Loading...
  • proliferating cell nu
  • Cell cycle progression may be also regulated, independently of cyclins and CDKs, thanks to the strong affinity binding to proliferating cell nuclear antigen (PCNA) [ 14 - 17 ], a protein playing a central role in DNA replication and repair, as well as in other processes of DNA metabolism [ 18 , 19 ]. (intechopen.com)
  • cascades
  • Signaling cascades initiated by nitric oxide (NO) and natriuretic peptides (NPs) play an important role in the maintenance of cardiovascular homeostasis. (ahajournals.org)
  • The activating signals are transduced by signaling cascades that converge on the IκB kinases (IKKs) that phosphorylate the NF-κB inhibitory molecules, including members of the IκB family and inhibitory domains of NF-κB precursors, leading to their ubiquitination and subsequent degradation by the proteasome. (biologists.org)
  • canonical
  • Kaiso is a BTB/POZ transcription factor that functions in vitro as a transcriptional repressor of the matrix metalloproteinase gene matrilysin and the non-canonical Wnt signaling gene Wnt-11 , and as an activator of the acetylcholine-receptor-clustering gene rapsyn . (biologists.org)
  • regulation
  • Whereas signal transduction by cytokines is nowadays known in molecular details, counteraction and termination by negative regulation are only partly understood. (springer.com)
  • A plethora of pharmacological studies as well as the analysis of transgenic mice that overexpress or lack NO synthases (NOS), NPs, or pGCs underscored the importance of NO/NP signaling in the regulation of blood pressure, hemostasis, and cardiac and vascular remodeling. (ahajournals.org)
  • Thus
  • Mapping of the major transcription initiation site of Nanog paves the way towards identification of the factor(s) that direct Nanog gene expression and thus determine the pluripotent state. (springer.com)
  • peptide
  • That LEDGF has a consensus Tat domain is consistent with the finding that LEDGF moves in and out of cells without a signal peptide. (arvojournals.org)
  • show
  • Studies with fusions to green fluorescent protein (GFP) have shown that the Snf1 isoform containing Gal83 is the only isoform to show significant nuclear localization ( 22 , 50 ) following glucose limitation. (asm.org)
  • the TNPO1 - Rab8 (show RAB8A Antibodies )-ciliary targeting signals complex mediates selective entry into and retention of cargos within cilia. (antibodies-online.com)