• Current studies are aimed at the further characterization of the mechanisms through which these genes act, the identification of other genes that play a role in this tumor type, and the application of this knowledge to patient management. (hopkinsmedicine.org)
  • Characterization of Schistosoma japonicum egg antigens / by Wilfred Uy Tiu. (who.int)
  • This proposal seeks to develop for the first time in humans a novel CD5 knocked out (KO) anti-CD5 chimeric antigen receptor T cell (CART) product for patients with relapsed or refractory T-cell lymphomas. (lls.org)
  • The present project seeks to translate this discovery into a first-in-human clinical trial to evaluate the feasibility, toxicity, and efficacy of CD5-deleted anti-CD5 chimeric antigen receptor CART for T-cell lymphoma. (lls.org)
  • Therefore, this study filtered candidate antigens and specific mRNA-suitable populations in BLCA via comprehensive multi-omics analysis. (frontiersin.org)
  • TIMER was used to evaluate the connection between candidate antigens and infiltration of antigen-presenting cells. (frontiersin.org)
  • When delivered in combination, the three candidate vaccines conferred significant protection in the lungs and spleen compared with BCG alone, demonstrating proof-of-concept for this unbiased approach to identifying new candidate antigens. (jenner.ac.uk)
  • First, chloramphenicol treatment allows the selection of bacteria expressing antigen-CAT fusion proteins in frame, which greatly reduces the number of colonies to be screened. (nih.gov)
  • Third, the uniformly high expression level of antigen-CAT fusion proteins permits the establishment of large and representative pool sizes. (nih.gov)
  • Using this approach, the BALF4 and BNRF1 proteins were identified as targets of the EBV-specific T-helper-cell response, demonstrating that lytic cycle antigens are a relevant component of the EBV-specific TH-cell response. (nih.gov)
  • The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. (wikipedia.org)
  • These findings provide six novel immunogenic Shigella proteins that could serve as candidate vaccine antigens, species-specific carrier proteins, or targeted adjuvants. (biomedcentral.com)
  • We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
  • We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
  • We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)
  • The in vivo immunogenicity of the antigens will be tested in the near future thanks to a recently funded follow-up project, Thus, the polyclonal sera obtained after immunization will allow confirming the VNA of the individual proteins and select the best antigen cocktail to rationally designed a future antibody based ASFV subunit vaccine. (intvetvaccnet.co.uk)
  • MHC-I and MHC-II proteins are key components of the antigen presentation machinery responsible for neoantigen presentation to CD8 + and CD4 + T lymphocytes, respectively. (portlandpress.com)
  • Screening of the Mycobacterium leprae cosmid library with pooled sera from lepromatous leprosy (LL) patients by a colony immunoblot technique resulted in the identification of about 100 colonies that produced immunologically reactive proteins. (elsevierpure.com)
  • BACKGROUND: The risk of death from prostate cancer (PC) depends on age, but the age at which to start prostate-specific antigen (PSA) screening remains uncertain. (lu.se)
  • PATIENT SUMMARY: In this study from the Göteborg-1 trial, we looked at the effect of prostate-specific antigen (PSA) screening in reducing men's risk of dying from prostate cancer given the age at which they begin testing. (lu.se)
  • Title : Prostate-Specific Antigen Testing Initiation and Shared Decision-Making: Findings from the 2000 and 2015 National Health Interview Surveys Personal Author(s) : Li, Jun;Ding, Helen;Richards, Thomas B.;Martin, Iman;Kobrin, Sarah;Marcus, Pamela M. (cdc.gov)
  • Some clinical trials have shown that high phytoestrogen intake may decrease serum concentrations of prostate-specific antigen (PSA), and phytoestrogens may also lower prostate cancer risk. (uzh.ch)
  • Prostate-specific antigen (PSA) is a protein produced by normal prostate cells. (medscape.com)
  • We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
