Loading...
  • neuroprotective
  • Different from most neuroprotective drugs that usually target only one mechanism, hypothermia therapy has the advantage of global protection on all cell types and tissues in both gray and white matters. (grantome.com)
  • The comprehensive neuroprotective effects of clinically feasible hypothermia therapy will be studied in two different stroke models, which will facilitate the translation of the therapy to clinical applications. (grantome.com)
  • temperature
  • 1. Ischemia induces opening of the blood-brain barrier, a process that seems to be very sensitive to brain temperature . (google.com)
  • Hypothermia as much as 10 C. at an ambient temperature of 20 C. is possible, with complete recovery and few, if any, side effects. (google.com)
  • Latency shifts could be reversed in hypothyroid animals by increasing the external heat source, and conversely, synaptic delays could be induced in control animals by removing the heat source with a consequent drop in body and brain temperature. (epa.gov)
  • The mechanism of protection appears to involve their ability to cross the blood brain barrier, bind to the NT receptor as agonists, and reduce the """"""""set point"""""""" of the central temperature control so that systemic hypothermia in the absence of shivering is promoted. (grantome.com)
  • Its features include normothermia management, controls induced hypothermia and provides precise re-warming, real time dynamic feedback loop from patient to machine, proprietary temperature management algorithms and it supports of wide range of perioperative procedures, both in the paediatric and adult settings. (freethesaurus.com)
  • This dissertation investigates the temperature in the torso and head during selective hypothermia using a cooling pad . (umbc.edu)
  • During mild hypothermia , the temperature on the back and in the spine is reduced by 8.76 +/- 0.31�C and 6.67 +/- 0.1�C , respectively . (umbc.edu)
  • 0.25°C/hour) till core temperature 36.5°C. To avoid shivering, we use sedatives and neuromuscular blocking agents during the therapeutic hypothermia. (clinicaltrials.gov)
  • neuroprotection
  • Inflammatory cytokines are involved in dihydrocapsaicin (DHC) and regional cooling infusion (RCI)-induced neuroprotection in ischemic rat. (bioportfolio.com)
  • More importantly, these findings led to the realization that hypothermia-induced neuroprotection is not only limited to decreased oxygen and glucose demands, but the mechanisms involved are indeed much more intricate. (springeropen.com)
  • ketamine-induced
  • RESULTS: We find that urethane- and ketamine-induced anaesthesia results in rapid activation of the phosphatidylinositol (PI) 3-kinase-protein kinase B (PKB) signalling pathway in the brain, increases tau phosphorylation while at the same time reducing basal activity of the Ras-ERK pathway. (ulster.ac.uk)
  • stroke patients
  • Re- lease of excitotoxic neurotransmitters might also cause progressive neuronal death in the penumbra in stroke patients , and hypothermia after cerebral ischemia could attenuate this process. (google.com)
  • Several important limitations, however, have precluded the widespread use of hypothermia therapy in stroke patients. (grantome.com)
  • This investigation will develop a chemical-induced hypothermia therapy for stroke patients. (grantome.com)
  • induction
  • During induction phase of hypothermia [ 10 ], decreasing serum levels of magnesium are warranted with high risk of arterial spasm due to higher intracellular levels of calcium in smooth muscle fibers. (clinmedjournals.org)
  • analgesia
  • The present study expanded the situational determinants by examining whether lesions placed in the amygdala altered analgesia or hypothermia elicited by exposure to either continuous (CCWS) or intermittent (ICWS) cold-water swims. (naver.com)
  • To avoid patient distress, administer in conjunction with adequate analgesia and sedation, and only after unconsciousness has been induced. (drugs.com)
  • attenuates
  • This is evident from studies of tracers and their migration across the blood-brain barrier, in which hypothermia attenuates extravasation several hours after ischemia and prevents vasogenic oedema . (google.com)
  • consistent
  • Minor increases infield potential EPSP slope, decreases in PS amplitudes, and increased latencies are consistent with previous reports of hypothermia. (epa.gov)