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  • gene
  • Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. (drugbank.ca)
  • This compound dose-dependently inhibited a variety of stimuli-induced NF-kappa B-regulated gene expression and the DNA-binding of NF-kappa B in different cell lines without affecting DNA-binding activity of AP-1. (semanticscholar.org)
  • We describe here a gene expression- and bioinformatics-based study showing that celastrol, a natural triterpenoid, acting via MAPK pathway regulates the downstream genes encoding serum/glucocorticoid regulated kinase 1 (SGK1), which plays a vital role in Th17/Treg differentiation, and brain-derived neurotrophic factor (BDNF), which is a neurotrophic factor, thereby offering protection against experimental autoimmune encephalomyelitis (EAE) in mice. (springer.com)
  • complexes
  • As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. (drugbank.ca)
  • cytokine
  • Consistent with the role of IKK/NF-kappa B in the regulation of cytokine transcription, BMS-345541 inhibited lipopolysaccharide-stimulated tumor necrosis factor alpha, interleukin-1 beta, interleukin-8, and interleukin-6 in THP-1 cells with IC(50) values in the 1- to 5-microm range. (duke.edu)
  • genes
  • In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. (drugbank.ca)
  • Thus
  • PTEN induced putative kinase 1 is a tantalizing player in familial forms of Parkinson's disease, in which it is inactivated by mutation, but thus far the kinase has been a no-fly zone for drug development. (biocentury.com)
  • study
  • Define and introduced by Cohen is calculated as follows: of the kappa statistic can be estimated by method since bootstrap sampling is conducted on clusters only [24 25 26 In our study a cluster is a physician and observations within the cluster are patients. (exposed-skin-care.net)