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  • hypoxia
  • Hypoxic hypoxia is a result of insufficient oxygen available to the lungs. (wikipedia.org)
  • Hypoxic hypoxia is seen in patients suffering from chronic obstructive pulmonary diseases (COPD), neuromuscular diseases or interstitial lung disease. (wikipedia.org)
  • discovered HIF-1 α in 1992, the hypoxia inducible factors (HIFs) have been identified as key regulators of genes involved in hypoxic responses [ 11 ]. (hindawi.com)
  • Furthermore, the sustained ingestion of pimonidazole revealed a larger hypoxic fraction than did a single injection of an alternative hypoxia marker, CCI-103F. (aacrjournals.org)
  • The "additional" hypoxia seen with longer-term oral administration apparently reflects the inclusion of transiently hypoxic tumor cells. (aacrjournals.org)
  • Thus, in addition to its convenience and versatility when compared with hypoxia marker injection, oral administration of pimonidazole appears to permit identification of all of the physiologically and therapeutically relevant hypoxic tumor cells. (aacrjournals.org)
  • Pimonidazole and CCI-103F are conducive to combined assays for hypoxia because they label comparable fractions of hypoxic cells, and neither inhibition of labeling nor cross-reactivity between primary antibodies has been observed in tumor section (11) or flow cytometry analyses (data not shown). (aacrjournals.org)
  • symptoms
  • Erythrapheresis significantly improved symptoms, mental function, and work performance in patients with polycythaemia secondary to hypoxic lung disease. (bmj.com)
  • tumors
  • Increased metabolism and poor perfusion in solid tumors creates a physical microenvironment that consists of either hypoxic and/or acidic regions. (agilent.com)
  • glucose
  • The HIF-regulated glucose transporter GLUT-1 facilitates increased influx of glucose and is upregulated in hypoxic conditions. (hindawi.com)
  • lung
  • Erythrapheresis in patients with polycythaemia secondary to hypoxic lung disease. (bmj.com)
  • differences
  • Although substantial differences exist between these methods of hypoxic training and/ or exposure, all have the same goal: to induce an improvement in athletic performance at sea level. (springer.com)
  • conditions
  • Fuhrmann V, Kneidinger N, Herkner H, et al (2009) Hypoxic hepatitis: underlying conditions and risk factors for mortality in critically ill patients. (springer.com)
  • role
  • The intensity of hypoxic exercise might play a role on adaptations at the molecular level in skeletal muscle tissue. (springer.com)
  • intact
  • Agilent Cell Analysis technology is capable of accurately assessing cell metabolism and characterizing metabolic phenotypes in real time, using intact cells, in hypoxic environments. (agilent.com)