• The DR4 serogroup is large and has a number of moderate frequency alleles spread over large regions of the world. (wikipedia.org)
  • Pemphigus vulgaris (PV) is a severe autoimmune blistering disorder characterized by the presence of pathogenic autoantibodies directed against desmoglein-3 (Dsg3), involving specific DR4 and DR6 alleles in Caucasians and DQ5 allele in Asians. (biomedcentral.com)
  • While specific DP, DQ or DR alleles at the HLA class II locus have been shown to correlate with particular autoimmune diseases, a variety of confounding factors including strong linkage disequilibrium between the different HLA alleles, especially DR and DQ, complicates the exact identification of MHC susceptibility alleles. (biomedcentral.com)
  • HLA-DR4 and DRB4: potential risk alleles for COVID-19 vaccination-related ANCA-associated vasculitis. (cdc.gov)
  • H-2-deficient mice transgenic for either A2, A24, B7, DR2, DR3, or DR4 HLA alleles were immunized with overlapping peptides of the WNV proteome, and peptide-specific T-cell activation was measured by gamma interferon (IFN-γ) enzyme-linked immunosorbent spot (ELISpot) assays. (ox.ac.uk)
  • We investigated the effect of suppressor of cytokine signaling (SOCS) 3 on the expression of TRAIL receptors (DR4) and on TRAIL sensitivity in renal cell carcinoma (RCC) cells. (oncotarget.com)
  • The DR4 and DR5 receptors are both produced as type I transmembrane proteins, which contain an extracellular domain, a transmembrane domain, and a cytoplasmic domain. (peprotech.com)
  • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potential anticancer drug that selectively induces apoptosis in a variety of cancer cells by interacting with death receptors DR4 and DR5. (crg.eu)
  • First, the major histocompatibility complex (MHC) and T-cell receptor (TCR) contact residues were identified by analysis of single site substituted analogue peptides for HLA-DR4 binding and cognate T cell recognition using both T hybridomas and polyclonal T cells from peptide-immunized HLA-DR4 transgenic mice. (biomedcentral.com)
  • Our findings ascertain that DRB1*0402 plays a crucial role in the selection of specific self-peptides in DR4 PV. (biomedcentral.com)
  • Sequence-based predictive systems, based on identifying patterns in peptides with experimentally determined binding strength, are widely used to facilitate the identification of binding peptides to MHC class II molecules. (biomedcentral.com)
  • This study focused on the identification of human leukocyte antigen (HLA)-restricted West Nile virus (WNV) T-cell ligands and characterization of their distribution in reported sequence data of WNV and other flaviviruses. (ox.ac.uk)
  • For this purpose we employed a panel of well-characterized T cell hybridomas generated from HC gp-39-immunized HLA-DR4 transgenic mice. (biomedcentral.com)
  • When these APLs were analysed, a partial TCR agonist was identified and found to modulate the HC gp-39(263-275)-specific, pro-inflammatory response in HLA-DR4 transgenic mice. (biomedcentral.com)
  • HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. (wikipedia.org)
  • Caspase-10 was reported to activate early in TRAIL-induced apoptosis and was found in association with the DR4 (TRAIL-R1) receptor complex in a thyroid carcinoma line. (enzolifesciences.com)
  • These variants do not induce apoptosis in DR4-responsive cell lines but show a large increase in biological activity in DR5-responsive cancer cell lines. (crg.eu)
  • DR4 is associated with extraarticular rheumatoid arthritis, hydralazine-induced female systemic lupus erythematosus, pemphigoid gestationis, pemphigus foliaceus, obstructive hypertrophic cardiomyopathy, IgA nephropathy, 'shared syndrome'-systemic sclerosis/rheumatoid arthritis and polymyalgia rheumatica. (wikipedia.org)
  • 1) The frequency of DR4 was increased in patients with IgA nephropathy. (nii.ac.jp)
  • Suppression of SOCS3 up-regulated DR4 expression and enhanced the TRAIL sensitivity in 786-O cells. (oncotarget.com)
  • In ACHN cells, DR4 expression was down-regulated by transfection with pCI-SOCS3, and the cells became resistant to TRAIL. (oncotarget.com)
  • TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins, and contain a cytoplasmic "death domain," which can activate the cell's apoptotic machinery. (peprotech.com)
