• To identify biomarkers for potential therapeutic interventions, we used a targeted metabolomics approach evaluating metabolite profiles in the nasal mucosa of COVID-19 patients and compared metabolite profiles to those of other respiratory viruses (influenza A, RSV). (medrxiv.org)
  • The African-specific biomarkers identified require validation in African cohorts to identify risk markers and increase our understanding of the pathophysiology of type 2 diabetes in African populations. (lu.se)
  • Identifying biomarkers that can detect cancer early or have therapeutic significance is imperative. (bvsalud.org)
  • Reference: Cheng F, Murray JL, Zhao J, Sheng J, Zhao Z, Rubin DH (2016) Systems Biology-Based Investigation of Cellular Antiviral Drug Targets Identified by Gene-Trap Insertional Mutagenesis. (infectioncontroltoday.com)
  • Here, we evaluate the nasopharyngeal metabolome of COVID-19 infected individuals and report several small molecules that may be used as potential therapeutic targets. (medrxiv.org)
  • This study demonstrates that COVID19 infection results in a unique NP metabolomic signature with carnosine and LysoPCaC18:2 as potential therapeutic targets. (medrxiv.org)
  • Managing just the top 10% of the highest importance areas mapped in the study could achieve conservation targets for 42.5% of all species considered, as well as conserve 26% of total carbon and 22.1% of potential clean water around the globe, the authors say. (nationofchange.org)
  • Provide developmental support for those who fail to meet those targets despite trying - potential can be trained and boosted. (sage.com)
  • Kasada's approach to bot mitigation not only identifies bots that others miss, but halts them in their tracks, from the start," said Andrew Morris, founder and CEO of GreyNoise Intelligence. (darkreading.com)
  • Using a stem-cell-derived model, researchers have identified two drug candidates that may slow dry age-related macular degeneration (AMD), a leading cause of blindness for which no treatment exists. (nih.gov)
  • And there are some 66 other stars in the catalog that Caballero identified as potential candidates but with less strong evidence. (astronomy.com)
  • Conclusions Using sleep as a bio-indicator of TNF-R-dependent neuroinflammation, we identified C7 and SGT11 as potential therapeutic candidates for TBI. (figshare.com)
  • Title : Primary Care Providers' Perspectives on Using Automated HIV Risk Prediction Models to Identify Potential Candidates for Pre-exposure Prophylaxis Personal Author(s) : van den Berg, Polly;Powell, Victoria E.;Wilson, Ira B.;Klompas, Michael;Mayer, Kenneth;Krakower, Douglas S. (cdc.gov)
  • New USGS maps identify potential ground-shaking hazards in 2017 from both human-induced and natural earthquakes in the central and eastern U.S., known as the CEUS. (securitymagazine.com)
  • This is the second consecutive year both types of hazards are forecasted, as previous USGS maps only identified hazards from natural earthquakes. (securitymagazine.com)
  • The questionnaire contains 30 statements and 32 hazards that employers use to identify safety program management elements and hazards for improvement. (cdc.gov)
  • A primary objective of the study was to determine whether potential risk factors identified for Tourette's in previous studies ― including maternal prenatal smoking and alcohol use, excessive vomiting during pregnancy, complications of delivery, low birth weight, and young gestational age at birth ― could be validated. (medscape.com)
  • A new, computer-based screening method could reveal the virus-fighting potential of drugs originally developed to treat other conditions, reports a study in PLOS Computational Biology. (infectioncontroltoday.com)
  • Our study presents a pragmatic approach for effective rare CNV screening of SNP-array data sets and implicates the potential contribution of rare structural variants in the pathogenesis of UC. (nih.gov)
  • A new study has mapped out the regions where conservation actions can maximize the protection of biodiversity, carbon stocks, and water, while a separate study has identified regions of the world where land animals are most at threat. (nationofchange.org)
  • The first study identifies areas that would be suitable for "conservation management," which includes sustainable use, Indigenous reserves and other forms of protection appropriate for actions at local scale. (nationofchange.org)
  • The second study identifies the six major threats to biodiversity as agriculture, climate change, hunting and trapping, invasive species, logging, and pollution. (nationofchange.org)
  • Recommend a validation study addressing cross-species biotransformation potential. (cefic-lri.org)
  • In a study published in Nature Communications, a team led by Krembil Brain Institute Senior Scientists, Drs. Lorraine Kalia and Suneil Kalia, and University of Toronto (U of T) Professor, Dr. Philip M. Kim, identified a protein-protein interaction that contributes to Parkinson's disease. (worldhealth.net)
  • This study examined the economic potential of producing short-rotation hybrid poplar on agricultural lands enrolled in the Conservation Reserve Program (CRP) to support biomass requirements of two proposed powerplants and to supplement industrial timber requirements in Minnesota. (umn.edu)
  • The aberrant DNA methylation markers identified in this study also warrant further functional characterization. (who.int)