  • This extensive immune cross-reactivity between SARS-CoV-2 antibodies and different antigen groups may play a role in the multi-system disease process of COVID-19, influence the severity of the disease, precipitate the onset of autoimmunity in susceptible subgroups, and potentially exacerbate autoimmunity in subjects that have pre-existing autoimmune diseases. (frontiersin.org)
  • Cross-reaction was found between S. equina antigens and antibodies in the sera of Wuchereria bancrofti-infected patients, with the highest levels observed between sera of chronic infected patients and Setaria spp. (who.int)
  • Intracellular antigens must be processed before presentation to CD8 + T cells by major histocompatibility complex (MHC) class I molecules. (johnshopkins.edu)
  • Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
  • Using a recombinant vaccinia virus (Vac) to transiently express the K d molecule, we studied the antigen processing efficiency of 26 different human tumor lines. (johnshopkins.edu)
  • The recombinant protein of the identified antigen was examined for their ability to induce AIP-like disorder in C57BL/6 mice. (elsevierpure.com)
  • Interestingly, Mycobacterium tuberculosis-stimulated T cells from M. leprae nonresponder (LL as well as borderline tuberculoid) patients were able to respond to the isolated recombinant M. leprae antigen, indicating that nonresponsiveness to M. leprae antigens can be reversible. (elsevierpure.com)
  • Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice. (ca.gov)
  • In utero hematopoietic cell transplantation (IUHCTx) is a promising method to induce donor-specific tolerance but the mechanisms of antigen presentation that educate host T cells and the relative importance of deletion vs. regulation in this setting are unknown. (ca.gov)
  • We studied the roles of direct and indirect antigen presentation (mediated by donor- and host-derived antigen presenting cells (APCs), respectively) in a mouse model of IUHCTx. (ca.gov)
  • We next performed allogeneic IUHCTx into donor-specific T cell receptor transgenic mice and confirmed that both direct and indirect antigen presentation lead to clonal deletion of effector T cells in chimeras. (ca.gov)
  • Thus, tolerance induction after IUHCTx depends on both direct and indirect antigen presentation and is secondary to thymic deletion, without de novo Treg induction. (ca.gov)
  • A key mechanism of immune evasion deployed by tumour cells is to reduce neoantigen presentation through down-regulation of the antigen presentation machinery. (portlandpress.com)
  • Infection with the most common serogroup of Legionella pneumophila , serogroup 1, can be detected by urinary antigen test, which is the most frequent way that Legionnaires' disease is diagnosed. (cdc.gov)
  • Protective antigen (PA) is the central component of the three-part protein toxin secreted by Bacillus anthracis, the organism responsible for anthrax. (rcsb.org)
  • Using an overlapping peptide library covering the HA protein, we identified a 15-mer peptide, H5(246-260), within the HA1 domain which induced activation of T cells in chickens immunized against the HA antigen of an H5 virus. (ucl.ac.uk)
  • The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. (elifesciences.org)
  • IgG and IgM antibody levels to mycobacterial lipoarabinomannan (LAM) antigen were determined by ELISA in eight sooty mangabey monkeys (Cercocebus atys) prior to and at intervals after experimental inoculation with Mycobacterium leprae. (unboundmedicine.com)
  • Anti-LAM antibody levels appear to be potentially valuable as an indicator of leprosy susceptibility, and when measured longitudinally together with antibody levels to M. leprae-specific phenolic glycolipid-I antigen, as a means to detect preclinical M. leprae infections in high-risk individuals. (unboundmedicine.com)
  • IgG sero-reactivity to key Shigella antigens was observed at birth, indicating transplacental antibody transfer. (biomedcentral.com)
  • Six antigens (FepA, EmrK, FhuA, MdtA, NlpB, and CjrA) were identified in in vivo testing as capable of producing binding IgG and complement-mediated bactericidal antibody. (biomedcentral.com)
  • The primary strategy of developing an efficacious Shigella vaccine has been to elicit antibody responses targeting Shigella O-antigen [ 10 ]. (biomedcentral.com)
  • Furthermore, the antibody titer against that antigen was determined in AIP patients. (elsevierpure.com)
