Identifying erythroid progenitors. Medical search. Frequent questions

Although donor-derived leukocytes were not detected in CD31 + Sca-1 - recipients, donor-derived erythroid cells were transiently produced during the initial phases of bone marrow recovery. (elsevierpure.com)
These results demonstrate CD31 expression on hematopoietic stem cells throughout ontogeny and identify a population of CD31 + short-term erythroid progenitors cells that confer protection from lethal doses of radiation. (elsevierpure.com)
HOXA9 knockout mice have been shown to develop a reduction in the number of circulating common myeloid progenitor cells, which differentiate into erythroid progenitor cells. (wikipedia.org)
Furthermore, transgenic mice with overexpressed HOXA9 developed a 15-fold increase in the amount of committed progenitor cells in the bone marrow, indicating that overexpressed HOXA9 induces expansion of the HSC population without disrupting differentiation. (wikipedia.org)
Hematopoietic stem/progenitor cells (HSPC) are known to be functionally diverse in terms of their self-renewal potential and lineage output. (lu.se)
erythroid cells after in vitro differentiation, despite having similar frequencies of phenotypic HSC initially. (lu.se)
Ddit3 loss impairs erythroid colony output from multipotent cells, while forcing Ddit3 in granulo-monocytic progenitors (GMPs) enhances self-renewal and impedes differentiation. (lu.se)
and (iii) inhibition of the differentiation and proliferation of erythroid progenitor cells. (haematologica.org)
12 In addition, the immunity-driven down-regulation of erythropoietin receptors on erythroid progenitor cells and the limited availability of iron for heme biosynthesis negatively affect the biological functions of erythropoetin. (haematologica.org)
All recurrent mutations identified in mononuclear cells could be tracked back to the phenotypically defined hematopoietic stem cell (HSC) compartment in all investigated patients and were also present in downstream myeloid and erythroid progenitor cells. (nih.gov)
While in agreement with previous studies, little or no evidence for clonal ( SF3B1 mutation) involvement could be found in mature B cells, consistent involvement at the pro-B-cell progenitor stage was established, providing definitive evidence for SF3B1 mutations targeting lymphomyeloid HSCs and compatible with mutated SF3B1 negatively affecting lymphoid development. (nih.gov)
The goal of the present study was to investigate the potential of ic-MPL dimerization to induce erythropoiesis from human embryonic stem cells (hESC) and to identify the signaling pathways activated by this strategy. (ca.gov)
AKT activation upregulates the GATA-1 and FOXO3 transcriptional pathways with resulting inhibition of apoptosis, modulation of cell cycle and enhanced maturation of erythroid cells. (ca.gov)
MPN-238 Single-Cell RNA Profiling of Myelofibrosis Patients Reveals Pelabresib-Induced Decrease of Megakaryocytic Progenitors and Normalization of CD4+ T Cells in Peripheral Blood. (ox.ac.uk)
Analysis of CD34- cells from myelofibrosis patients identified a significantly lower proportion of CD4+ T cells and increased numbers of erythroid cells at baseline versus HD. (ox.ac.uk)
In vitro analysis has demonstrated suppression of erythroid-committed progenitor cells and multipotential hematopoietic colonies by the virus. (medscape.com)
Cre ;Ai9 line that uniformly marks interneuron progenitors, We therefore collected a set of 15,522 single cells across a developmental timecourse (E13.5, E18, P10), obtaining 3,432 additional P56 cells from a public resource hosted by the Allen Brain Atlas. (authorea.com)
Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development. (ox.ac.uk)
Here, we isolated red blood cells from 5 controls and 5 HX patients carrying an identified and pathogenic PIEZO1 mutation and performed a comparative deep proteomic analysis. (bvsalud.org)
02:14 progenitors that make red blood cells. (yale.edu)
Signaling through SCF/c-Kit has an important role in stimulating myeloid and erythroid production of primitive hematopoietic progenitor cells. (southernbiotech.com)
A variety of cytokines act synergistically with SCF to stimulate proliferation and differentiation of bone marrow progenitor cells. (southernbiotech.com)
For example, SCF plus IL-7 can stimulate the combined myeloid and B cell differentiation of uncommitted hematopoietic progenitor cells. (southernbiotech.com)
CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. (southernbiotech.com)
Then in 1998 he established his research group and identified the differential impact of T helper cytokines on cells targeted by the immune response or chemotherapy. (nfcr.org)
We have shown that embryonic and fetal globin mRNA and peptides are expressed in cultured erythroid cells and in circulating blood cells from newborns, adult non-pregnant women and from men. (hku.hk)
Furthermore, these findings underscore the need for caution in using embryonic and fetal globin chains as markers to identify erythroid cells of fetal origin in maternal circulation for prenatal diagnosis. (hku.hk)
Identifying causal variants and genes from human genetic studies of hematopoietic traits is important to enumerate basic regulatory mechanisms underlying these traits, and could ultimately augment translational efforts to generate platelets and/or red blood cells in vitro. (biomedcentral.com)
CRISPR/Cas9-mediated TPM1 knockout in human induced pluripotent stem cells (iPSCs) enhanced hematopoietic progenitor development, increasing total megakaryocyte and erythroid cell yields. (biomedcentral.com)
To validate this putative candidate gene and to explore its function, we used CRISPR/Cas9 genome editing to discover that cultured TPM1 -deficient induced pluripotent stem cells enhanced hematopoietic progenitor cell formation. (biomedcentral.com)
The transcription factors that control lineage specification of haematopoietic stem cells (HSCs) have been well described for the myeloid and lymphoid lineages, whereas transcriptional control of erythroid (E) and megakaryocytic (Mk) fate is less understood. (ox.ac.uk)