  • Herein, a comprehensive bioinformatics -based transcriptomics study of breast cancer for identifying differentially expressed genes (DEGs), followed by a screening of potential compounds by molecular docking , was performed. (bvsalud.org)
  • The objective of this study was to identify potential facilitators and barriers for event reporting from the curative sector to the preventive medicine sector in Viet Nam. (who.int)
  • Discussion: This study identified potential opportunities to promote the detection and reporting of unusual events from health-care workers to the public health sector, and thus to improve the overall health security system in Viet Nam.The influenza virus is a respiratory pathogen that is transmitted through respiratory droplets. (who.int)
  • A new study from LUCSUS has identified seven ways in which farm. (lu.se)
  • Scientists who examined more than 10,000 chemical compounds during the last year in search of potential new drugs for a group of untreatable brain diseases, are reporting that one substance shows unusual promise. (scienceblog.com)
  • Regulations adopted by DPR to identify pesticides that have the potential to pollute groundwater based on their chemical properties and labeled uses. (ca.gov)
  • WASHINGTON-Comptroller of the Currency Joseph Otting today issued the following statement supporting the Financial Stability Oversight Council's (FSOC) decision to propose an activities-based approach for identifying potential market-wide risks and to amend the process for designating nonbank financial companies systemically important. (treas.gov)
  • The proposal shifts the FSOC's focus away from the designation of individual companies as systemically important to an activities-based approach for identifying potential market-wide risks to financial stability. (treas.gov)
  • This approach would rely on the expertise of the primary regulators to address the identified risks. (treas.gov)
  • It's crucial to identify cases and understand the symptoms of these infections to track the evolution of the virus and what health care workers should look out for. (infectioncontroltoday.com)
  • Regional integration will be a crucial factor in realizing Malawi's potential, as almost 40% of its export potential lies with neighbouring countries and fellow member of the Southern Africa Development Community. (intracen.org)
  • Hypergeometric analysis was used to identify canonical pathways and curated networks having statistically significant enrichment of differentially expressed genes. (urotoday.com)
  • The data support an important role for osteopontin in bladder cancer, and identify several pathways worthy of further investigation. (urotoday.com)
  • According to Dr. Suneil Kalia, once the group identified this interaction, they confirmed that they could use their peptide to disrupt it, preventing a-syn from evading the cell's natural clearance pathways. (worldhealth.net)
  • Hogan Assessments , a leader on personality assessments for business, defines high potential as "the ability to build and lead teams that can consistently outperform the competition. (sage.com)
  • Hogan Assessments has developed the Hogan High Potential Model that organizations of all sizes and sectors have successfully used. (sage.com)
  • he purpose of Arla's first human rights assessments is therefore to identify whether Arla's activities potentially cause, contribute or are linked to a deterioration of working opportunities, working conditions and adequate living standards for local farmers who depend on raw milk production, processing, distribution, marketing and sales of dairy products. (business-humanrights.org)
  • It can be concluded that widespread concerns regarding Arla's business model based primarily on import of dairy products and the potential adverse impact on the domestic dairy sector, were raised internationally and expressed also by stakeholders in Senegal. (business-humanrights.org)
  • Twenty-four rare copy number variants (14 deletions and 10 duplications), overrepresented in UC patients were identified in the initial screening panel. (nih.gov)
  • During the case investigation, the person reported demonstrating the importance of genomic surveillance at state having traveled to southeastern Brazil within the 14 days and federal levels to identify variants of concern and to track before symptom onset. (cdc.gov)
  • The public health tool for identifying mutations and monitoring diagnostic specimen from this household contact was obtained variants of concern ( 7 ). (cdc.gov)
  • Environmental risk factors are hard to look at because there are millions and millions of potentials out there. (medscape.com)
  • A Crown Commercial Service-funded digital platform used by the NHS has identified millions of pounds of potential savings in its first year, the government has announced. (wired-gov.net)
  • WASHINGTON (AP) - Some people told they have Alzheimer's may instead have a newly identified mimic of the disease - and scientists say even though neither is yet curable, it's critical to get better at telling different kinds of dementia apart. (rockrivertimes.com)
  • Scientists from the International Agency for Research on Cancer (IARC), working with international partners, have identified new epigenetic changes that are specific to oesophageal cancers in tumour samples from populations in different parts of the world. (who.int)
