• Most DEGs were involved in plant hormone signal transduction, plant-pathogen interaction and phenylalanine metabolism, and the genes significantly up-regulated in PI 114490 at 6 DPI were associated with defense response pathways. (frontiersin.org)
  • The conference "Metabolism 2012: From Signaling to Disease" is part of an annual forum series organized in Heidelberg by the DKFZ-ZMBH Alliance, which is a strategic alliance between the German Cancer Research Center (DKFZ) and the Center for Molecular Biology (ZMBH) at Heidelberg University. (dkfz.de)
  • Disrupted signaling pathways and resulting disruptions in metabolism are more common with increasing age. (dkfz.de)
  • Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
  • In addition to its role in glucose metabolism, this pathway also regulates the redirection of free amino acids to protein synthesis via the mTOR-signaling pathway. (hindawi.com)
  • The discovery of this ancient energy-sensing pathway has already led to fundamental insights into the mechanisms through which all eukaryotic organisms couple their growth to nutrient conditions and metabolism. (salk.edu)
  • A deeper understanding of the key components of this pathway connecting metabolism and cell growth will instruct us how to best exploit these endogenous mechanisms to combat specific forms of cancer and type 2 diabetes. (salk.edu)
  • The KEGG signalling pathway analysis enriched in the ether lipid metabolism. (biomedcentral.com)
  • We identified 150 genes responsive to heat shock including seven HSP genes, six of which belonging to the group of 17 HSP genes enriched in response to heat shock, according to weighted gene co-expression network analysis (WGCNA). (biomedcentral.com)
  • In the upregulated genes, we identified one HSP70 potentially regulated by HSF1 in response to heat shock. (biomedcentral.com)
  • Furthermore, based on differentially expressed genes and WGCNA analyses, we found that the hypoxia signaling pathway was enriched under heat shock conditions. (biomedcentral.com)
  • Analysis of the blue coral transcriptome revealed enrichment of genes involved in stress response, including heat-shock proteins and antioxidants, as well as genes participating in signal transduction and stimulus response. (nature.com)
  • The upregulated DEGs were primarily protein‑coding genes enriched in immune and inflammation response pathways, while the downregulated DEGs were mainly coding long non‑coding (lnc)RNAs, indicating the regulatory function of USF1. (spandidos-publications.com)
  • It was also demonstrated that USF1 directly binds to the promoter region of 2,492 genes, which may be involved in the viral progression and cell proliferation pathways. (spandidos-publications.com)
  • The pathways that are probably regulated by the identified plant phytoconstituents were analyzed using Kyoto encyclopedia of genes and genomes. (ijpsonline.com)
  • Kyoto encyclopedia of genes and genomes pathway identified eight pathways that are directly related to cognitive impairment. (ijpsonline.com)
  • In these organisms the presence of cAMP synthesis and degradation enzymes (AC and PDE, respectively) was demonstrated and genes encoding proteins involved in signal transduction pathway of cAMP were identified. (am-online.org)
  • Currently the sequences of 29 complete genomes of different species of cyanobacteria (and their strains) are known in which different genes connected with cAMP pathway have been identified. (am-online.org)
  • Current studies of cAMP signaling pathway in cyanobacteria may indicate that it is not a universal pathway regulating cell functioning in the genomes of some cyanobacteria AC, PDE, CRP genes and genes whose activity is regulated by CRP were not detected. (am-online.org)
  • With an attempt to help users efficiently identify the candidate biomarkers in cancers, 30 microarray experiments, including 39 cancerous versus normal cells, were analyzed for detecting cancer-specific expressed genes coding for kinases and their substrates. (nih.gov)
  • A total of 2992 differential expressed genes (DEGs) were identified among which 317 and 1334 were up-regulated and 225 and 1116 were down-regulated in the bulk red-vs-bulk pink RNA pools and Y9102-vs-ZH12, respectively. (biomedcentral.com)
  • KEGG analysis indicates that these genes were divided into significantly enriched metabolic pathways including phenylpropanoid, flavonoid/anthocyanin, isoflavonoid and lignin biosynthetic pathways. (biomedcentral.com)
  • In addition, the down-regulation of HCT , IFS , HID , 7- IOMT , and I2'H genes provided an alternative mechanism for promoting anthocyanin accumulation via perturbation of lignin and isoflavone pathways. (biomedcentral.com)
  • Random set analysis was used to identify biological pathways enriched for genes differentially regulated in tumors (compared with 59 samples of normal mucosa). (biomedcentral.com)
  • When comparing statistical tools, the negative binomial distribution-based methods, edgeR and DESeq, respectively identified 11,995 and 11,317 differentially expressed genes from an RNA-seq dataset generated from soybean leaf tissue grown in elevated O 3 . (biomedcentral.com)
  • Differentially expressed genes (DEGs) were identified and analysed. (biomedcentral.com)
  • The Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment was obtained. (biomedcentral.com)