FOG-1-deficient HSCs and preMegEs, the latter normally bipotent for the Mk and E lineages, underwent myeloid transcriptional reprogramming, and formed myeloid, but not erythroid and megakaryocytic cells in vitro. (ox.ac.uk)
Moreover, in human studies, JAK2V617F has been identified in the stem cell-enriched CD34 + CD38 − CD90 + Lin − compartment, common myeloid progenitors, granulocyte-monocyte precursors, and megakaryocyte-erythroid precursors as well as natural killer cells, B cells, and T cells in some patients, confirming its origin in an early hematopoietic progenitor. (oncohemakey.com)
She will also be experimenting with homology directed recombination of JMML intron enhancer mutation into human erythroid progenitor HuDEP-2 cells to test the effect on erythroid differentiation and globin gene expression. (thalassemia.org)
Studies using human hematopoietic progenitor cells demonstrated that AMT was 5- to 7-fold more toxic to human colony-forming units granulocyte-macrophage and burst-forming units erythroid than was AZT. (aspetjournals.org)
The current study evaluated the potential for a select number of environmental contaminants previously detected in the cluster area to induce DNA damage using in vitro assays with hematopoietic stem-cell derived progenitor cells. (cdc.gov)
CD34+ cells were isolated from normal cord blood samples and were cultured for 48-72 hours to generate erythroid progenitor cells. (cdc.gov)
Two respective gene signatures for proliferative cells and hepatocytes were established and used to identify proliferative hepatocytes from HCC and para-carcinoma tissues based on scRNA-Seq data. (biomedcentral.com)
This technique provides an unprecedented opportunity to identify cells in vivo and comprehensively characterize their transcriptomes. (biomedcentral.com)
I identified major functional deficits in pro-inflammatory cytokine levels compared to term cord blood, which were not due to a lack of immune cells. (ubc.ca)
HSC self-renewal capacity and multipotentiality are gradually lost as cells progress through numerous multi- oligo- and uni-lineage intermediates eventually DZNep acquiring either erythroid myeloid or lymphoid identity. (biopaqc.com)
In the molecular level targeted practical studies of solitary or combined transcription factors possess identified DZNep a relatively DZNep small number of key transcription factors that travel differentiation of progenitor cells by directing the sequential establishment of transcriptional programs essential for terminal differentiation 1. (biopaqc.com)
Initial gene expression analysis on 38 human being hematopoietic cell subtypes recognized gene modules and transcription factors circuits active in stem and progenitor cell-enriched fractions and reused HIRS-1 in terminally differentiated cells 7. (biopaqc.com)
These progenitors termed multi-lymphoid progenitors (MLP 13 or lymphoid-primed multipotent progenitors (LMPP 15 by analogy with the mouse system 16 are identified as CD34+CD38?Thy1?CD45RA+ 13 15 or by high expression of L-selectin on CD34+ cells 17. (biopaqc.com)
Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. (cun.es)
In this study, we used single cell RNA sequencing (scRNAseq) to characterize an enriched population of human hematopoietic stem and progenitor cells (HSPCs) obtained from young and elderly healthy individuals. (cun.es)
Using previous findings in healthy cells as a reference, we analyzed scRNA-seq data obtained from patients with myelodysplastic syndrome (MDS) and detected specific alterations of the expression dynamics of genes involved in erythroid differentiation in all patients with MDS such as TRIB2. (cun.es)
We have determined globally the sites of initiation of intergenic lncRNAs in erythroid cells, allowing us to distinguish two similarly abundant classes of transcripts. (biomedcentral.com)
The ability to genetically manipulate hematopoietic stem and progenitor cells (HSPCs) in particular has significantly advanced our understanding of the mechanisms that regulate hematopoiesis and is contributing to the development of novel cellular therapies. (stemcell.com)
Additionally, edited CD34 + cells can be further cultured in conditions stimulating lineage-specific differentiation by combining StemSpan™ media with expansion supplements designed for the expansion and differentiation of progenitors to erythroid, myeloid, megakaryocyte, natural killer (NK), or T cell lineages. (stemcell.com)
Our data show that selective silencing of α-globin expression in erythroid cells is pharmacologically feasible, and IOX1 is a lead compound to developing new therapy to treat β-thalassemia through the novel pathway of downregulating α-globin expression. (haematologica.org)
We first optimized a serum-free, miniature erythroid differentiation system starting from primary human CD34 cells, the exact type of cells we would ultimately like to target in vivo ( Figure 1 ). (haematologica.org)
Human CD34 + hematopoietic stem and progenitor cells purified from umbilical cord or adult peripheral blood were cultured in a two-phase liquid culture system in a serum-free medium for 21 days. (haematologica.org)
Top PDF Morphologic and gene expression criteria for identifying human induced pluripotent stem cells. (1library.org)
Human induced pluripotent stem cells differentiation into oligodendrocyte progenitors and transplantation in a rat model of optic chiasm demyelination. (1library.org)
Efficient commitment to functional CD34+ progenitor cells from human bone marrow mesenchymal stem-cell-derived induced pluripotent stem cells. (1library.org)
Early fate decisions in hematopoietic stem and progenitor cells. (lu.se)
Since the Notch signaling pathway molecules play an important role in differentiation of epithelial cells, it is important to identify the presence of notch signaling molecules in SHED during the process of cell differentiation. (bvsalud.org)
The Notch signaling pathway provides important intercellular signaling mechanisms essential for cell fate specification and it regulates differentiation and proliferation of stem or progenitor cells by para-inducing effects 3-4 . (bvsalud.org)

