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Hypothermia, InducedHypothermiaIschemiaCold IschemiaWarm IschemiaBrain IschemiaMyocardial IschemiaReperfusion InjuryOrgan PreservationDelayed Graft FunctionTime FactorsTissue DonorsGraft SurvivalBody TemperatureNephrectomyRewarmingKidney TransplantationLiver TransplantationTissue and Organ HarvestingDeathTissue and Organ ProcurementMyocardial Reperfusion InjuryCadaverLiving DonorsIschemic Attack, TransientOrgan Preservation SolutionsReperfusionRaffinoseHypoxia-Ischemia, BrainBiliary TractDisease Models, AnimalRats, Sprague-DawleyRetrospective StudiesTreatment OutcomePancreas TransplantationBrain DeathLaparoscopyGerbillinaeHeart ArrestIschemic PreconditioningTransplantsRats, WistarRoboticsSpinal Cord IschemiaBrainNeuroprotective AgentsGraft RejectionMyocardiumPostoperative ComplicationsAllopurinolInfarction, Middle Cerebral ArteryIschemic Preconditioning, MyocardialCerebrovascular CirculationKidneyMyocardial ReperfusionPrimary Graft DysfunctionKidney Tubular Necrosis, AcuteTissue PreservationBody Temperature RegulationBile DuctsBiliary Tract DiseasesLiver FailureHepatic ArteryCerebral InfarctionDonor SelectionRisk FactorsCoronary CirculationCirculatory Arrest, Deep Hypothermia InducedPerfusionHeartTissue FixationHindlimbFollow-Up StudiesTransplantation, HomologousDogsHemodynamicsMyocardial InfarctionNeuronsProspective StudiesHeart Arrest, InducedConstrictionCreatinineBrain EdemaHypoxia, BrainLiverAsphyxia NeonatorumRenal ArteryElectrocardiographyAnastomosis, SurgicalMice, Inbred C57BLCoronary DiseaseRisk AssessmentCardiopulmonary ResuscitationCardiotonic AgentsHippocampusSurvival RateMyocardial ContractionKidney NeoplasmsCold TemperatureNecrosis
TherapeuticAbrupt onsetReperfusionCerebralCardiac arrestAcuteTachycardiaNeuronal deathMyocardialAccidentalOccursOrganMetabolicHypoglycemiaPhysiologicalRectalTemperatureResolvesPrimarilyTissuesVitroSevereHeadacheStrokePhysicalCellularSymptomsClinicalWeaknessProfoundBrainTreatmentHeartCommonStudiesDeathPatientsLeadsMinutesPeriodDoseSigns
Therapeutic8
  • The narrow therapeutic window for benzodiazepines suggests that there is a critical time after ischemia when enhancement of GABA neurotransmission is beneficial to neurons. (jneurosci.org)
  • Hypothermia attenuated both the optical increase in intensity after MMPSense750 and the increase in MMP-9 protein expression supporting the proof of concept that NIRF imaging using MMPSense can be used to assess potential therapeutic strategies for stroke treatment. (biomedcentral.com)
  • In vivo visualization of MMP activity would provide important information regarding the spatial and temporal expression of MMP enzymatic activity with respect to the pathophysiology of the disease and to monitor response to interventions, such as therapeutic hypothermia. (biomedcentral.com)
  • Would therapeutic hypothermia be indicated during clipping of this aneurysm? (snacc.org)
  • We performed a systematic review of imaging biomarkers used in randomized controlled trials of acute ischemic stroke, in which a therapeutic intervention was trialed within 48 hours of symptom onset. (ajnr.org)
  • Olsen TS, Weber UJ, Kammersgaard LP: Therapeutic hypothermia for acute stroke. (symptoma.mt)
  • Evidence supporting the use of therapeutic hypothermia after brain ischemia, however, is limited. (symptoma.mt)
  • Therapeutic hypothermia (TH) has been shown to improve survival and neurological outcome in patients resuscitated after out of hospital cardiac arrest (OHCA) from ventricular fibrillation/ventricular tachycardia (VF/VT). (westjem.com)
Abrupt onset2
  • More serious illness develops in 15% of cases and presents with the abrupt onset of general malaise, fever, chills, headache, lower back pain, nausea, and dizziness. (medscape.com)
  • A healthy 26 year-old G3P2 12 weeks pregnant with twins presented to the emergency department after the abrupt onset of palpitations, dizziness, shortness of breath and chest pain. (westjem.com)
Reperfusion5
