Hypoxia preconditioned blood. Medical search. Frequent questions

Discuss the concept of preconditioning muscles through temporary ischemia and its potential benefits. (grindergym.com)
Ischemic tolerance defines transient resistance to lethal ischemia gained by a prior sublethal noxious stimulus (i.e., preconditioning). (biomedcentral.com)
The fate of the brain tissue after focal cerebral ischemia is determined by the degree and duration of ischemia, and even without preconditioning, resident brain cells naturally respond to brain ischemia by mobilizing a host of defences and counter responses to mitigate cell injury and death [ 5 ]. (biomedcentral.com)
In the absence of ischemic preconditioning (IPC), MCAO induces a large infarction (ischemia-sensitive phenotype). (biomedcentral.com)
In an in vitro model of cerebral ischemia (oxygen glucose deprivation, OGD) we investigated whether erythropoietin (EPO) plays a critical role in ischemic preconditioning. (jneurosci.org)
Reduced blood flow, corresponding to ischemia preconditions the heart in their behavior during the interview. (lowerbricktown.com)
Increases in knowledge have revealed that the common pathophysiological scenario, myocardial ischemia reperfusion injury, including ischemia/reperfusion (I/R) and hypoxia/reoxygenation (H/R) forms of injury, results in depressed myocardial function and harmful morphological alterations, which may lead to heart failure ( 4 ). (spandidos-publications.com)
1986 ) described ischemic preconditioning as endogenous cardioprotective mechanisms to limit ischemia/reperfusion injury (IRI) via repeated cycles of brief ischemia/reperfusion. (conditionmed.org)
In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)

Methods The present study used a chronic hypoxia rat model to simulate the hypoxic state of CCHD patients. (cams.cn)
Bone marrow mesenchymal stem cells (BMSCs) have been reported to attenuate myocardial I/R injury via their paracrine effects, which can be enhanced by hypoxic preconditioning. (researchsquare.com)
These therapeutic effects can be further enhanced by hypoxic preconditioning. (researchsquare.com)
MSCs were preconditioned in a hypoxic environment (5% oxygen) for 48 hours. (minervamedica.it)
The angiogenic potency was evaluated based on the area and length of blood vessels formed in the quail embryos on days 1, 3, 5, and 7 after transplantation with hypoxic AT-MSCs, normoxic AT-MSCs, hypoxic UC-MSCs, or normoxic UC-MSCs, and compared to placebo control (PBS injection). (minervamedica.it)
In vivo , hypoxic preconditioning could enhance the angiogenic potency of AT-MSCs, compared to normoxic AT-MSCs, although the angiogenic potency of hypoxic and normoxic UC-MSCs was not significantly different. (minervamedica.it)
Differential Effects of Cytokine Versus Hypoxic Preconditioning of Human Mesenchymal Stromal Cells in Pulmonary Sepsis Induced by Antimicrobial-Resistant Klebsiella pneumoniae. (np-monocyte.eu)
At 48 h after the injections, hypoxic-ischemic (HI) injury was induced by unilateral carotid artery ligation followed by hypoxia for 65 min. (biomedcentral.com)
We also measured superoxide dismutase as a marker of hypoxic preconditioning. (ox.ac.uk)
The fall in urinary F2-isoprostane and rise in superoxide dismutase implies that hypoxic preconditioning may have reduced oxidative stress. (ox.ac.uk)

In the present study, the protective effects of EGCG with zinc were assessed on cultures of rat cardiac myoblasts exposed to hypoxia/reoxygenation (H/R) injury. (spandidos-publications.com)
ABSTRACT: Performing hypoxia-reoxygenation cycles in cell culture with a cycle duration accurately reflecting what occurs in obstructive sleep apnea (OSA) patients is a difficult but crucial technical challenge. (mcqinst.com)
Intermittent hypoxia (IH) is the hallmark of obstructive sleep apnea (OSA), a common chronic disease affecting 5-20% of the general population and characterized by recurrent collapses of the upper airway, leading to the repetitive occurrence of oxygen desaturation/reoxygenation sequences. (mcqinst.com)
We evaluated the effect of DEX-MVs on NRK-52E cells migration, hypoxia/reoxygenation (H/R)-induced cell death, and reactive oxygen species (ROS) amount and renal IR model in rats. (ntnu.edu.tw)