  • Recombinant Human soluble TRAIL Receptor-1/DR4 is a 22.7 kDa protein (215 amino acid residues) consisting of the TNFR homologous, cysteine-rich portion of the extracellular domain. (peprotech.com)
  • We sought to identify an altered peptide ligand (APL) based on the endogenously expressed synovial auto-epitope of human cartilage glycoprotein-39 (HC gp-39) for modulation of cognate, HLA-DR4-restricted T cells. (biomedcentral.com)
  • Combination therapy with IFN-α, tocilizumab and an anti-DR4 agonistic ligand appears to effectively inhibit advanced RCC cell growth. (oncotarget.com)
  • Vector expression, RNA interference and IL-6 receptor antibody tocilizumab were used to investigate the functional role of SOCS3 in DR4 expression. (oncotarget.com)
  • A marked increase in IFN-induced DR4 protein expression after tocilizumab treatment was observed by immunohistochemical staining in the tumor from the mice xenograft model. (oncotarget.com)
  • The hybridomas all respond to the HC gp-39(263-275) epitope when bound to HLA-DR4(B1*0401) but differ in their fine specificities. (biomedcentral.com)
  • Thus, the identification of the naturally processed SVN epitope, together with the previous finding of class I-restricted SVN epitopes, provide a basis for the combined application of class I- and II-restricted SVN epitopes to induce potent, long-term CD4+ and CD8+ T cell responses against various tumors. (uni-goettingen.de)
  • DR4-DQ8 is a risk factor for papillary thyroid carcinoma, juvenile diabetes, coeliac disease and rheumatoid arthritis. (wikipedia.org)
  • The DR4 products presented here will be publicly released on the NASA Legacy Archive for Microwave Background Data Analysis. (cardiff.ac.uk)
  • Research involves identification of and development of new assays for autoantibodies against novel autoantigens and autoantigen candidates. (lu.se)
  • Our docking simulations are entirely consistent with functional data obtained from in vitro competitive binding assays and T cell proliferation studies in DR4 and DR6 PV patients. (biomedcentral.com)
  • Our model predicts that multiple disease variants broaden the risk distribution, facilitating the identification of susceptible populations. (cdc.gov)
  • The amino acids Ala268, Ser269, Glu271 and Thr272 constituted the major TCR contact residues, as substitution at these positions did not affect HLA-DR4(B1*0401) binding but abrogated T cell responses. (biomedcentral.com)
  • Major observations suggest that the association between HLA and autoimmune (type 1) diabetes is secondary to the first appearing autoantibody be it against insulin in children with HLA DR4-DQ8 or GAD65 in children with HLA DR3-DQ2. (lu.se)
  • this follows earlier work demonstrating the structure-function association of HLA-DR4 and anti-CCP in RA (J Exp Med, 2013). (lupusresearch.org)
  • This will facilitate identification of susceptible populations and help provide a framework to model the genetic contribution in probabilistic risk assessment. (cdc.gov)
  • Analysis of single site substituted APL by cognate T cells led to identification of Phe265 as the dominant MHC anchor. (biomedcentral.com)
  • Identification of differentially expressed genes and pathways in kidney of ANCA-associated vasculitis by integrated bioinformatics analysis. (cdc.gov)
  • Quick View {"id":11816881796,"title":"Galicia Bra \/ Black","handle":"galicia-bra-black-1","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cul\u003e\n\u003cli\u003eDelicate beauty and functional strength, combine into this favorite, created with simplicity and allure in mind. (belo-forte.com)
  • DR4 expression was up-regulated by IFN stimulation in RCC cells. (oncotarget.com)
  • ACHN cells showed higher DR4 expression and lower SOCS3 expression. (oncotarget.com)
  • Our results indicate that IFN and SOCS3 regulate DR4 expression in RCC cells. (oncotarget.com)
  • The expression of DR4 induced by combination with IFN-α and tocilizumab was also examined by immunohistochemical staining using mice xenograft model. (oncotarget.com)
  • The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors, including proapoptotic DR4 and KILLER/DR5, are located on 8p21-22. (nih.gov)