  • Matrix-metalloproteinase upregulation in ischemia reperfusion can be imaged acutely in-vivo with NIRF using MMPSense750. (biomedcentral.com)
  • The objective of the present study was to determine whether an alternate MMP activatable probe with a shorter optical imaging time, MMPSense ™ 750 FAST (MMPSense750), could be used for visualization of MMP activity in the early stages of ischemia reperfusion in a mouse model of stroke. (biomedcentral.com)
  • Ischemia and reperfusion can cause serious brain damage in stroke or cardiac arrest. (benbest.com)
  • Cryonics patients frequently experience ischemic & reperfusion injury between the time when the heart stops and cryostorage begins. (benbest.com)
  • To determine if ED activation of interventional cardiology could significantly improve reperfusion times and reach the ACC/AHA target of 90 minutes or less in a safety net hospital, a Level I trauma center and teaching hospital serving primarily uninsured and underinsured patient population with door-to-balloon times ranking in the lowest quartile of United States hospitals. (westjem.com)
Cerebral8
  • We used an in vitro model of cerebral ischemia (oxygen-glucose deprivation) to examine changes in [Cl - ] i and GABA A receptor-mediated responses in hippocampal slices from adult rats. (jneurosci.org)
  • Transient cerebral ischemia induces a cascade of cellular events that eventually produces neuronal death, especially in vulnerable areas such as the hippocampus. (jneurosci.org)
  • One of the first consequences of oxygen and glucose deprivation during cerebral ischemia is membrane depolarization, the rapid depletion of cellular ATP, and the accumulation of extracellular excitatory amino acids. (jneurosci.org)
  • In contrast, if anoxia is prolonged or if adult hippocampal slices are subjected to OGD under conditions that model cerebral ischemia, in vivo , the loss of synaptic transmission may become irreversible ( Zhu and Krnjević, 1999 ). (jneurosci.org)
  • Specifically, the gelatinases MMP-2 and MMP-9 have previously been considered to specifically injure the important components of the basal lamina around the cerebral blood vessels that precede microvascular damage in cerebral ischemia [ 1 ]. (biomedcentral.com)
  • How does delayed cerebral ischemia present? (snacc.org)
  • Delayed cerebral ischemia can manifest after a successful operation for securing the aneurysm and patients at risk require monitoring for this complication in the post-operative period. (snacc.org)
  • Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)
Cardiac arrest2
  • Phase 3: The Metabolic Phase - 10+ minutes post cardiac arrest Around the 10 minute mark, cellular ischemia, or lack of oxygen, begins turning into cellular death. At this point, increasing circulation has little effect, and according to some reports, may have adverse effects. (cprcertificationonlinehq.com)
  • Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)
Acute5
  • Therefore, over the past several years, research has been directed to limit the brain lesions produced by acute ischemia (neuroprotection) and to increase the recovery, plasticity and neuroregenerative processes that complement rehabilitation and enhance the possibility of recovery and return to normal functions (neurorepair). (mdpi.com)
  • At least a half-dozen times per year, an acute care physician sends me an ECG demonstrating a regular monomorphic wide complex tachycardia (WCT), asking me for my thoughts about the diagnosis. (medscape.com)
  • Thus, symptom onset in stroke patients is acute. (symptoma.mt)
  • A previously healthy 38-year-old woman, with no significant past medical history, presented to the emergency department with acute onset of weakness after outpatient sclerotherapy. (westjem.com)
  • Twenty minutes after completion of the procedure, she had acute onset of right upper and lower extremity weakness. (westjem.com)
Tachycardia2
Neuronal death2