Objective Many physiological and pathological conditions, including cyanotic congenital heart diseases (CCHD), are accompanied by chronic hypoxia, which might interfere with the transcription process. (cams.cn)
The present work aimed to explore the transcriptional profile alteration of peripheral blood in chronic hypoxia. (cams.cn)
Conclusions Our study demonstrated the transcriptional profile alteration in peripheral blood of chronic hypoxia rat model. (cams.cn)
Transcriptional Profile Alteration of Peripheral Blood in Chronic Hypoxia[J].Chinese Medical Sciences Journal, 2020, 35(1): 54-64. (cams.cn)
However, we have a poor understanding of the degree to which diminished cardiac function contributes to the reduction in fish swimming performance concomitant with acute exposure to hypoxia, or how fish cardiorespiratory physiology is altered by, or adapts to, chronic hypoxia. (biologists.com)

Danger signal evoked in the brain by the stressing preconditioning stimulus induces complex endogenous protective mechanisms resulting to a latent protective phenotype. (biomedcentral.com)
Ischemic tolerance or preconditioning is a phenomenon by which a sub-injurious stimulus is applied to a tissue such as the brain. (biomedcentral.com)

Explore how BFR Training impacts blood flow dynamics, leading to localized hypoxia and metabolite accumulation. (grindergym.com)

In humans, transient ischemic attacks may be the clinical correlate of preconditioning leading to ischemic tolerance. (biomedcentral.com)

6,7 Mesenchymal stem cells (MSCs) have also been isolated from other sources, such as bone marrow, 8 the placenta, 9 muscle, 10 or blood. (jcadonline.com)

Wistar rats were preconditioned with a sublethal dose of endotoxin on day −3 or −1. (akjournals.com)
We evaluated whether the transcription of a set of crucial prosurvival genes is affected differently by a single short-term (2 h) exposure to sublethal hypoxia compared with eight such successive hypoxia exposures (hypoxia preconditioning). (ipmallorca.com)

Results: In vitro assays confirmed that preconditioning enhances MSC function, accelerating pulmonary epithelial wound closure, reducing inflammation, attenuating cell death, and increasing bacterial killing. (np-monocyte.eu)

We hypothesized that TLRs other than TLR-4 may mediate preconditioning against cerebral ischemic injury in the developing brain. (biomedcentral.com)
Using epi-illumination microscopy in vivo to observe cerebral blood flow velocity on the brain surface, … Brain Blood Flow and Blood Pressure During Hypoxia in the Epaulette Shark Hemiscyllium Ocellatum, a Hypoxia-Tolerant Elasmobranch J Exp Biol. (ipmallorca.com)

Methods: The potential for naive and preconditioned MSCs to enhance wound healing, reduce inflammation, preserve metabolic activity, and enhance bacterial killing was assessed in vitro. (np-monocyte.eu)
The effects of progressive hypoxia on the metabolic and ventilatory responses of these elasmobranchs were examined in a closed respirometer. (ipmallorca.com)
The epaulette shark responds to hypoxia (e.g., on shallow reef platforms during low tide) by entering a phase of metabolic and ventilatory depression (Mulvey and Renshaw 2009;Routley et al. (ipmallorca.com)
Besides breaking the vicious circle of inflammation - oedema - hypoxia, HBO shifts local metabolic status to aerobic (using oxygen) thus, preventing tissues from shortage of energy deposits that are necessary for uninterrupted restoration of the injured site. (hyperbaric.gr)

This phenomenon named as preconditioning (PC) and tolerance has been shown to exist in many organs, most extensively in the heart. (biomedcentral.com)
Hypoxia tolerance has been studied in the epaulette shark inhabiting the reef platform surrounding Heron Island - a small and low coral cay situated close to the southern end of the Great Barrier Reef. (ipmallorca.com)
Hypoxia tolerance in the epaulette shark (Hemiscyllium ocellatum) Wise Graham, Mulvey Jamin M., Renshaw Gillian M. C. The Journal of Experimental Zoology. (ipmallorca.com)
The epaulette shark, Hemiscyllum ocellatum, is remarkably tolerant of severe hypoxia at temperatures up to 34°C, and therefore provides a valuable model to study warm hypoxia tolerance. (ipmallorca.com)
Epaulette sharks have a high tolerance of hypoxia, or being depleted of oxygen. (ipmallorca.com)