In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)

Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways. (ox.ac.uk)

Another study found that HOXA9 knockout HSCs displayed a 5-fold impairment to proliferation rate in vitro, as well as delayed maturation to committed progenitors, specifically myeloid maturation, and that normal proliferation and differentiation rates could be reinstated by reintroducing a HOXA9 vector into the culture. (wikipedia.org)
Assessment of stem cell function in vitro as well as in vivo established that only HSCs and not investigated progenitor populations could propagate the SF3B1 mutated clone. (nih.gov)
In vitro studies using serum and immunoglobulin G (IgG) from some patients with transient erythroblastopenia of childhood demonstrated erythroid colony suppression, suggesting an immunologic etiology. (medscape.com)
Our findings may help explain human genetic associations and identify a novel genetic strategy to enhance in vitro hematopoiesis. (biomedcentral.com)
In vitro hematopoietic systems might be improved by identifying novel factors from human genetic studies. (biomedcentral.com)
Thus, our framework stratified relevant functional loci and helped identify TPM1 manipulation as a novel strategy to enhance in vitro hematopoiesis. (biomedcentral.com)
STAT5 activation seems particularly important for JAK2V617F -induced cytokine independence in vitro and erythrocytosis in vivo and is in itself sufficient to support formation of endogenous erythroid colonies, a cardinal feature of PV. (oncohemakey.com)
Progenitor cell function may be measured post-modification by in vitro CFU assays. (stemcell.com)

