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  • perinatal
  • 2009). The Vannucci HI model has since been adapted to mouse models of perinatal brain injury, and this has allowed the technique to be used with a broader array of genetically modified animals. (bio-protocol.org)
  • mortality
  • 92%) in the prehospital setting in patients with potentially survivable brain injuries, and to prospectively examine the association of these secondary insults with mortality and disability at hospital discharge. (wikem.org)
  • Hypoxia in the prehospital setting significantly increases the odds of mortality after brain injury controlled for multiple variables. (wikem.org)
  • Multivariate analysis accounting for the above independent variables showed that hypoxia was an independent predictor of mortality (OR 2.66, p 0.05). (wikem.org)
  • Interestingly, most previous data found that hypotension and not hypoxia (the reverse findings of this paper) was linked with increased mortality in TBI. (wikem.org)
  • Hypotension but not hypoxia are associated with increased mortality. (wikem.org)
  • Conclusions: Both hypoxia and hyperoxia were associated with increased mortality in TBI patients, even after adjusting for multiple factors affecting outcomes. (ahajournals.org)
  • Analysis at 24 h included infarction volume, measurement of brain concentration of malondialdehyde (MDA) (an end-product of lipid peroxidation), daily weight, Nissl histology, and mortality. (molecularhydrogenstudies.com)
  • mitochondrial
  • Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. (springer.com)
  • JI-8 decreased NO production in brain slices and also showed significant preservation of mitochondrial function at both 3 and 6 days (p (figshare.com)
  • In Wt mice, hypoxia increased mRNA levels for peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1 alpha), nuclear respiratory factor-1, and mitochondrial transcription factor A. After 24 h, new mitochondria, localized in reporter mice expressing mitochondrial green fluorescence protein, were seen primarily in hippocampal neurons. (duke.edu)
  • In contrast, nuclear transcriptional regulation of mitochondrial biogenesis in nNOS-/- mice was normal at baseline but did not respond to hypoxia. (duke.edu)
  • blood-brain b
  • The Aβ upswell in blood probably reflects increased production of the peptide in brain, but it is also possible that the surge is due simply to greater leakage from the brain, perhaps through breakdown of the blood-brain barrier, the authors note. (alzforum.org)
  • Blood-brain barrier pericytes as a target for HIV-1 infection. (bioportfolio.com)
  • Sphingosine-1-phosphate (S1P) has known endothelial barrier protective properties, but whether this extends to the blood-brain barrier (BBB) is unclear. (bioportfolio.com)
  • The choroid plexus (CP), main component of blood-cerebrospinal fluid barrier (BCSFB), protects the brain from peripheral inflammation similar to the blood-brain barrier. (bioportfolio.com)
  • The purpose of this research study is to determine if sunitinib can get past the blood-brain barrier and into the brain tumor. (bioportfolio.com)
  • The purpose of this study is to evaluate the safety and efficacy of the ExAblate® Model 4000 Type 2.0 system as a tool to open the blood-brain barrier (BBB) in patients with probable Alzh. (bioportfolio.com)
  • The blood-brain barrier (BBB) is a complex vascular structure consisting of microvascular endothelial cells that line the vessel wall, astrocyte end-feet, pericytes, as well as the basal lamina. (uzh.ch)
  • insults
  • Patients with prehospital episodes of hypoxia and/or hypotension have a greater degree of disability at discharge and require longer hospital stays compared with those without secondary insults. (wikem.org)
  • ligation
  • The modifications of the RV model entail unilateral ligation and interruption of the common carotid artery followed by a period of relative hypoxia, applied to postnatal day zero mice. (unizg.hr)
  • FiO2
  • Aggressive airway management has been advocated to reverse hypoxia, including intubation and ventilation with 1.0 FiO2. (ahajournals.org)
  • postnatal
  • Multiple imaging modalities were employed in the analysis, including magnetic resonance imaging (MRI), histological Nissl staining, as well as immunohistochemical staining of exvivo day three and seven postnatal mice brains. (unizg.hr)
  • nNOS
  • We tested the efficacy of a selective nNOS inhibitor (JI-8) in fetal brains after in utero HI in our rabbit model. (figshare.com)
  • After hypoxia, subcortical mtDNA content increased in Wt and eNOS-/- mice but not in nNOS-/- mice. (duke.edu)
  • Hypoxia stimulated PGC-1alpha protein expression and phosphorylation of protein kinase A and cAMP response element binding (CREB) protein in Wt mice, but CREB only was activated in eNOS-/- mice and not in nNOS-/- mice. (duke.edu)
  • oxygenation
  • Reduced oxygenation, or hypoxia, is a characteristic of many brain diseases that significantly increases barrier permeability. (uzh.ch)
  • Thus, therapeutic doses of hyperbaric oxygenation did not normalize the homocarnosine content in brain of animals with hypoxia. (msk.ru)
  • Krichevskaia A.A., Bondarenko T.I., Makletsova M.G., Lobova E.F., Homocarnosine levels in various regions of the rat brain and blood in hypoxia and after hyperbaric oxygenation, Voprosy meditsinskoi khimii, 1985, vol: 31(1), 74-76. (msk.ru)
  • Mild and moderate forms of cerebral hypoxia may be caused by various diseases that interfere with breathing and blood oxygenation . (wikipedia.org)
  • energy metabolism
  • Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin. (springer.com)
  • Mayevsky, A., Brain energy metabolism of the conscious rat exposed to various physiological and pathological situations. (springer.com)
  • metabolism
  • Borowsky IW and RC Collins: Metabolic anatomy of brain: A comparison of regional capillary density, glucose metabolism, and enzyme activities. (springer.com)
  • injuries
  • Tighter fit' theory-physiologists explain why 'higher altitude' and jugular occlusion are unlikely to reduce risks for sports concussion and brain injuries. (semanticscholar.org)
  • Carnosine has been demonstrated to play a neuroprotective role in the adult brain injuries. (semanticscholar.org)
  • Brain injuries can heal if they are caught early and the right treatment is sought. (smithjonessolicitors.co.uk)
  • The Regeneration Center Does Not Accept Patients With Brain and/or Spinal Injuries older than 24 months old. (stemcellthailand.org)
  • A combination therapy will be required for most brain injuries with the goal of increased recovery of any lost cognitive function Our cell delivery systems are very safe and administered via Stereotactic-guided delivery, inhalation via micro-nebulizer, Intravenous Drip and/or Intrathecally. (stemcellthailand.org)
  • outcome
  • The magnitude and duration of the Aβ surge correlated with patient outcome, meaning the spikes were shorter and smaller in patients who recovered good cognitive function, while the brains of patients who died or remained in a vegetative state continued to pump out massive and rising levels of the peptide. (alzforum.org)
  • outcomes
  • Furthermore, the size and duration of the Aβ spike correlates with worse clinical outcomes, suggesting that more severe hypoxia results in greater Aβ release. (alzforum.org)