• In addition, the molecular function of some of the described proteins suggests a central role for SVEVs in the cytotoxicity of the snake venom and sheds new light in the envenomation process. (nature.com)
  • All the venomous species have a venom gland that synthesizes, stores and secretes a complex mixture of biological molecules including proteins. (nature.com)
  • By conducting a state-of-the-art interactome study between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and host cells, researchers from the University of Texas MD Anderson Cancer Center in Houston identified 437 human proteins as the high-confidence interacting proteins - with substantial implications for understanding coronavirus disease 2019 (COVID-19) pathology and potential treatments. (news-medical.net)
  • Genome annotation disclosed 29 SARS-CoV-2 gene products - including 16 non-structural proteins, 4 structural proteins and 9 accessory factors. (news-medical.net)
  • The identified proteins were filtered with the use of Significance Analysis of INTeractome (abbreviated as SAINTexpress). (news-medical.net)
  • In short, from a total of 437 high-confidence interacting proteins that bind to one or more SARS-CoV-2 genes, the researchers have identified several gene products, M protein, NSP6, ORF3a, ORF6 and ORF7b that interacted with host cell membrane proteins and complexes. (news-medical.net)
  • Moreover, 314 high-confidence interacting proteins were identified from tandem affinity purification experiments, while 130 of them with the use of BioID2 strategy. (news-medical.net)
  • Here we used an affinity-purification mass spectrometry-based (AP-MS) approach to identify novel and particularly intracellular sGAG-interacting proteins in human bone marrow stromal cells (hBMSC). (degruyter.com)
  • Enrichment analysis for protein localization showed that mainly intracellular and cell-associated interacting proteins were identified. (degruyter.com)
  • By identifying many sGAG-specific interacting proteins, our data provide a resource for upcoming studies aimed at molecular mechanisms and understanding of sGAG cellular effects. (degruyter.com)
  • The identification of the intracellular sGAG-interacting proteins could help to unravel these functions. (degruyter.com)
  • Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. (bioone.org)
  • RNA alternative splicing (AS) is an important post-transcriptional mechanism enabling single genes to produce multiple proteins. (nature.com)
  • The findings from the O'Donnell Brain Institute open new paths of research into how CLOCK proteins produced by the CLOCK gene affect brain function and the processes by which neurons find their proper place in the brain. (cshlpress.com)
  • The findings prompted further questions about what these body-clock proteins were doing in a neural region that is not traditionally considered a hub for circadian rhythm function. (cshlpress.com)
  • For some genes, the abundance of the circular RNA exceeds that of the associated linear mRNA by a factor of 10, raising the interesting possibility that the function of some protein-coding genes may actually be to produce circular noncoding RNAs, not proteins. (bcm.edu)
  • Using RNAi screening in Drosophila cells, we identified many hnRNPs, SR proteins, core spliceosome, and transcription termination factors that control the outputs of reporter and endogenous genes. (bcm.edu)
  • Research leader Ruan Elliott said his team studied "gene expression", the process by which genes are activated to make proteins that in turn carry out a range of functions in the body. (nutraingredients.com)
  • The functional repertoire of the identified interactome reveals interactions between proteins functioning in well-conserved as well as plant-specific biological processes. (ugent.be)
  • Gene ontology functional enrichment analysis was performed using search tool for the retrieval of interacting genes/proteins. (ijpsonline.com)
  • During my PhD studies I identified two such proteins - the Sad1/Unc84 (SUN) domain proteins. (brookes.ac.uk)
  • This includes finding out what other proteins the SUNs bind to and what functions they have during cell division. (brookes.ac.uk)
  • Protein-protein interaction (PPI) networks and modules were constructed to identify hub genes with the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape. (researchsquare.com)
  • Plant intracellular nucleotide binding and leucine-rich repeat proteins (NB-LRR, NLRs) function as immune receptors to detect microbial pathogens directly or indirectly. (ubc.ca)
  • In chapter 2, by using CRISPR/Cas9 gene editing, genetic analysis and biochemical assays, I identified the differential pairings of typical NLR receptor SOC3 with atypical NLR proteins CHS1 or TN2 to guard the homeostasis of the E3 ligase SAUL1. (ubc.ca)
  • Recent advances in technology allow scientists to study of the basic components of biological systems-genes, proteins, and other molecules-together as a group instead of one at a time. (nih.gov)
  • It has paved the way for studying how genes regulate the most basic functions of the cell, including what proteins to produce and how to make them. (cdc.gov)
  • New insights into the genome have led to the emergence of proteomics , the study of the structure and function of an individual's entire set of expressed proteins. (cdc.gov)
  • When a cell is perturbed, it responds by altering expressing levels of specific proteins and adjusting cellular functions in response to the new environmental stimuli. (cdc.gov)
  • In 2014, scientists developed a draft map of the human proteome , which catalogued proteins encoded by over 17,000 human genes, or about 84% of all protein-coding genes in the human genome. (cdc.gov)
  • There, I visited Dr. Mark Hahn's lab and performed functional analyses of the Atlantic salmon AHR genes and their expressed proteins in order to find out more about their role in the mediation of toxicity from dioxin exposure. (lu.se)
  • Genes are stretches of DNA that encode for the proteins that literally run our bodies and brains. (medscape.com)
  • We calculated the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment scores of all fibrotic disease genes. (frontiersin.org)
  • In addition, using Kyoto Encyclopedia of Genes and Genomes database, 191 metabolic pathways were identified. (figshare.com)
  • The pathways that are probably regulated by the identified plant phytoconstituents were analyzed using Kyoto encyclopedia of genes and genomes. (ijpsonline.com)
  • Kyoto encyclopedia of genes and genomes pathway identified eight pathways that are directly related to cognitive impairment. (ijpsonline.com)