  • A gain of function screen for genes that enable proliferation independently of matrix anchorage identified a cell adhesion molecule PVRL4 (poliovirus-receptor-like 4), also known as Nectin-4. (elifesciences.org)
  • DEGs containing NBS-LRR domain or defense-related WRKY transcription factors were also identified. (frontiersin.org)
  • The volcanic plots in the 4 samples a lot more intuitively show the expression levels of DEGs in gonads from distinctive sexes at two developmental stages (Fig. S4C).Enrichment evaluation of DEGsWe carried out Gene Ontology (GO)/KEGG pathway enrichment evaluation of your DEGs involving the unique groups, and GO functions and KEGG pathways connected with all the DEGs were determined. (trpv1inhibitor.com)
  • By way of important pathway enrichment, the major biochemical metabolic pathways and signal transduction pathways in which DEGs are involved may be determined. (trpv1inhibitor.com)
  • To figure out active biological pathways during the sexual improvement of H. rugulosus, we carried out pathway enrichment evaluation with the DEGs. (trpv1inhibitor.com)
  • Comparison in the 3F group with the 3 M group revealed that the DEGs had been enriched in 340 KEGG pathways. (trpv1inhibitor.com)
  • Comparison on the 3F with the 15F group revealed DEGs that were enriched in 334 KEGG pathways. (trpv1inhibitor.com)
  • Finally, comparison with the 3 M group with all the 15 M group revealed DEGs that have been enriched in 321 KEGG pathways. (trpv1inhibitor.com)
  • We used a molecular pathway-based approach to analyze transcriptomic profiles of 59 colorectal tumors representing early and late preinvasive stages and the invasive stage of tumorigenesis. (biomedcentral.com)
  • Of the 880 canonical pathways we investigated, 112 displayed significant tumor-related upregulation or downregulation at one or more stages of tumorigenesis. (biomedcentral.com)
  • This allowed us to distinguish between pathways whose dysregulation is probably necessary throughout tumorigenesis and those whose involvement specifically drives progression from one stage to the next. (biomedcentral.com)
  • Current efforts in our laboratory are aimed at further identifying the key components of the LKB1-AMPK signaling pathway that suppress tumorigenesis and metabolic disease, as well as decoding the circuits linking fundamental cell biological processes to physiology. (salk.edu)
  • Our data have implications on the link between the metabolic action of insulin signal transduction and tumorigenesis, identifying Akt2 as a potential therapeutical target in liver malignancies depending on cancer genotype. (silverchair.com)
  • Since their discovery, several research groups worldwide have been investigating the metabolic pathways that contribute to the biosynthesis of JAs and accumulation of their precursors, as well as catabolic reactions that transform bioactive hormones into inactive compounds (nicely reviewed by Wasternack & Hause, 2013 and Wasternack & Song, 2017 ). (botany.one)
  • Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
  • Some of thesignaling pathways identified are critical for development, like steroid hormone biosynthesis (ko00140), ovarian steroidogenesis (ko04913), Gnrh signaling pathway (ko04912), cortisol synthesis and secretion (ko04927), estrogen signaling pathway (ko04915), steroid biosynthesis (ko00100), oocyte meiosis (ko04114), and progesterone-mediated oocyte maturation (ko04914). (trpv1inhibitor.com)
  • It has also been revealed that the TTG1/bHLH/Myb transcriptional complex regulates the anthocyanin biosynthesis pathway in Arabidopsis seedlings [ 7 ]. (biomedcentral.com)
  • The biosynthesis of anthocyanin and its derivatives are catalyzed by a number of enzymes through the flavonoid pathway [ 9 ]. (biomedcentral.com)
  • Multicellular organisms (such as animals, plants, and fungi) produce signalling molecules called hormones that move through their bodies to regulate developmental and physiological processes. (botany.one)
  • A case study shows that analyzing the phosphoproteome profile of time-dependent cell activation obtained from Liquid chromatography-mass spectrometry (LC-MS/MS) analysis, the RegPhos deciphered not only the consistent scheme in B cell receptor (BCR) signaling pathway but also novel regulatory molecules that may involve in it. (nih.gov)
  • Mutagenesis signalling molecules cade. (who.int)
  • In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
  • This review describes OR expression in various types of cancer and the association of these receptors with various types of signaling mechanisms. (bmbreports.org)
  • e.g. inflammation, genotoxicity, and This chapter focuses on issues as- ellers, growth factors, growth factor epigenetic alterations) and can have sociated with the understanding and receptors, signal transducers, and both genetic and epigenetic origins. (who.int)
  • Tolerance to thermal stress requires compensation for the metabolic energy used through molecular regulatory processes. (biomedcentral.com)
  • Plant/ crop productivity effected by the environmental strains such as water deficit condition (drought), Low temperature (cold), salt and High temperature (heat) these stresses disturb the signal transduction of gene regulatory systems of plants. (scielo.br)
