of calcium are deposited within the skin due to local and/or systemic factors. (medscape.com)
Granulomatous1
- A literature search in PubMed was performed using the search terms 'granulomatous mastitis', 'idiopathic granulomatous mastitis', 'granulomatous mastitis and immunology', and 'granulomatous mastitis and pathology' for the years 2000-2018. (karger.com)
Occurs1
- Idiopathic scrotal calcinosis usually occurs in males between 20 to 40 years of age. (biomedres.info)
Symptoms3
- The scrotal calcinosis appears, without any symptoms, as yellowish nodules that range in size from 1 mm to several centimeters. (wikipedia.org)
- Do the signs and symptoms of calcinosis cutis warrant treatment? (medilib.ir)
- Decision to treat - Consideration of the severity of the signs and symptoms of calcinosis cutis is important because the response to treatment is variable and unpredictable, and there is risk for treatment-related adverse effects. (medilib.ir)
Rare2
- A few rare types have been variably classified as dystrophic or idiopathic. (medscape.com)
- Scrotal calcinosis: a very rare multiple clinical presentation // Clin. (radp.ru)
Recurrence2
- Surgery should include the removal of even small nodules, to prevent the recurrence of the scrotal calcinosis. (wikipedia.org)
- Because calcinosis cutis are not always well defined, a recurrence of the lesions may occur. (biomedcentral.com)
Asymptomatic1
- Clinical follow-up without intervention to reduce calcium deposits is a reasonable option for calcinosis cutis that is asymptomatic, nonprogressive, unassociated with internal involvement, and of minimal concern to the patient. (medilib.ir)
Therapies1
- A better understanding of the process of calcinosis cutis will lead to therapies to improve patient morbidity. (biomedcentral.com)
Deposits2
- Calcinosis cutis is a term used to describe a group of disorders in which calcium deposits form in the skin. (medscape.com)
- Histological presentations of skin calcinosis in various locations were substantially similar, showing calcium deposits of varying sizes that stained dark blue with Hematoxylin and Eosin (HE) staining and black with von Kossa staining ( Figure 1D ). (biomedres.info)
Skin3
- Calcinosis cutis Skin lesion List of cutaneous conditions Rapini, Ronald P. (wikipedia.org)
- Some people also have hardened bumps under the skin called calcinosis. (myositis.ca)
- Some children have calcinosis (hardened lumps under the skin) or contractures (when muscle shortens and causes joints to stay bent). (myositis.ca)
Secondary1
- The controversy is currently focused on whether the occurrence of calcinosis is idiopathic or secondary to dermoid cysts or sweat gland cysts [ 4 ]. (biomedres.info)
Surgical1
- Medical and surgical treatments are options to cure calcinosis cutis. (biomedcentral.com)
Males1
- Idiopathic scrotal calcinosis typically affects young males, with an onset between adolescence and early adulthood. (wikipedia.org)
Damage1
- Calcinosis cutis with normal laboratory values of calcium and phosphorus and an underlying disease causing tissue damage. (bvsalud.org)
Cases2
- Metabolic and physical factors are pivotal in the development of most cases of calcinosis. (medscape.com)
- some cases are idiopathic. (msdmanuals.com)
Treatment1
- The treatment of calcinosis cutis is often challenging, and the subtype influences the approach to treatment. (medilib.ir)
Metabolism2
- Calcinosis cutis with abnormal calcium and phosphate metabolism and associated with HYPERCALCAEMIA and HYPERPHOSPHATAEMIA. (bvsalud.org)
- Regional brain metabolism differs between narcolepsy type 1 and idiopathic hypersomnia Sleep. (usc.edu)
Include1
- Some infectious granulomas produce 1,25-vitamin D. Infections that may result in calcinosis cutis include onchocerciasis, cysticercosis, histoplasmosis, cryptococcosis, and intrauterine herpes simplex. (medscape.com)
Management1
- Idiopathic scrotal calcinosis, Management, Surgery. (biomedres.info)