  • Then, the DEGs were analysed to identify biological pathways of dental pulp inflammation with Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and Gene Set Enrichment Analysis (GSEA). (researchsquare.com)
  • Second, most disease-causing mutations occur within a gene's coding or regulatory regions and affect the function of the protein encoded by the gene. (utah.edu)
  • Unlike mutations, SNPs are not necessarily located within genes, and they do not always affect the way a protein functions. (utah.edu)
  • Those gene variants, or mutations, also interfered with larger-scale functioning of the brain, interfering with communication among layers and hemispheres, a phenomenon confirmed by previous study of the autistic brain, according to Geschwind. (medicaldaily.com)
  • The researchers compared sequencing data to look for genetic differences and identify new loss-of-function mutations-which are rarer, but have a more severe effect on ordinary gene function-in cases of schizophrenia that had not been inherited from the patients' parents. (science20.com)
  • They found an excess of such mutations in a variety of genes across different chromosomes. (science20.com)
  • These mutations were also found to occur more frequently in genes with a low tolerance for genetic variation. (science20.com)
  • Taking a closer look at severe loss-of-function mutations revealed the contribution of both inherited (yellow pieces) and new (red piece) mutations to the puzzling genetic architecture of schizophrenia. (science20.com)
  • These mutations are important signposts toward identifying the genes involved in schizophrenia," said Dr. Karayiorgou. (science20.com)
  • They were able to verify two key damaging mutations in a gene called SETD1A, suggesting that this gene contributes significantly to the disease. (science20.com)
  • By combining the mutational data from this and related studies on schizophrenia, the authors found that "chromatin regulation" was the most common description for genes that had damaging mutations. (science20.com)
  • A clinical implication of this finding is the possibility of using the number and severity of mutations involved in chromatin regulation as a way to identify children at risk of developing schizophrenia and other neurodevelopmental disorders," said Dr. Gogos. (science20.com)
  • To maximize the potential disease relevance, genes with a genome-wide significant excess burden of loss-of-function mutations in NPDs such as intellectual disability/developmental delay, autism spectrum disorder, and schizophrenia are the focus. (nih.gov)
  • Phylogenetic analysis of the VP2 gene showed that amino acid and nucleotide mutations promoted the evolution of FPV and CPV lineages. (bvsalud.org)
  • Certain gene mutations are one culprit in this toxic accumulation. (medscape.com)
  • Denys-Drash syndrome (DDS) is a rare disorder consisting of the triad of congenital nephropathy, Wilms tumor , and intersex disorders resulting from mutations in the Wilms tumor suppressor ( WT1 ) gene. (medscape.com)
  • Denys-Drash syndrome is the result of mutations in the WT1 gene on chromosome band 11p13. (medscape.com)
  • Point mutations in the WT1 gene result in loss of its regulatory function, with the consequent abnormalities in glomerular formation and gonadal differentiation seen in Denys-Drash syndrome. (medscape.com)
  • Mutations that disrupt the second alternative splicing site of the WT1 gene alter the normal ratio of KTS-positive/negative isoforms from 2:1 to 1:2 and result in abnormalities in glomerular formation and gonadal differentiation seen in Frasier syndrome. (medscape.com)
  • Transcription factors (TFs) drive gene expression programs that shape specific phenotypes [ 3 ], and are frequently dysregulated in cancer [ 4 ]. (aging-us.com)
  • Thus, MRs comprise typically a small number of TF-encoding genes (and their products) that control a disproportionate level of gene expression, giving rise to distinct molecular phenotypes associated with a particular disease. (aging-us.com)
  • Since the expression of genes defining discrete phenotypes is highly coordinated, application of reverse engineering algorithms to transcriptome datasets allows interpreting transcriptional networks by defining MRs and their associated regulons and gene circuits. (aging-us.com)
  • While it is anticipated that assays should aim to characterize 100-250 genes, some phenotypes and assay formats may be more amenable to moderate scale screening against a subset (50-100) of the gene set. (nih.gov)
  • The identification of causal or predictive variants/genes/mechanisms for disease-associated traits is characterized by 'complex' networks of molecular phenotypes. (researchgate.net)
  • Genomewide association studies (GWAS) are increasingly used to detect novel genes and genetic elements associated with bacterial phenotypes, which may provide insight for future preventive strategies and control measures ( 9 - 12 ). (cdc.gov)
  • In brief, traditional GWAS methods can be used to identify large numbers of common genetic variants, usually single-nucleotide polymorphisms (SNPs), to determine the genetic basis of bacterial phenotypes of interest. (cdc.gov)
  • These new modules include extended and platform-independent functional analysis, featuring gene ontology and gene set enrichment, as well as functionality for seamless integration of data from different platforms that make, for example, validation of array or RNAseq results with qPCR or integration of miRNA expression with their corresponding target genes easily available. (scientific-computing.com)
  • By identifying target genes for where toxic responses originate we can make better predictions about resulting effects both on a short and long term scale. (lu.se)
  • Exons 1-6 of the WT1 gene encode the regulatory domain, which regulates expression of target genes, and exons 7-10 encode the 4 zinc fingers of the DNA-binding region of the WT1 protein. (medscape.com)
  • Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene. (wikipedia.org)
  • This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. (wikipedia.org)
  • The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. (wikipedia.org)
  • The researchers have also built an interaction network by utilizing the 437 identified virus-host protein-protein interactions, which enabled all the complex analyses that they have pursued. (news-medical.net)
  • The transmembrane domain prediction also indicated that these viral gene products contain at least one transmembrane domain in their protein sequences - with the exception of ORF6, which is actually a short protein with only 61 amino acids. (news-medical.net)
  • Linked SNPs (also called indicative SNPs) do not reside within genes and do not affect protein function. (utah.edu)