From these results, it appears that HOXA9 is important in maintaining HSC populations, as well as guiding their differentiation, especially towards myeloid (erythroid and granulocyte) lineages. (wikipedia.org)
Finally, C/EBPs and FOG-1 exhibited transcriptional cross-regulation in early myelo-erythroid progenitors making their functional antagonism a potential mechanism for separation of the myeloid and Mk/E lineages. (ox.ac.uk)

We have previously shown that homo-dimerization of the intracellular component of MPL (ic-MPL) induces erythropoiesis from human cord blood progenitors. (ca.gov)
Recent advances deeply increase our understanding of erythropoiesis control and its deregulation in pathological conditions thanks to the studies of chromatin organization and post-transcriptional regulatory mechanisms occurring during erythroid cell differentiation. (esh.org)
He demonstrated the existence of a key physiological and pathological mechanisms of erythropoiesis regulation by caspase-mediated cleavage of erythroid transcription factors. (nfcr.org)

RESULTS: Analysis of CD34+ HSPCs at baseline demonstrated increased numbers of megakaryocytic, neutrophilic, and erythroid progenitors in myelofibrosis patients compared with HDs and a significant reduction of myeloid and B-cell lineage progenitors. (ox.ac.uk)

The earliest thymic progenitors (ETP) and granulocyte-monocyte progenitors (GMP) long thought to be unilineage retained residual myeloid or lymphoid potential respectively 10 13 14 Importantly recent studies in human wire blood and bone marrow shown the living of early lymphoid-biased progenitors that maintain myeloid but not erythroid potential. (biopaqc.com)

ring sideroblasts represent 15% or more of nucleated erythroid precursors. (medscape.com)
Although dysplasia is limited to the erythroid precursors, neutropenia or thrombocytopenia may be present. (medscape.com)
Most often, the bone marrow is hypercellular with a significant increase in erythroid precursors. (medscape.com)
Ring sideroblasts (see the images below) represent at least 15% of the nucleated erythroid precursors. (medscape.com)
Ring sideroblasts, defined as nucleated erythroid precursors with 5 iron granules or fewer surrounding at least one third of the nucleus, represent 15% or more of the erythroid lineage. (medscape.com)
Acquired pure red blood cell aplasia is a disorder of erythroid precursors that results in an isolated normocytic anemia. (msdmanuals.com)
Diagnosis requires demonstration of peripheral normocytic anemia and a normocellular bone marrow biopsy with absence of erythroid precursors. (msdmanuals.com)

The enrichment of Gata2 target genes in Ddit3-dependent transcriptional responses suggests that Ddit3 functions in an erythroid transcriptional network nucleated by Gata2. (lu.se)
These results identify FOG-1 and GATA-1 as required for formation of bipotent Mk/E progenitors and their E-lineage commitment, respectively, and show that FOG-1 mediates transcriptional Mk/E programming of HSCs as well as their subsequent Mk/E-lineage commitment. (ox.ac.uk)
Complex transcriptional DZNep networks integrated round the GATA1-PU.1 bimodal switch symbolize a paradigm for myeloid vs erythroid lineage specification 2. (biopaqc.com)
One limitation of this study was the lack of highly purified immature progenitor and stem cell populations which precluded dissection of the very first transcriptional events linked to commitment. (biopaqc.com)
In mouse several studies have explained the manifestation of lineage-affiliated transcriptional programs within multilineage progenitors 8-10. (biopaqc.com)
Based on their transcriptional profile, we identified changes in the proportions of progenitor compartments during aging, and differences in their functionality, as evidenced by gene set enrichment analysis. (cun.es)