  • Recently, more attention has been focused on changes in intracellular Cl - and its role in ischemia-induced neuronal death. (jneurosci.org)
  • Neurons are unable to tolerate oxygen and glucose deficiency for prolonged periods of time and neuronal death ensues shortly afterwards. (symptoma.mt)
Myocardial3
  • Myocardial ischemia and bradycardia," added the goggles through his earbud. (edwardterry.co.uk)
  • Patients with known coronary artery disease undergoing surgery should be monitored for evidence of myocardial ischemia and provided therapy to prevent and treat ischemia in the perioperative period. (medscape.com)
  • Many centers are switching to normothermic CPB because of shorter CPB and operating room times and improved myocardial protection. (asahq.org)
Accidental2
  • Hypothermia occurs when the core temperature of the body falls below 95 °F.7 The most common mechanisms of accidental hypothermia are convective heat loss to cold air and conductive heat loss to water. (health.mil)
  • Accidental hypothermia and impaired temperature homoeostasis in the elderly. (symptoma.mt)
Occurs3
  • In vivo , diazepam is neuroprotective when given early after ischemia, although the mechanism by which this occurs is not well understood. (jneurosci.org)
  • [ 7 ] Hypothermia occurs commonly in drowning and is usually secondary to conductive heat loss during submersion, not synonymous with cold-water drowning. (medscape.com)
  • It usually occurs between the second and fourth day after the onset of stroke symptoms [6] and possibly involves an exacerbation of neurological deficits. (symptoma.mt)
Organ2
  • This process clinically presents as a combination of a bleeding diathesis and organ ischemia secondary to fibrin deposition throughout the microcirculation. (medscape.com)
  • Organ ischemia, which primarily affects the kidneys and central nervous system, leads to altered mental status and/or signs of volume overload. (medscape.com)
Metabolic2
  • Metabolic acidosis and hyperkalemia may occur if hypothermia is prolonged. (wildliferesearch.com)
  • In times of high metabolic demand and adequate availability of oxygen, elevated calcium in mitochondria can increase ATP production by stimulation of three enzymes in the Krebs citric acid cycle: pyruvate dehydrogenase, alpha-ketoglutarate and isocitrate dehydrogenase. (benbest.com)
Hypoglycemia1
  • The result is a rapid decline in food intake, which can result in hypoglycemia and dehydration, factors that further predispose the otter to hypothermia. (wildliferesearch.com)
Physiological2
  • Peripheral vasoconstriction and shivering are frequent physiological manifestations of mild hypothermia as core temperature declines to 32°C (90°F). At lower core temperatures, hyporeflexia, stupor, cessation of shivering, and muscle rigidity become evident (Knochel, 1985). (wildliferesearch.com)
  • Neuroprotective mechanisms, mainly the blood-brain barrier, reduce neuronal firing in response to ischemia (a common physiological cause of unresponsiveness at the end of life), which could protect the brain from irreversible brain damage under these conditions 14 . (nature.com)
Rectal2
  • The neurologic examination suggested a L4-S3 myelopathy, but physical examination revealed lack of femoral pulses and rectal hypothermia, as well as a grade II/VI systolic heart murmur, so ischemic neuromyopathy was suspected. (hindawi.com)
  • On physical examination, the patient had rectal hypothermia at 26.4°C, with a euthermic axillary temperature of 37.7°C. The quality of femoral pulses was decreased, and the distal pelvic limbs were cool to the touch. (hindawi.com)
Temperature3
  • For most mammals, hypothermia is defined as a core temperature less than 35°C (95°F) (Knochel, 1985). (wildliferesearch.com)
  • The human physiologic response to cold exposure is to retard heat loss and preserve core body temperature, but this response may not be sufficient to prevent hypothermia if heat loss is prolonged. (health.mil)
  • Body temperature (BT) can increase by an average of 1℃ or more as early as 4-8 hours from onset of infarction, and it usually resolves after 4-5 days [ 4 ]. (e-jmls.org)
