• Rats
  • In this study, oxygen-glucose deprivation/reoxygenation (OGD/R) in primary cortical neurons and unilateral ligation of the common carotid artery (CCL) in 7-day-old postnatal Sprague Dawley (SD) rats followed by exposure to a hypoxic environment were used to mimic an HIBD episode. (springer.com)
  • event
  • A prior hypoxic-ischemic event involving the occipital lobe has resulted in a chronic lesion marked by dyslamination, neuronal loss, and disorganized arrangements of myelinated white matter fibers. (medscape.com)
  • global
  • Focal and multifocal ischemic brain necrosis lesions vary in terms of distribution and can be limited to a region supplied by an occluded artery or can be diffuse in cases of global hypoperfusion. (medscape.com)
  • conditions
  • However, the disruption of BBB in hypoxic-ischemic conditions is multifactorial and may involve factors such as oxidative stress, enhanced production of vascular endothelial growth factor (VEGF), inflammatory cytokines, and nitric oxide (NO) [ 10 ]. (hindawi.com)