  • Causative SNPs affect the way a protein functions, correlating with a disease or influencing a person's response to medication. (utah.edu)
  • Coding SNPs , located within the coding region of a gene, change the amino acid sequence of the gene's protein product. (utah.edu)
  • We present evidence for the de novo origin of the Wookiee wookiee protein-coding gene GLABR since their divergence from humans. (ubc.ca)
  • This gene has no protein-coding homolog in any other genome but its presence is supported by evidence from expression and hybridization data. (ubc.ca)
  • To begin, we hypothesize that distinct morphological features, in other words, hairiness are a result of Wookiee specific protein-coding gene(s). (ubc.ca)
  • For example, the current Ensembl version proposes a Chiss ortholog of BLU31 (gene responsible for their characteristic blue skin), but further investigation concluded that the "gene" lacks possible introns and thus cannot produce any resemblance of a protein in wookiee. (ubc.ca)
  • The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Deep sequencing has revealed thousands of eukaryotic protein-coding genes that defy the central dogma, producing circular noncoding RNAs rather than linear messenger RNAs. (bcm.edu)
  • In total, these results indicate that inhibition or slowing of canonical pre-mRNA processing events shifts the steady-state output of protein-coding genes towards circular RNAs, which likely helps explain why and how circular RNAs show tissue-specific expression profiles. (bcm.edu)
  • While the long-term goal of the SSPsyGene Consortium is to build a comprehensively annotated resource describing the CNS function of all neurodevelopmental and psychiatric disorder risk genes, the current target for the initiative is 100-250 protein coding genes. (nih.gov)
  • The goal of this initiative is to fill a very specific knowledge gap area, which is that many protein-coding genes are now associated with NPD risk, but their basic neurobiology remains poorly understood. (nih.gov)
  • Localization, biological process, and co-expression data are used as powerful indicators for protein-protein interactions. (ugent.be)
  • Through this approach, a high number of novel protein-protein interactions with diverse biological roles is discovered. (ugent.be)
  • De Bodt S, Proost S, Vandepoele K, Rouzé P, Van de Peer Y. Predicting protein-protein interactions in Arabidopsis thaliana through integration of orthology, gene ontology and co-expression. (ugent.be)
  • We first identified the bioactive phytoconstituents from Amaranthus tricolor and predicted their potential protein targets involved in the pathogenesis of cognitive dysfunction using BindingDB (p≥0.7). (ijpsonline.com)
  • Thirty nine phytoconstituents were identified in Amaranthus tricolor , five of which were predicted to modulate eight potential protein targets involved in cognitive impairment. (ijpsonline.com)
  • Proteomics is highly linked to genomics, since the blueprint for each protein is inscribed on an organism's genes. (cdc.gov)
  • The life cycle of a protein starts with a blueprint transcribed from a gene, followed by folding, which translates the blueprint to a three-dimensional structure that allows it to carry out its biological function, and ends with degradation. (cdc.gov)
  • Some challenges for translating proteomics include technical issues in measuring proteomic markers, identifying clinically useful markers in patient samples, the need for large sample sizes to be able to distinguish protein variability among samples, and challenges in implementing strict protocols for sample handling. (cdc.gov)
  • The WT1 protein mediates the mesenchymal-epithelial transition and differentiation during morphogenesis of the kidney and gonad by repressing genes that encode cell proliferation factors and by activating genes that encode markers of epithelial cell differentiation. (medscape.com)
  • Multiple transcript variants encoding distinct isoforms have been identified for this gene. (wikipedia.org)
  • Other alternative splice variants have been described but their biological nature has not been determined. (wikipedia.org)
  • Now, investigators from the University of California, Los Angeles, say they've developed a map describing genetic variants - "risk genes" - associated with the development of autism spectrum disorder (ASD), in addition to those implicated in neural disturbances unrelated to the disorder. (medicaldaily.com)
  • Identifying gene variants that boost risk is only the first step of unraveling a disease," Geschwind said in a statement . (medicaldaily.com)
  • Investigator Neelroop Parikshak said that the team found gene variants expressing themselves in the developing brain as cells that determined their future roles in the neural circuitry. (medicaldaily.com)
  • Recent studies have identified common and rare genetic variants associated with both sporadic and familial forms of pulmonary fibrosis. (medscape.com)
  • [ 6 ] A recent resequencing study confirms that host defense and cell senescence gene variants contribute to the risk of IPF. (medscape.com)
  • ADGCs supported in Phase 2 of the initiative will be involved in continued efforts to refine and expand the list, as well as developing a rigorous, data-informed approach for selecting patient variants in allelic series from a subset of NPD risk genes. (nih.gov)
  • In order to investigate the origin of CPV-2 variants in cats, we amplified full-length VP2 genes from seven fecal samples of dogs infected with CPV-2, which were further classified as CPV-2c. (bvsalud.org)
  • However, considering the high genomic plasticity of many species of bacteria, traditional GWAS methods can only partially identify the phenotype-associated genetic variants. (cdc.gov)
  • For instance, scientists can identify molecular functions, biological processes or reported diseases that are correlated with the underlying experiment. (scientific-computing.com)
  • These predicted genes may have applications in molecular breeding programs and wheat drought and salinity research. (figshare.com)
  • We now have evidence that CLOCK regulates many genes outside of circadian rhythms, so we can place it as a key point in the hierarchy of important molecular pathways for human brain development and evolution. (cshlpress.com)
  • Parikshak emphasized that ASD should be considered distinct on the molecular level from intellectual disability, even though they share common risk genes. (medicaldaily.com)
  • Identification of master regulator (MR) genes offers a relatively rapid and efficient way to characterize disease-specific molecular programs. (aging-us.com)