  • The researchers used a molecular biology technique called gene-trap insertional mutagenesis to identify hundreds of human genes that enable viruses to hijack a human cell, but are not necessary for the cell itself to survive. (infectioncontroltoday.com)
  • The team found that seven alterations affecting three genes could identify tumours with high sensitivity and specificity. (who.int)
  • By teaming up with Kasada, GreyNoise will be able to provide users with an improved understanding of their security environment and more accurate information about which potential threats demand their attention. (darkreading.com)
  • By enriching GreyNoise's IP scan and attack data with Kasada bot intelligence, the companies will give security analysts a clearer understanding of which potential threats to be worried about, helping them apply their limited time and resources to those attacks targeted towards their businesses. (darkreading.com)
  • Farming practices have the potential to slow climate change by pulling carbon from the air and store it in the soil. (lu.se)
  • We transcribed the interviews and focus group discussions and used thematic analysis to identify the factors that appeared to affect public health event reporting. (who.int)
  • Researchers hope this discovery could pave the way for a potential vaccine that could help prevent type 1 diabetes in people at higher risk. (diabetesaustralia.com.au)
  • The new Export Potential Map ▪ Malawi is a free, customized tool that simplifies market research by translating rigorous trade analysis and practical information about untapped export opportunities for Malawi's businesses, trade policy advisors and policymakers. (intracen.org)
  • We recommended identifying potential security gaps and more. (gao.gov)
  • According to DHS, public water systems and wastewater treatment facilities are frequently subject to safety regulations that may have some security value, but in most cases, these facilities are not required to implement security measures commensurate to their level of security risk, which may lead to potential security gaps. (gao.gov)
  • Finally, DHS and EPA leaders acknowledged that there are differences between CFATS requirements and the security requirements for public water systems and wastewater treatment facilities, but they have not assessed the extent to which potential security gaps may exist. (gao.gov)
  • These alterations have the potential to be used as markers of oesophageal squamous cell carcinoma in low-resource settings. (who.int)
  • By doing so, they have been able to identify a potential treatment to reduce blood vessel calcification without any adverse effects on bone. (kcl.ac.uk)
  • ATSDR, a federal public health agency of the U.S. Department of Health and Human Services, evaluates the potential for adverse human health effects of exposure to hazardous substances in the environment. (cdc.gov)
  • Maragakis says it's equally important because it furthers his team's work to identify new drugs that can block this particular hemichannel, serving as future therapeutics for ALS. (newswise.com)
  • Feixiong Cheng of Vanderbilt University School of Medicine, Tennessee, and colleagues have developed a new strategy to quickly identify drugs with this potential. (infectioncontroltoday.com)
  • Lab experiments and clinical trials are needed to validate the antiviral properties of any promising drugs identified using the new method. (infectioncontroltoday.com)
  • According to a USGS release, approximately 3.5 million people live and work in areas of the CEUS with significant potential for damaging shaking from induced seismicity in 2017. (securitymagazine.com)
  • Winners at the 2017 Indiana Medicaid Data Challenge used 25 sets of Medicaid data released by the state to identify more than $150 million in potential savings. (govtech.com)
  • The two travel-associated cases of the SARS-CoV-2 variant P.1 the two cases described in this report, followed by one case each in Minnesota represent the first identified occurrences of in Alaska, Florida, Maryland, and Oklahoma ( 5 ). (cdc.gov)
  • In Florida , four cases within close geographic proximity have been identified, and active surveillance for additional cases is ongoing. (cdc.gov)
  • According to Dr. Kim, the team took the reverse approach to expedite the discovery of potential therapies. (worldhealth.net)
  • So Caballero repeated the search, looking for Sun-like stars among the thousands that have been identified by Gaia in this region of the sky. (astronomy.com)
  • A machine learning model identified 28 discriminating analytes and correctly categorized patients with a viral infection with an accuracy of 96% (R 2 =0.771, Q 2 =0.72). (medrxiv.org)
  • A second model identified 5 analytes to differentiate COVID19-infected patients from those with INFA or RSV with an accuracy of 85% (R 2 =0.442, Q 2 =0.301). (medrxiv.org)
  • Hogan's high potential model identifies leadership potential along three dimensions. (sage.com)
  • The scheduling model identified supply schedules reflecting the optimal location of timber and biomass production for each demand center under several land base and cost assumptions. (umn.edu)
  • The compounds appear to be among the most promising potential treatments for prion diseases yet discovered, the report suggests. (scienceblog.com)
  • These findings open a new avenue to explore potential new ways to prevent and treat diseases like Parkinson's," Brundin said. (sciencedaily.com)