  • The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and its functional receptors, DR4 and DR5, have been recognized as promising targets for cancer treatment. (nih.gov)
  • Except for QDD-400G-DR4-S, QDD-4X100G-FR-S, QDD-4X100G-LR-S, only connections with patch cords with PC or Ultra-Physical Contact (UPC) connectors are supported. (jhj.cn)
  • QDD-400G-DR4-S, QDD- 4X100G-FR-S, QDD-4X100G-LR-S require patch cords with Angled Physical Contact (APC) MPO connectors. (jhj.cn)
  • For Caucasian populations, possessing the HLA-DQw7, HLA-Bw62, and HLA-DR4 antigens is correlated to a genetic predisposition to ARN. (wikidoc.org)
  • Identification and characterization of a novel agonistic anti-DR4 human monoclonal antibody. (nih.gov)
  • Identification of differentially expressed genes and pathways in kidney of ANCA-associated vasculitis by integrated bioinformatics analysis. (cdc.gov)
  • This will facilitate identification of susceptible populations and help provide a framework to model the genetic contribution in probabilistic risk assessment. (nih.gov)
  • Amino acid sequence differences between DR1 and DR4, which are located deep in the peptide binding groove and out of reach for direct contact by the TCR, are able to indirectly influence the antigenicity of the pMHC surface by changing the conformation of HA peptide residues at position P5 and P6. (rcsb.org)
  • We also find a dependence of the width of the MHC class II peptide-binding groove on the sequence of the bound peptide by comparing the HA1.7/DR4/HA complex with the structure of DR4 presenting a collagen peptide. (rcsb.org)
  • To investigate the involvement of DR4 in human cancer, we have determined the genomic structure of DR4 and screened 31 lung cancer cell lines [14 small cell lung cancer and 17 non-small cell lung cancer (NSCLC)], many with deletions at 8p21-22, and 21 primary NSCLC samples for mutations in DR4. (nih.gov)
  • The two mAbs were selected from a human phage-displayed Fab library by panning against a recombinant DR4 extracellular domain. (nih.gov)
  • T (rs13278062) polymorphism, in the promoter of Death Receptor 4 (DR4) had been reported to be associated with a significantly increased risk for bladder cancer. (nih.gov)
  • In an ongoing collaborative prospective study aimed at the identification of prognostic factors for the development of erosive disease and clinical severity of disease in early rheumatoid arthritis (RA) [ 1 ], 48 patients were followed for more than 4 years, and 87 patients were seen for 2 years. (biomedcentral.com)
  • drug resistance identification and patients stratification in clinical studies. (medxtmc.net)
  • DR4 mediates the progression, invasion, metastasis and survival of colorectal cancer through the Sp1/NF1 switch axis on genomic locus. (nih.gov)
  • We found two missense alterations in the ectodomain of DR4. (nih.gov)
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  • IRSA provides access to data from the final delivery ( DR4, Fall 2006 and Fall 2007 ) of the Spitzer Space Telescope "From Molecular Cores to Planet-Forming Disks" ( c2d ) Legacy Project . (caltech.edu)
  • DR4-DQ8 is a risk factor for papillary thyroid carcinoma, juvenile diabetes, coeliac disease and rheumatoid arthritis. (wikipedia.org)
  • This disaster exercise may draw upon the Campus Closure Exercise (DR4) current in the preparations stage. (wcuquad.com)
  • Further, these antibodies could be used as a research tool for the study of DR4. (nih.gov)
  • When faced with a processor that does not have a usable cpuid instruction from which to learn the processor identification signature, the kernel doesn't try to retrieve it but instead invents family, model and stepping numbers from the results of various tests. (geoffchappell.com)
  • We report here the structure of the HA1.7/DR4/HA complex, determined by X-ray crystallography at a resolution of 2.4 A. The overall structure of this complex is very similar to the previously reported structure of the HA1.7/DR1/HA complex. (rcsb.org)
  • In the 1980s, emergence of pathological and electron findings from analysis of vitrectomy and enucleation specimens led to the identification of members of the herpes virus family as the cause of acute retinal necrosis . (wikidoc.org)