  • Previous studies have demonstrated the key role that humoral and cellular response can play in protection and several antigens targeting CD8+ T-cell and antibody response were identified. (intvetvaccnet.co.uk)
  • The tested antigens eliciting an antibody response were immunodominant in the domestic pig sera, and very little is known about other possible subdominant antigens. (intvetvaccnet.co.uk)
  • Epstein-Barr virus (EBV)-specific T cells have been successfully used to treat or prevent EBV-positive lymphoproliferative disease in hematopoietic stem cell transplant recipients, but the antigens recognized by the infused CD4+ T cells have remained unknown. (nih.gov)
  • This direct antigen identification method is based on the random expression of viral polypeptides fused to chloramphenicol acetyltransferase (CAT) in bacteria, which are subsequently fed to major histocompatibility complex class II+ antigen-presenting cells and probed with antigen-specific T cells. (nih.gov)
  • A vaccination strategy designed to enhance the immunogenicity of self-antigens that are overexpressed in tumor cells is to identify and slightly modify immunodominant epitopes that elicit T-cell responses. (aacrjournals.org)
  • Protective vaccines require the induction of antigen-specific CD4+ T cells via mycobacterial peptides presented by MHC class-II in infected macrophages. (jenner.ac.uk)
  • Our objectives are to evaluate safety, clinical practicality and demonstrate first proof-of-principle of therapeutic efficacy of antigen-specific tolerance-inducing dendritic cells (tolDC) in MS patients in two single-center clinical trials. (europa.eu)
  • T cells mediate neuropathology during viral infection via antigen-independent cytotoxicity. (bvsalud.org)
  • Furthermore, spleen and brain CD8+ T cells exhibited antigen -independent cytotoxicity that correlated with NKG2D expression. (bvsalud.org)
  • We demonstrate that CD8+ T cells mediate virus -induced neuropathology via antigen -independent, NKG2D-mediated cytotoxicity, which may serve as a therapeutic target for treatment of virus -induced neurological disease . (bvsalud.org)
  • However, the identification of internalizing surface antigens for specific drug targeting of tumor cells remains a challenge of high clinical relevance. (lu.se)
  • Here, we describe a simple procedure that permits the identification of viral T-helper (TH)-cell antigens and epitopes. (nih.gov)
  • Three antigens were expressed in viral vectors, and evaluated as vaccine candidates alone or in combination in a murine aerosol M.tb challenge model. (jenner.ac.uk)
  • These data show that viral capacity to trigger specific inflammatory pathways at sites where T cell responses to dietary antigens take place interferes with the development of tolerance to an oral antigen. (broadinstitute.org)
  • Coronavirus antigen detection test system. (fda.gov)
  • This was the starting point of this project, to identify new antigens in the ASFV genome with potential protective capacity. (intvetvaccnet.co.uk)
  • Antigens are any substances that the immune system can recognize and that can thus stimulate an immune response. (msdmanuals.com)
  • In order to identify mycobacterial antigens bound to MHC, we have immunoprecipitated MHC class-I and class-II complexes from THP-1 macrophages infected with BCG, purified MHC class-I and MHC class-II peptides and analysed them by liquid chromatography tandem mass spectrometry. (jenner.ac.uk)
  • We have successfully identified 94 mycobacterial peptides presented by MHC-II and 43 presented by MHC-I, from 76 and 41 antigens, respectively. (jenner.ac.uk)
  • On the basis of the results reviewed here, there are two major mechanisms whereby tumour rejection antigens may arise. (ox.ac.uk)
  • Not much is known about the pathogenic mechanisms of thedisease, although associations with the human leucocitary antigens (HLA) and local immune responses seemto play an important role in its expression, as is the case in other skin autoimmune disorders, suchas pemphigus and psoriasis. (medscimonit.com)
  • has complicated the identification of the mechanisms of protections against ASFV. (intvetvaccnet.co.uk)
  • The objective of the present study was to identify putative T cell epitopes of the hemagglutinin (HA) antigen of an H5 AIV in chickens. (ucl.ac.uk)