  • Transcriptomic and molecular pathway analyses identified BIRC5/ survivin as a significant DEG. (bvsalud.org)
  • Pesticide chemistry data provided by registrants of agricultural pesticides and used by DPR to identify potential groundwater contaminants and fulfill mandated reporting requirements. (ca.gov)
  • DPR samples for agricultural pesticides identified as potential contaminants to determine if their legal use may contaminate groundwater and to better understand their fate and behavior in the environment. (ca.gov)
  • Inadequate maternal weight gain, cannabis use during pregnancy, and birth order have been identified as 3 new potential risk factors for Tourette syndrome and chronic tic disorders in children, new research shows. (medscape.com)
  • In research published today in Cell Reports, the team of researchers from King's and the University of Cambridge have identified the mechanism behind hardening of the arteries for which there is no treatment. (kcl.ac.uk)
  • We've scoured the latest research and studies on high potential employees to answer five questions that frequently come up when businesses first start considering a high potential strategy. (sage.com)
  • Identifying a particular interaction that contributes to a disease and then finding ways to disrupt it, can be a painstaking and incredibly slow process," explains Dr. Lorraine Kalia, who is also a staff neurologist at UHN and a scientist at U of T's Tanz Centre for Research in Neurodegenerative Diseases, in the Temerty Faculty of Medicine. (worldhealth.net)
  • We have pioneered research on post-traumatic sleep, identifying that injury-induced sleep lasting for 6 h in brain-injured mice coincides with increased cortical levels of inflammatory cytokines, including tumor necrosis factor (TNF). (figshare.com)
  • 5. Publish research on the dermal uptake potential of benzene and other chemicals in gasoline and crude oil after occupational exposures. (cdc.gov)
  • Aims/hypothesis: Using a targeted proteomics approach, we aimed to identify and validate circulating proteins associated with impaired glucose metabolism (IGM) and type 2 diabetes in a Black South African cohort. (lu.se)
  • Patterns of hospital visits could help identify patients suffering from a precursor condition to myeloma, a UK conference heard earlier this week. (b-s-h.org.uk)
  • RNA sequencing suggests that Ddit3 acts through development or stabilization of a precursor upstream of GMPs with inherent Meg-E potential. (lu.se)
  • As proof-of-concept, the established target antigen CD44 was identified as a commonly and abundantly expressed surface protein with high endocytic activity. (lu.se)
  • In Texas , one case has been identified, and surveillance for additional cases, as well as mosquito surveillance and control, are ongoing. (cdc.gov)
  • Yet many businesses struggle with how to effectively identify, develop and retain high-potential talent in their organizations. (sage.com)
  • To ensure they were releasing data that could help technical minds identify and solve unanswered questions, staffers at MPH and Indianapolis-based KSM Consulting (KSMC) had conversations with doctors, health-care providers and organizations around the states first to learn about their needs. (govtech.com)
  • By tapping into its significant unexplored export potential estimated at $333.5 mn, Malawi can improve its trade performance and create new opportunities for its local businesses. (intracen.org)
  • Third, participants described the potential benefits of reporting, such as support provided during outbreaks and information received about local outbreaks. (who.int)
  • Carnosine is a promising potential target against SARS-CoV-2 as it has been shown to interfere with binding of SARS-CoV-2 to the ACE2 receptor. (medrxiv.org)
  • Once we identified candidate peptides, we determined which protein-protein interactions they target. (worldhealth.net)
  • These findings indicate that the a-syn-CHMP2B interaction is a potential therapeutic target for the disease, as well as other conditions that involve a buildup of a-syn, such as dementia with Lewy bodies. (worldhealth.net)
  • The purpose of segmentation is to identify high yield segments so they can become target markets. (carwashmag.com)
  • Companies have used any number of criteria to create demographic profiles for identifying target markets for their products and services. (carwashmag.com)
  • Results Brain-injured mice treated with Compound 7 (C7) or SGT11 slept significantly less than those treated with vehicle, suggesting a therapeutic potential to target neuroinflammation. (figshare.com)
  • BIRC5 is a promising predictive marker and a potential therapeutic target in breast cancer . (bvsalud.org)
  • Companies mistakenly misinterpret high performance for high potential, while others don't address it in an analytical reliable way, relying solely on managers' instincts or observations about who has future leadership potential. (sage.com)
  • What Measures Can Companies Use to Evaluate Safety Management Practices and Identify Opportunities for Improvement? (cdc.gov)
  • These data are used to identify and sample for pesticides with the greatest chance to contaminate groundwater. (ca.gov)
  • The goal is to identify and recognise the project or startup showing the greatest potential, reflected mainly by its ability to generate interest and enlist support, to give it international visibility. (telefonica.com)