  • Chromatin is the molecular apparatus that packages DNA into a smaller volume so it can fit into the cell and physically regulates how genes are expressed. (science20.com)
  • We carried out a series of bioinformatics studies with the phytoconstituents of Amaranthus tricolor to elicit their possible molecular functions in cognitive disorders including Alzheimer's disease. (ijpsonline.com)
  • Gene ontology functional enrichment analysis revealed twenty eight biological processes and 10 molecular functions associated with cognitive impairment. (ijpsonline.com)
  • Our study was limited to computer simulations and calls for wet lab validation of the predicted molecular functions. (ijpsonline.com)
  • In the last few decades, high-throughput technologies using various "omics" have enabled unprecedented views of biological systems at the molecular level. (energy.gov)
  • Gradually, I changed methodologies, biochemical, molecular biological and physiological, and I have had the pleasure of being part of how plant respiration over time has proven to be involved in many fundamental life processes, developing a more integrated view of plant metabolism. (lu.se)
  • A second function is comparative analysis which, using an integrative module, allows scientists to integrate and compare results from different experiments for the purpose of validation, as an example. (scientific-computing.com)
  • Scientists are identifying, cataloging, and studying small genetic variations among humans that will lead to more specialized and effective medical treatments. (utah.edu)
  • The challenge for scientists is to identify SNPs that correlate with a particular effect in patients. (utah.edu)
  • Each project involves hundreds of scientists, who compare the genomes of numerous individuals to identify the differences. (utah.edu)
  • Scientists interested in a particular process select genes known to be involved in the process and examine them in people who have a response or disease, as well as those who don't. (utah.edu)
  • By comparing people's DNA sequences, scientists can identify SNPs that correspond with a particular function or response. (utah.edu)
  • While scientists have extensively explored the anatomy and function of memory, its biological basis remains a mystery. (sfn.org)
  • A study of how genes vary between individuals could help determine how to adjust the nutritional content of foods to suit individual diets, according to UK scientists. (nutraingredients.com)
  • While we all share the same genetic code, how those genes express themselves at an individual level presents a challenge for scientists in developing medicines and dietary advice. (nutraingredients.com)
  • In this paper, ARS scientists collaborated with scientists at the Gyeongsang National University in South Korea to clone and study biological function of important duck cytokine, IL-17 which is involved in the control of host innate immunity to many viral diseases such as avian influenza. (usda.gov)
  • In this report, scientists first identified duck IL-17 gene and studies its evolutionary closeness to chicken IL-17 gene. (usda.gov)
  • They can act as biological markers, helping scientists locate genes that are associated with disease. (medlineplus.gov)
  • Indeed, all sequenced genomes, both microbes and plants, contain large numbers of genes of "unknown function" that significantly limit scientists' ability to model, predict, and engineer organisms with enhanced functions relevant to DOE. (energy.gov)
  • Scientists find more and more that biological processes driven by these components are extremely interconnected, and alteration in one component of the system can have dramatic and difficult-to-predict effects on many of the other components. (nih.gov)
  • As increasing number of next-generation sequencing (NGS) datasets are being produced from various-omics initiatives, transcriptome sequencing of flora and fauna for a specific developmental stage/condition gains its popularity in biological research. (nature.com)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Since strong consensus regarding commonly altered MRs in hepatocellular carcinoma (HCC) is lacking, we generated a compendium of HCC datasets from 21 studies and identified a comprehensive signature consisting of 483 genes commonly deregulated in HCC. (aging-us.com)
  • By integrating different datasets from the Gene Expression Omnibus (GEO) database, we analysed a merged expression matrix of pulpitis, aiming to identify biological pathways and diagnostic biomarkers of pulpitis. (researchsquare.com)
  • By integrating two datasets (GSE77459 and GSE92681) in the GEO database using the sva and limma packages of R, differentially expressed genes (DEGs) of pulpitis were identified. (researchsquare.com)
  • In parallel, the integration of omic datasets using computational modeling has provided new understanding of biological processes in organisms relevant to the U.S. Department of Energy's (DOE) missions in energy and the environment. (energy.gov)
  • However, as high-throughput omic technologies and integrative systems biology efforts have improved our understanding of some biological systems, analyzing and finding meaningful answers within these massive datasets remain extremely challenging, in large part due to the lack of fundamental knowledge of gene function. (energy.gov)
  • This "bottleneck" in genome understanding could be broken with new, innovative, and transformative experimental tools, datasets, and computation that can define gene function on a massive and high-throughput scale compatible with the pace of DNA sequencing. (energy.gov)
  • To explore the common genes and pathogenic pathways among different fibrotic diseases, we collected all the reported genes of the eight fibrotic diseases: eye fibrosis, heart fibrosis, hepatic fibrosis, intestinal fibrosis, lung fibrosis, pancreas fibrosis, renal fibrosis, and skin fibrosis. (frontiersin.org)
  • Moreover, we interestingly found overlaps of pathways between renal fibrosis and skin fibrosis, such as GO:1901890-positive regulation of cell junction assembly, as well as common regulatory genes, such as CTGF, which is the key molecule regulating fibrogenesis. (frontiersin.org)
  • A new research project was initiated to identify the genes important to the processes and related signal transduction pathways. (usda.gov)
  • Correspondingly, most cancer signaling pathways seem to converge on one or more TFs, termed "master regulators" (MRs) [ 4 ], which direct tumor development, progression, and metastasis through hierarchical control of gene expression patterns. (aging-us.com)
  • Serotonergic and cholinergic synapse was identified as key pathways. (ijpsonline.com)