Resolves1
Primarily2
  • The term cold weather injuries is used to describe injuries that have a central effect, such as hypothermia, as well as injuries that primarily affect the peripheries of the body, such as frostbite and immersion injuries. (health.mil)
  • Ischemia primarily affects the kidneys and central nervous system leading to altered mental status and/or signs of volume overload (jugular venous distension, presence of rales, and S 3 gallop, or edema). (medscape.com)
Tissues2
  • Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
  • 9 Moreover, the response includes constriction of the peripheral (superficial) vascular system, which may result in non-freezing injuries or hasten the onset of actual freezing of tissues (frostbite). (health.mil)
Vitro1
  • The accumulation of Na + and Ca 2+ during ischemia or oxygen-glucose deprivation (OGD), an in vitro model for transient global ischemia, has been investigated extensively. (jneurosci.org)
Severe2
Headache1
  • She was in her usual state of health at work when she had a sudden onset of headache and nausea and lost consciousness and collapsed. (snacc.org)
Stroke1
Physical1
  • Bad reactions are common particularly with first time users, particularly in the face of physical exertion. (vin.com)
Cellular1
Symptoms2
Clinical1
Weakness1
  • In the video, The Village People's iconic 1970's hit 'Y.M.C.A.' refreshes its lyrics to"F.A.S.T.," a memory aid that stands for face drooping, arm weakness , speech difficulty, and time to call 911. (symptoma.mt)
Profound1
  • This can be a profound and spiritual time for families, but it is currently unknown whether unresponsive patients are aware of the touch or words of their loved ones. (nature.com)
Brain3
  • A closely related disease to brain ischemia is brain hypoxia. (symptoma.mt)
  • Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)
  • We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)
Treatment2
  • Despite the advent of hypothermia therapy for the treatment of hypoxic-ischemic encephalopathy (HIE), treatment options following asphyxia at birth remain limited, particularly in low-resource settings where the incidence of birth asphyxia is highest. (frontiersin.org)
  • Restoring the patient to a normal physiologic state requires careful attention to the prevention, identification, and treatment of complications that may develop at any time during the hospital stay. (thoracickey.com)
Heart1
Common1
  • Common causes of diastolic dysfunction are cardiac ischemia, LVH, and infiltrative diseases. (umaryland.edu)
Studies2
  • An increase in intracellular Ca 2+ is well established, but there are few studies of changes in intracellular Cl - ([Cl - ] i ) after ischemia. (jneurosci.org)
  • This could explain the discrepancies between the above-cited human studies [9-12] concerning the relation between MAP and renal function as they included patients regardless of the existence or not of AKI at the time of inclusion. (igfprotein.com)
Death1
Patients1
  • In more critically ill patients who may require an additional period of ventilatory or pharmacologic support, adherence to these time‐related recommendations may need to be modified, and withdrawal of "intensive care" must be carefully evaluated and not rushed. (thoracickey.com)
Leads1
  • What is the time frame that leads to the best patient outcome for securing intracranial aneurysms? (snacc.org)
Minutes1
  • Within two minutes of ischemia, extracellular pH can drop from about 7.3 to about 6.7. (benbest.com)
Period1
  • Beta-blockers provide the single best therapy for prevention of ischemia during the perioperative period. (medscape.com)
Dose2
  • That's 8-times the normal dose than a typical albuterol neb (one of those albuterol "bullets" has 2.5 mg in 3 cc of solution, so a 20 mg dose would be 24 cc of the albuterol solution). (umaryland.edu)
  • the oral lethal dose is generally 2 to 4 times higher. (vin.com)
Signs1