  • The endolysosomal pathway is underexplored, so it was not an obvious place to look for potential disease-related protein-protein interactions. (worldhealth.net)
  • 2. Identify occupational allergens that cause disease in workers in the industries with the highest burden. (cdc.gov)
  • Many regions of the State are known to have significant mineral-resource potential, and there are currently six operating mines in the State along with numerous active mineral exploration projects. (usgs.gov)
  • While growth in Malawi's traditional exports has been faltering over the recent decade, Malawi has significant untapped export potential across diverse products. (intracen.org)
  • Integrated High-throughput Transcriptomic Data Identifies Survivin as a Potential Breast Cancer Therapeutic Biomarker. (bvsalud.org)
  • Through this approach, the team identified a peptide that reduced a-syn levels in cells by disrupting the interaction between a-syn and a protein subunit of the cellular machinery called 'endosomal sorting complex required for transport III' (ESCRT-III). (worldhealth.net)
  • Ongoing studies are also determining the best approach for delivering potential therapeutics to the brain. (worldhealth.net)
  • He stressed that the 15 anomalies identified by his team are not necessarily graves but constitute a "medium probability of a grave. (yukon-news.com)
  • Unsupervised hierarchical clustering was used to identify samples with similar expression profiles. (urotoday.com)
  • Locally acquired mosquito-borne malaria has not occurred in the United States since 2003 when eight cases of locally acquired P. vivax malaria were identified in Palm Beach County, FL (1). (cdc.gov)
  • Dr. Tomas Chamorro-Premuzic , an international authority in psychological profiling and talent management, outlines these tips for how businesses can identify true high potential employees. (sage.com)
  • 7 They should be valid, reliable, and help identify deficiencies in safety management programs. (cdc.gov)
  • Trends that may help identify certain groups of chemicals as being universally or partly degradable should be identified. (cefic-lri.org)
  • Effects of reduced temperatures from 36º to 34.5º, resulting in increase in latency throughout evoked potentials from N9-P20. (medscape.com)
  • Quantitative PCR and high density custom array-CGH were used for validation of identified CNVs and fine mapping. (nih.gov)
  • High potential employees can have a huge impact across a business. (sage.com)
  • Here's five questions for companies considering a high potential strategy. (sage.com)
  • High potential employees are 91% more valuable to a business than non-high potential workers. (sage.com)
  • 1. What do you want employees to have high potential for? (sage.com)
  • It's important for businesses to establish what it is that they want employees to have high potential for? (sage.com)
  • A common error for businesses is defining high potential as the ability of an individual to advance up the ranks. (sage.com)
  • While Bersin by Deloitte describes a high potential employee as one who has "the potential, ability, and aspiration to hold successive leadership positions in an organization. (sage.com)
  • The exact detail of what your business wants to uncover high potential employees to do will vary. (sage.com)
  • 2. How should businesses identify high potential employees? (sage.com)
  • Set clear criteria for promotion that define explicitly what behaviors, achievements, and key performance indicators (KPIs) you equate to high potential. (sage.com)
  • What's evident is that performance appraisals and supervisor nominations are not reliable methods for discovering high potential employees. (sage.com)
  • Instead, successful high potential programs need to be based on science and analytics. (sage.com)
  • According to Hogan, personality assessment is the ideal empirical base on which to build any high-potential program. (sage.com)
  • We have now identified that HIF-1A is an important factor in this decision about whether the cells recover or die. (diabetesaustralia.com.au)
  • Malawi has the potential to spark dynamic, trade-led growth and to move up the value chain into higher value-added products. (intracen.org)
  • This paper concludes that challenges, potentials and also dynamic of adoption of the HRBA through HRC and SDGs can be understood meaningfully in particular social and political contexts. (lu.se)
  • DomainKeys Identified Mail (DKIM) is an email authentication method designed to detect forged sender addresses in email (email spoofing), a technique often used in phishing and email spam. (wikipedia.org)
  • GreyNoise has enriched its IP data with Kasada's intelligence on persistent bot traffic, allowing users to quickly identify and triage emerging bot activity. (darkreading.com)
  • Indiana Chief Data Officer Darshan Shah emphasized how important it was for the state to "start with the key outcomes" and partners and "work backward" to identify helpful data. (govtech.com)
  • In addition to supporting NHS organisations to identify savings, Atamis provides procurement teams with a unified view of the data, which can be segmented according to the need of the organisation, ensuring it's easier for procurement and commercial teams to make informed decisions that ensure the best value for money for the taxpayer. (wired-gov.net)