Remote ischaemic preconditioning (RIPC) is known to minimise IRI in previous studies. (medsci.org)
Meanwhile, the organ protective effect of ischaemic preconditioning could be induced when the episodic ischaemia is at distant tissues or organs, the concept being termed remote ischaemic preconditioning (RIPC) [ 9 ]. (medsci.org)
The application of RIPC into clinical fields is more useful than ischaemic preconditioning because it is easy to apply briefly preceding ischaemia to distant organs such as the limbs. (medsci.org)
The role of remote ischemic preconditioning (rIPC) in hypoxia is not yet fully understood. (conditionmed.org)
Since rIPC influences autonomic nervous system activity, we investigated the effects of rIPC on cardiopulmonary parameters during exercise in hypoxia. (conditionmed.org)
1993 ) introduced remote ischemic preconditioning (rIPC) as a strategy to limit IRI in an area far from that subject to the preconditioning protocol. (conditionmed.org)

Ischaemic preconditioning describes the phenomenon where transient and brief ischaemia confers protection against a subsequent prolonged and injurious period of ischaemia. (medsci.org)

Conclusions: Preconditioning with cytokines, but not hypoxia, enhances the therapeutic potential of MSCs in clinically relevant models of K. pneumoniae-induced pneumosepsis. (np-monocyte.eu)
We examined whether intrarenal arterial transplantation of dexmedetomidine (DEX) preconditioning ADSC-derived microvesicles (DEX-MVs) could promote further therapeutic potential to reduce renal IR injury. (ntnu.edu.tw)

Two groups of Sprague-Dawley rats ( n =6 per group) were either exposed to hypoxia (10% O 2 ) or normoxia (21% O 2 ) for 3 weeks. (cams.cn)
Although surgery (flow probe implantation) reduced the U crit of normoxia-acclimated cod by 14% (from 1.74 to 1.50 BL s −1 ) under normoxic conditions, exposure to acute hypoxia lowered the U crit of both groups (surgery and non-surgery) by ~30% (to 1.23 and 1.02 BL s −1 , respectively). (biologists.com)
The concentrations of growth factors (such as HGF, bFGF, and VEGF) in the cell culture supernatants collected from culture media of the hypoxia-preconditioned AT-MSCs and UC-MSCs (as well as those from AT-MSCs and UC-MSCs cultured in normoxia) were measured by ELISA. (minervamedica.it)
For AT-MSCs, there was a significant increase in VEGF and bFGF production when preconditioned with hypoxia, compared to normoxia, while HGF production was only slightly increased. (minervamedica.it)
After a 2-h wash-out in normoxia, participants performed a second incremental-exercise (2nd-Exercise) in hypoxia. (conditionmed.org)
With gas flows as low as 200 ml/min, our combination of plate holders with gas-permeable cultureware generates rapid normoxia-hypoxia cycles. (mcqinst.com)

For example, when blood pressure drops in circulatory shock, Starling forces drive fluid into the interstitium, causing third spacing. (wikipedia.org)
the epaulette shark is the best-studied example of a hypoxia-tolerant reef ﬁsh, its respiratory and circulatory response to hypoxia has not been examined. (ipmallorca.com)

PI3K deactivates BAD via Akt-mediated phosphorylation and thus may inhibit hypoxia-induced apoptosis in neurons. (jneurosci.org)
Consistently, DEX-MVs were better than MV in increasing CD44 expression, improving IR-depressed renal hemodynamics and renal erythropoietin expression, inhibiting IR-enhanced renal ROS level, tubular injury score, miR-122-5p expression, pNF-κB expression, Bax/caspase 3/poly(ADP-ribose) polymerase (PARP)-mediated apoptosis, blood urea nitrogen, and creatinine levels. (ntnu.edu.tw)

Ischemic preconditioning, therefore, protects against subsequent ischemic injury. (biomedcentral.com)
Furthermore, it causes vasoconstriction leading to reduced blood supply to the tissues and subsequent oedema (swelling) reduction . (hyperbaric.gr)
Effort in hypoxia is capable of impairing cardiopulmonary performance during a subsequent exercise. (conditionmed.org)

abstract = "Cardiac function is required for blood circulation and systemic oxygen delivery. (johnshopkins.edu)
Russell, B.C. of hypoxia preconditioned epaulette sharks Kalle T Rytkönen*1,2, Gillian MC Renshaw3,5, Kevin J Ashton 4, Grant Williams-Pritchard5, Erica H Leder 1,2 and Mikko Nikinmaa1,2 Abstract Background: Elasmobranch fishes are an ancient group of vertebra tes which have high potential as model species for research into evolutionary physiology and genomics. (ipmallorca.com)

