• Febuxostat (Fx) is a recently developed xanthine oxidase (XO) inhibitor, which has been definitively proved to be effective and safe for gout treatment [ 7 ]. (hindawi.com)
  • Febuxostat is a nonpurine selective xanthine oxidase inhibitor that does not require dose reduction in patients with renal impairment. (medscape.com)
  • Rasburicase, a recombinant urate oxidase that converts existing uric acid into allantoin which is soluble, even at acidic pH, and easily excreted by the kidney. (standardofcare.com)
  • It is a recombinant urate oxidase that is indicated for preventing complications of hyperuricemia during the tumor lysis syndrome. (medscape.com)
  • Sulfite oxidase deficiency is an inborn error of the metabolism of sulfated amino acids. (medscape.com)
  • Sulfite oxidase deficiency and molybdenum cofactor deficiency in the metabolism of sulfated amino acids. (medscape.com)
  • Oxygen rapidly faces with free electrons by means of hypoxanthinexanthine oxidase-xanthine system during the reperfusion/reoxygenation phase after ischemia/hypoxia. (cshd.org.tr)
  • Incubation of freshly isolated smooth muscle cells from control subjects with the *O2- -generating system xanthine oxidase/hypoxanthine mimicked the effect of diabetic patients on subcellular Ca2+ distribution in a superoxide dismutase-sensitive manner. (diabetesjournals.org)
  • Oxidative stress was induced by the exposure of cells to the hypoxanthine/xanthine oxidase system as a generator of superoxide radicals. (water-quality-journal.org)
  • However, there is only limited evidence on the clinical implications of xanthine oxidase inhibitors on atherosclerotic cardiovascular disease in patients with hyperuricemia. (biomedcentral.com)
  • Causes of kidney disease include deposition of the Immunoglobulin A antibodies in the glomerulus, administration of analgesics, xanthine oxidase deficiency, toxicity of chemotherapy agents, and a long-term exposure to lead or its salts. (wikipedia.org)
  • Individuals affected with sulfite oxidase deficiency most commonly present in the neonatal period with intractable seizures, characteristic dysmorphic features, and profound intellectual disability. (medscape.com)
  • Molybdenum cofactor deficiency, which affects the functioning of sulfite oxidase, leads to a similar phenotype. (medscape.com)
  • Inherited defects in the sulfite oxidase enzyme can cause the phenotype of sulfite oxidase deficiency. (medscape.com)
  • Deficiency of xanthine oxidase and aldehyde oxidase is not known to cause neurologic disease and may not produce symptoms. (medscape.com)
  • As sulfite oxidase deficiency and molybdenum cofactor deficiency have virtually identical phenotypes, the CNS toxicity appears to be secondary to loss of function of sulfite oxidase. (medscape.com)
  • The pathogenesis of the brain damage in those with sulfite oxidase deficiency is not known but may be related to sulfite accumulation or lack of sulfate in the CNS. (medscape.com)
  • Worldwide, approximately 50 cases of sulfite oxidase deficiency have been reported. (medscape.com)
  • In most cases, sulfite oxidase deficiency is fatal in infancy or early childhood. (medscape.com)
  • Survivors of sulfite oxidase deficiency often have profound intellectual disability. (medscape.com)
  • Traditionally, infants with sulfite oxidase deficiency were reported to present in the neonatal period. (medscape.com)
  • Sulfite oxidase is located in the mitochondrial intermembranous space and is involved in electron transport. (medscape.com)
  • When sulfite oxidase is deficient, alternate metabolic pathways for sulfite are augmented, including formation of metabolites s-sulfocysteine and thiosulfate. (medscape.com)
  • Metabolomics investigation revealed that C1QBP dramatically diminished the hypoxanthine content in RCC cells. (medsci.org)
  • Xanthine oxidase is also recognized as a pivotal enzyme in the production of oxidative stress. (biomedcentral.com)
  • L'évolution dans le temps des paramètres mesurés permet de conclure à une meilleure protection vis-à-vis des radicaux libres en présence d'eau de La Bourboule (par rapport à l'eau reconstituée) : d'une part la production de MDA est inférieure dans le cas de l'eau thermale, d'autre part les activités enzymatiques des cellules cultivées dans l'eau thermale sont plus élevées notamment dans les études de régénération et de prévention. (water-quality-journal.org)
  • C1QBP promotes the catabolism of hypoxanthine and elevates the apoptosis of RCC cells by modulating XDH-mediated ROS generation. (medsci.org)
  • PubMed, Cochrane Library, and Lilacs databases were searched until April 24, 2021, for randomized clinical trials of CKD patients on uric acid-lowering treatment with xanthine-oxidase (XO) inhibitors. (revistanefrologia.com)