  • Regarding their predicted biological function, 35% of the proteins modulated by GS are involved in signal transduction pathways, 15% in redox and stress response, and 25% in protein synthesis and folding processes. (biomedcentral.com)
  • This review describes current knowledge about the expression of distinct ORs in cancers, as well as the canonical and non-canonical signaling pathways induced by these ORs. (bmbreports.org)
  • In diabetes, for example, the insulin signal that tells the cell via its insulin receptor to take up glucose from the bloodstream does not function. (dkfz.de)
  • They have also made critical discoveries in identifying transcription factors and signaling components that are responsible for hematopoiesis in Drosophila. (wikipedia.org)
  • Thus, there will be lectures about insulin signaling pathways in Drosophila just as about inflammatory signals in obesity. (dkfz.de)
  • His laboratory has also identified novel means by which different signal transduction cascades combine to distinguish between neural and non-neural cell types. (wikipedia.org)
  • Graphical abstract of the Cell article that studied the external signals that stressed plants emit after drought stress or wounding. (botany.one)
  • JAs derive from polyunsaturated fatty acids, such as α-linolenic acid , through a complex series of metabolic reactions that take place sequentially in different compartments of the plant cell (e.g., chloroplast, peroxisome, cytosol). (botany.one)
  • The aim of this study was to identify S. aucheniae B-cell epitopes suitable for the development of diagnostic methods for SAC sarcocystosis. (mdpi.com)
  • This is mediated by cytokines and other mediators released by the activated immune cells invading the islets, which activate secondary pathways of cell death in the target beta cells. (europa.eu)
  • This Specific Targeted Research Project (STREP) aims to utilise functional genomics to identify pathways responsible for the reduction of beta cell mass in diabetes, and use this knowledge to define targets for intervention to preserve beta cell mass. (europa.eu)
  • This step should identify and validate targets to preserve beta cell mass in diabetes. (europa.eu)
  • These findings validate the proposed systems biology approach to understand the molecular pathways underlying decreased beta cell mass in diabetes mellitus and have provided important information for the development of novel alternatives to preserve beta cell mass in early diabetes. (europa.eu)
  • The role of EGFR signalling in beta cell expansion has been characterised using a Pdx-1-EGFR-dominant negative mouse, developed by members of the consortium. (europa.eu)
  • Role of cAMP pathway in the reaction to environmental factors and in the regulation of cell growth of cyanobacteria. (am-online.org)
  • Chapter 3 Biochemistry and cell biology of calcium channels and signaling involved in plant growth and environmental responses. (globalsciencebooks.info)
  • To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
  • The early preinvasive stage was characterized by cell-cycle checkpoint activation triggered by DNA replication stress and dramatic downregulation of basic transmembrane signaling processes that maintain epithelial/stromal homeostasis in the normal mucosa. (biomedcentral.com)
  • S transition in the cell cycle, upregulated expression of tumor-promoting microenvironmental factors, and profound dysregulation of metabolic pathways (e.g., increased aerobic glycolysis, downregulation of pathways that metabolize drugs and xenobiotics). (biomedcentral.com)
  • As an outcome of the two-part signalling and/or cell-cycle control. (who.int)
  • Activating mutations upstream may also underlie some epigenetic or within the ERK1/2 cascade are events that change cell signalling. (who.int)
  • DeMarini, and Chapter 20, by Rice and cell death determine the size protein in several signal ing path- and Herceg). (who.int)
  • RegPhos 2.0 aims to provide a more comprehensive view of intracellular signaling networks by integrating the information of metabolic pathways and protein-protein interactions. (nih.gov)
  • In the plants being exposed to environmental stresses, ion channels are likely activated to convert these external stimuli into intracellular signals. (globalsciencebooks.info)
  • Participation of cAMP signaling pathway in the regulation of metabolic processes in cyanobacteria cells has been demonstrated by the studies showing a distinct response of these organisms to exogenous cAMP in the medium. (am-online.org)
  • Metabolic adaptations of cancer cells. (hindawi.com)
  • To sustain increased growth, rapidly proliferating cells, such as tumour cells, undergo metabolic adaptations. (silverchair.com)
  • The PI3K (phosphoinositide 3-kinase)/mTOR [mammalian (or mechanistic) target of rapamycin] signalling pathway is a central signalling hub co-ordinating the growth in response to growth factor signalling and nutrient availability. (silverchair.com)
  • In recent years, the mechanisms of glycolysis activation as a key metabolic adaptation in proliferating cells became the topic of intense research. (silverchair.com)
  • Chronically increased calorie intake and resulting obesity is associated with excessive production of signaling substances that attract highly active immune cells, which ultimately leads to metabolic malfunctions in various tissues. (dkfz.de)