Our results establish EPO as an important paracrine neuroprotective mediator of ischemic preconditioning. (jneurosci.org)

RESULTS: The data showed that preconditioning with hypoxia promoted the secretion of bFGF, VEGF, and HGF by both AT-MSCs and UC-MSCs. (minervamedica.it)

We have shown that preconditioning by lipopolysaccharide (LPS) will result in 90% reduction in ischemic brain damage in P7 rats. (biomedcentral.com)
The results showed that the TFs significantly attenuated cell injury and markedly decreased serum creatinine (Cr) and blood urea nitrogen (BUN) levels in rats. (mdpi.com)
Thirty rats with fasting blood glucose higher than 11.7 mmol/L were randomly divided into diabetes (DM) and TSF groups, 15 rats in each group. (bvsalud.org)

Considering that tourniquet application during TKR is related to ischaemic injury, the organ protective effect of ischaemic preconditioning can have a beneficial role after tourniquet release during TKR. (medsci.org)
The volume-regulated anion channel (LRRC8) in nodose neurons is acid pH sensitive and provides protective post ischemic preconditioning. (uiowa.edu)

In addition, some tests have to be done with whole blood, such as the determination of the amount of blood cells in blood via flow cytometry. (wikipedia.org)
Blood Flow Restriction (BFR) Training has emerged as a revolutionary approach to fitness and rehabilitation. (grindergym.com)
This section provides a foundational overview of BFR Training, introducing the concept of controlled blood flow restriction and its underlying principles. (grindergym.com)
Uncover the balance between restricted blood flow and mechanical tension, which drives muscle activation. (grindergym.com)
Both aim at removing the clot and restoring blood flow to the brain. (explorationpub.com)
The poor outcome amongst these patients has been attributed to the effects of the restoration of blood flow to previously ischemic tissue ( 3 ). (spandidos-publications.com)
Brain blood flow and blood pressure during hypoxia in the epaulette shark Hemiscyllium ocellatum, a hypoxia-tolerant elasmobranch. (ipmallorca.com)

These results provide important insights into how fish cardiorespiratory physiology is impacted by short-term and prolonged exposure to hypoxia, and further highlight the tremendous capacity of the fish cardiorespiratory system to deal with environmental challenges. (biologists.com)
We validated the physiological relevance of this model by showing that hypoxia inducible factor-1α expression was significantly increased by IH exposure in human aortic endothelial cells, murine breast carcinoma (4T1) cells as well as in a blood-brain barrier model (2.5-, 1.5-, and 6-fold increases, respectively). (mcqinst.com)
Since stroke and coronary heart disease are common OSA-associated comorbidities, increased knowledge of the effects of IH exposure of endothelial cells and blood brain barrier appears to be crucial. (mcqinst.com)

were significantly lower in hypoxia-acclimated cod at both levels of oxygenation, because of lower values for V S . However, hypoxia-acclimated cod were able to consume more oxygen for a given cardiac output. (biologists.com)

Therefore, this study aimed to investigate the effects of hypoxia-preconditioned MSCs from human adipose tissue-derived MSCs (AT-MSCs) and from human umbilical cord-derived MSCs (UC-MSCs). (minervamedica.it)

Low water oxygen content (hypoxia) is a common feature of many freshwater and marine environments. (biologists.com)
The combination of reduced blood supply and increased tissue oxygenation due to increased oxygen content, named "Oxygen Paradox", is a unique property of Hyperbaric Oxygen Therapy. (hyperbaric.gr)

Until now, the recanalization of occluded blood vessels via thrombolysis and thrombectomy, although highly potent, remains the only treatment in humans that enhances stroke outcome. (explorationpub.com)

The changes in serum cytokine and lactate dehydrogenase (LDH) levels were assessed and arterial blood gas analysis was performed. (medsci.org)

Among all, 803 genes were down-regulated, while only 69 genes were up-regulated in the hypoxia group. (cams.cn)
Red dot represents down-regulated genes, blue dot represents up-regulated genes and gray dot represents not changed genes in the hypoxia group. (cams.cn)

