The authors hypothesized that, compared with normothermia, hypothermic CPB would result in superior neurologic and neurocognitive function after coronary artery bypass graft surgery. (asahq.org)
In the first group (control), myocardial anoxia was induced in normothermia and no cardioplegic solution was administered. (rbccv.org.br)
Normothermic3
Three hundred patients undergoing elective coronary artery bypass graft surgery were prospectively enrolled and randomly assigned to either normothermic (35.5-36.5 degrees C) or hypothermic (28-30 degrees C) CPB. (asahq.org)
There were no differences in neurologic or neurocognitive outcomes between normothermic and hypothermic groups in multivariable models, adjusting for covariable effects of baseline cognitive function, age, and years of education, as well as interaction of these with temperature treatment. (asahq.org)
Isolated rat hearts perfused with Krebs-Henseleit buffer were subjected to 30min of normothermic perfusion, then 4h of cardioplegic arrest at 4°C with St Thomas' Hospital solution, followed by reperfusion for 2h. (portlandpress.com)
Arrest2
Thus we conclude that ECE mRNA expression is increased following prolonged hypothermic cardioplegic arrest. (portlandpress.com)
Increasingly complex repairs subsequently became possible with the refinement of cardiopulmonary bypass (CPB) techniques and the use of hypothermic circulatory arrest that Barratt-Boyes et al (1971) and Castaneda et al (1974) popularized. (medscape.com)
Coronary2
The main goals of hypothermic cardioplegia are: Immediate and sustained electromechanical quiescence Rapid and sustained homogeneous myocardial cooling Maintenance of therapeutic additives in effective concentrations Periodic washout of metabolic inhibitors The most common procedure for accomplishing asystole is infusing cold cardioplegic solution into the coronary circulation. (wikipedia.org)
In the third and fourth groups, in addition to 28ºC systemic hypothermia, coronary infusion of 4ºC cardioplegic solutions were performed immediately and after 30 minutes of clamping of the aorta. (rbccv.org.br)
Conclude1
We may conclude that both cardioplegic solutions used, associated to hipothermia, protect efficiently the myocardial cells against anoxia. (rbccv.org.br)
Cardioplegia4
Cardioplegia is a solution given to the heart during cardiac surgery, to minimize the damage caused by myocardial ischemia while the heart is paused. (wikipedia.org)
Most commonly, however, the word cardioplegia refers to the solution used to bring about asystole of the heart, or heart paralysis. (wikipedia.org)
As the cardioplegia solution distributes to the entire myocardium, the ECG will change and eventually asystole will ensue. (wikipedia.org)
A compounding factor in critically ill or cardiac surgical patients with compromised circulation is that the glycocalyx is easily disrupted by hypoxia, 6 by use of cold cardioplegia solutions, 7 and with ischemia-reperfusion. (silverchair.com)
Preservation solution1
Our results indicate that cardioplegic solution-enriched with hypoxic CM-BMSCs can be a novel and promising preservation solution for donor hearts. (researchsquare.com)
Vehicle1
Donor hearts were explanted, stored in cardioplegic solution supplemented with either a medium (Vehicle), normoxic CM (N-CM), or hypoxic CM (H-CM), and then heterotopically transplanted. (researchsquare.com)
Cold1
Donor hearts were stored in cold histidine-tryptophan- α -ketoglutarate-N solution for 12 h and underwent heterotopic, isogenic transplantation, except 5 hearts of each group, which were analysed immediately after preservation. (frontierspartnerships.org)
Hearts1
Donor hearts from untreated Lewis rats were explanted, preserved in a cardioplegic solution, and subsequently heterotopically implanted. (bvsalud.org)
Blood3
Given the relatively low circulating blood volume of newborns and infants compared with that of adults, the priming solution in the CPB circuit plays an important role in hemodilution. (medscape.com)
It was not possible, however, to demonstrate any superiority of the blood solution over an acellular solution. (rbccv.org.br)
A consecutive series of 4014 patients underwent cardiosurgical procedures in the period from January 2001 to December 2006 in our centre, where modified Calafiore warm blood-cardioplegic solution was used. (shengsci.com)
Increasingly complex repairs subsequently became possible with the refinement of cardiopulmonary bypass (CPB) techniques and the use of hypothermic circulatory arrest that Barratt-Boyes et al (1971) and Castaneda et al (1974) popularized. (medscape.com)
The warm ischemic phase includes the time from the interruption of circulation to the donor organ to the time the organ is flushed with hypothermic preservation solution. (medscape.com)