  • Overall, the present findings highlight the efficacy of T. parthenium water extract in controlling the inflammatory pathways that occur during cortical-spreading depression. (researchgate.net)
  • DKFZ scientists identify cancer risk factors, investigate how cancer progresses and develop new cancer prevention strategies. (dkfz.de)
  • This is a bioinformatic study revealing the key factors contributed to the metabolic difference between subjects with different endurance activity capacities. (biomedcentral.com)
  • We first identified the bioactive phytoconstituents from Amaranthus tricolor and predicted their potential protein targets involved in the pathogenesis of cognitive dysfunction using BindingDB (p≥0.7). (ijpsonline.com)
  • Thirty nine phytoconstituents were identified in Amaranthus tricolor , five of which were predicted to modulate eight potential protein targets involved in cognitive impairment. (ijpsonline.com)
  • Owing to an increasing number of in vivo phosphorylation sites that have been identified by mass spectrometry (MS)-based proteomics, the RegPhos, available online at http://csb.cse.yzu.edu.tw/RegPhos2/, was developed to explore protein phosphorylation networks in human. (nih.gov)
  • Our work is focused on a highly conserved signal transduction pathway controlled by the AMP-activated protein kinase (AMPK) that, when deregulated, leads to cancer and metabolic disease. (salk.edu)
  • His lab utilizes biochemistry and genetic mouse models to study an ancient signaling pathway that is deregulated in both cancer and type 2 diabetes. (salk.edu)
  • In the present article, we discuss the requirement of different PI3K/mTOR downstream effectors for the metabolic adaptation in liver cancer cells driven by this signalling pathway. (silverchair.com)
  • Banerjee's research focuses on the maintenance of blood stem cells, specifically hematopoietic stem cells that are maintained within a microenvironment where signals from a niche are important for the maintenance of quiescence within a precursor population. (wikipedia.org)
  • However, there is a possibility that their genomes may contain modified, not yet identified sequences encoding individual elements of the cAMP pathway. (am-online.org)
  • Disrupted signal transduction pathways cause various metabolic disorders such as obesity and diabetes. (dkfz.de)
  • They are not only the cause of severe metabolic disorders such as diabetes and arteriosclerosis but also a characteristic or even the cause of a number of cancers. (dkfz.de)
  • In certain metabolic disorders ( ADA and PNP deficiency) enzyme substitution therapy can be applied. (lu.se)
  • intervention in the defective signal transduction pathways identified above using genetically modified mice, long-acting viral vectors and small interfering RNAs. (europa.eu)
  • to other RNAs may initiate epige- cleus pathways. (who.int)
  • Our analysis revealed specific pathways whose dysregulation might play a role in each transition of the transformation process. (biomedcentral.com)
  • Here, quantitative trait loci (QTLs) for UID with high-density genetic maps were identified in five wheat recombinant inbred line (RIL) populations. (chinaagrisci.com)
  • Efforts of this type have already identified several genetic and epigenetic changes that seem to occur at the transition from normal mucosa to precancerous lesions. (biomedcentral.com)
  • Recent studies have identified the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) as a regulator of mitochondrial function in tissues specialized for thermogenesis, such as brown adipose. (jci.org)
  • Results from Banerjee's lab have shown that the "stemness" of these cells is maintained through the combined action of a Niche Signal, that is generated by Hedgehog (Hh), a local signal generated by Wingless/Wnt and a reverse signal from the differentiated cells to the stem cells. (wikipedia.org)
  • Although some immune-related biomarkers can identify individuals at risk to develop T1D, the process by which the beta cells are destroyed is not well understood. (europa.eu)
  • Moreover, PVRL4 triggers a form of signaling between the cells called integrin β4 signaling that allows them to survive without being anchored to the extracellular matrix. (elifesciences.org)
  • Our study identified flavonoids from Amaranthus tricolor as having benefits in managing cognitive impairment and offers a broader scope to mine for potential drug candidates from this natural resource. (ijpsonline.com)
  • This bioinformatic study can help to reveal the key node of improving the metabolic capabilities and thus the performance. (biomedcentral.com)
  • During the 1950s and 1970s, many new bone dysplasias were identified based on clinical manifestations, radiographic findings, inheritance patterns, and morphology of the growth plate. (medscape.com)
  • Pyruvate, which is at the crossroad between lactate production and OXPHOS, constitutes a key metabolic intermediate. (hindawi.com)
  • Earlier work from Banerjee's laboratory identified the Son of sevenless (Sos) gene that links RTKs to the oncogene Ras. (wikipedia.org)
  • We used chemoinformatics to identify the bioactive compounds from Amaranthus tricolor L. a common leafy vegetable and often used in traditional medicine to manage cognitive dysfunction. (ijpsonline.com)