• pathology
  • We injected the excitotoxin ibotenic acid unilaterally into the dorsal subiculum in 6-week old Tg APParc mice, i.e. an age when the first signs of Aβ pathology have not yet appeared, to examine if destruction of neurons not only connecting to but also from the subiculum alter the spread of Aβ. (biomedcentral.com)
  • activity
  • Additionally, calcium pump activity and calbindin-D28k expression were dramatically increased after GHE treatment, implicating that the modulation of calcium homeostasis could be involved in the mechanism underlying neuroprotection of GHE against ibotenic acid-induced excitotoxicity. (biomedsearch.com)