This plasma shift causes an increase in hematocrit, serum total protein, blood viscosity and, as a result of increased concentration of coagulation factors, it causes orthostatic hypercoagulability. (wikipedia.org)
The second most common type of protein in the blood plasma are globulins. (wikipedia.org)
The delay to protection may be minutes to few hours (rapid or early preconditioning) or days (delayed preconditioning) requiring protein synthesis [ 10 - 12 ]. (biomedcentral.com)

We evaluated the role of hypoxia on the angiogenic potency of these MSCs. (minervamedica.it)
However, when preconditioned with hypoxia (5% O 2 ), the angiogenic potency of both AT-MSCs and UC-MSCs was similar. (minervamedica.it)
Here we investigated the potential of mesenchymal stromal cells (MSCs) to combat established Klebsiella pneumoniae pneumosepsis and further evaluated MSC preconditioning and pre-activation methods. (np-monocyte.eu)
Cytomix-pre-activated MSCs are superior to naive and hypoxia-exposed MSCs in attenuating Klebsiella pneumosepsis, improving lung compliance and oxygenation, reducing bacteria, and attenuating histologic injuries in lungs. (np-monocyte.eu)

Semenza, GL 2014, ' Hypoxia-inducible factor 1 and cardiovascular disease ', Annual review of physiology , vol. 76, pp. 39-56. (johnshopkins.edu)

It is capable of surviving complete anoxia for an hour without ill effects, and at a much higher temperature than most other hypoxia-tolerant animals. (ipmallorca.com)
Moreover, clinical research is limited by confounding factors that make it difficult to distinguish between the respective effects of intermittent hypoxia and comorbidities. (mcqinst.com)

As soon as syringe caps, needle covers, and temperature for newborns is the medic-alert identification, a stainless steel probe, which is having three times higher if underlying heart or with sexual abuse an essential role,63 lead- ing to fetal hypoxia and acidemia. (lowerbricktown.com)
During NREM sleep, the largest portion (up to 80%) of normal adult sleep, the autonomic system is stabilized with vagal dominance, reduced sympathetic tone, and heightened baroreceptor gain, contributing to a significant reduction in blood pressure and heart rate, with the greatest drop occurring during slow wave sleep [ 21 - 24 ]. (j-stroke.org)
A radical approach to beating hypoxia: depressed free radical release from heart fibres of the hypoxia-tolerant epaulette shark (Hemiscyllum ocellatum) ResearchSpace/Manakin Repository. (ipmallorca.com)

Searching for molecular hypoxia sensors among oxygen-dependent enzymes. (ucsf.edu)

It plays a vital role in an intravascular osmotic effect that keeps electrolyte concentration balanced and protects the body from infection and other blood-related disorders. (wikipedia.org)
Alpha-1 and Alpha-2 globulins are formed in the liver and play an important role in mineral transport and the inhibition of blood coagulation. (wikipedia.org)

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species. (johnshopkins.edu)
filter by provider show all FAO species catalogs Fishbase wikipedia EN. (ipmallorca.com)

This is not surprising, considering that oedema and hypoxia of the injured tissues are common causes of complications that delay healing. (hyperbaric.gr)

The increased viscosity of blood prevents fluid from entering the bloodstream from outside the capillaries. (wikipedia.org)
Hypoxia also prevents radiotherapy from working. (canceractive.com)

Modifiable risk factors such as high blood pressure, hyperlipidemia, diabetes, smoking, physical inactivity, and unhealthy diet are responsible for 90% of the risk of stroke [ 6 , 7 ]. (j-stroke.org)

In astrocytes the OGD enhanced the nuclear translocation of hypoxia-inducible factor 1 (HIF-1), the major transcription factor regulating EPO expression. (jneurosci.org)

Various noxious stimuli can precondition the brain, presumably through a common mechanism, genomic reprogramming. (biomedcentral.com)
This is the first study to show that TLR-3 is expressed in the immature brain and mediates preconditioning against ischemic injury. (biomedcentral.com)
Future student enquiries 1800 677 728 Current student enquiries 1800 154 055 International enquiries +61 7 3735 6425 General enquiries 07 3735 7111 They do this by increasing the blood supply to its brain and selectively shutting down non-essential neural functions. (ipmallorca.com)
Peripherally administered EPO crosses the blood-brain barrier and activates in the brain anti-apoptotic, anti-oxidant and anti-inflammatory signaling in neurons, glial and cerebrovascular endothelial cells and stimulates angiogenesis and neurogenesis. (biomedcentral.com)

Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but which contains proteins and other constituents of whole blood in suspension. (wikipedia.org)
Blood plasma is separated from the blood by spinning a vessel of fresh blood containing an anticoagulant in a centrifuge until the blood cells fall to the bottom of the tube. (wikipedia.org)
An example of beta globulin found in blood plasma includes low-density lipoproteins (LDL) which are responsible for transporting fat to the cells for steroid and membrane synthesis. (wikipedia.org)
Dark brown or reddish color can appear due to hemolysis, in which methemoglobin is released from broken blood cells. (wikipedia.org)
Cancer tumours have areas of hypoxia to prevent oxygen entering the cancer cells. (canceractive.com)
Using oxygen under a little pressure overcomes the areas of hypoxia and pre-sensitises (weakens) cancer cells so that more are killed by the action of radiotherapy. (canceractive.com)
Numerous reports showed that tumor EVs are not restricted only to tumor microenvironment but are also present in the blood circulation and other body fluids, supporting the idea that EVs can also stimulate cells at distant sites in the organism [10-13]. (unicyte.ch)
H9c2 cells were subjected to 3‑h hypoxia, followed by 1‑h reperfusion. (spandidos-publications.com)
Using samples from two similar studies at two sites, we measured early morning blood malondialdehyde (MDA, a primary outcome in one study and a secondary outcome in the other), lipid hydroperoxides, total antioxidant capacity, superoxide generation from mononuclear cells and urinary F2-isoprostane. (ox.ac.uk)
Patch-clamping glomus cells of the carotid bodies allowed us to uncover new ionic determinants of sensitivity to hypoxia and low pH. (uiowa.edu)

Serum albumins are the most common plasma proteins and they are responsible for maintaining the osmotic pressure of blood. (wikipedia.org)
Fibrinogen proteins make up most of the remaining proteins in the blood. (wikipedia.org)

This is characterized by a marked increase in fecal urobilinogen excretion and a normal or near-normal red blood cell lifespan. (medscape.com)
TITLE: An innovative intermittent hypoxia model for cell cultures allowing fast Po2 oscillations with minimal gas consumption. (mcqinst.com)
Our goal was to develop a novel device to expose multiple cell culture dishes to intermittent hypoxia (IH) cycles relevant to OSA with limited gas consumption. (mcqinst.com)
In conclusion, we have established a new device to perform rapid intermittent hypoxia cycles in cell cultures, with minimal gas consumption and the possibility to expose several culture dishes simultaneously. (mcqinst.com)

For example, the decrease in blood pressure during sleep, "dipping," is a key biomarker of cardiovascular health, secondary to changes in activity and posture and also under the influence of sleep and circadian rhythms [ 20 , 21 ]. (j-stroke.org)
Inhalation of 100% Oxygen at usually prescribed pressures in a hyperbaric chamber, multiplies the amount of Oxygen carried by the blood, reaching levels that can not be achieved in normal pressure conditions. (hyperbaric.gr)
The mechanosensors PIEZO1 and 2 are important determinants of blood pressure and the baroreflex. (uiowa.edu)

Anatomy41

Organisms14

Diseases28

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Psychiatry and Psychology1

Phenomena and Processes74

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science2

Health Care3

Geographicals1

Ischemia9

Hypoxic10

Reoxygenation4

Chronic hypoxia5

Stimulus2

Leading to localized1

Ischemic tolerance1

Mesenchymal stem1

Sublethal2

Pulmonary1

Cerebral2

Metabolic4

Tolerance5

RIPC6

Confers1

Therapeutic2

Normoxia6

Circulatory2

Apoptosis2

Subsequent3

Abstract2

Paracrine1

BFGF1

Rats3

Protective2

Flow7

Exposure3

Cardiac1

Adipose1

Oxygen content2

Humans1

Arterial1

Genes2

Protein3

MSCs4

Physiology1

Effects2

Heart3

Molecular1

Role2

Species2

Tissues1

Prevents2

Stroke1

Transcription factor1

Brain4

Cells10

Proteins2

Cell4

Pressure3