Moreover, he discovered that chemotherapy-induced anemia is due to the selective destruction of early erythroblasts, while chemotherapy-induced thrombocytopenia from destruction of megakaryocytic progenitors. (nfcr.org)

We present here evidence that ic-MPL dimerization induces erythropoietin (EPO)-independent erythroid differentiation from hESC by inducing the generation of erythroid progenitors and by promoting more efficient erythroid maturation with increased RBC enucleation as well as increased gamma:epsilon globin ratio and production of beta-globin protein. (ca.gov)
Although the pathophysiologic mechanisms underlying RARS are not entirely elucidated, there is compelling evidence of mitochondrial dysfunction in early stages of erythroid maturation, leading to abnormal mitochondrial iron deposition and ineffective hematopoiesis. (medscape.com)

RNA sequencing revealed that genes involved in G protein-coupled receptor (GPCR) signaling were significantly up-regulated in the high-erythroid output donors. (lu.se)
In parallel, we used a version of the SMART-Seq2 protocol to obtain deep sequencing data (4-7,000 genes/cell) from 400 mitotic progenitors. (authorea.com)
Finally, we added data produced using the 10X genomics system for 7,000 postmitotic progenitors with significantly increased sequencing depth (1,500-11,000 UMI/cell, 1,000-4,000 genes/cell), and observed identical branching patterns as in our original Drop-seq dataset. (authorea.com)
RNA-seq can also help to identify novel transcripts, alternately spliced genes, and allele-specific expression. (nature.com)
To identify putative causal genes from these data, we performed computational modeling using available genome-wide association datasets for platelet and red blood cell traits. (biomedcentral.com)
Here, we aimed to identify proliferative hepatocytes from HCC and para-carcinoma tissues, detect differentially expressed genes between the two types of proliferative hepatocytes, and investigate their potential roles in aberrant proliferation. (biomedcentral.com)
These studies support the lineage priming hypothesis which argues that multipotent progenitors communicate before lineage restriction low levels of genes known to be important determinants of unique fates 11. (biopaqc.com)

Furthermore, they developed 60% less myeloid and erythroid colonies in the bone marrow when compared to the wild type. (wikipedia.org)

Accordingly, in the presence of circulating interferon-γ or TNF-α, much higher amounts of erythropoietin are needed to restore the formation of erythroid colony-forming units (CFU-E) in the bone marrow. (haematologica.org)
We investigated the origin of SF3B1 mutations within the bone marrow hematopoietic stem and progenitor cell compartments in patients with MDS-RS. (nih.gov)
The bone marrow microenvironment supports and educates the hematopoietic progenitors. (esh.org)

Hence, there is a clear need to more specifically identify putatively functional sites. (biomedcentral.com)

The findings suggest that during erythroid cell differentiation in newborns and adults, there is a transient recapitulation of sequential globin chain expression as found during embryonic and fetal development. (hku.hk)
5 3 Herein, we have developed and performed a targeted small molecule screen to identify compounds which downregulate α-globin expression. (haematologica.org)
This identified IOX1, a pan-histone demethylase inhibitor, which selectively downregulates α-globin expression without perturbing erythroid differentiation or general gene expression, more specifically β-like globin expression. (haematologica.org)

He performed some of the first studies to identify transcription factors that regulate the gene expression and differentiation of eosinophils, which are known to play a major role in allergic and asthmatic responses. (ubc.ca)
We here use conditional removal of the GATA-1 and FOG-1 transcription factors to identify FOG-1 as required for the formation of all committed Mk- and E-lineage progenitors, whereas GATA-1 was observed to be specifically required for E-lineage commitment. (ox.ac.uk)

To understand how stem lymphoid and myeloid programs are coordinated during hematopoietic differentiation we systematically profiled the transcriptome of MLP in the context of nine additional human being hematopoietic stem and progenitor cell populations for which self-renewal and. (biopaqc.com)