  • GO analysis revealed that the DEGs were enriched in biological processes related to inflammation, and the enriched pathways in the KEGG pathway analysis were cytokine-cytokine receptor interaction, chemokine signalling pathway and NF-κB signalling pathway. (researchsquare.com)
  • Conclusions This study provides further evidence of non-infection related inflammatory pathways contributing to term labour, in particular identifying inflammatory changes in the decidua similar to those in myometrium and cervix. (bmj.com)
  • ADR1s and NRG1s function in two distinct parallel pathways contributing to TNL-specific immunity. (ubc.ca)
  • In this study, we performed a new bioinformatics analysis on microarray-based gene expression data obtained from the public domain to explore genes that were differentially induced by drugs between the group of capreomycin and PA-824 and the group of mainly the first-line TB drugs. (hindawi.com)
  • The product completes the existing 'Click and Go' automatic workflows for RNAseq, ChipSeq, qPCR and microarray-based gene expression with a set of powerful modules for the downstream integration and analysis of results from these technologies. (scientific-computing.com)
  • Consecutive pathway and cluster analysis led to the identification of biological processes, namely processes involving binding and processing of nucleic acids, LRP1-dependent endocytosis, and exosome formation. (degruyter.com)
  • We further developed improved methods for circular RNA identification and purification using RNase R by identifying a way to better remove linear RNAs containing G-quadruplexes or structured 3' ends. (bcm.edu)
  • Keratoconus-susceptibility gene identification by corneal thickness genome-wide association study and artificial intelligence IBM Watson. (cdc.gov)
  • One cannot deny that the development of biotechnologies allows the identification of monogenic diseases, i.e., diseases which are highly probable to be caused by the expression of a single gene (for example, cystic fibrosis and Huntington's disease). (bvsalud.org)
  • The Konopka Lab will seek to expand on the findings by studying brain organoids - essentially mini human brains grown in a dish - to understand the CLOCK Genes specific targets that CLOCK regulates. (cshlpress.com)
  • In further sequencing studies, the researchers hope to identify and characterize more genes that might play a role in schizophrenia and to elucidate common biological functions of the genes. (science20.com)
  • In vitro model for identifying subchronic carbon nanotube exposure and lung cancer gene markers. (cdc.gov)
  • To date, no particle specific nanomaterial exposure or lung cancer markers have been identified. (cdc.gov)
  • Here, we use our subchronic in vitro exposure model coupled with toxicogenomic profiling and correlation feature selection strategies to identify particle-specific, key gene markers from our CNT-transformed cell lines. (cdc.gov)
  • Toxicogenomic signature profiling in a subchronic in vitro exposure model identified particle-specific gene markers which can potentially aid in assessing detection of early onset of CNT pulmonary disease. (cdc.gov)
  • Examples of 2-omics analyses include expression quantitative trait locus eQTL (Franke & Jansen, 2009) and methylation quantitative trait locus meQTL (Smith, Kilaru, Kocak, Almli, & Mercer, 2014) that, respectively, assess the influence of genetic and epigenetic markers on gene expression. (researchgate.net)
  • These evidences are often based on the derivation of standard measures of association, linking (epi-)genetic markers to gene expression combined with gene expression analysis (Wagner, Busche, Ge, Kwan, & Pastinen, 2014). (researchgate.net)
  • Differentially expressed PRGs (DEPRGs) were identified between PAAD and control samples. (hindawi.com)
  • The functional analysis tool can assess if a gene ontology functional category, a KEGG Pathway or an InterPro motif is statistically over or under-represented in a set of genes of interest. (scientific-computing.com)
  • Over the last two decades, studies based on genome-wide gene expression and functional profiling have revealed the great diversity of transcriptional alterations occurring in liver carcinogenesis. (aging-us.com)
  • SSPsyGene is designed to provide a collaborative and efficient framework for identifying biological function beyond current small-scale and often ad hoc single gene efforts in order to generate a standardized, experimentally derived, functional catalog of NPD risk genes. (nih.gov)
  • B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)
  • Identifying the membrane components needed for protection against this peptide type can therefore clarify how a complex vulnerable structure can be modified to be fit for a different functional scenario. (lu.se)
  • The gene expression profiling data, selection of candidate genes and transcriptional regulation of the seed germination and seedling growth will be presented and discussed. (usda.gov)
  • We then used reverse engineering of transcriptional networks to identify the MRs that underpin the development and progression of HCC. (aging-us.com)
  • MicroRNAs (miRNAs or miRs) are small non-coding RNAs that participate in diverse cellular processes and negatively regulate gene expression at the post-transcriptional level by binding with 3′-untranslated regions (3′-UTRs) ( 2 - 4 ). (spandidos-publications.com)
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
  • In this work, we describe Regression2Net, a computational approach that is able to integrate gene expression and genomic or methylation data in two steps. (researchgate.net)
  • Unless otherwise noted, publications and webpages on this site were created for the U.S. Department of Energy Genomic Science program by Biological and Environmental Research Information System (BERIS). (energy.gov)
  • The high-dimensional genomic data can provide unprecedented resolution for identifying subtle genomic variations. (cdc.gov)
  • In addition, we performed genome-wide stratified and interaction analyses by gender, smoking and airway obstruction status, and assessed associations between gene expression and methylation for genome-wide significant CpGs (n=2802). (bmj.com)
  • In univariate and multivariate Cox regression analyses, GSDMC, IRF1, and PLCG1 were identified as prognostic biomarkers in PAAD. (hindawi.com)
  • Proteomics provides valuable information on cellular activities, which is integral for identifying and monitoring clinically relevant biomarkers, advancing our understanding of health and medicine. (cdc.gov)
  • Eventually, we aim to identify novel epigenetic biomarkers that predict response to exercise and mediate the beneficial effects of exercise, which may lead to more effective prediction, prevention, and treatment strategies for type 2 diabetes and metabolic disorders. (lu.se)