  • It is our hope that other genes coding for mouse and human tumour rejection antigens will soon be identified, so that it will become clear whether the activational mechanism is the rule or the exception. (ox.ac.uk)
  • LY6G5C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. (nih.gov)
  • Potential therapeutic applications of these findings include enhancing antigen processing at the level of the transcription of MHC-encoded proteasome and transporter genes. (johnshopkins.edu)
  • CD1E+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human CD1A genome location and CD1A gene details page in the UCSC Genome Browser. (wikipedia.org)
  • In the case of diagnostic tests, in addition to the well-known PCR tests, antigen tests are a very useful tool for rapid detection and prevention screening. (macsa.com)
  • Using accurate and easy to use rapid antigen detection tests (RADTs) to identify group A beta-haemolytic Streptococci (GABHS) sore throat infections could reduce unnecessary antibiotic prescribing and antimicrobial resistance. (soton.ac.uk)
  • Plausible candidates for the mutational mechanism are the "tumour specific transplantation antigens" observed on methylcholanthrene induced tumours and tumours induced by ultraviolet light. (ox.ac.uk)
  • Gene ontology analysis suggests most of these antigens are associated with membranes and involved in lipid biosynthesis and transport. (jenner.ac.uk)
  • A core genome analysis of Shigella species, pathogenic and non-pathogenic Escherichia coli , led to the selection of 234 predicted immunogenic Shigella antigens. (biomedcentral.com)
  • Immune responses to isolated human skin antigens in actinic prurigo. (medscimonit.com)
  • In the presence of active S. equina infection, antigens from the adult and microfilaraemic stages showed the highest degree of cross-reaction with human sera. (who.int)
  • Finally, antigen identification does not require knowledge of the restriction element and often leads directly to the identification of the T-cell epitope. (nih.gov)
  • T-cell receptors (TCR) and B-cell receptors (BCR) are hypervariable immunoglobulins that play a key role in recognizing antigens in the vertebrate immune system. (elifesciences.org)
  • From this, a multidisciplinary team from four different EU countries (B, ES, NL and GER) with two additional partners now aims to safely reach the next level of testing and joins efforts to bring antigen-specific cell therapy for MS to the clinic. (europa.eu)
  • Defining antigen targets to dissect vaccinia virus and monkeypox virus-specific T cell responses in humans. (jcvi.org)
  • AP2S1 , P3H4 , and RAC3 were identified as candidate tumor-specific antigens, and patients with the BCS2 and BCS1A subtypes were identified as candidate populations for mRNA vaccines. (frontiersin.org)
  • This would probably not result in the expression of the same antigen in all these tumours, because the patients would differ in their presenting molecules, which are determined by their HLA haplotype. (ox.ac.uk)
  • Results: Autoantibody reactivities on the skin and also proliferative responsesto isolated autologous skin antigens were higher in patients than in controls. (medscimonit.com)
  • Wepostulate that AP patients may have one or more skin antigens that stimulate an autoimmune response,which causes the observed skin lesions. (medscimonit.com)
  • The A15 antigen also reacted with pooled sera from patients with tuberculoid leprosy from the United States and Brazil. (elsevierpure.com)
  • If antigens are perceived as dangerous (for example, if they can cause disease), they can stimulate an immune response in the body. (msdmanuals.com)
  • SCC antigen is useful in the clinical management of advanced cervical cancer. (medscape.com)
  • Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. (elifesciences.org)
  • These antigens were expressed and probed with acute and convalescent serum from microbiologically confirmed Shigella infections. (biomedcentral.com)
  • Methods: To determine the pathogenetically relevant antigen of E. coli, the outer membrane fractions of E. coli were subjected to two-dimensional gel electrophoresis followed by immunoblotting against sera from the AIP model. (elsevierpure.com)
  • Our findings suggest that downregulation of antigen processing may be one of the strategies used by tumors to escape immune surveillance. (johnshopkins.edu)