Examples of the former are mast cell deficiency and severe macrocytic anemia while the latter mutation has been identified in mastocytomas. (southernbiotech.com)
Although a relationship between these disorders was originally suggested by Dameshek in 1951, it was not until 2005 that a molecular basis for this was identified, in the form of an acquired activating mutation in JAK2 ( JAK2V617F ). (oncohemakey.com)

29. High throughput screening identifies inhibitors for parvovirus B19 infection of human erythroid progenitors. (wangchembio.org)

In addition, using invitro methylation assay we identified 4 new substrates for PRMT6, extending the involvement of this enzyme to other cellular processes beyond its well-established role in gene expression regulation. (embl.de)

Thus, our work identifies significant changes in the protein content of PIEZO1-HX erythrocytes, revealing a "PIEZO1 signature" and identifying potentially targetable pathways in this disease characterized by a heterogeneous clinical expression and contra-indication of splenectomy. (bvsalud.org)

Consequently, investigation of molecular heterogeneity in the differentiation potential of HSPC is vital to identify novel regulators that affect generation of specific cell types, especially RBC. (lu.se)
In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)
Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets. (ox.ac.uk)
Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution. (ox.ac.uk)
Recent studies identified proteomics as an accurate and high-input tool to study erythroid progenitors and circulating red cell physiology. (bvsalud.org)

Our model identified a joint collection of genomic features enriched at established trait associations and plausible candidate variants. (biomedcentral.com)

As its mechanism of action remains unclear, we identified Chtop-interacting proteins using a biotinylation-proteomics approach. (embl.de)
The EPO-induced post-transfusion RBC recovery improvement was abrogated in irradiated or in macrophage-depleted recipients, but maintained in splenectomized recipients, suggesting a mechanism requiring erythroid progenitors and macrophages, but which is not spleen-specific. (bvsalud.org)

Our findings suggest that GPCR signaling, and particularly the cAMP-related pathway, contributes to the diversity of erythroid potential among UCB donors. (lu.se)
Taken together, these new data demonstrate that our original findings and interpretations were not skewed by technical limitations, and could be fully reproduced from complementary scRNA-seq techniques.Identifying the emergence of distinct subtypes. (authorea.com)

Reviewers #2 and #3 both highlighted that the sequencing depth in our original Drop-seq data could limit the interpretation of our dataset, particularly our finding that mitotic progenitors do not show transcriptomic evidence of fate specification. (authorea.com)

These primary datasets are used to identify and compare proliferative hepatocytes between non-tumor and HCC tissues. (biomedcentral.com)

To identify in an unbiased manner substrates and potential regulators of PRMT6 we have used a yeast two-hybrid approach. (embl.de)
Ddit3 emerges as a regulatory node with positive linkage to erythroid regulators and negative association with myeloid determinants. (lu.se)

however, ErythronDB shows HOXA7 as being insignificantly expressed in all stages of each erythroid lineage. (wikipedia.org)

More than 170 RPS19 gene mutations have been identified in individuals with Diamond-Blackfan anemia. (medlineplus.gov)

While our initial manuscript focused on our unexpected finding that committed progenitor subsets could not be identified in mitotic progenitors, all reviewers requested further analysis of when distinct interneuron subsets first emerge during development, and how heterogeneity in the eminences could be connected to later timepoints. (authorea.com)

A total of 603 proteins were identified among which 56 were differentially expressed (40 over expressed and 16 under expressed) between controls and HX with a homogenous expression profile within each group. (bvsalud.org)

Identifying the causes of treatment resistance and following the dynamics of erythroid response will provide valuable information to improve patients care through the design of innovative clinical trials. (esh.org)

One important cause of impaired erythroid responses in children with SMA is dysregulation in the innate immune response. (ijbs.com)

FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors. (ox.ac.uk)

Anatomy48

Organisms15

Diseases22

Chemicals and Drugs92

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes52

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Cells59

CD341

Megakaryocyte-erythroid1

Vitro8

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Erythropoiesis3

Myeloid and B-cell1

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Precursors7

Transcriptional6

Megakaryocytic Progenitors1

Maturation2

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Populations1

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Assay1

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