  • CLOCK regulates genes linked to cognitive disorders, and has an important role in human neuronal migration - the process by which neurons born in other parts of the brain travel to the appropriate neural circuits. (cshlpress.com)
  • The subcortex expressed genes associated with generating new neurons and genes that give rise to non-neuronal brain cells. (sfn.org)
  • Changes made in the genes influence the brain's wiring by altering the synapse, and shaping how neurons transmit signals to each other. (medicaldaily.com)
  • The researchers embraced a similar model but instead of capturing dependencies among the words, "We captured them among the neurons to identify cells," Chaudhary said, noting that this approach limits error propagation as compared to other methods that examine the geographic location of each cell. (neurosciencenews.com)
  • CLOCK regulates a set of genes important to brain evolution that have differences in terms of where and how much they are expressed compared to other primates. (cshlpress.com)
  • The team distilled the gene expression into memory gene signatures using bioinformatics. (sfn.org)
  • Using bioinformatics, a luciferase reporter assay and western blot analyses, the current study identified that runt‑related transcription factor 2 (RUNX2) was a target of miR‑205 in PC and overexpression of miR‑205 suppressed the expression of RUNX2. (spandidos-publications.com)
  • Autism 'Risk Genes' Can Be Mapped By Function: What Genetic Behaviors Cause ASD? (medicaldaily.com)
  • Investigators at the University of California, Los Angeles say they've mapped risk genes for autism spectrum disorder across the brain, by function. (medicaldaily.com)
  • Although sharing common risk genes, the disorder and the more generalized "intellectual disability" develop distinctly as genes express themselves, copying data from DNA to RNA, says Daniel Geschwind, a neurologist at UCLA. (medicaldaily.com)
  • For their study , Geschwind and his colleagues became the first to report mapping groups of autism-risk genes by function, and to identify behavioral roles in early brain development. (medicaldaily.com)
  • The Scalable and Systematic Neurobiology of Psychiatric and Neurodevelopmental Disorder Risk Genes (SSPsyGene) Consortium: Assay and Data Generation Centers (RM1) (RFA-MH-24-145). (nih.gov)
  • The finding fits with accumulating evidence that damage to chromatin regulatory genes is a common feature of various psychiatric and neurodevelopmental disorders. (science20.com)
  • The microenvironments of the low- and high-risk groups were assessed using xCell, the expression of immune checkpoints was determined, and gene set variation analysis (GSVA) was performed. (hindawi.com)
  • Genes preferentially expressed in the cortex are involved in memory processes and immune signaling. (sfn.org)
  • The initial study on 18 individuals found that the way our genes function varies significantly, particularly in some key areas including the immune system. (nutraingredients.com)
  • In-depth biological analysis of connected genes in ANDnet and XORnet revealed genes that are related to energy metabolism, cell cycle control (AATF), immune system response, and several cancer types. (researchgate.net)
  • We identified 8 consensus k-mers associated with adherence, antimicrobial resistance, and immune modulation, which were unevenly distributed in the infection isolates. (cdc.gov)
  • Over the past couple decades, researchers have identified numerous genes involved in various immune system functions that may also contribute to Alzheimer's. (medscape.com)
  • Some of the prime suspects are genes that control immune cells called microglia, now the focus of intense research in developing new Alzheimer's drugs. (medscape.com)
  • To date, nearly a dozen genes involved in immune and microglial function have been tied to Alzheimer's. (medscape.com)
  • There is clearly a need to identify accu- allergy research and in the definition of the important rately chemicals that have the potential to induce aller- immune mechanisms that influence the acquisition and gic sensitization and to assess the risks they pose to regulation of allergic sensitization to chemicals. (cdc.gov)
  • SWCNT-, MWCNT-, crocidolite asbestos (ASB)-, ultrafine carbon black (UFCB)-treated and control SAECs genome expression signatures were subjected to comparative marker and class neighbor analyses to identify genes with highly correlated expression for each treatment. (cdc.gov)
  • Therefore, the results of the present study revealed that miR‑205 functions as a tumor suppressor in PC by targeting RUNX2. (spandidos-publications.com)
  • Furthermore, the authors identified that miR-205 mimics could sensitize the tumor to radiation in a xenograft model. (spandidos-publications.com)
  • See Wilms Tumor: A Pediatric Oncology Success Story , a Critical Images slideshow, to help identify the clinical features, staging evaluation, prognostic factors, and therapeutic options for this disease. (medscape.com)
  • The epigenome consists of chemical modifications attached to our DNA, which can be altered due to environmental factors, e.g., exercise, and thereby provides dynamic gene regulation and gives each cell or tissue its unique identity and functions. (lu.se)
  • However, due to the distinct bioavailability and biological activities of VKs, exactly which of these activities and by what mechanisms they might act still need to be elucidated. (frontiersin.org)
  • However, the underlying mechanisms and cellular functions triggered by internalized sGAG-derivatives are still not well understood. (degruyter.com)
  • The resulting phenotypic data will be integrated across modalities, levels of organization, and genes to create a harmonized, integrated knowledge base needed to substantively advance our understanding of basic gene function and, ultimately, make robust inferences into potential shared and unique disease mechanisms. (nih.gov)
  • Using a range of tools from machine learning to graphical models, researchers have discovered a new way to identify cells and explore the mechanisms behind neurodegenerative diseases. (neurosciencenews.com)
  • A multidisciplinary team of Georgia Institute of Technology neuroscience researchers, borrowing from existing tools such as graphical models, have uncovered a better way to identify cells and understand the mechanisms of the diseases, potentially leading to better understanding, diagnosis, and treatment. (neurosciencenews.com)
