Loading...
  • normobaric hypoxia
  • Methods: During normoxia (FI(O(2)) = 0.21) and 4 hours of normobaric hypoxia (FI(O(2)) = 0.12, corresponding to an altitude of 4,500 m above sea level) endothelium-dependent and endothelium-independent vasodilator responses to intraarterial infusion of acetylcholine (ACh) and sodium nitroprusside, respectively, were measured by forearm venous occlusion plethysmography in nine HAPE-S subjects and in nine HAPE-resistant control subjects. (clinicaltrials.gov)
  • responses
  • Despite similar responses during normoxia in both groups, ACh-induced changes in forearm blood flow markedly decreased during hypoxia in HAPE-S subjects (p = 0.01) but not in control subjects. (clinicaltrials.gov)
  • ischemia
  • Research-clinicians at Children's National Health System led the first study to identify a promising treatment to reduce or prevent brain injury in newborns who have suffered hypoxia-ischemia, a serious complication in which restricted blood flow deprives the brain of oxygen. (news-medical.net)
  • We believe this new template may be important because it's showing different mechanisms of action-different ways to interact with neurons, possibly with a good therapeutic effect for such diseases as epilepsy, hypoxia-ischemia and several neurodegenerative disorders," said Alban Pereira, a postdoctoral researcher in Scripps' CMBB. (acronymfinder.com)
  • 00 Hardcover RC388 Twenty-eight international academics, researchers, and practitioners contribute nine chapters on recent and significant research on brain hypoxia-ischemia . (acronymfinder.com)
  • Effects of the 21-amino steroid tirilazad mesylate (U-74006F) on brain damage and edema after perinatal hypoxia-ischemia in the rat. (acronymfinder.com)
  • oxidative stress
  • Patients with the condition have increases in circulating markers of oxidative stress and inflammation and develop losses of regional gray and white matter -- changes that have been mimicked in mice experimentally exposed to intermittent hypoxia during their sleep cycle, Dr. Gozal and colleagues said. (medpagetoday.com)
  • A growing body of evidence suggests that the adverse neurobehavioral consequences imposed by (intermittent hypoxia) stem, at least in part, from oxidative stress and inflammatory signaling cascades," Dr. Gozal said in a statement. (medpagetoday.com)
  • oxygen levels
  • The Human Hypoxia Signaling Pathway RT² Profiler PCR Array profiles the expression of 84 genes that respond to low oxygen levels. (qiagen.com)
  • Scientific assessments have concluded that the nutrients from the Mississippi River watershed are the primary cause of the dramatic drop in oxygen levels (" hypoxia ") sparking the Gulf of Mexico's summer time "dead zone. (epa.gov)
  • Recently it has been discovered that the hypoxia (low oxygen levels) present at such sites plays a vital role in these diseases. (coventry.ac.uk)
  • abnormal
  • We can now start to exploit these findings into novel clinical trials to target hypoxia and abnormal genetics at the same time,' adds Bristow. (news-medical.net)
  • mediate
  • Hypoxia-inducible target genes mediate multiple biological functions, such as vasculogenesis, wound healing, and chondrocyte survival in bone growth plates. (qiagen.com)
  • hallmarks
  • In a landmark pan-cancer study analyzing more than 8,000 tumors across 19 different cancer types, researchers have identified molecular hallmarks of hypoxia in human tumors - a well-known cause of treatment resistance and cancer spread. (news-medical.net)
  • expression
  • Nitric Oxide Regulates the Expression of Vasoconstrictors and Growth Factors by Vascular Endothelium under both Normoxia and Hypoxia" J. Clin. (freepatentsonline.com)
  • Hypoxia is a Strong Inducer of Vascular Endothelial Growth Factor mRNA expression in the Heart" Academic Press (1993) 195(2):1005. (freepatentsonline.com)
  • 6 The dysregulated calcium expression following hypoxia in central neurons may contribute to the neurotoxicity of β- amyloid protein and subsequent development of Alzheimer disease. (pubmedcentralcanada.ca)
  • researchers
  • The November 1st issue of Biological Psychiatry includes an article by researchers who show that the presence of a specific indicator of fetal distress following hypoxia was more likely to be present among people who later develop schizophrenia. (innovations-report.com)
  • symptoms
  • Fresh on the heels of yesterday's announcement by the Air Force that it thinks the hypoxia-like symptoms suffered by F-22 Raptor pilots may be caused by the jets high-altitude performance, reports are emerging that ground crew are also suffering from similar ailments when they stand near the jet while it's engines are running. (military.com)
  • mechanisms
  • In this review, we comprehensively discuss the transcription factors that have been reported to be hypoxia-responsive and the signalling mechanisms leading to their activation. (nih.gov)
  • Hypoxia was previously associated with aggressive disease, but the mechanisms by which it drives this process in human tumors was poorly understood from a genetic angle,' says Robert Bristow, a director at the Manchester Cancer Research and CRUK Manchester Centres at the University of Manchester. (news-medical.net)
  • Although hypercapnic hypoxia (HH) can affect certain specific immune mechanisms, its direct effect on the inactivation, degradation and elimination of bacteria in oysters is unknown. (mendeley.com)
  • human
  • Human dermal fibroblast-seeded dense-collagen depots were pre-conditioned under physiological cell-generated hypoxia to up-regulate production of key angiogenic factors, including HIF1α and VEGF(165). (nih.gov)
  • mechanism
  • Barsoum IB, Smallwood CA, Siemens DR, Graham CH. A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells. (springer.com)
  • angiogenic
  • First implantable device for hypoxia-mediated angiogenic induction. (nih.gov)
  • Hypoxia and ischaemia (poor blood flow) alter the phenotype of macrophages in a way that can promote development of disease, for example by causing the macrophage to secrete pro-inflammatory and pro-angiogenic (blood vessel growth stimulating) proteins. (coventry.ac.uk)
  • cancer
  • EMT: a new vision of hypoxia promoting cancer progression. (springer.com)
  • Hypoxia-inducible factors mediators of cancer progression and targets for cancer therapy. (springer.com)
  • Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. (springer.com)
  • The markers the team identified pave the way for new opportunities to develop therapies that target hypoxia-related treatment resistance and cancer spread across many different types of cancer. (news-medical.net)
  • The conversion of 5-methylcytosine to 5-hydroxymethylcytosine by TET enzymes requires oxygen whereas hypoxia is common in cancer, suggesting a potential synergistic effect. (europa.eu)
  • chamber
  • The Hypoxia Incubator Chamber utilizes a surface-type seal where all portions of the O-ring are uniformly compressed by a stainless steel ring clamp for a reliable air-tight seal. (bio-medicine.org)
  • colleagues
  • The results indicate that GTPs "are capable of attenuating (intermittent hypoxia-induced) spatial learning deficits," Dr. Gozal and colleagues said. (medpagetoday.com)
  • Christopher Patterson and colleagues reviewed the modifiable risk factors for Alzheimer disease but did not mention that hypoxia may stimulate the development of this illness. (pubmedcentralcanada.ca)
  • Research
  • This line of thinking was sparked by a recent trip, and my current research studying the effects of nitrogen-driven eutrophication (too much organic matter) and the consequent hypoxia (too little dissolved oxygen) on the clams, crabs, and other animals living on and in the bottom sediments. (epa.gov)