  • The candidate genes will be identified by comparing gene expression profiling data from plant tissues at different physiological conditions and genetic backgrounds. (usda.gov)
  • 14 transcription factor families in 29 contigs were identified. (figshare.com)
  • Runt-related transcription factor 2 (RUNX2), a member of the RUNX family, functions as a critical regulator for osteoblast differentiation ( 14 ). (spandidos-publications.com)
  • The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
  • Non-coding SNPs , located within the gene's regulatory sequences, change the timing, location, or level of gene expression. (utah.edu)
  • They were found to have from one to three locations on the subgenomes A, B, and D. Full-length gene sequences were designed for these contigs, which were further validated using promoter analysis. (figshare.com)
  • The precise ratio of the KTS-positive/negative isoforms seems to be crucial for the normal function of the WT1 gene. (medscape.com)
  • However, our results showed that VK2 can significantly influence the expression of genes related to fat metabolism, including those that regulate fatty acid elongation, desaturation, and synthesis of fatty acid-CoA. (frontiersin.org)
  • Of the 14,000 genes analysed, 3,302 were identified as varying significantly in their expression among human volunteers. (nutraingredients.com)
  • By contrast, miR-205 expression has been identified to be significantly increased in several human cancer types, including ovarian cancer, endometrial cancer and laryngeal squamous cell carcinoma, in which it was identified to function as an oncoprotein ( 10 , 11 , 13 ). (spandidos-publications.com)
  • Six among the 42 genes identified in this study are on the list of the top 100 persistence targets selected by the TB Structural Genomics Consortium. (hindawi.com)
  • I address these questions in two steps: firstly, I discuss epistemological implications of the development of Genomics, understood as a data-intensive science, by delving into the theoretical commitments of the concept of gene and the notion of circular causality. (bvsalud.org)
  • Several large-scale projects have combined the efforts of many institutions to identify and catalog all of the SNPs in the 3-billion-base pair human genome. (utah.edu)
  • This offers new biological insights into the results. (scientific-computing.com)
  • application of these biological insights to drive new treatment and preventive options. (eurekalert.org)
  • Further studies in immunological function of these cytokines will provide enhanced insights on their role in mediating innate immunity in avian species. (usda.gov)
  • Using samples from exercise interventions helps us understand how regular exercise interferes with these dynamic features and gives biological insights into metabolic adaptation to exercise. (lu.se)
  • We compared the gene overlaps among eight fibrotic diseases and connective tissue growth factor (CTGF) was finally identified as the common key molecule. (frontiersin.org)
  • The biological processes involved in diseases and drug responses are controlled by the activities of many genes. (utah.edu)
  • The intestinal microbiota impact obesity, fatty liver diseases, and weight loss by way of the ability to induce the expression of genes related to lipid metabolism ( 6 , 10 ). (frontiersin.org)
  • Several of the identified genes, for example, RYR1 , ALLC , PTPRN2 , LRRC3B , PAX2 and VTRNA2-1 , are genes previously linked to either pesticide exposure or lung-related diseases. (bmj.com)
  • The researchers also note the evolution of how diseases were discovered and identified. (eurekalert.org)
  • By using new technologies to understand natural and dysfunctional states of biological systems, neuroscientists hope to ultimately bring cures to diseases. (neurosciencenews.com)
  • Research is ongoing to identify SNPs associated with complex diseases such as heart disease, diabetes, and cancer. (medlineplus.gov)
  • Multigenic diseases challenge our understanding of the mechanism behind the genome echoing in our misunderstanding of the concept of gene. (bvsalud.org)
  • The discussions included the breadth of diverse, high-throughput technologies needed for characterizing genes of unknown function and how the diverse data from these technologies could be integrated with new and existing computational platforms to accurately propagate these annotations to newly sequenced genomes. (energy.gov)
  • The functions of the candidate genes will be further validated using genetic approaches in Arabidopsis and barley. (usda.gov)
  • It is now very necessary to identify the new potential targets for the drugs which not only control the disease but also can treat it. (researchgate.net)
  • In the past few decades, several miRs have been identified to be associated with the overall survival of patients with PC and have been demonstrated to be potential therapeutic targets. (spandidos-publications.com)
  • Ongoing studies focus on identifying potential targets to suppress decidual inflammation as a potential means of arresting labour. (bmj.com)
  • Further biological elucidation of their roles in mycobacterial persistence is warranted. (hindawi.com)
  • Moreover, the genes related to fat metabolism that were up-regulated following VK2 treatment play key roles in improving survival. (frontiersin.org)
  • As the nascent brain develops, genes scattered throughout the brain begin to express themselves, to define their future roles, and to interplay with others - not unlike adolescents milling through a locker-lined hallway at school. (medicaldaily.com)
  • Despite those advances, significant questions remain unanswered about the functioning of those viral capsids and their roles in release, transmission, or cellular infection. (bvsalud.org)
  • Many of these genes are related to stress responses. (hindawi.com)
  • Exploring this border is now proving hugely rewarding, with implications for many aspects of cell function and plant responses to the environment. (brookes.ac.uk)
  • To achieve this goal, the LINCS program is generating data to identify patterns of cellular responses to various stress signals. (nih.gov)
  • These cellular responses include changes in gene expression and other cellular characteristics. (nih.gov)
  • Genes expressed in both areas are involved in mRNA production and the cellular changes needed for memory creation. (sfn.org)
  • In particular, we are interested in determining how cellular cues can alter the ratio of linear mRNA to circular RNA for a given gene. (bcm.edu)
  • The data can also be searched for a particular cellular response to identify new drug candidates related to that response. (nih.gov)
  • Further, we analyse what role that the cellular changes to the plant, and the plant genes doing it, have for the ability of plants to be promoted by growth- and protection-promoting fungi. (lu.se)
  • Despite their common involvement in memory, the human cortex and subcortex display a distinct collection of gene signatures. (sfn.org)
  • For example, a recent article in Nature Communications described proteomic profiling of 300 breast cancer samples, which revealed biological subtypes with distinct clinical outcomes and different survival rates. (cdc.gov)
  • Most commonly, SNPs are found in the DNA between genes . (medlineplus.gov)
  • When SNPs occur within a gene or in a regulatory region near a gene, they may play a more direct role in disease by affecting the gene's function. (medlineplus.gov)
  • This GLABR gene was further characterized by a conditional knockout experiment as well as an in situ hybridization on sectioned epithelial cells in order to better determine its function. (ubc.ca)
  • Here, we present robust SWCNT-, MWCNT-, ASB- and UFCB-induced specific gene marker sets for in vitro chronically exposed lung epithelial cells. (cdc.gov)
  • The main objective of research in my laboratory is to understand how environmental pollutants interfere with and change biological processes in organisms from natural, wild populations. (lu.se)
  • To do so, the research team examined data from the Allen Human Brain Atlas, containing expression data for ~24,000 genes, in memory areas defined by a neuroimaging database. (sfn.org)
  • Using this data, they demonstrated that schizophrenia arises from collective damage across several genes. (science20.com)
  • The researchers then looked more deeply into the sequencing data to try to determine the biological functions of the disrupted genes involved in schizophrenia. (science20.com)
  • A Gene Selection Task Group within the SSPsyGene Consortium has initiated efforts to prioritize a set of ~100-250 genes associated with NPDs to be interrogated by all Assay and Data Generation Centers (ADGCs), the list of which can be found on the "Resources" tab of the SSPsyGene Consortium website operated by the UC Santa Cruz Data Resource and Administrative Coordinating Center (DRACC). (nih.gov)
  • The researchers explained that before this advance, their lab might take 20 minutes to record a set of data, but it would take them weeks to identify cells and analyze data. (neurosciencenews.com)
  • This workshop brought together leaders in microbiology, plant sciences, technology, and computation, who collectively identified the experimental and data analysis gaps preventing large-scale gene function determination as well as opportunities for overcoming these gaps. (energy.gov)
  • The analysis revealed a set of unique genes expressed in the cortical memory areas, containing the entorhinal cortex, and another set in the subcortex, including the hippocampus. (sfn.org)
  • He sees people alerted to nascent tumors in their bodies by internal biological sensors, and cars fueled by bacteria-produced gasoline. (good.is)
  • Several bioinformatic approaches were used to analyze the biological functions of DEPRGs and to identify prognostic DERPGs. (hindawi.com)
  • The paper, titled "A brief history of human disease genetics," reviews breakthroughs in the association of specific genes with particular disorders, progress mostly driven by advances in technology and analytical approaches. (eurekalert.org)
  • adapting the crop plants for taking best use of biological pest management approaches. (lu.se)
  • In light of this grand challenge, DOE's Office of Biological and Environmental Research (BER) convened the Breaking the Bottleneck of Genomes: Understanding Gene Function Across Taxa workshop on November 1-2, 2018. (energy.gov)
  • 2019. Breaking the Bottleneck of Genomes: Understanding Gene Function Across Taxa Workshop Report , DOE/SC-0199, U.S. Department of Energy Office of Science. (energy.gov)
  • [ 5 ] Genome-wide association studies have reported IPF-associated genetic loci that are implicated in diverse biological processes including alveolar cell stability, host defense, cell-cell barrier function, and cell senescence. (medscape.com)
  • A number of these loci contain genes implicated in structure and function of skeletal muscle fibres (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic syndromes with involvement of psychomotor impairment (PEX14, LRPPRC and KANSL1). (lu.se)
  • Biological functions associated with each small gene marker subset for each particle were predictive of the entire genome signature and exposed cell phenotype. (cdc.gov)
  • Particularly for moderate throughput assays, strategies for selecting a subset of genes from the list should be discussed in the context of the chosen assay(s) or readout(s). (nih.gov)
  • Upon inhibiting RNA polymerase II termination, circular RNA levels were similarly increased due to readthrough transcripts extending into downstream genes and being subjected to backsplicing. (bcm.edu)
  • Helper NLRs (hNLRs) with their characteristic RPW8 domain function downstream of diverse sNLRs and are evolutionarily conserved. (ubc.ca)
  • With the exception of the first and last exons of genes, every other exon in the genome has splicing signals at its 5' and 3' ends and theoretically can circularize. (bcm.edu)
  • Splicing at the second alternative site (exon 9) is thought to have a great biological importance and results in the inclusion or exclusion of 3 amino acids, lysine, threonine, and serine (KTS), yielding the KTS-positive isoform when the amino acids are included and KTS-negative isoform when excluded. (medscape.com)
  • 0.05) associated with differential DNA methylation of 31 CpGs annotated to 29 genes. (bmj.com)
  • Integration of gene expression and methylation to unravel biological networks in glioblastoma patients: Gadaleta et al. (researchgate.net)
  • When applying our approach, Regression2Net to gene expression and methylation profiles for individuals with glioblastoma multiforme, we identified, respectively, 284 and 447 potentially interesting genes in relation to glioblastoma pathology. (researchgate.net)
  • In terms of the distribution of identified genes in a specific category relative to the whole genome, only the categories of PE/PPE and conserved hypotheticals have statistical significance. (hindawi.com)
  • A new study provides insight on the matter by demonstrating that a gene controlling our biological clocks also plays a vital role in regulating human-specific genes important to brain evolution. (cshlpress.com)
  • But genes tied to autism tend to affect specific functions, such as the connections between brain regions that are essential to many human-specific behaviors, such as speech and language. (medicaldaily.com)